Substrate profile analysis and ACP-mediated acyl transfer in Streptomyces coelicolor Type III polyketide synthases.

Polyketide proofreading by an acyltransferase-like enzyme. Chem Biol (2012) 1.57

In vivo and in vitro analysis of the hedamycin polyketide synthase. Chem Biol (2009) 1.08

Direct transfer of starter substrates from type I fatty acid synthase to type III polyketide synthases in phenolic lipid synthesis. Proc Natl Acad Sci U S A (2008) 1.04

Biosynthesis of aliphatic polyketides by type III polyketide synthase and methyltransferase in Bacillus subtilis. J Bacteriol (2009) 0.95

Engineering polyketide synthases and nonribosomal peptide synthetases. Curr Opin Struct Biol (2013) 0.92

Biochemical and structural characterization of germicidin synthase: analysis of a type III polyketide synthase that employs acyl-ACP as a starter unit donor. J Am Chem Soc (2012) 0.92

A Streptomyces coelicolor host for the heterologous expression of Type III polyketide synthase genes. Microb Cell Fact (2015) 0.77

Germicidins H-J from Streptomyces sp. CB00361. J Antibiot (Tokyo) (2016) 0.75

Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome. Cancer Res (2007) 3.85

Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula. J Nat Prod (2004) 2.71

Metamorphic enzyme assembly in polyketide diversification. Nature (2009) 2.64

Identification of the putative bryostatin polyketide synthase gene cluster from "Candidatus Endobugula sertula", the uncultivated microbial symbiont of the marine bryozoan Bugula neritina. J Nat Prod (2007) 2.45

Automated genome mining for natural products. BMC Bioinformatics (2009) 2.29

Radio-wave heating of iron oxide nanoparticles can regulate plasma glucose in mice. Science (2012) 2.14

The barbamide biosynthetic gene cluster: a novel marine cyanobacterial system of mixed polyketide synthase (PKS)-non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit. Gene (2002) 2.09

Three-dimensional cellular microarray for high-throughput toxicology assays. Proc Natl Acad Sci U S A (2007) 2.09

Biosynthetic characterization and chemoenzymatic assembly of the cryptophycins. Potent anticancer agents from cyanobionts. ACS Chem Biol (2006) 1.94

Silica nanoparticle size influences the structure and enzymatic activity of adsorbed lysozyme. Langmuir (2004) 1.86

Structural basis for macrolactonization by the pikromycin thioesterase. Nat Chem Biol (2006) 1.79

E. coli K5 fermentation and the preparation of heparosan, a bioengineered heparin precursor. Biotechnol Bioeng (2010) 1.65

High-throughput cellular microarray platforms: applications in drug discovery, toxicology and stem cell research. Trends Biotechnol (2009) 1.56

Metabolic coupling of dehydration and decarboxylation in the curacin A pathway: functional identification of a mechanistically diverse enzyme pair. J Am Chem Soc (2006) 1.55

Structure and function of enzymes adsorbed onto single-walled carbon nanotubes. Langmuir (2004) 1.52

Uncovering genes with divergent mRNA-protein dynamics in Streptomyces coelicolor. PLoS One (2008) 1.46

Inhibition of NADPH oxidase activation in endothelial cells by ortho-methoxy-substituted catechols. Endothelium (2002) 1.46

Ionic liquid-mediated selective extraction of lignin from wood leading to enhanced enzymatic cellulose hydrolysis. Biotechnol Bioeng (2009) 1.46

Structural and mechanistic insights into polyketide macrolactonization from polyketide-based affinity labels. Nat Chem Biol (2006) 1.45

Isolation and characterization of novel marine-derived actinomycete taxa rich in bioactive metabolites. Appl Environ Microbiol (2004) 1.42

Crystal structures of dehydratase domains from the curacin polyketide biosynthetic pathway. Structure (2010) 1.39

GNAT-like strategy for polyketide chain initiation. Science (2007) 1.36

Resveratrol selectively remodels soluble oligomers and fibrils of amyloid Abeta into off-pathway conformers. J Biol Chem (2010) 1.35

Polyketide decarboxylative chain termination preceded by o-sulfonation in curacin a biosynthesis. J Am Chem Soc (2009) 1.35

Diversity of P450 enzymes in the biosynthesis of natural products. Nat Prod Rep (2012) 1.34

Control of the heparosan N-deacetylation leads to an improved bioengineered heparin. Appl Microbiol Biotechnol (2011) 1.33

Room temperature ionic liquids as emerging solvents for the pretreatment of lignocellulosic biomass. Biotechnol Bioeng (2011) 1.31

Biochemical evidence for an editing role of thioesterase II in the biosynthesis of the polyketide pikromycin. J Biol Chem (2002) 1.31

Analysis of E. coli K5 capsular polysaccharide heparosan. Anal Bioanal Chem (2010) 1.30

Ultra-performance ion-pairing liquid chromatography with on-line electrospray ion trap mass spectrometry for heparin disaccharide analysis. Anal Biochem (2011) 1.28

bryA: an unusual modular polyketide synthase gene from the uncultivated bacterial symbiont of the marine bryozoan Bugula neritina. Chem Biol (2004) 1.27

Unfolding of ribonuclease A on silica nanoparticle surfaces. Nano Lett (2007) 1.26

Meta-omic characterization of the marine invertebrate microbial consortium that produces the chemotherapeutic natural product ET-743. ACS Chem Biol (2011) 1.26

Functional analysis of MycCI and MycG, cytochrome P450 enzymes involved in biosynthesis of mycinamicin macrolide antibiotics. Chem Biol (2008) 1.25

Characterization of the initial enzymatic steps of barbamide biosynthesis. J Nat Prod (2006) 1.25

Identification of a novel class in the alpha/beta hydrolase fold superfamily: the N-myc differentiation-related proteins. Proteins (2002) 1.25

Three-dimensional cell culture microarray for high-throughput studies of stem cell fate. Biotechnol Bioeng (2010) 1.22

New tricks from ancient algae: natural products biosynthesis in marine cyanobacteria. Curr Opin Chem Biol (2009) 1.22

Genome-based characterization of two prenylation steps in the assembly of the stephacidin and notoamide anticancer agents in a marine-derived Aspergillus sp. J Am Chem Soc (2010) 1.22

Biosynthetic analysis of the petrobactin siderophore pathway from Bacillus anthracis. J Bacteriol (2006) 1.22

Characterization and analysis of early enzymes for petrobactin biosynthesis in Bacillus anthracis. Biochemistry (2007) 1.21

Aromatic small molecules remodel toxic soluble oligomers of amyloid beta through three independent pathways. J Biol Chem (2010) 1.20

Enzyme activation for organic solvents made easy. Trends Biotechnol (2007) 1.19

Enantiomeric natural products: occurrence and biogenesis. Angew Chem Int Ed Engl (2012) 1.19

The unique mechanistic transformations involved in the biosynthesis of modular natural products from marine cyanobacteria. Nat Prod Rep (2010) 1.19

Fungal origins of the bicyclo[2.2.2]diazaoctane ring system of prenylated indole alkaloids. J Nat Prod (2012) 1.19

Engineering of routes to heparin and related polysaccharides. Appl Microbiol Biotechnol (2011) 1.19

Engineering and analysis of a self-sufficient biosynthetic cytochrome P450 PikC fused to the RhFRED reductase domain. J Am Chem Soc (2007) 1.18

Merging the potential of microbial genetics with biological and chemical diversity: an even brighter future for marine natural product drug discovery. Nat Prod Rep (2003) 1.18

Crystal structure of the ECH2 catalytic domain of CurF from Lyngbya majuscula. Insights into a decarboxylase involved in polyketide chain beta-branching. J Biol Chem (2007) 1.18

Phylogenetic and chemical diversity of three chemotypes of bloom-forming lyngbya species (Cyanobacteria: Oscillatoriales) from reefs of southeastern Florida. Appl Environ Microbiol (2009) 1.17

Structural basis for binding specificity between subclasses of modular polyketide synthase docking domains. ACS Chem Biol (2009) 1.17

Biochemical investigation of pikromycin biosynthesis employing native penta- and hexaketide chain elongation intermediates. J Am Chem Soc (2005) 1.15

Chemoenzymatic synthesis of the polyketide macrolactone 10-deoxymethynolide. J Am Chem Soc (2005) 1.15

Protein-assisted solubilization of single-walled carbon nanotubes. Langmuir (2006) 1.14

Metabolizing enzyme toxicology assay chip (MetaChip) for high-throughput microscale toxicity analyses. Proc Natl Acad Sci U S A (2005) 1.13

Osmolyte trimethylamine-N-oxide does not affect the strength of hydrophobic interactions: origin of osmolyte compatibility. Biophys J (2005) 1.13

Selective oxidation of carbolide C-H bonds by an engineered macrolide P450 mono-oxygenase. Proc Natl Acad Sci U S A (2009) 1.13

Utilizing the power of microbial genetics to bridge the gap between the promise and the application of marine natural products. Chembiochem (2005) 1.13

Genome-wide transcriptome analysis reveals that a pleiotropic antibiotic regulator, AfsS, modulates nutritional stress response in Streptomyces coelicolor A3(2). BMC Genomics (2008) 1.12

Biomimetic total synthesis of malbrancheamide and malbrancheamide B. J Org Chem (2008) 1.12

Generation of multiple bioactive macrolides by hybrid modular polyketide synthases in Streptomyces venezuelae. Chem Biol (2002) 1.10

Recent progress and applications in glycosaminoglycan and heparin research. Curr Opin Chem Biol (2009) 1.10

Developing tools for engineering hybrid polyketide synthetic pathways. Curr Opin Biotechnol (2006) 1.09

Effect of gold nanoparticle morphology on adsorbed protein structure and function. Biomaterials (2011) 1.08

Isolation and characterization of tirandamycins from a marine-derived Streptomyces sp. J Nat Prod (2009) 1.08

Isolation of the biosynthetic gene cluster for tautomycetin, a linear polyketide T cell-specific immunomodulator from Streptomyces sp. CK4412. Microbiology (2007) 1.08

Conformational switch triggered by alpha-ketoglutarate in a halogenase of curacin A biosynthesis. Proc Natl Acad Sci U S A (2010) 1.08

Enzyme activation for nonaqueous media. Curr Opin Biotechnol (2002) 1.08

Enzymatic assembly of the bis-indole core of rebeccamycin. J Am Chem Soc (2006) 1.08

Spaceflight promotes biofilm formation by Pseudomonas aeruginosa. PLoS One (2013) 1.08

Structural characterization of heparins from different commercial sources. Anal Bioanal Chem (2011) 1.07

Identification of the tirandamycin biosynthetic gene cluster from Streptomyces sp. 307-9. Chembiochem (2010) 1.07

Interrogating the molecular basis for multiple macrolactone ring formation by the pikromycin polyketide synthase. Chem Biol (2007) 1.07

On-chip, cell-based microarray immunofluorescence assay for high-throughput analysis of target proteins. Anal Chem (2008) 1.06

Biochemical characterization of NotB as an FAD-dependent oxidase in the biosynthesis of notoamide indole alkaloids. J Am Chem Soc (2011) 1.06

Tirandamycin biosynthesis is mediated by co-dependent oxidative enzymes. Nat Chem (2011) 1.06

The 1.92-A structure of Streptomyces coelicolor A3(2) CYP154C1. A new monooxygenase that functionalizes macrolide ring systems. J Biol Chem (2003) 1.06

Structural and functional analysis of AsbF: origin of the stealth 3,4-dihydroxybenzoic acid subunit for petrobactin biosynthesis. Proc Natl Acad Sci U S A (2008) 1.06

Complementary cell-based high-throughput screens identify novel modulators of the unfolded protein response. J Biomol Screen (2011) 1.05

A framework to analyze multiple time series data: a case study with Streptomyces coelicolor. J Ind Microbiol Biotechnol (2005) 1.05

Premalbrancheamide: synthesis, isotopic labeling, biosynthetic incorporation, and detection in cultures of Malbranchea aurantiaca. Org Lett (2008) 1.04

Toward an artificial Golgi: redesigning the biological activities of heparan sulfate on a digital microfluidic chip. J Am Chem Soc (2009) 1.04

Glycosaminoglycans in infectious disease. Biol Rev Camb Philos Soc (2013) 1.04

Baulamycins A and B, broad-spectrum antibiotics identified as inhibitors of siderophore biosynthesis in Staphylococcus aureus and Bacillus anthracis. J Am Chem Soc (2014) 1.04

Heterologous expression of tylosin polyketide synthase and production of a hybrid bioactive macrolide in Streptomyces venezuelae. Appl Microbiol Biotechnol (2006) 1.04

Biochemical and structural characterization of the tautomycetin thioesterase: analysis of a stereoselective polyketide hydrolase. Angew Chem Int Ed Engl (2010) 1.04

The hidden steps of domain skipping: macrolactone ring size determination in the pikromycin modular polyketide synthase. Chem Biol (2002) 1.03

Terminal alkene formation by the thioesterase of curacin A biosynthesis: structure of a decarboxylating thioesterase. J Biol Chem (2011) 1.03

In vivo and in vitro trans-acylation by BryP, the putative bryostatin pathway acyltransferase derived from an uncultured marine symbiont. Chem Biol (2008) 1.03

Molecular analysis of the rebeccamycin L-amino acid oxidase from Lechevalieria aerocolonigenes ATCC 39243. J Bacteriol (2005) 1.03

Comparative genomic hybridizations reveal absence of large Streptomyces coelicolor genomic islands in Streptomyces lividans. BMC Genomics (2007) 1.02

Establishment and maintenance of alternative chromatin states at a multicopy gene locus. Cell (2011) 1.02

Comparison of the 1.85 A structure of CYP154A1 from Streptomyces coelicolor A3(2) with the closely related CYP154C1 and CYPs from antibiotic biosynthetic pathways. Protein Sci (2004) 1.02

Hydration of enzyme in nonaqueous media is consistent with solvent dependence of its activity. Biophys J (2004) 1.02

Comparative analysis of the biosynthetic systems for fungal bicyclo[2.2.2]diazaoctane indole alkaloids: the (+)/(-)-notoamide, paraherquamide and malbrancheamide pathways. Medchemcomm (2012) 1.02

STUDIES ON THE BIOSYNTHESIS OF THE STEPHACIDINS AND NOTOAMIDES. TOTAL SYNTHESIS OF NOTOAMIDE S. Heterocycles (2010) 1.01