Published in Brain Res on March 24, 2007
Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium. Proc Natl Acad Sci U S A (2008) 2.07
Where is mTOR and what is it doing there? J Cell Biol (2013) 1.91
Macrophage deficiency of p38alpha MAPK promotes apoptosis and plaque necrosis in advanced atherosclerotic lesions in mice. J Clin Invest (2009) 1.83
Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling. Blood (2011) 1.79
Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner. J Neurosci (2009) 1.67
Activation of the Akt-NF-kappaB pathway by subtilase cytotoxin through the ATF6 branch of the unfolded protein response. J Immunol (2009) 1.44
Akt determines cell fate through inhibition of the PERK-eIF2α phosphorylation pathway. Sci Signal (2011) 1.24
PERK-dependent regulation of IAP translation during ER stress. Oncogene (2008) 1.23
Selective abrogation of BiP/GRP78 blunts activation of NF-κB through the ATF6 branch of the UPR: involvement of C/EBPβ and mTOR-dependent dephosphorylation of Akt. Mol Cell Biol (2011) 1.10
TRB3 function in cardiac endoplasmic reticulum stress. Circ Res (2010) 1.04
Tamoxifen enhances the cytotoxic effects of nelfinavir in breast cancer cells. Breast Cancer Res (2010) 0.96
Avoiding cytotoxicity of transposases by dose-controlled mRNA delivery. Nucleic Acids Res (2011) 0.96
Wogonin induced calreticulin/annexin A1 exposure dictates the immunogenicity of cancer cells in a PERK/AKT dependent manner. PLoS One (2012) 0.95
Modulation of the Akt pathway reveals a novel link with PERK/eIF2α, which is relevant during hypoxia. PLoS One (2013) 0.88
Endoplasmic Reticulum (ER) Stress Induces Sirtuin 1 (SIRT1) Expression via the PI3K-Akt-GSK3β Signaling Pathway and Promotes Hepatocellular Injury. J Biol Chem (2015) 0.87
Inhibition of casein kinase 2 modulates XBP1-GRP78 arm of unfolded protein responses in cultured glial cells. PLoS One (2012) 0.86
Transgenic zebrafish model to study translational control mediated by upstream open reading frame of human chop gene. Nucleic Acids Res (2011) 0.84
A unique modulator of endoplasmic reticulum stress-signalling pathways: the novel pharmacological properties of amiloride in glial cells. Br J Pharmacol (2009) 0.83
Disturbance of Ca2+ homeostasis converts pro-Met into non-canonical tyrosine kinase p190MetNC in response to endoplasmic reticulum stress in MHCC97 cells. J Biol Chem (2012) 0.82
Akt as a victim, villain and potential hero in Parkinson's disease pathophysiology and treatment. Cell Mol Neurobiol (2011) 0.80
Saturated free fatty acid sodium palmitate-induced lipoapoptosis by targeting glycogen synthase kinase-3β activation in human liver cells. Dig Dis Sci (2013) 0.80
Open reading frame 3 of genotype 1 hepatitis E virus inhibits nuclear factor-κappa B signaling induced by tumor necrosis factor-α in human A549 lung epithelial cells. PLoS One (2014) 0.79
Target identification of grape seed extract in colorectal cancer using drug affinity responsive target stability (DARTS) technique: role of endoplasmic reticulum stress response proteins. Curr Cancer Drug Targets (2014) 0.78
Integration of Downstream Signals of Insulin-like Growth Factor-1 Receptor by Endoplasmic Reticulum Stress for Estrogen-Induced Growth or Apoptosis in Breast Cancer Cells. Mol Cancer Res (2015) 0.76
S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration. Nature (2006) 4.54
Brain stem is a direct target for leptin's action in the central nervous system. Endocrinology (2002) 2.16
Ubiquilin interacts with ubiquitylated proteins and proteasome through its ubiquitin-associated and ubiquitin-like domains. FEBS Lett (2004) 1.91
Sodium 4-phenylbutyrate protects against cerebral ischemic injury. Mol Pharmacol (2004) 1.76
Activation signal of nuclear factor-kappa B in response to endoplasmic reticulum stress is transduced via IRE1 and tumor necrosis factor receptor-associated factor 2. Biol Pharm Bull (2003) 1.71
Endoplasmic reticulum stress induces leptin resistance. Mol Pharmacol (2008) 1.66
Human HRD1 protects against ER stress-induced apoptosis through ER-associated degradation. FEBS Lett (2002) 1.60
Involvement of a polymorphism in the 5-HT2A receptor gene in impulsive behavior. Psychopharmacology (Berl) (2006) 1.51
Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins. FASEB J (2002) 1.47
Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone. J Neurochem (2007) 1.34
Role of ubiquilin associated with protein-disulfide isomerase in the endoplasmic reticulum in stress-induced apoptotic cell death. J Biol Chem (2002) 1.34
Loss of HRD1-mediated protein degradation causes amyloid precursor protein accumulation and amyloid-beta generation. J Neurosci (2010) 1.33
Perineural invasion in pancreatic cancer. Pancreas (2002) 1.31
ER signaling in unfolded protein response. Life Sci (2003) 1.23
Endoplasmic reticulum stress in disease: mechanisms and therapeutic opportunities. Clin Sci (Lond) (2009) 1.19
Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress. J Neurochem (2006) 1.18
Myeloid differentiation factor 88 (MyD88)-deficiency increases risk of diabetes in mice. PLoS One (2010) 1.15
A different pathway in the endoplasmic reticulum stress-induced expression of human HRD1 and SEL1 genes. FEBS Lett (2007) 1.13
Novel pathway for LPS-induced afferent vagus nerve activation: possible role of nodose ganglion. Auton Neurosci (2005) 1.10
A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin. J Neurochem (2006) 1.03
Neurochemistry, neuropathology, and heredity in SAMP8: a mouse model of senescence. Neurochem Res (2009) 0.99
Edaravone protects against hypoxia/ischemia-induced endoplasmic reticulum dysfunction. J Pharmacol Exp Ther (2004) 0.97
Preconditioning prevents ischemia-induced neuronal death through persistent Akt activation in the penumbra region of the rat brain. J Vet Med Sci (2004) 0.97
PI3K-Akt inactivation induced CHOP expression in endoplasmic reticulum-stressed cells. Biochem Biophys Res Commun (2006) 0.97
MyD88 plays a key role in LPS-induced Stat3 activation in the hypothalamus. Am J Physiol Regul Integr Comp Physiol (2009) 0.95
Minute invasive ductal carcinoma of the residual pancreas after distal pancreatectomy for intraductal papillary-mucinous tumor. Int J Gastrointest Cancer (2002) 0.95
Age-related changes of Nrf2 and phosphorylated GSK-3β in a mouse model of accelerated aging (SAMP8). Arch Gerontol Geriatr (2011) 0.92
The presence and functions of muscarinic receptors in human T cells: the involvement in IL-2 and IL-2 receptor system. Life Sci (2003) 0.92
Relationship between SUMO-1 modification of caspase-7 and its nuclear localization in human neuronal cells. Neurosci Lett (2005) 0.91
Potential down-regulation of salivary gland AQP5 by LPS via cross-coupling of NF-kappaB and p-c-Jun/c-Fos. Am J Pathol (2010) 0.89
Protective effects of 4-phenylbutyrate derivatives on the neuronal cell death and endoplasmic reticulum stress. Biol Pharm Bull (2012) 0.88
Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress. EMBO Mol Med (2014) 0.88
2-Aminopurine inhibits leptin receptor signal transduction. Eur J Pharmacol (2006) 0.88
Neuroprotective mechanisms of antiparkinsonian dopamine D2-receptor subfamily agonists. Neurochem Res (2003) 0.87
Involvement of the system L amino acid transporter on uptake of S-nitroso-L-cysteine, an endogenous S-nitrosothiol, in PC12 cells. Eur J Pharmacol (2003) 0.87
Leptin regulates interleukin-1beta expression in the brain via the STAT3-independent mechanisms. Brain Res (2002) 0.87
Inhibition of casein kinase 2 modulates XBP1-GRP78 arm of unfolded protein responses in cultured glial cells. PLoS One (2012) 0.86
4-Phenylbutyric acid protects against neuronal cell death by primarily acting as a chemical chaperone rather than histone deacetylase inhibitor. Bioorg Med Chem Lett (2013) 0.85
Bacterial DNA induced iNOS expression through MyD88-p38 MAP kinase in mouse primary cultured glial cells. Brain Res Mol Brain Res (2004) 0.85
Involvement of polyubiquitin chains via specific chain linkages in stress response in mammalian cells. Biol Pharm Bull (2005) 0.85
Novel functions of ubiquitin ligase HRD1 with transmembrane and proline-rich domains. J Pharmacol Sci (2008) 0.85
Relationship between the activation of cyclic AMP responsive element binding protein and ischemic tolerance in the penumbra region of rat cerebral cortex. Neurosci Lett (2002) 0.85
Psychological, neuroimaging, and biochemical studies on functional association between impulsive behavior and the 5-HT2A receptor gene polymorphism in humans. Ann N Y Acad Sci (2006) 0.85
Stearoyl-CoA Desaturase 1 (SCD1) is a key factor mediating diabetes in MyD88-deficient mice. Gene (2012) 0.84
Possible involvement of pyruvate kinase in acquisition of tolerance to hypoxic stress in glial cells. J Neurochem (2004) 0.84
Leptin induces IL-1 receptor antagonist expression in the brain. Biochem Biophys Res Commun (2002) 0.84
Endoplasmic reticulum stress and Parkinson's disease: the role of HRD1 in averting apoptosis in neurodegenerative disease. Oxid Med Cell Longev (2013) 0.83
A unique modulator of endoplasmic reticulum stress-signalling pathways: the novel pharmacological properties of amiloride in glial cells. Br J Pharmacol (2009) 0.83
Stress proteins and glial functions: possible therapeutic targets for neurodegenerative disorders. Pharmacol Ther (2003) 0.83
The mechanisms of immune-to-brain communication in inflammation as a drug target. Curr Drug Targets Inflamm Allergy (2002) 0.82
TEK/Tie2 is a novel gene involved in endoplasmic reticulum stress. J Pharmacol Sci (2010) 0.82
Bacterial endotoxin induces STAT3 activation in the mouse brain. Brain Res (2004) 0.81
Homocysteine induces X-box-binding protein 1 splicing in the mice brain. Neurochem Int (2009) 0.81
Effect of pranoprofen on endoplasmic reticulum stress in the primary cultured glial cells. Neurochem Int (2008) 0.81
Immunohistochemical localization of a ubiquitin ligase HRD1 in murine brain. J Neurosci Res (2008) 0.81
Inhibition of leptin-induced IL-1beta expression by glucocorticoids in the brain. Brain Res (2003) 0.81
[Concurrent chemoradiotherapy for advanced hypopharyngeal cancer]. Nihon Jibiinkoka Gakkai Kaiho (2005) 0.80
Skin surface electric potential as an indicator of skin condition: a new, non-invasive method to evaluate epidermal condition. Exp Dermatol (2008) 0.80
Clinical study of medial area infarction in the region of posterior inferior cerebellar artery. J Stroke Cerebrovasc Dis (2013) 0.79
Impairment of CREB phosphorylation in the hippocampal CA1 region of the senescence-accelerated mouse (SAM) P8. Brain Res (2007) 0.79
Molecular pathopharmacology of 5-HT2C receptors and the RNA editing in the brain. J Pharmacol Sci (2006) 0.79
Correlation between decrease in protein levels of ubiquitin ligase HRD1 and amyloid-beta production. J Pharmacol Sci (2010) 0.79
Expression of the ubiquitin ligase HRD1 in neural stem/progenitor cells of the adult mouse brain. J Pharmacol Sci (2011) 0.79
Glucocorticoid modulatory element-binding protein 1 binds to initiator procaspases and inhibits ischemia-induced apoptosis and neuronal injury. J Biol Chem (2006) 0.79
Aberrant neuronal differentiation and inhibition of dendrite outgrowth resulting from endoplasmic reticulum stress. J Neurosci Res (2014) 0.79