Marc A Vos

Author PubWeight™ 93.42‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Reduced heterogeneous expression of Cx43 results in decreased Nav1.5 expression and reduced sodium current that accounts for arrhythmia vulnerability in conditional Cx43 knockout mice. Heart Rhythm 2011 2.21
2 Increased short-term variability of repolarization predicts d-sotalol-induced torsades de pointes in dogs. Circulation 2004 2.09
3 Probing the contribution of IKs to canine ventricular repolarization: key role for beta-adrenergic receptor stimulation. Circulation 2003 2.06
4 Assessing predictors of drug-induced torsade de pointes. Trends Pharmacol Sci 2003 1.97
5 Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy. Heart Rhythm 2012 1.91
6 Biology of cardiac sodium channel Nav1.5 expression. Cardiovasc Res 2011 1.86
7 Characterization of in vitro and in vivo lesions made by a novel multichannel ablation generator and a circumlinear decapolar ablation catheter. J Cardiovasc Electrophysiol 2009 1.62
8 Quantified proarrhythmic potential of selected human embryonic stem cell-derived cardiomyocytes. Stem Cell Res 2010 1.51
9 Altered Na/Ca exchange activity in cardiac hypertrophy and heart failure: a new target for therapy? Cardiovasc Res 2002 1.45
10 Absence of reverse electrical remodeling during regression of volume overload hypertrophy in canine ventricles. Cardiovasc Res 2003 1.45
11 Accumulation of slowly activating delayed rectifier potassium current (IKs) in canine ventricular myocytes. J Physiol 2003 1.39
12 Microvolt T-wave alternans and beat-to-beat variability of repolarization during early postischemic remodeling in a pig heart. Heart Rhythm 2011 1.38
13 Assessing the proarrhythmic potential of drugs: current status of models and surrogate parameters of torsades de pointes arrhythmias. Pharmacol Ther 2006 1.30
14 A novel mutation L619F in the cardiac Na+ channel SCN5A associated with long-QT syndrome (LQT3): a role for the I-II linker in inactivation gating. Hum Mutat 2003 1.27
15 Late na(+) current inhibition by ranolazine reduces torsades de pointes in the chronic atrioventricular block dog model. J Am Coll Cardiol 2010 1.26
16 Beat-to-Beat variability of repolarization determines proarrhythmic outcome in dogs susceptible to drug-induced torsades de pointes. J Am Coll Cardiol 2006 1.25
17 Na+-dependent SR Ca2+ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation. Cardiovasc Res 2010 1.22
18 Proteome-wide protein concentrations in the human heart. Mol Biosyst 2010 1.21
19 Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG. J Mol Cell Cardiol 2012 1.20
20 Heterogeneous Connexin43 distribution in heart failure is associated with dispersed conduction and enhanced susceptibility to ventricular arrhythmias. Eur J Heart Fail 2010 1.15
21 Proarrhythmic electrical remodelling is associated with increased beat-to-beat variability of repolarisation. Cardiovasc Res 2006 1.12
22 Reorganized PKA-AKAP associations in the failing human heart. J Mol Cell Cardiol 2011 1.10
23 Analysis of the cGMP/cAMP interactome using a chemical proteomics approach in mammalian heart tissue validates sphingosine kinase type 1-interacting protein as a genuine and highly abundant AKAP. J Proteome Res 2006 1.09
24 Na/Ca exchange and cardiac ventricular arrhythmias. Ann N Y Acad Sci 2007 1.07
25 Biomarkers of myocardial fibrosis. J Cardiovasc Pharmacol 2011 1.05
26 Beat-to-beat variability of QT intervals is increased in patients with drug-induced long-QT syndrome: a case control pilot study. Eur Heart J 2007 1.04
27 Window Ca2+ current and its modulation by Ca2+ release in hypertrophied cardiac myocytes from dogs with chronic atrioventricular block. J Physiol 2006 1.03
28 Usefulness of short-term variability of QT intervals as a predictor for electrical remodeling and proarrhythmia in patients with nonischemic heart failure. Am J Cardiol 2010 1.02
29 Intracellular Na+ and altered Na+ transport mechanisms in cardiac hypertrophy and failure. J Mol Cell Cardiol 2003 1.01
30 Molecular and electrical characterization of the canine cardiac ventricular septum. J Mol Cell Cardiol 2004 1.01
31 Novel insights in the congenital long QT syndrome. Ann Intern Med 2002 1.01
32 Short-term variability of repolarization predicts ventricular tachycardia and sudden cardiac death in patients with structural heart disease: a comparison with QT variability index. Heart Rhythm 2011 0.99
33 Beat-to-beat variability of repolarization as a new biomarker for proarrhythmia in vivo. Heart Rhythm 2012 0.98
34 Reduced Cx43 expression triggers increased fibrosis due to enhanced fibroblast activity. Circ Arrhythm Electrophysiol 2012 0.98
35 Diversity of cAMP-dependent protein kinase isoforms and their anchoring proteins in mouse ventricular tissue. J Proteome Res 2007 0.98
36 Inhibition of cardiomyocyte automaticity by electrotonic application of inward rectifier current from Kir2.1 expressing cells. Med Biol Eng Comput 2006 0.97
37 Direct detection of myocardial fibrosis by MRI. J Mol Cell Cardiol 2011 0.96
38 Relation of increased short-term variability of QT interval to congenital long-QT syndrome. Am J Cardiol 2009 0.95
39 Combined Na(+)/Ca(2+) exchanger and L-type calcium channel block as a potential strategy to suppress arrhythmias and maintain ventricular function. Circ Arrhythm Electrophysiol 2013 0.93
40 Sudden cardiac death in dogs with remodeled hearts is associated with larger beat-to-beat variability of repolarization. Basic Res Cardiol 2005 0.93
41 Beta-, not alpha-adrenergic stimulation enhances conduction velocity in cultures of neonatal cardiomyocytes. Circ J 2007 0.92
42 Increased Na+ concentration and altered Na/K pump activity in hypertrophied canine ventricular cells. Cardiovasc Res 2003 0.92
43 Chronic kidney disease in patients with cardiac rhythm disturbances or implantable electrical devices: clinical significance and implications for decision making-a position paper of the European Heart Rhythm Association endorsed by the Heart Rhythm Society and the Asia Pacific Heart Rhythm Society. Europace 2015 0.91
44 The canine model with chronic, complete atrio-ventricular block. Pharmacol Ther 2008 0.91
45 Temporal patterns of electrical remodeling in canine ventricular hypertrophy: focus on IKs downregulation and blunted beta-adrenergic activation. Cardiovasc Res 2006 0.90
46 Lysosome mediated Kir2.1 breakdown directly influences inward rectifier current density. Biochem Biophys Res Commun 2008 0.90
47 Connexin43 repression following epithelium-to-mesenchyme transition in embryonal carcinoma cells requires Snail1 transcription factor. Differentiation 2007 0.89
48 Asynchronous development of electrical remodeling and cardiac hypertrophy in the complete AV block dog. Cardiovasc Res 2003 0.88
49 Tridimensional activation patterns of acquired torsade-de-pointes tachycardias in dogs with chronic AV-block. Basic Res Cardiol 2004 0.87
50 Electrophysiological safety of sertindole in dogs with normal and remodeled hearts. J Pharmacol Exp Ther 2003 0.87
51 Experimental Mapping of the Canine KCNJ2 and KCNJ12 Gene Structures and Functional Analysis of the Canine K(IR)2.2 ion Channel. Front Physiol 2012 0.87
52 Cellular basis for triggered ventricular arrhythmias that occur in the setting of compensated hypertrophy and heart failure: considerations for diagnosis and treatment. J Electrocardiol 2007 0.86
53 Phosphoproteomics study based on in vivo inhibition reveals sites of calmodulin-dependent protein kinase II regulation in the heart. J Am Heart Assoc 2013 0.86
54 Atrial-specific drugs: the way to treat atrial fibrillation? J Cardiovasc Electrophysiol 2004 0.86
55 Impact of acute and enduring volume overload on mechanotransduction and cytoskeletal integrity of canine left ventricular myocardium. Am J Physiol Heart Circ Physiol 2007 0.85
56 Effects of proarrhythmic drugs on relaxation time and beating pattern in rat engineered heart tissue. Basic Res Cardiol 2014 0.85
57 Atrial-specific drug AVE0118 is free of torsades de pointes in anesthetized dogs with chronic complete atrioventricular block. Heart Rhythm 2006 0.85
58 Improvement of cardiac efficacy and safety models in drug discovery by the use of stem cell-derived cardiomyocytes. Expert Opin Drug Discov 2009 0.85
59 The JT-area indicates dispersion of repolarization in dogs with atrioventricular block. J Interv Card Electrophysiol 2002 0.85
60 Drug-induced torsade de pointes arrhythmias in the chronic AV block dog are perpetuated by focal activity. Circ Arrhythm Electrophysiol 2011 0.84
61 High-rate pacing reduces variability of repolarization and prevents repolarization-dependent arrhythmias in dogs with chronic AV block. J Cardiovasc Electrophysiol 2010 0.83
62 Efficient and specific cardiac IK₁ inhibition by a new pentamidine analogue. Cardiovasc Res 2013 0.83
63 Beat-to-beat variability of repolarization: a new parameter to determine arrhythmic risk of an individual or identify proarrhythmic drugs. Anadolu Kardiyol Derg 2007 0.83
64 Cardiac arrhythmias in acute coronary syndromes: position paper from the joint EHRA, ACCA, and EAPCI task force. Europace 2014 0.83
65 Circadian rhythms in cell maturation. Physiology (Bethesda) 2014 0.83
66 Discontinuous conduction in mouse bundle branches is caused by bundle-branch architecture. Circulation 2005 0.81
67 Decreasing the infusion rate reduces the proarrhythmic risk of NS-7: confirming the relevance of short-term variability of repolarisation in predicting drug-induced torsades de pointes. Br J Pharmacol 2005 0.81
68 In calcineurin-induced cardiac hypertrophy expression of Nav1.5, Cx40 and Cx43 is reduced by different mechanisms. J Mol Cell Cardiol 2008 0.81
69 Pro-arrhythmogenic potential of immature cardiomyocytes is triggered by low coupling and cluster size. Cardiovasc Res 2006 0.81
70 Alternative promoter usage and splicing of the human SCN5A gene contribute to transcript heterogeneity. DNA Cell Biol 2010 0.80
71 Beat-to-Beat Variability in Preload Unmasks Latent Risk of Torsade de Pointes in Anesthetized Chronic Atrioventricular Block Dogs. Circ J 2016 0.80
72 Inhibiting the clathrin-mediated endocytosis pathway rescues K(IR)2.1 downregulation by pentamidine. Pflugers Arch 2012 0.79
73 Cloning, embryonic expression, and functional characterization of two novel connexins from Xenopus laevis. Biochem Biophys Res Commun 2006 0.79
74 Exploring chemical substructures essential for HERG k(+) channel blockade by synthesis and biological evaluation of dofetilide analogues. ChemMedChem 2009 0.79
75 Relevance of calmodulin/CaMKII activation for arrhythmogenesis in the AV block dog. Heart Rhythm 2012 0.78
76 Rationale, objectives, and design of the EUTrigTreat clinical study: a prospective observational study for arrhythmia risk stratification and assessment of interrelationships among repolarization markers and genotype. Europace 2011 0.78
77 Inhibition of lysosomal degradation rescues pentamidine-mediated decreases of K(IR)2.1 ion channel expression but not that of K(v)11.1. Eur J Pharmacol 2010 0.78
78 Role of the Na/Ca exchanger in arrhythmias in compensated hypertrophy. Ann N Y Acad Sci 2002 0.78
79 Exercise capacity in children with isolated congenital complete atrioventricular block: does pacing make a difference? Pediatr Cardiol 2012 0.78
80 Do we understand the electrophysiologic mechanisms responsible for drug-induced cardiac arrhythmias? J Cardiovasc Pharmacol 2002 0.78
81 The wearable cardioverter-defibrillator: current technology and evolving indications. Europace 2016 0.78
82 Electrophysiological and proarrhythmic parameters in transmural canine left-ventricular needle biopsies. Pflugers Arch 2004 0.77
83 Effects of K201 on repolarization and arrhythmogenesis in anesthetized chronic atrioventricular block dogs susceptible to dofetilide-induced torsade de pointes. Eur J Pharmacol 2011 0.77
84 Anesthesia and arrhythmogenesis in the chronic atrioventricular block dog model. J Cardiovasc Pharmacol 2010 0.77
85 AV-block and conduction slowing prevail over TdP arrhythmias in the methoxamine-sensitized pro-arrhythmic rabbit model. J Cardiovasc Electrophysiol 2014 0.77
86 Ventricular remodelling is a prerequisite for the induction of dofetilide-induced torsade de pointes arrhythmias in the anaesthetized, complete atrio-ventricular-block dog. Europace 2011 0.77
87 European Heart Rhythm Association/Heart Failure Association joint consensus document on arrhythmias in heart failure, endorsed by the Heart Rhythm Society and the Asia Pacific Heart Rhythm Society. Europace 2015 0.77
88 Short-term Variability of Repolarization Is Superior to Other Repolarization Parameters in the Evaluation of Diverse Antiarrhythmic Interventions in the Chronic Atrioventricular Block Dog. J Cardiovasc Pharmacol 2017 0.76
89 Cardiac arrhythmias in acute coronary syndromes: position paper from the joint EHRA, ACCA, and EAPCI task force. EuroIntervention 2015 0.76
90 Vernakalant is devoid of proarrhythmic effects in the complete AV block dog model. Eur J Pharmacol 2013 0.76
91 Verapamil as an antiarrhythmic agent in congestive heart failure: hopping from rabbit to human? Br J Pharmacol 2012 0.76
92 Anchored protein kinase A signalling in cardiac cellular electrophysiology. J Cell Mol Med 2014 0.76
93 Microvolt T-wave alternans in an unselected heart failure population: pros and cons. Eur J Heart Fail 2012 0.76
94 Primary structure, organization, and expression of the rat connexin45 gene. DNA Cell Biol 2007 0.76
95 High-septal pacing reduces ventricular electrical remodeling and proarrhythmia in chronic atrioventricular block dogs. J Am Coll Cardiol 2007 0.76
96 Cloning and functional characterization of a novel connexin expressed in somites of Xenopus laevis. Dev Dyn 2005 0.75
97 Early rate control in complete atrioventricular block is warranted to prevent electrical remodeling: No role for ventricular activation? Heart Rhythm 2005 0.75
98 The molecular labyrinth of electrical remodeling: making sense of cardiac memory. Heart Rhythm 2010 0.75
99 Impairment of trafficking by downregulation of an anchor protein: novel insights into additional mechanisms responsible for heart failure. Heart Rhythm 2012 0.75
100 The quest for an anti-arrhythmic drug against atrial fibrillation that combines efficacy with safety. Europace 2010 0.75
101 Enhanced efficacy with MgSO4 due to an additive, alternative, or dual mode of action? Europace 2009 0.75
102 Increased sarcolemmal Na(+)/H(+) exchange activity in hypertrophied myocytes from dogs with chronic atrioventricular block. Front Physiol 2013 0.75
103 Ex vivo and in vivo administration of fluorescent CNA35 specifically marks cardiac fibrosis. Mol Imaging 2014 0.75
104 Cardiac ion channel trafficking defects and drugs. Pharmacol Ther 2013 0.75
105 Serial left-ventricular biopsy sampling using a minimally invasive trans-thoracic approach in adult dogs. Pflugers Arch 2007 0.75