Published in J Cell Biol on July 02, 2007
A comparison of mathematical models for polarization of single eukaryotic cells in response to guided cues. PLoS Comput Biol (2011) 2.00
Directional sensing during chemotaxis. FEBS Lett (2008) 1.84
Chemotaxis, chemokine receptors and human disease. Cytokine (2008) 1.63
Incoherent feedforward control governs adaptation of activated ras in a eukaryotic chemotaxis pathway. Sci Signal (2012) 1.53
Rescaling of Spatio-Temporal Sensing in Eukaryotic Chemotaxis. PLoS One (2016) 1.40
Multiscale modeling for biologists. Wiley Interdiscip Rev Syst Biol Med (2010) 1.16
Neutrophils establish rapid and robust WAVE complex polarity in an actin-dependent fashion. Curr Biol (2009) 1.15
RACK1 regulates directional cell migration by acting on G betagamma at the interface with its effectors PLC beta and PI3K gamma. Mol Biol Cell (2008) 1.11
Fluorescence resonance energy transfer imaging reveals that chemokine-binding modulates heterodimers of CXCR4 and CCR5 receptors. PLoS One (2008) 1.10
Quantifying cellular interaction dynamics in 3D fluorescence microscopy data. Nat Protoc (2009) 1.09
Oscillatory signaling and network responses during the development of Dictyostelium discoideum. Ageing Res Rev (2008) 1.01
Rectified directional sensing in long-range cell migration. Nat Commun (2014) 0.97
Excitable signal transduction induces both spontaneous and directional cell asymmetries in the phosphatidylinositol lipid signaling system for eukaryotic chemotaxis. Biophys J (2014) 0.94
An excitable cortex and memory model successfully predicts new pseudopod dynamics. PLoS One (2012) 0.90
Computational reconstruction of cell and tissue surfaces for modeling and data analysis. Nat Protoc (2009) 0.82
Understanding diseases by mouse click: the promise and potential of computational approaches in Systems Biology. Clin Exp Immunol (2007) 0.80
Imaging G-protein coupled receptor (GPCR)-mediated signaling events that control chemotaxis of Dictyostelium discoideum. J Vis Exp (2011) 0.80
A shortcut from GPCR signaling to Rac-mediated actin cytoskeleton through an ELMO/DOCK complex. Small GTPases (2012) 0.77
Chemoattractant stimulation of TORC2 is regulated by receptor/G protein-targeted inhibitory mechanisms that function upstream and independently of an essential GEF/Ras activation pathway in Dictyostelium. Mol Biol Cell (2013) 0.77
Arrestins function in cAR1 GPCR-mediated signaling and cAR1 internalization in the development of Dictyostelium discoideum. Mol Biol Cell (2014) 0.75
Cellular motility driven by assembly and disassembly of actin filaments. Cell (2003) 26.05
Polarization of chemoattractant receptor signaling during neutrophil chemotaxis. Science (2000) 6.93
The molecular biology of leukocyte chemoattractant receptors. Annu Rev Immunol (1994) 6.82
G protein signaling events are activated at the leading edge of chemotactic cells. Cell (1998) 6.60
Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils. Cell (2003) 6.46
Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis. Cell (2002) 6.36
Tumor suppressor PTEN mediates sensing of chemoattractant gradients. Cell (2002) 6.06
A cell's sense of direction. Science (1999) 6.00
Chemotaxis in eukaryotic cells: a focus on leukocytes and Dictyostelium. Annu Rev Cell Biol (1988) 5.30
Chemotaxis: signalling the way forward. Nat Rev Mol Cell Biol (2004) 4.96
Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction. Science (2000) 4.61
Regulation of PTEN by Rho small GTPases. Nat Cell Biol (2005) 4.51
Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium. EMBO J (1999) 4.34
Receptor-mediated activation of heterotrimeric G-proteins in living cells. Science (2001) 4.04
Eukaryotic chemotaxis: distinctions between directional sensing and polarization. J Biol Chem (2003) 3.95
Models of eukaryotic gradient sensing: application to chemotaxis of amoebae and neutrophils. Biophys J (2002) 3.93
Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement. J Cell Biol (2004) 3.44
Orientation of chemotactic cells and growth cones: models and mechanisms. J Cell Sci (1999) 3.31
Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma. Science (2003) 3.27
Role of phosphatidylinositol 3' kinase and a downstream pleckstrin homology domain-containing protein in controlling chemotaxis in dictyostelium. J Cell Biol (2001) 3.03
A local coupling model and compass parameter for eukaryotic chemotaxis. Dev Cell (2005) 3.02
The great escape: when cancer cells hijack the genes for chemotaxis and motility. Annu Rev Cell Dev Biol (2005) 2.97
Single-molecule analysis of chemotactic signaling in Dictyostelium cells. Science (2001) 2.89
Localization of the G protein betagamma complex in living cells during chemotaxis. Science (2000) 2.87
Signaling pathways controlling cell polarity and chemotaxis. Trends Biochem Sci (2001) 2.58
Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton. Proc Natl Acad Sci U S A (2004) 2.52
Temporal and spatial regulation of chemotaxis. Dev Cell (2002) 2.35
Chemotaxis by polymorphonuclear leukocytes. J Cell Biol (1978) 2.20
Key role of local regulation in chemosensing revealed by a new molecular interaction-based modeling method. PLoS Comput Biol (2006) 2.13
Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa. Mol Cell (2001) 2.07
Cyclic 3',5' AMP relay in Dictyostelium discoideum. II. Requirements for the initiation and termination of the response. J Cell Biol (1979) 2.05
A diffusion-translocation model for gradient sensing by chemotactic cells. Biophys J (2001) 2.04
Directional sensing in eukaryotic chemotaxis: a balanced inactivation model. Proc Natl Acad Sci U S A (2006) 1.98
Feedback signaling controls leading-edge formation during chemotaxis. Curr Opin Genet Dev (2006) 1.95
Roles of PI3Ks in leukocyte chemotaxis and phagocytosis. Curr Opin Cell Biol (2002) 1.80
Quantitative imaging of single live cells reveals spatiotemporal dynamics of multistep signaling events of chemoattractant gradient sensing in Dictyostelium. Mol Biol Cell (2004) 1.76
G protein-linked signaling pathways control the developmental program of Dictyostelium. Neuron (1994) 1.74
Modeling the cell's guidance system. Sci STKE (2002) 1.68
Sensitization of Dictyostelium chemotaxis by phosphoinositide-3-kinase-mediated self-organizing signalling patches. J Cell Sci (2004) 1.67
Cyclic 3',5'-AMP relay in Dictyostelium discoideum V. Adaptation of the cAMP signaling response during cAMP stimulation. J Cell Biol (1980) 1.56
Cyclic 3',5'-AMP relay in Dictyostelium discoideum IV. Recovery of the cAMP signaling response after adaptation to cAMP. J Cell Biol (1980) 1.53
PI 3-kinases and PTEN: how opposites chemoattract. Cell (2002) 1.46
Chemotaxis in Dictyostelium. Annu Rev Physiol (1982) 1.43
The PI3K-mediated activation of CRAC independently regulates adenylyl cyclase activation and chemotaxis. Curr Biol (2005) 1.31
Identification of the ras GTPase-activating protein GAP1(m) as a phosphatidylinositol-3,4,5-trisphosphate-binding protein in vivo. Curr Biol (1999) 1.15
A G alpha-dependent pathway that antagonizes multiple chemoattractant responses that regulate directional cell movement. Genes Dev (2004) 1.08
RasC plays a role in transduction of temporal gradient information in the cyclic-AMP wave of Dictyostelium discoideum. Eukaryot Cell (2004) 0.97
Chemotactic antagonists of cAMP inhibit Dictyostelium phospholipase C. J Cell Sci (1993) 0.81
CD4+ T-cell depletion in HIV infection: are we closer to understanding the cause? Nat Med (2002) 5.18
Pathogenesis of HIV infection: what the virus spares is as important as what it destroys. Nat Med (2006) 4.23
CD4 T cell depletion is linked directly to immune activation in the pathogenesis of HIV-1 and HIV-2 but only indirectly to the viral load. J Immunol (2002) 3.85
Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection. J Exp Med (2007) 3.45
Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis. Nature (2009) 2.79
Systems biology in immunology: a computational modeling perspective. Annu Rev Immunol (2011) 2.15
Key role of local regulation in chemosensing revealed by a new molecular interaction-based modeling method. PLoS Comput Biol (2006) 2.13
Spontaneous proliferation, a response of naive CD4 T cells determined by the diversity of the memory cell repertoire. Proc Natl Acad Sci U S A (2004) 2.08
Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Ralpha, IL-13Ralpha1, and gammac regulates relative cytokine sensitivity. J Exp Med (2008) 1.83
Quantitative imaging of single live cells reveals spatiotemporal dynamics of multistep signaling events of chemoattractant gradient sensing in Dictyostelium. Mol Biol Cell (2004) 1.76
Exact Green's function of the reversible diffusion-influenced reaction for an isolated pair in two dimensions. J Chem Phys (2012) 1.66
Fluorescence resonance energy transfer in living cells reveals dynamic membrane changes in the initiation of B cell signaling. Proc Natl Acad Sci U S A (2006) 1.45
Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death. Mol Cell Biol (2004) 1.43
Computational modeling of cellular signaling processes embedded into dynamic spatial contexts. Nat Methods (2012) 1.37
lncRNA H19/miR-675 axis represses prostate cancer metastasis by targeting TGFBI. FEBS J (2014) 1.36
Dictyostelium Ric8 is a nonreceptor guanine exchange factor for heterotrimeric G proteins and is important for development and chemotaxis. Proc Natl Acad Sci U S A (2013) 1.34
Concomitant regulation of T-cell activation and homeostasis. Nat Rev Immunol (2004) 1.29
Evidence for ligand-independent multimerization of the IL-17 receptor. J Immunol (2006) 1.29
Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo. J Exp Med (2010) 1.28
Inflammation-induced interstitial migration of effector CD4⁺ T cells is dependent on integrin αV. Nat Immunol (2013) 1.24
Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques. Blood (2007) 1.17
Theory of reversible diffusion-influenced reactions with non-Markovian dissociation in two space dimensions. J Chem Phys (2013) 1.15
Spontaneous clustering and tyrosine phosphorylation of NK cell inhibitory receptor induced by ligand binding. J Immunol (2003) 1.15
Association between Gαi2 and ELMO1/Dock180 connects chemokine signalling with Rac activation and metastasis. Nat Commun (2013) 1.14
A Gβγ effector, ElmoE, transduces GPCR signaling to the actin network during chemotaxis. Dev Cell (2012) 1.13
How human leukocytes track down and destroy pathogens: lessons learned from the model organism Dictyostelium discoideum. Immunol Res (2009) 1.13
Mechanistic analysis of a DNA damage-induced, PTEN-dependent size checkpoint in human cells. Mol Cell Biol (2011) 1.11
Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines. Nat Chem Biol (2012) 1.10
Fluorescence resonance energy transfer imaging reveals that chemokine-binding modulates heterodimers of CXCR4 and CCR5 receptors. PLoS One (2008) 1.10
Quantifying cellular interaction dynamics in 3D fluorescence microscopy data. Nat Protoc (2009) 1.09
Dual Phosphorylation of suppressor of fused (Sufu) by PKA and GSK3beta regulates its stability and localization in the primary cilium. J Biol Chem (2011) 1.05
Cutting edge: identification of a pre-ligand assembly domain (PLAD) and ligand binding site in the IL-17 receptor. J Immunol (2007) 1.05
Ligand-induced partitioning of human CXCR1 chemokine receptors with lipid raft microenvironments facilitates G-protein-dependent signaling. Mol Cell Biol (2005) 1.05
Genetic analysis of the role of G protein-coupled receptor signaling in electrotaxis. J Cell Biol (2002) 1.02
HIV gp120-induced interaction between CD4 and CCR5 requires cholesterol-rich microenvironments revealed by live cell fluorescence resonance energy transfer imaging. J Biol Chem (2006) 1.01
Attenuation of phospholipid signaling provides a novel mechanism for the action of valproic acid. Eukaryot Cell (2007) 1.00
Feedback regulation of proliferation vs. differentiation rates explains the dependence of CD4 T-cell expansion on precursor number. Proc Natl Acad Sci U S A (2011) 1.00
Coupling mechanism of a GPCR and a heterotrimeric G protein during chemoattractant gradient sensing in Dictyostelium. Sci Signal (2010) 0.98
The chemotaxis response regulator CheY can catalyze its own acetylation. J Mol Biol (2006) 0.96
An Elmo-like protein associated with myosin II restricts spurious F-actin events to coordinate phagocytosis and chemotaxis. Dev Cell (2008) 0.95
The Simmune Modeler visual interface for creating signaling networks based on bi-molecular interactions. Bioinformatics (2013) 0.92
Microblogging, online expression, and political efficacy among young chinese citizens: the moderating role of information and entertainment needs in the use of weibo. Cyberpsychol Behav Soc Netw (2012) 0.92
The neuroprotective agent, valproic acid, regulates the mitogen-activated protein kinase pathway through modulation of protein kinase A signalling in Dictyostelium discoideum. Eur J Cell Biol (2006) 0.91
The Elmo family forms an ancient group of actin-regulating proteins. Commun Integr Biol (2009) 0.86
Computational reconstruction of cell and tissue surfaces for modeling and data analysis. Nat Protoc (2009) 0.82
Using quantitative fluorescence microscopy and FRET imaging to measure spatiotemporal signaling events in single living cells. Methods Mol Biol (2006) 0.82
Slamming the DOR on chemokine receptor signaling: heterodimerization silences ligand-occupied CXCR4 and delta-opioid receptors. Eur J Immunol (2008) 0.82
A vesicle surface tyrosine kinase regulates phagosome maturation. J Cell Biol (2007) 0.81
Imaging protein-protein interactions by Förster resonance energy transfer (FRET) microscopy in live cells. Curr Protoc Protein Sci (2009) 0.81
Imaging G-protein coupled receptor (GPCR)-mediated signaling events that control chemotaxis of Dictyostelium discoideum. J Vis Exp (2011) 0.80
Opposing roles for RhoH GTPase during T-cell migration and activation. Proc Natl Acad Sci U S A (2012) 0.79
NetworkViewer: visualizing biochemical reaction networks with embedded rendering of molecular interaction rules. BMC Syst Biol (2014) 0.78
High production rates sustain in vivo levels of PD-1high simian immunodeficiency virus-specific CD8 T cells in the face of rapid clearance. J Virol (2013) 0.78
Endothelin signaling axis activates osteopontin expression through PI3 kinase pathway in A375 melanoma cells. J Dermatol Sci (2008) 0.78
Monitoring dynamic GPCR signaling events using fluorescence microscopy, FRET imaging, and single-molecule imaging. Methods Mol Biol (2009) 0.77
Chemotaxis: new role for Ras revealed. Protein Cell (2010) 0.77
A shortcut from GPCR signaling to Rac-mediated actin cytoskeleton through an ELMO/DOCK complex. Small GTPases (2012) 0.77
HIV gp120 is an aberrant chemoattractant for blood resting CD4 T cells. Curr HIV Res (2012) 0.77
Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2. J Med Chem (2012) 0.77
Genistein interferes with SDF-1- and HIV-mediated actin dynamics and inhibits HIV infection of resting CD4 T cells. Retrovirology (2013) 0.75
The Novel Functions of the PLC/PKC/PKD Signaling Axis in G Protein-Coupled Receptor-Mediated Chemotaxis of Neutrophils. J Immunol Res (2015) 0.75
Signaling network from GPCR to the actin cytoskeleton during chemotaxis. Bioarchitecture (2012) 0.75
[Comparison of paravertebral soft tissue tension changes in patients with chronic lower back pain treated by sliver needle and traditional Chinese medicine fumigation]. Zhongguo Gu Shang (2014) 0.75
A predictive Bayesian approach to the design and analysis of bridging studies. J Biopharm Stat (2012) 0.75
Thiazolothiazole-linked porous organic polymers. Chem Commun (Camb) (2014) 0.75
Portable optical resolution photoacoustic microscopy (pORPAM) for human oral imaging. Opt Lett (2017) 0.75
[EXPRESS] Translocator protein agonist Ro5-4864 alleviates neuropathic pain and promotes remyelination in the sciatic nerve. Mol Pain (2017) 0.75