1
|
Reduced heterogeneous expression of Cx43 results in decreased Nav1.5 expression and reduced sodium current that accounts for arrhythmia vulnerability in conditional Cx43 knockout mice.
|
Heart Rhythm
|
2011
|
2.21
|
2
|
Increased short-term variability of repolarization predicts d-sotalol-induced torsades de pointes in dogs.
|
Circulation
|
2004
|
2.09
|
3
|
Probing the contribution of IKs to canine ventricular repolarization: key role for beta-adrenergic receptor stimulation.
|
Circulation
|
2003
|
2.06
|
4
|
Assessing predictors of drug-induced torsade de pointes.
|
Trends Pharmacol Sci
|
2003
|
1.97
|
5
|
Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy.
|
Heart Rhythm
|
2012
|
1.91
|
6
|
Biology of cardiac sodium channel Nav1.5 expression.
|
Cardiovasc Res
|
2011
|
1.86
|
7
|
Characterization of in vitro and in vivo lesions made by a novel multichannel ablation generator and a circumlinear decapolar ablation catheter.
|
J Cardiovasc Electrophysiol
|
2009
|
1.62
|
8
|
Quantified proarrhythmic potential of selected human embryonic stem cell-derived cardiomyocytes.
|
Stem Cell Res
|
2010
|
1.51
|
9
|
Altered Na/Ca exchange activity in cardiac hypertrophy and heart failure: a new target for therapy?
|
Cardiovasc Res
|
2002
|
1.45
|
10
|
Absence of reverse electrical remodeling during regression of volume overload hypertrophy in canine ventricles.
|
Cardiovasc Res
|
2003
|
1.45
|
11
|
Accumulation of slowly activating delayed rectifier potassium current (IKs) in canine ventricular myocytes.
|
J Physiol
|
2003
|
1.39
|
12
|
Microvolt T-wave alternans and beat-to-beat variability of repolarization during early postischemic remodeling in a pig heart.
|
Heart Rhythm
|
2011
|
1.38
|
13
|
Assessing the proarrhythmic potential of drugs: current status of models and surrogate parameters of torsades de pointes arrhythmias.
|
Pharmacol Ther
|
2006
|
1.30
|
14
|
A novel mutation L619F in the cardiac Na+ channel SCN5A associated with long-QT syndrome (LQT3): a role for the I-II linker in inactivation gating.
|
Hum Mutat
|
2003
|
1.27
|
15
|
Late na(+) current inhibition by ranolazine reduces torsades de pointes in the chronic atrioventricular block dog model.
|
J Am Coll Cardiol
|
2010
|
1.26
|
16
|
Beat-to-Beat variability of repolarization determines proarrhythmic outcome in dogs susceptible to drug-induced torsades de pointes.
|
J Am Coll Cardiol
|
2006
|
1.25
|
17
|
Na+-dependent SR Ca2+ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation.
|
Cardiovasc Res
|
2010
|
1.22
|
18
|
Proteome-wide protein concentrations in the human heart.
|
Mol Biosyst
|
2010
|
1.21
|
19
|
Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG.
|
J Mol Cell Cardiol
|
2012
|
1.20
|
20
|
Heterogeneous Connexin43 distribution in heart failure is associated with dispersed conduction and enhanced susceptibility to ventricular arrhythmias.
|
Eur J Heart Fail
|
2010
|
1.15
|
21
|
Proarrhythmic electrical remodelling is associated with increased beat-to-beat variability of repolarisation.
|
Cardiovasc Res
|
2006
|
1.12
|
22
|
Reorganized PKA-AKAP associations in the failing human heart.
|
J Mol Cell Cardiol
|
2011
|
1.10
|
23
|
Analysis of the cGMP/cAMP interactome using a chemical proteomics approach in mammalian heart tissue validates sphingosine kinase type 1-interacting protein as a genuine and highly abundant AKAP.
|
J Proteome Res
|
2006
|
1.09
|
24
|
Na/Ca exchange and cardiac ventricular arrhythmias.
|
Ann N Y Acad Sci
|
2007
|
1.07
|
25
|
Biomarkers of myocardial fibrosis.
|
J Cardiovasc Pharmacol
|
2011
|
1.05
|
26
|
Beat-to-beat variability of QT intervals is increased in patients with drug-induced long-QT syndrome: a case control pilot study.
|
Eur Heart J
|
2007
|
1.04
|
27
|
Window Ca2+ current and its modulation by Ca2+ release in hypertrophied cardiac myocytes from dogs with chronic atrioventricular block.
|
J Physiol
|
2006
|
1.03
|
28
|
Usefulness of short-term variability of QT intervals as a predictor for electrical remodeling and proarrhythmia in patients with nonischemic heart failure.
|
Am J Cardiol
|
2010
|
1.02
|
29
|
Intracellular Na+ and altered Na+ transport mechanisms in cardiac hypertrophy and failure.
|
J Mol Cell Cardiol
|
2003
|
1.01
|
30
|
Molecular and electrical characterization of the canine cardiac ventricular septum.
|
J Mol Cell Cardiol
|
2004
|
1.01
|
31
|
Novel insights in the congenital long QT syndrome.
|
Ann Intern Med
|
2002
|
1.01
|
32
|
Short-term variability of repolarization predicts ventricular tachycardia and sudden cardiac death in patients with structural heart disease: a comparison with QT variability index.
|
Heart Rhythm
|
2011
|
0.99
|
33
|
Beat-to-beat variability of repolarization as a new biomarker for proarrhythmia in vivo.
|
Heart Rhythm
|
2012
|
0.98
|
34
|
Reduced Cx43 expression triggers increased fibrosis due to enhanced fibroblast activity.
|
Circ Arrhythm Electrophysiol
|
2012
|
0.98
|
35
|
Diversity of cAMP-dependent protein kinase isoforms and their anchoring proteins in mouse ventricular tissue.
|
J Proteome Res
|
2007
|
0.98
|
36
|
Inhibition of cardiomyocyte automaticity by electrotonic application of inward rectifier current from Kir2.1 expressing cells.
|
Med Biol Eng Comput
|
2006
|
0.97
|
37
|
Direct detection of myocardial fibrosis by MRI.
|
J Mol Cell Cardiol
|
2011
|
0.96
|
38
|
Relation of increased short-term variability of QT interval to congenital long-QT syndrome.
|
Am J Cardiol
|
2009
|
0.95
|
39
|
Combined Na(+)/Ca(2+) exchanger and L-type calcium channel block as a potential strategy to suppress arrhythmias and maintain ventricular function.
|
Circ Arrhythm Electrophysiol
|
2013
|
0.93
|
40
|
Sudden cardiac death in dogs with remodeled hearts is associated with larger beat-to-beat variability of repolarization.
|
Basic Res Cardiol
|
2005
|
0.93
|
41
|
Beta-, not alpha-adrenergic stimulation enhances conduction velocity in cultures of neonatal cardiomyocytes.
|
Circ J
|
2007
|
0.92
|
42
|
Increased Na+ concentration and altered Na/K pump activity in hypertrophied canine ventricular cells.
|
Cardiovasc Res
|
2003
|
0.92
|
43
|
Chronic kidney disease in patients with cardiac rhythm disturbances or implantable electrical devices: clinical significance and implications for decision making-a position paper of the European Heart Rhythm Association endorsed by the Heart Rhythm Society and the Asia Pacific Heart Rhythm Society.
|
Europace
|
2015
|
0.91
|
44
|
The canine model with chronic, complete atrio-ventricular block.
|
Pharmacol Ther
|
2008
|
0.91
|
45
|
Temporal patterns of electrical remodeling in canine ventricular hypertrophy: focus on IKs downregulation and blunted beta-adrenergic activation.
|
Cardiovasc Res
|
2006
|
0.90
|
46
|
Lysosome mediated Kir2.1 breakdown directly influences inward rectifier current density.
|
Biochem Biophys Res Commun
|
2008
|
0.90
|
47
|
Connexin43 repression following epithelium-to-mesenchyme transition in embryonal carcinoma cells requires Snail1 transcription factor.
|
Differentiation
|
2007
|
0.89
|
48
|
Asynchronous development of electrical remodeling and cardiac hypertrophy in the complete AV block dog.
|
Cardiovasc Res
|
2003
|
0.88
|
49
|
Tridimensional activation patterns of acquired torsade-de-pointes tachycardias in dogs with chronic AV-block.
|
Basic Res Cardiol
|
2004
|
0.87
|
50
|
Electrophysiological safety of sertindole in dogs with normal and remodeled hearts.
|
J Pharmacol Exp Ther
|
2003
|
0.87
|
51
|
Experimental Mapping of the Canine KCNJ2 and KCNJ12 Gene Structures and Functional Analysis of the Canine K(IR)2.2 ion Channel.
|
Front Physiol
|
2012
|
0.87
|
52
|
Cellular basis for triggered ventricular arrhythmias that occur in the setting of compensated hypertrophy and heart failure: considerations for diagnosis and treatment.
|
J Electrocardiol
|
2007
|
0.86
|
53
|
Phosphoproteomics study based on in vivo inhibition reveals sites of calmodulin-dependent protein kinase II regulation in the heart.
|
J Am Heart Assoc
|
2013
|
0.86
|
54
|
Atrial-specific drugs: the way to treat atrial fibrillation?
|
J Cardiovasc Electrophysiol
|
2004
|
0.86
|
55
|
Impact of acute and enduring volume overload on mechanotransduction and cytoskeletal integrity of canine left ventricular myocardium.
|
Am J Physiol Heart Circ Physiol
|
2007
|
0.85
|
56
|
Effects of proarrhythmic drugs on relaxation time and beating pattern in rat engineered heart tissue.
|
Basic Res Cardiol
|
2014
|
0.85
|
57
|
Atrial-specific drug AVE0118 is free of torsades de pointes in anesthetized dogs with chronic complete atrioventricular block.
|
Heart Rhythm
|
2006
|
0.85
|
58
|
Improvement of cardiac efficacy and safety models in drug discovery by the use of stem cell-derived cardiomyocytes.
|
Expert Opin Drug Discov
|
2009
|
0.85
|
59
|
The JT-area indicates dispersion of repolarization in dogs with atrioventricular block.
|
J Interv Card Electrophysiol
|
2002
|
0.85
|
60
|
Drug-induced torsade de pointes arrhythmias in the chronic AV block dog are perpetuated by focal activity.
|
Circ Arrhythm Electrophysiol
|
2011
|
0.84
|
61
|
High-rate pacing reduces variability of repolarization and prevents repolarization-dependent arrhythmias in dogs with chronic AV block.
|
J Cardiovasc Electrophysiol
|
2010
|
0.83
|
62
|
Efficient and specific cardiac IK₁ inhibition by a new pentamidine analogue.
|
Cardiovasc Res
|
2013
|
0.83
|
63
|
Beat-to-beat variability of repolarization: a new parameter to determine arrhythmic risk of an individual or identify proarrhythmic drugs.
|
Anadolu Kardiyol Derg
|
2007
|
0.83
|
64
|
Cardiac arrhythmias in acute coronary syndromes: position paper from the joint EHRA, ACCA, and EAPCI task force.
|
Europace
|
2014
|
0.83
|
65
|
Circadian rhythms in cell maturation.
|
Physiology (Bethesda)
|
2014
|
0.83
|
66
|
Discontinuous conduction in mouse bundle branches is caused by bundle-branch architecture.
|
Circulation
|
2005
|
0.81
|
67
|
Decreasing the infusion rate reduces the proarrhythmic risk of NS-7: confirming the relevance of short-term variability of repolarisation in predicting drug-induced torsades de pointes.
|
Br J Pharmacol
|
2005
|
0.81
|
68
|
In calcineurin-induced cardiac hypertrophy expression of Nav1.5, Cx40 and Cx43 is reduced by different mechanisms.
|
J Mol Cell Cardiol
|
2008
|
0.81
|
69
|
Pro-arrhythmogenic potential of immature cardiomyocytes is triggered by low coupling and cluster size.
|
Cardiovasc Res
|
2006
|
0.81
|
70
|
Alternative promoter usage and splicing of the human SCN5A gene contribute to transcript heterogeneity.
|
DNA Cell Biol
|
2010
|
0.80
|
71
|
Beat-to-Beat Variability in Preload Unmasks Latent Risk of Torsade de Pointes in Anesthetized Chronic Atrioventricular Block Dogs.
|
Circ J
|
2016
|
0.80
|
72
|
Inhibiting the clathrin-mediated endocytosis pathway rescues K(IR)2.1 downregulation by pentamidine.
|
Pflugers Arch
|
2012
|
0.79
|
73
|
Cloning, embryonic expression, and functional characterization of two novel connexins from Xenopus laevis.
|
Biochem Biophys Res Commun
|
2006
|
0.79
|
74
|
Exploring chemical substructures essential for HERG k(+) channel blockade by synthesis and biological evaluation of dofetilide analogues.
|
ChemMedChem
|
2009
|
0.79
|
75
|
Relevance of calmodulin/CaMKII activation for arrhythmogenesis in the AV block dog.
|
Heart Rhythm
|
2012
|
0.78
|
76
|
Rationale, objectives, and design of the EUTrigTreat clinical study: a prospective observational study for arrhythmia risk stratification and assessment of interrelationships among repolarization markers and genotype.
|
Europace
|
2011
|
0.78
|
77
|
Inhibition of lysosomal degradation rescues pentamidine-mediated decreases of K(IR)2.1 ion channel expression but not that of K(v)11.1.
|
Eur J Pharmacol
|
2010
|
0.78
|
78
|
Role of the Na/Ca exchanger in arrhythmias in compensated hypertrophy.
|
Ann N Y Acad Sci
|
2002
|
0.78
|
79
|
Exercise capacity in children with isolated congenital complete atrioventricular block: does pacing make a difference?
|
Pediatr Cardiol
|
2012
|
0.78
|
80
|
Do we understand the electrophysiologic mechanisms responsible for drug-induced cardiac arrhythmias?
|
J Cardiovasc Pharmacol
|
2002
|
0.78
|
81
|
The wearable cardioverter-defibrillator: current technology and evolving indications.
|
Europace
|
2016
|
0.78
|
82
|
Electrophysiological and proarrhythmic parameters in transmural canine left-ventricular needle biopsies.
|
Pflugers Arch
|
2004
|
0.77
|
83
|
Effects of K201 on repolarization and arrhythmogenesis in anesthetized chronic atrioventricular block dogs susceptible to dofetilide-induced torsade de pointes.
|
Eur J Pharmacol
|
2011
|
0.77
|
84
|
Anesthesia and arrhythmogenesis in the chronic atrioventricular block dog model.
|
J Cardiovasc Pharmacol
|
2010
|
0.77
|
85
|
AV-block and conduction slowing prevail over TdP arrhythmias in the methoxamine-sensitized pro-arrhythmic rabbit model.
|
J Cardiovasc Electrophysiol
|
2014
|
0.77
|
86
|
Ventricular remodelling is a prerequisite for the induction of dofetilide-induced torsade de pointes arrhythmias in the anaesthetized, complete atrio-ventricular-block dog.
|
Europace
|
2011
|
0.77
|
87
|
European Heart Rhythm Association/Heart Failure Association joint consensus document on arrhythmias in heart failure, endorsed by the Heart Rhythm Society and the Asia Pacific Heart Rhythm Society.
|
Europace
|
2015
|
0.77
|
88
|
Short-term Variability of Repolarization Is Superior to Other Repolarization Parameters in the Evaluation of Diverse Antiarrhythmic Interventions in the Chronic Atrioventricular Block Dog.
|
J Cardiovasc Pharmacol
|
2017
|
0.76
|
89
|
Cardiac arrhythmias in acute coronary syndromes: position paper from the joint EHRA, ACCA, and EAPCI task force.
|
EuroIntervention
|
2015
|
0.76
|
90
|
Vernakalant is devoid of proarrhythmic effects in the complete AV block dog model.
|
Eur J Pharmacol
|
2013
|
0.76
|
91
|
Verapamil as an antiarrhythmic agent in congestive heart failure: hopping from rabbit to human?
|
Br J Pharmacol
|
2012
|
0.76
|
92
|
Anchored protein kinase A signalling in cardiac cellular electrophysiology.
|
J Cell Mol Med
|
2014
|
0.76
|
93
|
Microvolt T-wave alternans in an unselected heart failure population: pros and cons.
|
Eur J Heart Fail
|
2012
|
0.76
|
94
|
Primary structure, organization, and expression of the rat connexin45 gene.
|
DNA Cell Biol
|
2007
|
0.76
|
95
|
High-septal pacing reduces ventricular electrical remodeling and proarrhythmia in chronic atrioventricular block dogs.
|
J Am Coll Cardiol
|
2007
|
0.76
|
96
|
Cloning and functional characterization of a novel connexin expressed in somites of Xenopus laevis.
|
Dev Dyn
|
2005
|
0.75
|
97
|
Early rate control in complete atrioventricular block is warranted to prevent electrical remodeling: No role for ventricular activation?
|
Heart Rhythm
|
2005
|
0.75
|
98
|
The molecular labyrinth of electrical remodeling: making sense of cardiac memory.
|
Heart Rhythm
|
2010
|
0.75
|
99
|
Impairment of trafficking by downregulation of an anchor protein: novel insights into additional mechanisms responsible for heart failure.
|
Heart Rhythm
|
2012
|
0.75
|
100
|
The quest for an anti-arrhythmic drug against atrial fibrillation that combines efficacy with safety.
|
Europace
|
2010
|
0.75
|
101
|
Enhanced efficacy with MgSO4 due to an additive, alternative, or dual mode of action?
|
Europace
|
2009
|
0.75
|
102
|
Increased sarcolemmal Na(+)/H(+) exchange activity in hypertrophied myocytes from dogs with chronic atrioventricular block.
|
Front Physiol
|
2013
|
0.75
|
103
|
Ex vivo and in vivo administration of fluorescent CNA35 specifically marks cardiac fibrosis.
|
Mol Imaging
|
2014
|
0.75
|
104
|
Cardiac ion channel trafficking defects and drugs.
|
Pharmacol Ther
|
2013
|
0.75
|
105
|
Serial left-ventricular biopsy sampling using a minimally invasive trans-thoracic approach in adult dogs.
|
Pflugers Arch
|
2007
|
0.75
|