Published in J Virol on October 13, 2010
Interferon-stimulated genes: roles in viral pathogenesis. Curr Opin Virol (2014) 1.22
Myxoma virus protein M029 is a dual function immunomodulator that inhibits PKR and also conscripts RHA/DHX9 to promote expanded host tropism and viral replication. PLoS Pathog (2013) 0.97
CD8 T cells use IFN-γ to protect against the lethal effects of a respiratory poxvirus infection. J Immunol (2014) 0.90
Comparative analysis of poxvirus orthologues of the vaccinia virus E3 protein: modulation of protein kinase R activity, cytokine responses, and virus pathogenicity. J Virol (2011) 0.90
Genomic Analysis, Phenotype, and Virulence of the Historical Brazilian Smallpox Vaccine Strain IOC: Implications for the Origins and Evolutionary Relationships of Vaccinia Virus. J Virol (2015) 0.89
Natural Killer Cells and Innate Interferon Gamma Participate in the Host Defense against Respiratory Vaccinia Virus Infection. J Virol (2015) 0.84
Host-range restriction of vaccinia virus E3L deletion mutant can be overcome in vitro, but not in vivo, by expression of the influenza virus NS1 protein. PLoS One (2011) 0.82
Essential role of protein kinase R antagonism by TRS1 in human cytomegalovirus replication. Virology (2015) 0.81
Knockout of the Host Resistance Gene Pkr Fully Restores Replication of Murine Cytomegalovirus m142 and m143 Mutants In Vivo. J Virol (2015) 0.79
Recombinant modified vaccinia virus Ankara generating excess early double-stranded RNA transiently activates protein kinase R and triggers enhanced innate immune responses. J Virol (2014) 0.78
Virus infection rapidly activates the P58(IPK) pathway, delaying peak kinase activation to enhance viral replication. Virology (2011) 0.78
The NYCBH vaccinia virus deleted for the innate immune evasion gene, E3L, protects rabbits against lethal challenge by rabbitpox virus. Vaccine (2011) 0.77
Deletion of Fifteen Open Reading Frames from Modified Vaccinia Virus Ankara Fails to Improve Immunogenicity. PLoS One (2015) 0.77
Regulation of PACT-Mediated Protein Kinase Activation by the OV20.0 Protein of Orf Virus. J Virol (2015) 0.76
Genomic expression libraries for the identification of cross-reactive orthopoxvirus antigens. PLoS One (2011) 0.76
Variola virus E3L Zα domain, but not its Z-DNA binding activity, is required for PKR inhibition. RNA (2013) 0.76
The Interferon-Inducible Mouse Apolipoprotein L9 and Prohibitins Cooperate to Restrict Theiler's Virus Replication. PLoS One (2015) 0.75
An efficient method for generating poxvirus recombinants in the absence of selection. Viruses (2011) 0.75
Suppression of NYVAC Infection in HeLa Cells Requires RNase L but Is Independent of Protein Kinase R Activity. J Virol (2015) 0.75
An Evolutionary View of the Arms Race between Protein Kinase R and Large DNA Viruses. J Virol (2016) 0.75
How cells respond to interferons. Annu Rev Biochem (1998) 24.27
Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell (2000) 17.44
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature (2007) 13.56
Antiviral actions of interferons. Clin Microbiol Rev (2001) 13.06
Interferon-inducible antiviral effectors. Nat Rev Immunol (2008) 9.68
Viruses and interferon: a fight for supremacy. Nat Rev Immunol (2002) 7.92
Innate immunity to virus infection. Immunol Rev (2009) 7.04
Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase. EMBO J (1995) 6.94
Gene-specific regulation by general translation factors. Cell (2002) 6.05
PKR; a sentinel kinase for cellular stress. Oncogene (1999) 5.29
The E3L gene of vaccinia virus encodes an inhibitor of the interferon-induced, double-stranded RNA-dependent protein kinase. Proc Natl Acad Sci U S A (1992) 4.74
Translational control in the endoplasmic reticulum stress response. J Clin Invest (2002) 4.56
The interferon response circuit: induction and suppression by pathogenic viruses. Virology (2006) 4.56
Interferon action and apoptosis are defective in mice devoid of 2',5'-oligoadenylate-dependent RNase L. EMBO J (1997) 4.53
Expression cloning of 2-5A-dependent RNAase: a uniquely regulated mediator of interferon action. Cell (1993) 4.10
Interferon signalling network in innate defence. Cell Microbiol (2006) 3.90
The dsRNA protein kinase PKR: virus and cell control. Biochimie (2007) 3.67
Interferon action in triply deficient mice reveals the existence of alternative antiviral pathways. Virology (1999) 3.44
Isolation and preliminary characterization of temperature-sensitive mutants of vaccinia virus. Virology (1981) 3.43
The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion. Cytokine Growth Factor Rev (2001) 3.34
Isolation, characterization, and physical mapping of temperature-sensitive mutants of vaccinia virus. Virology (1983) 3.33
The eIF-2 alpha protein kinases, regulators of translation in eukaryotes from yeasts to humans. J Biol Chem (1993) 3.18
PKR and RNase L contribute to protection against lethal West Nile Virus infection by controlling early viral spread in the periphery and replication in neurons. J Virol (2006) 3.13
Viral encounters with 2',5'-oligoadenylate synthetase and RNase L during the interferon antiviral response. J Virol (2007) 3.04
Both carboxy- and amino-terminal domains of the vaccinia virus interferon resistance gene, E3L, are required for pathogenesis in a mouse model. J Virol (2001) 2.73
Vaccinia virus-encoded eIF-2 alpha homolog abrogates the antiviral effect of interferon. Virology (1991) 2.63
Mechanism of interferon action: identification of a RNA binding domain within the N-terminal region of the human RNA-dependent P1/eIF-2 alpha protein kinase. Virology (1992) 2.42
Blockade of interferon induction and action by the E3L double-stranded RNA binding proteins of vaccinia virus. J Virol (2002) 2.37
Structure and function of the protein kinase R. Curr Top Microbiol Immunol (2007) 2.34
Regulation of protein synthesis by the heme-regulated eIF2alpha kinase: relevance to anemias. Blood (2007) 2.33
Identification of a conserved motif that is necessary for binding of the vaccinia virus E3L gene products to double-stranded RNA. Virology (1993) 2.24
Protein kinase R reveals an evolutionary model for defeating viral mimicry. Nature (2008) 2.13
A role for Z-DNA binding in vaccinia virus pathogenesis. Proc Natl Acad Sci U S A (2003) 2.07
Recombinant vaccinia virus K3L gene product prevents activation of double-stranded RNA-dependent, initiation factor 2 alpha-specific protein kinase. J Biol Chem (1993) 2.04
Vaccinia virus immune evasion. Immunol Rev (1997) 2.03
Ectromelia virus: the causative agent of mousepox. J Gen Virol (2005) 1.99
Pathological integrin signaling enhances proliferation of primary lung fibroblasts from patients with idiopathic pulmonary fibrosis. J Exp Med (2008) 1.93
Efficacy of delayed treatment with ST-246 given orally against systemic orthopoxvirus infections in mice. Antimicrob Agents Chemother (2006) 1.92
Bioluminescence imaging of vaccinia virus: effects of interferon on viral replication and spread. Virology (2005) 1.89
Efficacy of the antipoxvirus compound ST-246 for treatment of severe orthopoxvirus infection. Am J Trop Med Hyg (2007) 1.86
The role of the PKR-inhibitory genes, E3L and K3L, in determining vaccinia virus host range. Virology (2002) 1.76
Rescue of vaccinia virus lacking the E3L gene by mutants of E3L. J Virol (1995) 1.70
Distinct gene expression profiling after infection of immature human monocyte-derived dendritic cells by the attenuated poxvirus vectors MVA and NYVAC. J Virol (2007) 1.68
Respiratory infection of mice with vaccinia virus. J Gen Virol (1967) 1.67
Regulation of the protein kinase PKR by the vaccinia virus pseudosubstrate inhibitor K3L is dependent on residues conserved between the K3L protein and the PKR substrate eIF2alpha. Mol Cell Biol (1997) 1.67
Microarray analysis reveals characteristic changes of host cell gene expression in response to attenuated modified vaccinia virus Ankara infection of human HeLa cells. J Virol (2004) 1.65
Induction of natural killer cell responses by ectromelia virus controls infection. J Virol (2007) 1.62
Host-range restriction of vaccinia virus E3L-specific deletion mutants. Virus Genes (1996) 1.53
PERK and PKR: old kinases learn new tricks. Cell Cycle (2008) 1.45
Loss of protein kinase PKR expression in human HeLa cells complements the vaccinia virus E3L deletion mutant phenotype by restoration of viral protein synthesis. J Virol (2007) 1.45
Complementation of vaccinia virus deleted of the E3L gene by mutants of E3L. Virology (1997) 1.44
Neonatal intraperitoneal or intravenous injections of recombinant adeno-associated virus type 8 transduce dorsal root ganglia and lower motor neurons. Hum Gene Ther (2008) 1.42
A scientific journey through the 2-5A/RNase L system. Cytokine Growth Factor Rev (2007) 1.42
A poxvirus protein forms a complex with left-handed Z-DNA: crystal structure of a Yatapoxvirus Zalpha bound to DNA. Proc Natl Acad Sci U S A (2004) 1.39
Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors. Nat Struct Mol Biol (2008) 1.38
Dermal infection with vaccinia virus reveals roles for virus proteins not seen using other inoculation routes. J Gen Virol (2002) 1.36
Distinct patterns of IFN sensitivity observed in cells infected with vaccinia K3L- and E3L- mutant viruses. Virology (1995) 1.36
Mechanism of interferon action: structure of the mouse PKR gene encoding the interferon-inducible RNA-dependent protein kinase. Proc Natl Acad Sci U S A (1994) 1.31
Evidence that vaccinia virulence factor E3L binds to Z-DNA in vivo: Implications for development of a therapy for poxvirus infection. Proc Natl Acad Sci U S A (2004) 1.30
Interferon-induced and double-stranded RNA-activated enzymes: a specific protein kinase and 2',5'-oligoadenylate synthetases. J Interferon Res (1991) 1.26
Microarray analysis of A549 cells infected with rabbitpox virus (RPV): a comparison of wild-type RPV and RPV deleted for the host range gene, SPI-1. Virology (2003) 1.23
On the discovery of interferon-inducible, double-stranded RNA activated enzymes: the 2'-5'oligoadenylate synthetases and the protein kinase PKR. Cytokine Growth Factor Rev (2007) 1.22
Molecular framework for the activation of RNA-dependent protein kinase. J Biol Chem (2007) 1.21
X-ray crystal structure and functional analysis of vaccinia virus K3L reveals molecular determinants for PKR subversion and substrate recognition. Mol Cell (2002) 1.18
Fascination with 2-5A-dependent RNase: a unique enzyme that functions in interferon action. J Interferon Res (1994) 1.17
Vaccinia virus subverts a mitochondrial antiviral signaling protein-dependent innate immune response in keratinocytes through its double-stranded RNA binding protein, E3. J Virol (2008) 1.16
Mutational analysis of the RNA triphosphatase component of vaccinia virus mRNA capping enzyme. J Virol (1996) 1.12
The kinase insert domain of interferon-induced protein kinase PKR is required for activity but not for interaction with the pseudosubstrate K3L. J Biol Chem (1996) 1.10
The effects of serpin gene mutations on the distinctive pathobiology of cowpox and rabbitpox virus following intranasal inoculation of Balb/c mice. Virology (1993) 1.10
The N-terminal domain of the vaccinia virus E3L-protein is required for neurovirulence, but not induction of a protective immune response. Virology (2005) 1.09
Surviving mousepox infection requires the complement system. PLoS Pathog (2008) 1.07
Homologous regions of the alpha subunit of eukaryotic translational initiation factor 2 (eIF2alpha) and the vaccinia virus K3L gene product interact with the same domain within the dsRNA-activated protein kinase (PKR). Eur J Biochem (1997) 1.07
Mousepox in the C57BL/6 strain provides an improved model for evaluating anti-poxvirus therapies. Virology (2008) 1.03
Vaccinia viruses with mutations in the E3L gene as potential replication-competent, attenuated vaccines: intra-nasal vaccination. Vaccine (2007) 1.02
Protective effect of Toll-like receptor 4 in pulmonary vaccinia infection. PLoS Pathog (2008) 1.02
Mousepox in inbred mice innately resistant or susceptible to lethal infection with ectromelia virus. V. Genetics of resistance to the Moscow strain. Arch Virol (1989) 0.97
The role of the cowpox virus crmA gene during intratracheal and intradermal infection of C57BL/6 mice. Virology (2008) 0.94
Poxvirus immune modulators: functional insights from animal models. Virus Res (2002) 0.94
Chromosome mapping of Rmp-4, a gonad-dependent gene encoding host resistance to mousepox. J Virol (1995) 0.92
Protein kinase PKR mutants resistant to the poxvirus pseudosubstrate K3L protein. Proc Natl Acad Sci U S A (2008) 0.91
Attenuation of B5R mutants of rabbitpox virus in vivo is related to impaired growth and not an enhanced host inflammatory response. Virology (1997) 0.89
Vaccinia virus protein C16 acts intracellularly to modulate the host response and promote virulence. J Gen Virol (2008) 0.89
Modulation of gene expression in a human cell line caused by poliovirus, vaccinia virus and interferon. Virol J (2007) 0.82
Microarray assay for evaluation of the genetic stability of modified vaccinia virus Ankara B5R gene. J Med Virol (2007) 0.78
Normal breast tissue implanted into athymic nude mice identifies biomarkers of the effects of human pregnancy levels of estrogen. Cancer Prev Res (Phila) (2009) 0.78
Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci U S A (2013) 16.74
A network-based analysis of systemic inflammation in humans. Nature (2005) 12.60
A genomic storm in critically injured humans. J Exp Med (2011) 6.67
MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis. J Exp Med (2007) 5.48
Kaposi's sarcoma-associated herpesvirus encodes an ortholog of miR-155. J Virol (2007) 4.19
Application of genome-wide expression analysis to human health and disease. Proc Natl Acad Sci U S A (2005) 3.49
Whole blood and leukocyte RNA isolation for gene expression analyses. Physiol Genomics (2004) 3.22
Identification of cellular genes targeted by KSHV-encoded microRNAs. PLoS Pathog (2007) 3.16
Quantitative proteome analysis of human plasma following in vivo lipopolysaccharide administration using 16O/18O labeling and the accurate mass and time tag approach. Mol Cell Proteomics (2005) 2.50
Structural basis for the proinflammatory cytokine activity of high mobility group box 1. Mol Med (2003) 2.30
High dynamic range characterization of the trauma patient plasma proteome. Mol Cell Proteomics (2006) 2.25
Persistent inflammation and immunosuppression: a common syndrome and new horizon for surgical intensive care. J Trauma Acute Care Surg (2012) 2.24
Anti-TNF-alpha therapies: the next generation. Nat Rev Drug Discov (2003) 2.18
The changing pattern and implications of multiple organ failure after blunt injury with hemorrhagic shock. Crit Care Med (2012) 2.17
Benchmarking outcomes in the critically injured trauma patient and the effect of implementing standard operating procedures. Ann Surg (2012) 2.07
A paradoxical role for myeloid-derived suppressor cells in sepsis and trauma. Mol Med (2010) 2.06
Clinical microfluidics for neutrophil genomics and proteomics. Nat Med (2010) 2.02
Different roles of EIIABMan and EIIGlc in regulation of energy metabolism, biofilm development, and competence in Streptococcus mutans. J Bacteriol (2006) 2.00
B cells enhance early innate immune responses during bacterial sepsis. J Exp Med (2011) 1.99
Comparative proteome analyses of human plasma following in vivo lipopolysaccharide administration using multidimensional separations coupled with tandem mass spectrometry. Proteomics (2005) 1.94
Development of a genomic metric that can be rapidly used to predict clinical outcome in severely injured trauma patients. Crit Care Med (2013) 1.94
Defective innate immunity predisposes murine neonates to poor sepsis outcome but is reversed by TLR agonists. Blood (2008) 1.94
Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis. J Immunol (2006) 1.86
Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways. Proc Natl Acad Sci U S A (2006) 1.82
Interleukin-10: a complex role in the pathogenesis of sepsis syndromes and its potential as an anti-inflammatory drug. Crit Care Med (2002) 1.78
Molecular characterization of the acute inflammatory response to infections with gram-negative versus gram-positive bacteria. Infect Immun (2003) 1.75
Impaired autophagy: A mechanism of mitochondrial dysfunction in anoxic rat hepatocytes. Hepatology (2008) 1.73
CD11c+ dendritic cells are required for survival in murine polymicrobial sepsis. J Immunol (2005) 1.71
Plasma cytokine measurements augment prognostic scores as indicators of outcome in patients with severe sepsis. Shock (2005) 1.71
Longitudinal studies of inter-alpha inhibitor proteins in severely septic patients: a potential clinical marker and mediator of severe sepsis. Crit Care Med (2007) 1.63
A better understanding of why murine models of trauma do not recapitulate the human syndrome. Crit Care Med (2014) 1.62
Human transcriptome array for high-throughput clinical studies. Proc Natl Acad Sci U S A (2011) 1.62
Continuous flow microfluidic device for rapid erythrocyte lysis. Anal Chem (2004) 1.61
CD14 receptor occupancy in severe sepsis: results of a phase I clinical trial with a recombinant chimeric CD14 monoclonal antibody (IC14). Crit Care Med (2004) 1.58
Role of Toll-like receptors in the development of sepsis. Shock (2008) 1.57
ALDH isozymes downregulation affects cell growth, cell motility and gene expression in lung cancer cells. Mol Cancer (2008) 1.56
Sepsis induces early alterations in innate immunity that impact mortality to secondary infection. J Immunol (2010) 1.54
Distinct transcriptional profiles characterize oral epithelium-microbiota interactions. Cell Microbiol (2005) 1.51
Increased mortality and altered immunity in neonatal sepsis produced by generalized peritonitis. Shock (2007) 1.50
Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10. J Exp Med (2010) 1.50
A genomic score prognostic of outcome in trauma patients. Mol Med (2009) 1.48
Gingival epithelial cell transcriptional responses to commensal and opportunistic oral microbial species. Infect Immun (2007) 1.44
Influence of BrpA on critical virulence attributes of Streptococcus mutans. J Bacteriol (2006) 1.42
Aberrant signaling in the TNFalpha/TNF receptor 1 pathway of the NZM2410 lupus-prone mouse. Clin Immunol (2004) 1.41
Commonality and differences in leukocyte gene expression patterns among three models of inflammation and injury. Physiol Genomics (2005) 1.40
Characterization of the systemic loss of dendritic cells in murine lymph nodes during polymicrobial sepsis. J Immunol (2004) 1.36
Furfural inhibits growth by limiting sulfur assimilation in ethanologenic Escherichia coli strain LY180. Appl Environ Microbiol (2009) 1.35
Analysis of factorial time-course microarrays with application to a clinical study of burn injury. Proc Natl Acad Sci U S A (2010) 1.33
The addition of tumor necrosis factor plus beta interferon induces a novel synergistic antiviral state against poxviruses in primary human fibroblasts. J Virol (2008) 1.32
Generating aptamers for recognition of virus-infected cells. Clin Chem (2009) 1.31
Comparison of longitudinal leukocyte gene expression after burn injury or trauma-hemorrhage in mice. Physiol Genomics (2007) 1.30
Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis. Blood (2007) 1.29
MucA-mediated coordination of type III secretion and alginate synthesis in Pseudomonas aeruginosa. J Bacteriol (2004) 1.29
Incidence, clinical predictors, genomics, and outcome of acute kidney injury among trauma patients. Ann Surg (2010) 1.27
An in vivo inducible gene of Pseudomonas aeruginosa encodes an anti-ExsA to suppress the type III secretion system. Mol Microbiol (2004) 1.26
Cost and Mortality Associated With Postoperative Acute Kidney Injury. Ann Surg (2015) 1.26
Large-scale multiplexed quantitative discovery proteomics enabled by the use of an (18)O-labeled "universal" reference sample. J Proteome Res (2009) 1.24
Microarray analysis of A549 cells infected with rabbitpox virus (RPV): a comparison of wild-type RPV and RPV deleted for the host range gene, SPI-1. Virology (2003) 1.23
Preclinical models of shock and sepsis: what can they tell us? Shock (2005) 1.23
The origins of cachexia in acute and chronic inflammatory diseases. Nutr Clin Pract (2006) 1.23
Neutrophil mobilization from the bone marrow during polymicrobial sepsis is dependent on CXCL12 signaling. J Immunol (2011) 1.21
Severe injury is associated with insulin resistance, endoplasmic reticulum stress response, and unfolded protein response. Ann Surg (2012) 1.21
Role of Porphyromonas gingivalis SerB in gingival epithelial cell cytoskeletal remodeling and cytokine production. Infect Immun (2008) 1.21
Direct evidence for tumor necrosis factor-alpha signaling in arteriogenesis. Circulation (2002) 1.19
Ultrasensitive detection of biomolecules with fluorescent dye-doped nanoparticles. Anal Biochem (2004) 1.17
Role of innate immunity in neonatal infection. Am J Perinatol (2013) 1.16
Parallels between cancer and infectious disease. N Engl J Med (2014) 1.16
Biology of interleukin-10 and its regulatory roles in sepsis syndromes. Crit Care Med (2005) 1.16
Expression profiling after activation of amino acid deprivation response in HepG2 human hepatoma cells. Physiol Genomics (2010) 1.15
Changes in transcription within the CA1 field of the hippocampus are associated with age-related spatial learning impairments. Neurobiol Learn Mem (2006) 1.14
The cowpox virus fusion regulator proteins SPI-3 and hemagglutinin interact in infected and uninfected cells. Virology (2005) 1.14
Biology of tumor necrosis factor-alpha- implications for psoriasis. Exp Dermatol (2004) 1.14
Patterns of gene expression reveal a temporally orchestrated wound healing response in the injured spinal cord. J Neurosci (2004) 1.13
Cytokine profile after lung transplantation: correlation with allograft injury. Ann Thorac Surg (2006) 1.13
Flagellin enhances NK cell proliferation and activation directly and through dendritic cell-NK cell interactions. J Leukoc Biol (2005) 1.12
Superoxide production by macrophages and T cells is critical for the induction of autoreactivity and type 1 diabetes. Diabetes (2011) 1.12
Critical role for CXC ligand 10/CXC receptor 3 signaling in the murine neonatal response to sepsis. Infect Immun (2011) 1.11
Microfluidic isolation of leukocytes from whole blood for phenotype and gene expression analysis. Anal Chem (2006) 1.11
Modulation of NKp30- and NKp46-mediated natural killer cell responses by poxviral hemagglutinin. PLoS Pathog (2011) 1.11
The vaccinia virus fusion inhibitor proteins SPI-3 (K2) and HA (A56) expressed by infected cells reduce the entry of superinfecting virus. Virology (2008) 1.10
Neutrophil elastase, MIP-2, and TLR-4 expression during human and experimental sepsis. Shock (2005) 1.09
Highly attenuated smallpox vaccine protects rabbits and mice against pathogenic orthopoxvirus challenge. Vaccine (2006) 1.08
A dynamic network of transcription in LPS-treated human subjects. BMC Syst Biol (2009) 1.07
Persistent inflammation, immunosuppression, and catabolism syndrome after severe blunt trauma. J Trauma Acute Care Surg (2014) 1.06