Attenuation of phospholipid signaling provides a novel mechanism for the action of valproic acid.

PubWeight™: 1.00‹?› | Rank: Top 15%

🔗 View Article (PMC 1951516)

Published in Eukaryot Cell on April 13, 2007

Authors

Xuehua Xu1, Annette Müller-Taubenberger, Kathryn E Adley, Nadine Pawolleck, Vivian W Y Lee, Claudia Wiedemann, Talvinder S Sihra, Markus Maniak, Tian Jin, Robin S B Williams

Author Affiliations

1: School of Biological Sciences, Royal Holloway University of London, Egham, United Kingdom.

Articles citing this

Seizure control by decanoic acid through direct AMPA receptor inhibition. Brain (2015) 1.56

The mood stabiliser lithium suppresses PIP3 signalling in Dictyostelium and human cells. Dis Model Mech (2009) 1.04

Seizure control by ketogenic diet-associated medium chain fatty acids. Neuropharmacology (2012) 0.99

The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium. Dis Model Mech (2011) 0.95

Inhibition of enveloped virus infection of cultured cells by valproic acid. J Virol (2010) 0.88

Molecular pharmacology in a simple model system: implicating MAP kinase and phosphoinositide signalling in bipolar disorder. Semin Cell Dev Biol (2010) 0.87

G protein-linked signaling pathways in bipolar and major depressive disorders. Front Genet (2013) 0.86

Treatment of Lennox-Gastaut syndrome: overview and recent findings. Neuropsychiatr Dis Treat (2008) 0.85

RpkA, a highly conserved GPCR with a lipid kinase domain, has a role in phagocytosis and anti-bacterial defense. PLoS One (2011) 0.83

Seizure-induced reduction in PIP3 levels contributes to seizure-activity and is rescued by valproic acid. Neurobiol Dis (2013) 0.82

Investigating the effect of emetic compounds on chemotaxis in Dictyostelium identifies a non-sentient model for bitter and hot tastant research. PLoS One (2011) 0.81

Conserved valproic-acid-induced lipid droplet formation in Dictyostelium and human hepatocytes identifies structurally active compounds. Dis Model Mech (2011) 0.79

Valproate Attenuates Nitroglycerin-Induced Trigeminovascular Activation by Preserving Mitochondrial Function in a Rat Model of Migraine. Med Sci Monit (2016) 0.77

A novel human receptor involved in bitter tastant detection identified using Dictyostelium discoideum. J Cell Sci (2013) 0.77

Inhibition of multiplication of the prototypic arenavirus LCMV by valproic acid. Antiviral Res (2013) 0.77

Bio-electrospraying and aerodynamically assisted bio-jetting the model eukaryotic Dictyostelium discoideum: assessing stress and developmental competency post treatment. J R Soc Interface (2011) 0.76

Transcriptomic analysis in a Drosophila model identifies previously implicated and novel pathways in the therapeutic mechanism in neuropsychiatric disorders. Front Neurosci (2011) 0.76

Valproic acid protects against haemorrhagic shock-induced signalling changes via PPARγ activation in an in vitro model. Br J Pharmacol (2015) 0.75

An epigenome-wide DNA methylation study of PTSD and depression in World Trade Center responders. Transl Psychiatry (2017) 0.75

Articles cited by this

Polarization of chemoattractant receptor signaling during neutrophil chemotaxis. Science (2000) 6.93

Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem (2001) 6.85

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. Proc Natl Acad Sci U S A (2005) 6.62

G protein signaling events are activated at the leading edge of chemotactic cells. Cell (1998) 6.60

A cell's sense of direction. Science (1999) 6.00

Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration. Science (2000) 5.84

The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation. Gene Expr (1996) 4.62

The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Proc Natl Acad Sci U S A (2004) 4.59

Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium. EMBO J (1999) 4.34

Neural and developmental actions of lithium: a unifying hypothesis. Cell (1989) 4.13

Receptor-mediated activation of heterotrimeric G-proteins in living cells. Science (2001) 4.04

Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis. J Cell Biol (2003) 4.02

Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease. Nat Genet (2001) 3.45

Role of phosphatidylinositol 3' kinase and a downstream pleckstrin homology domain-containing protein in controlling chemotaxis in dictyostelium. J Cell Biol (2001) 3.03

Dynamic actin patterns and Arp2/3 assembly at the substrate-attached surface of motile cells. Curr Biol (2004) 2.95

Localization of the G protein betagamma complex in living cells during chemotaxis. Science (2000) 2.87

Synapsins as mediators of BDNF-enhanced neurotransmitter release. Nat Neurosci (2000) 2.62

A common mechanism of action for three mood-stabilizing drugs. Nature (2002) 2.58

Coronin involved in phagocytosis: dynamics of particle-induced relocalization visualized by a green fluorescent protein Tag. Cell (1995) 2.42

Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactions. Cell (2003) 2.31

The mood-stabilizing agent valproate inhibits the activity of glycogen synthase kinase-3. J Neurochem (1999) 2.20

Histone deacetylase is a target of valproic acid-mediated cellular differentiation. Cancer Res (2004) 2.17

Mood stabilizer valproate promotes ERK pathway-dependent cortical neuronal growth and neurogenesis. J Neurosci (2004) 2.17

Fluid-phase uptake by macropinocytosis in Dictyostelium. J Cell Sci (1997) 1.86

Quantitative imaging of single live cells reveals spatiotemporal dynamics of multistep signaling events of chemoattractant gradient sensing in Dictyostelium. Mol Biol Cell (2004) 1.76

Movin' on up: the role of PtdIns(4,5)P(2) in cell migration. Trends Cell Biol (2006) 1.72

Distinct roles of PI(3,4,5)P3 during chemoattractant signaling in Dictyostelium: a quantitative in vivo analysis by inhibition of PI3-kinase. Mol Biol Cell (2006) 1.67

A phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: biological roles of putative mammalian p110 and yeast Vps34p PI 3-kinase homologs during growth and development. Mol Cell Biol (1995) 1.64

Synaptosomes possess an exocytotic pool of glutamate. Nature (1986) 1.54

Anionic phospholipids regulate native and expressed epithelial sodium channel (ENaC). J Biol Chem (2002) 1.48

Valproic acid inhibits angiogenesis in vitro and in vivo. Mol Pharmacol (2004) 1.41

Direct activation of the epithelial Na(+) channel by phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-bisphosphate produced by phosphoinositide 3-OH kinase. J Biol Chem (2004) 1.40

Evolving anticancer drug valproic acid: insights into the mechanism and clinical studies. Med Res Rev (2005) 1.38

Inactivation of two Dictyostelium discoideum genes, DdPIK1 and DdPIK2, encoding proteins related to mammalian phosphatidylinositide 3-kinases, results in defects in endocytosis, lysosome to postlysosome transport, and actin cytoskeleton organization. J Cell Biol (1997) 1.36

Disruption of Dictyostelium PI3K genes reduces [32P]phosphatidylinositol 3,4 bisphosphate and [32P]phosphatidylinositol trisphosphate levels, alters F-actin distribution and impairs pinocytosis. J Cell Sci (1998) 1.33

Coronin and vacuolin identify consecutive stages of a late, actin-coated endocytic compartment in Dictyostelium. Curr Biol (1997) 1.26

Visualizing PI3 kinase-mediated cell-cell signaling during Dictyostelium development. Curr Biol (2002) 1.21

Effects of valproic acid derivatives on inositol trisphosphate depletion, teratogenicity, glycogen synthase kinase-3beta inhibition, and viral replication: a screening approach for new bipolar disorder drugs derived from the valproic acid core structure. Mol Pharmacol (2005) 1.20

Modulation of sodium currents in rat CA1 neurons by carbamazepine and valproate after kindling epileptogenesis. Epilepsia (1999) 1.19

Synapsin I-associated phosphatidylinositol 3-kinase mediates synaptic vesicle delivery to the readily releasable pool. J Biol Chem (2003) 1.18

Rac and Rho mediate opposing hormonal regulation of the ether-a-go-go-related potassium channel. Curr Biol (2002) 1.13

Localized Ca2+ entry preferentially effects protein dephosphorylation, phosphorylation, and glutamate release. J Biol Chem (1992) 1.10

The effects of central nervous system-active valproic acid constitutional isomers, cyclopropyl analogs, and amide derivatives on neuronal growth cone behavior. Mol Pharmacol (2006) 1.06

Isozyme-specific stimulation of phospholipase C-gamma2 by Rac GTPases. J Biol Chem (2005) 1.05

GSK-3 activity in neocortical cells is inhibited by lithium but not carbamazepine or valproic acid. Bipolar Disord (2005) 1.05

Safety and efficacy of intravenous valproate in pediatric status epilepticus and acute repetitive seizures. Epilepsia (2003) 1.02

p110-related PI 3-kinases regulate phagosome-phagosome fusion and phagosomal pH through a PKB/Akt dependent pathway in Dictyostelium. J Cell Sci (2001) 1.02

Computer-assisted three-dimensional reconstruction and motion analysis of living, crawling cells. Comput Med Imaging Graph (1999) 1.00

Inhibition of phosphatidylinositol 3-kinase/Akt and histone deacetylase activity induces apoptosis in non-small cell lung cancer in vitro and in vivo. J Thorac Cardiovasc Surg (2005) 0.97

Valproic acid selectively inhibits conversion of arachidonic acid to arachidonoyl-CoA by brain microsomal long-chain fatty acyl-CoA synthetases: relevance to bipolar disorder. Psychopharmacology (Berl) (2005) 0.96

Neural crest cell motility in valproic acid. Reprod Toxicol (2002) 0.94

The neuroprotective agent, valproic acid, regulates the mitogen-activated protein kinase pathway through modulation of protein kinase A signalling in Dictyostelium discoideum. Eur J Cell Biol (2006) 0.91

Valproate suppresses status epilepticus induced by 4-aminopyridine in CA1 hippocampus region. Epilepsia (2003) 0.87

Diffusion of the new antiepileptic drug lamotrigine in Dutch clinical practice. Eur J Clin Pharmacol (2004) 0.86

Dynamic release of amino acid transmitters induced by valproate in PTZ-kindled epileptic rat hippocampus. Neurochem Int (2004) 0.83

Mechanisms in the regulation of neurotransmitter release from brain nerve terminals: current hypotheses. Neurochem Res (1993) 0.82

Co-operation of phosphatidylinositol transfer protein with phosphoinositide 3-kinase gamma in the formylmethionyl-leucylphenylalanine-dependent production of phosphatidylinositol 3,4,5-trisphosphate in human neutrophils. Biochem J (1997) 0.82

Polymorphism screening of PIP5K2A: a candidate gene for chromosome 10p-linked psychiatric disorders. Am J Med Genet B Neuropsychiatr Genet (2003) 0.81

Incorporation of [3H]valproic acid into lipids in GT1-7 neurons. Biochem Pharmacol (1998) 0.78

Mechanism of butyrate-induced hyperpolarization of cultured rat myenteric neurones. Neurogastroenterol Motil (2004) 0.78

Different dependence of lithium and valproate on PI3K/PKB pathway. Bipolar Disord (2002) 0.78

Valproate reduced synaptic activity increase induced by 4-aminopyridine at the hippocampal CA3-CA1 synapse. Epilepsia (2004) 0.78

Articles by these authors

Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding. N Engl J Med (2005) 6.39

Omeprazole before endoscopy in patients with gastrointestinal bleeding. N Engl J Med (2007) 4.29

Dynamic actin patterns and Arp2/3 assembly at the substrate-attached surface of motile cells. Curr Biol (2004) 2.95

Key role of local regulation in chemosensing revealed by a new molecular interaction-based modeling method. PLoS Comput Biol (2006) 2.13

Visualizing cytoskeleton dynamics in mammalian cells using a humanized variant of monomeric red fluorescent protein. FEBS Lett (2006) 2.08

Mobile actin clusters and traveling waves in cells recovering from actin depolymerization. Biophys J (2004) 1.96

The three-dimensional dynamics of actin waves, a model of cytoskeletal self-organization. Biophys J (2009) 1.89

Quantitative imaging of single live cells reveals spatiotemporal dynamics of multistep signaling events of chemoattractant gradient sensing in Dictyostelium. Mol Biol Cell (2004) 1.76

Subsecond reorganization of the actin network in cell motility and chemotaxis. Proc Natl Acad Sci U S A (2005) 1.66

A brilliant monomeric red fluorescent protein to visualize cytoskeleton dynamics in Dictyostelium. FEBS Lett (2004) 1.63

Identification of the Axin and Frat binding region of glycogen synthase kinase-3. J Biol Chem (2001) 1.49

Fluorescence resonance energy transfer in living cells reveals dynamic membrane changes in the initiation of B cell signaling. Proc Natl Acad Sci U S A (2006) 1.45

Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death. Mol Cell Biol (2004) 1.43

A Lim protein involved in the progression of cytokinesis and regulation of the mitotic spindle. Cell Motil Cytoskeleton (2003) 1.34

Dictyostelium Ric8 is a nonreceptor guanine exchange factor for heterotrimeric G proteins and is important for development and chemotaxis. Proc Natl Acad Sci U S A (2013) 1.34

Evidence for ligand-independent multimerization of the IL-17 receptor. J Immunol (2006) 1.29

Locally controlled inhibitory mechanisms are involved in eukaryotic GPCR-mediated chemosensing. J Cell Biol (2007) 1.25

Towards a molecular understanding of human diseases using Dictyostelium discoideum. Trends Mol Med (2006) 1.22

Spontaneous clustering and tyrosine phosphorylation of NK cell inhibitory receptor induced by ligand binding. J Immunol (2003) 1.15

14-3-3 coordinates microtubules, Rac, and myosin II to control cell mechanics and cytokinesis. Curr Biol (2010) 1.14

Association between Gαi2 and ELMO1/Dock180 connects chemokine signalling with Rac activation and metastasis. Nat Commun (2013) 1.14

A Gβγ effector, ElmoE, transduces GPCR signaling to the actin network during chemotaxis. Dev Cell (2012) 1.13

Structure-function studies for the panacea, valproic acid. Biochem Soc Trans (2009) 1.12

Mechanistic analysis of a DNA damage-induced, PTEN-dependent size checkpoint in human cells. Mol Cell Biol (2011) 1.11

Fluorescence resonance energy transfer imaging reveals that chemokine-binding modulates heterodimers of CXCR4 and CCR5 receptors. PLoS One (2008) 1.10

Mechanically induced actin-mediated rocketing of phagosomes. Mol Biol Cell (2006) 1.10

Curvature recognition and force generation in phagocytosis. BMC Biol (2010) 1.08

Quantitative and microscopic methods for studying the endocytic pathway. Methods Mol Biol (2006) 1.07

Adiponectin is required for PPARγ-mediated improvement of endothelial function in diabetic mice. Cell Metab (2011) 1.07

Dual Phosphorylation of suppressor of fused (Sufu) by PKA and GSK3beta regulates its stability and localization in the primary cilium. J Biol Chem (2011) 1.05

Ligand-induced partitioning of human CXCR1 chemokine receptors with lipid raft microenvironments facilitates G-protein-dependent signaling. Mol Cell Biol (2005) 1.05

Cutting edge: identification of a pre-ligand assembly domain (PLAD) and ligand binding site in the IL-17 receptor. J Immunol (2007) 1.05

The mood stabiliser lithium suppresses PIP3 signalling in Dictyostelium and human cells. Dis Model Mech (2009) 1.04

Genetic analysis of the role of G protein-coupled receptor signaling in electrotaxis. J Cell Biol (2002) 1.02

Loss of phosphatidylinositol 4-kinase 2alpha activity causes late onset degeneration of spinal cord axons. Proc Natl Acad Sci U S A (2009) 1.01

HIV gp120-induced interaction between CD4 and CCR5 requires cholesterol-rich microenvironments revealed by live cell fluorescence resonance energy transfer imaging. J Biol Chem (2006) 1.01

The contractile vacuole in Ca2+-regulation in Dictyostelium: its essential function for cAMP-induced Ca2+-influx. BMC Dev Biol (2006) 0.99

Seizure control by ketogenic diet-associated medium chain fatty acids. Neuropharmacology (2012) 0.99

Coupling mechanism of a GPCR and a heterotrimeric G protein during chemoattractant gradient sensing in Dictyostelium. Sci Signal (2010) 0.98

The BEACH protein LvsB is localized on lysosomes and postlysosomes and limits their fusion with early endosomes. Traffic (2007) 0.97

Presynaptic signaling by heterotrimeric G-proteins. Handb Exp Pharmacol (2008) 0.96

Cholesterol goal attainment in patients with coronary heart disease and elevated coronary risk: results of the Hong Kong hospital audit study. Value Health (2008) 0.96

The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium. Dis Model Mech (2011) 0.95

Reversal of cell polarity and actin-myosin cytoskeleton reorganization under mechanical and chemical stimulation. Biophys J (2007) 0.95

Loss of the beta-catenin homologue aardvark causes ectopic stalk formation in Dictyostelium. Mech Dev (2002) 0.95

An Elmo-like protein associated with myosin II restricts spurious F-actin events to coordinate phagocytosis and chemotaxis. Dev Cell (2008) 0.95

An inverse PCR technique to rapidly isolate the flanking DNA of dictyostelium insertion mutants. Mol Biotechnol (2004) 0.94

Systemic lupus erythematosus with neuropsychiatric manifestation incurs high disease costs: a cost-of-illness study in Hong Kong. Rheumatology (Oxford) (2009) 0.92

A Dictyostelium mutant with reduced lysozyme levels compensates by increased phagocytic activity. J Biol Chem (2005) 0.92

PIP3 waves and PTEN dynamics in the emergence of cell polarity. Biophys J (2012) 0.92

Microblogging, online expression, and political efficacy among young chinese citizens: the moderating role of information and entertainment needs in the use of weibo. Cyberpsychol Behav Soc Netw (2012) 0.92

The actinome of Dictyostelium discoideum in comparison to actins and actin-related proteins from other organisms. PLoS One (2008) 0.92

A pharmacist care program: positive impact on cardiac risk in patients with type 2 diabetes. J Cardiovasc Pharmacol Ther (2011) 0.91

Actin-binding proteins required for reliable chromosome segregation in mitosis. Cell Motil Cytoskeleton (2004) 0.91

The neuroprotective agent, valproic acid, regulates the mitogen-activated protein kinase pathway through modulation of protein kinase A signalling in Dictyostelium discoideum. Eur J Cell Biol (2006) 0.91

Positive feedback regulation between gamma-aminobutyric acid type A (GABA(A)) receptor signaling and brain-derived neurotrophic factor (BDNF) release in developing neurons. J Biol Chem (2011) 0.91

Activation of Ran GTPase by a Legionella effector promotes microtubule polymerization, pathogen vacuole motility and infection. PLoS Pathog (2013) 0.91

Time-resolved responses to chemoattractant, characteristic of the front and tail of Dictyostelium cells. FEBS Lett (2006) 0.90

Two peptidase activities decrease in treated bipolar disorder not schizophrenic patients. Bipolar Disord (2004) 0.90

Metabotropic actions of kainate receptors in the CNS. J Neurochem (2007) 0.90

Identifying an uptake mechanism for the antiepileptic and bipolar disorder treatment valproic acid using the simple biomedical model Dictyostelium. J Cell Sci (2011) 0.89

Genetic evidence for concerted control of actin dynamics in cytokinesis, endocytic traffic, and cell motility by coronin and Aip1. Cytoskeleton (Hoboken) (2010) 0.88

Redundant and unique roles of coronin proteins in Dictyostelium. Cell Mol Life Sci (2010) 0.88

Kainate receptors with a metabotropic modus operandi. Trends Neurosci (2007) 0.88

Clinical and economic impact of clinical pharmacy service on hyperlipidemic management in Hong Kong. J Cardiovasc Pharmacol Ther (2010) 0.88

Molecular pharmacology in a simple model system: implicating MAP kinase and phosphoinositide signalling in bipolar disorder. Semin Cell Dev Biol (2010) 0.87

Overlapping functions of the two talin homologues in Dictyostelium. Eukaryot Cell (2008) 0.87

Presynaptic kainate receptor facilitation of glutamate release involves protein kinase A in the rat hippocampus. J Physiol (2004) 0.87

Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release. J Biol Chem (2009) 0.87

A coat of filamentous actin prevents clustering of late-endosomal vacuoles in vivo. Curr Biol (2003) 0.87

Effects of vitamins C and E on oxidative stress markers and endothelial function in patients with systemic lupus erythematosus: a double blind, placebo controlled pilot study. J Rheumatol (2005) 0.87

A Cdc42- and Rac-interactive binding (CRIB) domain mediates functions of coronin. Proc Natl Acad Sci U S A (2013) 0.86

Presynaptic roles of intracellular Ca(2+) stores in signalling and exocytosis. Biochem Soc Trans (2010) 0.86

Combined antibiotic/corticosteroid cream in the empirical treatment of moderate to severe eczema: friend or foe? J Drugs Dermatol (2012) 0.86

The Elmo family forms an ancient group of actin-regulating proteins. Commun Integr Biol (2009) 0.86

Levofloxacin-resistant Helicobacter pylori in Hong Kong. Chemotherapy (2007) 0.85

GFP-fusion proteins as fluorescent reporters to study organelle and cytoskeleton dynamics in chemotaxis and phagocytosis. Methods Enzymol (2003) 0.84

The Rac GEF ZizB regulates development, cell motility and cytokinesis in Dictyostelium. J Cell Sci (2012) 0.84

Genetic control of lithium sensitivity and regulation of inositol biosynthetic genes. PLoS One (2010) 0.84

Icm/Dot-dependent inhibition of phagocyte migration by Legionella is antagonized by a translocated Ran GTPase activator. Cell Microbiol (2014) 0.84

Relationship between flare and health-related quality of life in patients with systemic lupus erythematosus. J Rheumatol (2010) 0.84

Release of Ca2+ from the endoplasmic reticulum contributes to Ca2+ signaling in Dictyostelium discoideum. Eukaryot Cell (2005) 0.83

RpkA, a highly conserved GPCR with a lipid kinase domain, has a role in phagocytosis and anti-bacterial defense. PLoS One (2011) 0.83

Quantifying in vivo phosphoinositide turnover in chemotactically competent Dictyostelium cells. Methods Mol Biol (2009) 0.83

Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients. Pharmacogenet Genomics (2010) 0.83

Slamming the DOR on chemokine receptor signaling: heterodimerization silences ligand-occupied CXCR4 and delta-opioid receptors. Eur J Immunol (2008) 0.82

Using quantitative fluorescence microscopy and FRET imaging to measure spatiotemporal signaling events in single living cells. Methods Mol Biol (2006) 0.82

Dabigatran compared with warfarin for stroke prevention with atrial fibrillation: experience in Hong Kong. Clin Cardiol (2012) 0.82

Imaging protein-protein interactions by Förster resonance energy transfer (FRET) microscopy in live cells. Curr Protoc Protein Sci (2009) 0.81

A vesicle surface tyrosine kinase regulates phagosome maturation. J Cell Biol (2007) 0.81

Corticosteroids are not present in a traditional Chinese medicine formulation for atopic dermatitis in children. Ann Acad Med Singapore (2006) 0.81

A Coronin7 homolog with functions in actin-driven processes. J Biol Chem (2010) 0.81

Investigating the effect of emetic compounds on chemotaxis in Dictyostelium identifies a non-sentient model for bitter and hot tastant research. PLoS One (2011) 0.81

Noncompetitive metabotropic glutamate5 receptor antagonist (E)-2-methyl-6-styryl-pyridine (SIB1893) depresses glutamate release through inhibition of voltage-dependent Ca2+ entry in rat cerebrocortical nerve terminals (synaptosomes). J Pharmacol Exp Ther (2004) 0.81

Vacuolin, a flotillin/reggie-related protein from Dictyostelium oligomerizes for endosome association. Eur J Cell Biol (2006) 0.80

Economic evaluation of universal infant vaccination with 7vPCV in Hong Kong. Value Health (2010) 0.80

Unexpected inhibitory regulation of glutamate release from rat cerebrocortical nerve terminals by presynaptic 5-hydroxytryptamine-2A receptors. J Neurosci Res (2006) 0.80