Published in Am J Trop Med Hyg on April 01, 2007
Nonhuman primates are protected from smallpox virus or monkeypox virus challenges by the antiviral drug ST-246. Antimicrob Agents Chemother (2009) 1.52
ST-246 antiviral efficacy in a nonhuman primate monkeypox model: determination of the minimal effective dose and human dose justification. Antimicrob Agents Chemother (2009) 1.45
Comparative analysis of monkeypox virus infection of cynomolgus macaques by the intravenous or intrabronchial inoculation route. J Virol (2010) 1.25
Single-dose safety and pharmacokinetics of ST-246, a novel orthopoxvirus egress inhibitor. Antimicrob Agents Chemother (2008) 1.24
In vitro efficacy of ST246 against smallpox and monkeypox. Antimicrob Agents Chemother (2008) 1.19
ST-246 inhibits in vivo poxvirus dissemination, virus shedding, and systemic disease manifestation. Antimicrob Agents Chemother (2009) 1.07
Effective antiviral treatment of systemic orthopoxvirus disease: ST-246 treatment of prairie dogs infected with monkeypox virus. J Virol (2011) 1.05
Roles of vaccinia virus genes E3L and K3L and host genes PKR and RNase L during intratracheal infection of C57BL/6 mice. J Virol (2010) 1.04
Efficacy of ST-246 versus lethal poxvirus challenge in immunodeficient mice. Proc Natl Acad Sci U S A (2009) 1.03
A review of experimental and natural infections of animals with monkeypox virus between 1958 and 2012. Future Virol (2013) 1.01
Immune responses to the smallpox vaccine given in combination with ST-246, a small-molecule inhibitor of poxvirus dissemination. Vaccine (2007) 0.98
Update on new antivirals under development for the treatment of double-stranded DNA virus infections. Clin Pharmacol Ther (2010) 0.97
Safety and pharmacokinetics of the antiorthopoxvirus compound ST-246 following repeat oral dosing in healthy adult subjects. Antimicrob Agents Chemother (2010) 0.91
Identification of polymerase and processivity inhibitors of vaccinia DNA synthesis using a stepwise screening approach. Antiviral Res (2008) 0.91
Cowpox virus infection of cynomolgus macaques as a model of hemorrhagic smallpox. Virology (2011) 0.90
Principles of antidote pharmacology: an update on prophylaxis, post-exposure treatment recommendations and research initiatives for biological agents. Br J Pharmacol (2010) 0.89
Monkeypox virus infections in small animal models for evaluation of anti-poxvirus agents. Viruses (2010) 0.87
Efficacy of tecovirimat (ST-246) in nonhuman primates infected with variola virus (Smallpox). Antimicrob Agents Chemother (2013) 0.85
The effects of post-exposure smallpox vaccination on clinical disease presentation: addressing the data gaps between historical epidemiology and modern surrogate model data. Vaccine (2013) 0.84
Development of ST-246® for Treatment of Poxvirus Infections. Viruses (2010) 0.84
Comparison of the safety and pharmacokinetics of ST-246® after i.v. infusion or oral administration in mice, rabbits and monkeys. PLoS One (2011) 0.83
Historical perspectives in the development of antiviral agents against poxviruses. Viruses (2010) 0.83
Unusual features of vaccinia virus extracellular virion form neutralization resistance revealed in human antibody responses to the smallpox vaccine. J Virol (2012) 0.82
Development of the small-molecule antiviral ST-246 as a smallpox therapeutic. Future Virol (2011) 0.82
Pharmacokinetic comparison of a single oral dose of polymorph form i versus form V capsules of the antiorthopoxvirus compound ST-246 in human volunteers. Antimicrob Agents Chemother (2012) 0.79
Application of the Ibis-T5000 pan-Orthopoxvirus assay to quantitatively detect monkeypox viral loads in clinical specimens from macaques experimentally infected with aerosolized monkeypox virus. Am J Trop Med Hyg (2010) 0.78
Use of a recombinant vaccinia virus expressing interferon gamma for post-exposure protection against vaccinia and ectromelia viruses. PLoS One (2013) 0.77
Discovery and development of antiviral drugs for biodefense: experience of a small biotechnology company. Antiviral Res (2007) 0.76
Pharmacokinetics and interspecies allometric scaling of ST-246, an oral antiviral therapeutic for treatment of orthopoxvirus infection. PLoS One (2013) 0.75
Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia. Virology (2016) 0.75
Laboratory Investigations of African Pouched Rats (Cricetomys gambianus) as a Potential Reservoir Host Species for Monkeypox Virus. PLoS Negl Trop Dis (2015) 0.75
Small particle aerosol inoculation of cowpox Brighton Red in rhesus monkeys results in a severe respiratory disease. Virology (2015) 0.75
Pharmacokinetic and pharmacodynamic modeling to determine the dose of ST-246 to protect against smallpox in humans. Antimicrob Agents Chemother (2012) 0.75
Probable non-vector-borne transmission of Zika virus, Colorado, USA. Emerg Infect Dis (2011) 6.06
Genetic characterization of Zika virus strains: geographic expansion of the Asian lineage. PLoS Negl Trop Dis (2012) 5.31
Molecular viral oncology of hepatocellular carcinoma. Oncogene (2003) 3.58
An orally bioavailable antipoxvirus compound (ST-246) inhibits extracellular virus formation and protects mice from lethal orthopoxvirus Challenge. J Virol (2005) 3.36
Persistent infection with West Nile virus years after initial infection. J Infect Dis (2010) 3.33
Phylogenetic analysis of North American West Nile virus isolates, 2001-2004: evidence for the emergence of a dominant genotype. Virology (2005) 3.14
Zika virus infection, Cambodia, 2010. Emerg Infect Dis (2012) 3.07
Visualizing hepatitis C virus infections in human liver by two-photon microscopy. Gastroenterology (2009) 3.07
Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus. Gastroenterology (2002) 3.02
A novel rhabdovirus associated with acute hemorrhagic fever in central Africa. PLoS Pathog (2012) 2.63
Persistent shedding of West Nile virus in urine of experimentally infected hamsters. Am J Trop Med Hyg (2005) 2.60
Limited evolution of West Nile virus has occurred during its southwesterly spread in the United States. Virology (2003) 2.59
West Nile virus in Mexico: evidence of widespread circulation since July 2002. Emerg Infect Dis (2003) 2.27
APRI: an easy and validated predictor of hepatic fibrosis in chronic hepatitis C. J Clin Gastroenterol (2006) 2.27
Durable complete response of metastatic gastric cancer with anti-Met therapy followed by resistance at recurrence. Cancer Discov (2011) 2.22
Immunization with heterologous flaviviruses protective against fatal West Nile encephalitis. Emerg Infect Dis (2002) 2.17
Oral GS-5806 activity in a respiratory syncytial virus challenge study. N Engl J Med (2014) 2.07
Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis. Proc Natl Acad Sci U S A (2008) 2.04
Persistent West Nile virus infection in the golden hamster: studies on its mechanism and possible implications for other flavivirus infections. J Infect Dis (2005) 2.03
The 2002 introduction of West Nile virus into Harris County, Texas, an area historically endemic for St. Louis encephalitis. Am J Trop Med Hyg (2004) 2.02
Severe eczema vaccinatum in a household contact of a smallpox vaccinee. Clin Infect Dis (2008) 2.00
Ribonucleoside analogue that blocks replication of bovine viral diarrhea and hepatitis C viruses in culture. Antimicrob Agents Chemother (2003) 1.99
Efficacy of delayed treatment with ST-246 given orally against systemic orthopoxvirus infections in mice. Antimicrob Agents Chemother (2006) 1.92
Phylogeography of West Nile virus: from the cradle of evolution in Africa to Eurasia, Australia, and the Americas. J Virol (2010) 1.88
An animal model for studying the pathogenesis of chikungunya virus infection. Am J Trop Med Hyg (2008) 1.83
Chimeric alphavirus vaccine candidates for chikungunya. Vaccine (2008) 1.78
Emergence of attenuated West Nile virus variants in Texas, 2003. Virology (2004) 1.75
Genome sequence and attenuating mutations in West Nile virus isolate from Mexico. Emerg Infect Dis (2004) 1.73
Genetic variation among temporally and geographically distinct West Nile virus isolates, United States, 2001, 2002. Emerg Infect Dis (2003) 1.71
Pox proteomics: mass spectrometry analysis and identification of Vaccinia virion proteins. Virol J (2006) 1.69
Negevirus: a proposed new taxon of insect-specific viruses with wide geographic distribution. J Virol (2012) 1.67
Efficacy of killed virus vaccine, live attenuated chimeric virus vaccine, and passive immunization for prevention of West Nile virus encephalitis in hamster model. Emerg Infect Dis (2002) 1.64
The vaccinia virus I7L gene product is the core protein proteinase. J Virol (2002) 1.61
Introductions of West Nile virus strains to Mexico. Emerg Infect Dis (2006) 1.61
Genetic divergence and dispersal of yellow fever virus, Brazil. Emerg Infect Dis (2004) 1.60
Molecular epidemiology of group C viruses (Bunyaviridae, Orthobunyavirus) isolated in the Americas. J Virol (2005) 1.60
Endoluminal suturing may overcome the limitations of clip closure of a gaping wide colon perforation (with videos). Gastrointest Endosc (2007) 1.56
Yunnan orbivirus, a new orbivirus species isolated from Culex tritaeniorhynchus mosquitoes in China. J Gen Virol (2005) 1.54
Variation in interferon sensitivity and induction among strains of eastern equine encephalitis virus. J Virol (2005) 1.53
Identification of novel viruses using VirusHunter--an automated data analysis pipeline. PLoS One (2013) 1.53
Nonhuman primates are protected from smallpox virus or monkeypox virus challenges by the antiviral drug ST-246. Antimicrob Agents Chemother (2009) 1.52
Characterization of Culex Flavivirus (Flaviviridae) strains isolated from mosquitoes in the United States and Trinidad. Virology (2009) 1.51
Comparison of the live attenuated yellow fever vaccine 17D-204 strain to its virulent parental strain Asibi by deep sequencing. J Infect Dis (2013) 1.51
Dengue emergence and adaptation to peridomestic mosquitoes. Emerg Infect Dis (2004) 1.50
Evaluation of orally delivered ST-246 as postexposure prophylactic and antiviral therapeutic in an aerosolized rabbitpox rabbit model. Antiviral Res (2008) 1.50
Massilia virus, a novel Phlebovirus (Bunyaviridae) isolated from sandflies in the Mediterranean. Vector Borne Zoonotic Dis (2009) 1.50
Sylvatic dengue virus type 2 activity in humans, Nigeria, 1966. Emerg Infect Dis (2008) 1.49
Host feeding pattern of Culex quinquefasciatus (Diptera: Culicidae) and its role in transmission of West Nile virus in Harris County, Texas. Am J Trop Med Hyg (2007) 1.48
Endemic Venezuelan equine encephalitis in northern Peru. Emerg Infect Dis (2004) 1.47
ST-246 antiviral efficacy in a nonhuman primate monkeypox model: determination of the minimal effective dose and human dose justification. Antimicrob Agents Chemother (2009) 1.45
Evaluation of the aspartate aminotransferase/platelet ratio index and enhanced liver fibrosis tests to detect significant fibrosis due to chronic hepatitis C. J Clin Gastroenterol (2014) 1.44
Experimental infection of ground squirrels (Spermophilus tridecemlineatus) with monkeypox virus. Emerg Infect Dis (2004) 1.43
Characterization of the Bhanja serogroup viruses (Bunyaviridae): a novel species of the genus Phlebovirus and its relationship with other emerging tick-borne phleboviruses. J Virol (2013) 1.43
Experimental transmission of Mayaro virus by Aedes aegypti. Am J Trop Med Hyg (2011) 1.42
Quaranfil, Johnston Atoll, and Lake Chad viruses are novel members of the family Orthomyxoviridae. J Virol (2009) 1.40
Arcuate line of the rectus sheath: clinical approach. Anat Sci Int (2008) 1.39
The genome of Yoka poxvirus. J Virol (2011) 1.39
Identification and characterization of potent small molecule inhibitor of hemorrhagic fever New World arenaviruses. Antiviral Res (2005) 1.38
Comment on "a new device for cricothyroidotomy". Clin Anat (2006) 1.38
Synergistic efficacy of the combination of ST-246 with CMX001 against orthopoxviruses. Antimicrob Agents Chemother (2007) 1.38
Endemic eastern equine encephalitis in the Amazon region of Peru. Am J Trop Med Hyg (2007) 1.38
Potential role of sylvatic and domestic African mosquito species in dengue emergence. Am J Trop Med Hyg (2005) 1.36
Metabolism of 3'-deoxy-3'-[F-18]fluorothymidine in proliferating A549 cells: validations for positron emission tomography. Nucl Med Biol (2004) 1.34
Induction of severe disease in hamsters by two sandfly fever group viruses, Punta toro and Gabek Forest (Phlebovirus, Bunyaviridae), similar to that caused by Rift Valley fever virus. Am J Trop Med Hyg (2003) 1.33
Nyamanini and midway viruses define a novel taxon of RNA viruses in the order Mononegavirales. J Virol (2009) 1.33
Genetic relationships among Mayaro and Una viruses suggest distinct patterns of transmission. Am J Trop Med Hyg (2006) 1.33
West Nile Virus isolation in human and mosquitoes, Mexico. Emerg Infect Dis (2005) 1.32
Monitoring tumor cell proliferation by targeting DNA synthetic processes with thymidine and thymidine analogs. J Nucl Med (2003) 1.32
Systemic distribution of West Nile virus infection: postmortem immunohistochemical study of six cases. Brain Pathol (2007) 1.30
Hepatic iron overload induces hepatocellular carcinoma in transgenic mice expressing the hepatitis C virus polyprotein. Gastroenterology (2006) 1.29
Year-round West Nile virus activity, Gulf Coast region, Texas and Louisiana. Emerg Infect Dis (2004) 1.28
Experimental infection of prairie dogs with monkeypox virus. Emerg Infect Dis (2005) 1.28
Colorectal papillomavirus infection in patients with colorectal cancer. Clin Cancer Res (2005) 1.27
Biting rates and developmental substrates for biting midges (Diptera: Ceratopogonidae) in Iquitos, Peru. J Med Entomol (2003) 1.26
Characterization of a novel Negevirus and a novel Bunyavirus isolated from Culex (Culex) declarator mosquitoes in Trinidad. J Gen Virol (2013) 1.26
Biological and phylogenetic characterization of pigeon paramyxovirus serotype 1 circulating in wild North American pigeons and doves. J Clin Microbiol (2008) 1.25
Acute spotted fever rickettsiosis among febrile patients, Cameroon. Emerg Infect Dis (2004) 1.25
Experimental infection of rhesus macaques with West Nile virus: level and duration of viremia and kinetics of the antibody response after infection. J Infect Dis (2004) 1.25
Expression of adiponectin and its receptors in livers of morbidly obese patients with non-alcoholic fatty liver disease. J Gastroenterol Hepatol (2008) 1.24
Single-dose safety and pharmacokinetics of ST-246, a novel orthopoxvirus egress inhibitor. Antimicrob Agents Chemother (2008) 1.24
Identification of a broad-spectrum arenavirus entry inhibitor. J Virol (2008) 1.23
Exogenous ACE2 expression allows refractory cell lines to support severe acute respiratory syndrome coronavirus replication. J Virol (2005) 1.22
Vaccination of BALB/c mice with Escherichia coli-expressed vaccinia virus proteins A27L, B5R, and D8L protects mice from lethal vaccinia virus challenge. J Virol (2008) 1.22
NS1 protein secretion during the acute phase of West Nile virus infection. J Virol (2005) 1.22
Preparation and immunogenic properties of a recombinant West Nile subunit vaccine. Vaccine (2006) 1.21