Published in Ann N Y Acad Sci on April 18, 2007
Runx1-mediated hematopoietic stem-cell emergence is controlled by a Gata/Ets/SCL-regulated enhancer. Blood (2007) 1.82
Transcriptome analysis of mammary epithelial subpopulations identifies novel determinants of lineage commitment and cell fate. BMC Genomics (2008) 1.70
A single cis element maintains repression of the key developmental regulator Gata2. PLoS Genet (2010) 1.14
Characterizing heterogeneity in leukemic cells using single-cell gene expression analysis. Genome Biol (2014) 0.97
Form and Function: how Estrogen and Progesterone Regulate the Mammary Epithelial Hierarchy. J Mammary Gland Biol Neoplasia (2015) 0.88
Model discrimination in dynamic molecular systems: application to parotid de-differentiation network. J Comput Biol (2013) 0.75
Genetic variegation of clonal architecture and propagating cells in leukaemia. Nature (2010) 8.48
Transcriptome-wide noise controls lineage choice in mammalian progenitor cells. Nature (2008) 7.60
Forcing cells to change lineages. Nature (2009) 5.99
Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators. Cell Stem Cell (2010) 5.05
DNA repair is limiting for haematopoietic stem cells during ageing. Nature (2007) 4.71
JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature (2009) 4.60
A HaemAtlas: characterizing gene expression in differentiated human blood cells. Blood (2009) 3.63
Bifurcation dynamics in lineage-commitment in bipotent progenitor cells. Dev Biol (2007) 3.49
Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genes. Proc Natl Acad Sci U S A (2004) 3.39
Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia. Science (2008) 3.38
Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors. Immunity (2007) 3.26
BLUEPRINT to decode the epigenetic signature written in blood. Nat Biotechnol (2012) 3.24
Coexistence of LMPP-like and GMP-like leukemia stem cells in acute myeloid leukemia. Cancer Cell (2011) 3.12
Esrrb is a pivotal target of the Gsk3/Tcf3 axis regulating embryonic stem cell self-renewal. Cell Stem Cell (2012) 3.03
Fast and sensitive multiple alignment of large genomic sequences. BMC Bioinformatics (2003) 2.94
MicroRNA expression distinguishes between germinal center B cell-like and activated B cell-like subtypes of diffuse large B cell lymphoma. Int J Cancer (2007) 2.94
Hedgehog signaling is required for adult blood stem cell formation in zebrafish embryos. Dev Cell (2005) 2.94
Gene Expression Dynamics Inspector (GEDI): for integrative analysis of expression profiles. Bioinformatics (2003) 2.92
Non-genetic heterogeneity--a mutation-independent driving force for the somatic evolution of tumours. Nat Rev Genet (2009) 2.69
Functional and molecular characterisation of mammary side population cells. Breast Cancer Res (2002) 2.63
Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis. Blood (2005) 2.47
High-betweenness proteins in the yeast protein interaction network. J Biomed Biotechnol (2005) 2.44
Characterization of transcriptional networks in blood stem and progenitor cells using high-throughput single-cell gene expression analysis. Nat Cell Biol (2013) 2.40
Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors. EMBO J (2002) 2.40
Inferring rules of lineage commitment in haematopoiesis. Nat Cell Biol (2012) 2.36
Single-cell gene expression analysis reveals genetic associations masked in whole-tissue experiments. Nat Biotechnol (2013) 2.33
Genetically tagging endothelial cells in vivo: bone marrow-derived cells do not contribute to tumor endothelium. Blood (2004) 2.30
Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell (2011) 2.30
Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development. Proc Natl Acad Sci U S A (2007) 2.15
Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1. Nat Struct Mol Biol (2010) 2.15
Alteration of nuclear lamin organization inhibits RNA polymerase II-dependent transcription. J Cell Biol (2002) 2.14
Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by Rho and cytoskeletal tension. Dev Dyn (2005) 2.13
Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogenesis. Blood (2004) 2.11
Identification of endoglin as a functional marker that defines long-term repopulating hematopoietic stem cells. Proc Natl Acad Sci U S A (2002) 2.08
Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif. Dev Cell (2006) 2.06
CD56bright human NK cells differentiate into CD56dim cells: role of contact with peripheral fibroblasts. J Immunol (2007) 1.99
Role of RhoA, mDia, and ROCK in cell shape-dependent control of the Skp2-p27kip1 pathway and the G1/S transition. J Biol Chem (2004) 1.98
Genetic regulatory networks programming hematopoietic stem cells and erythroid lineage specification. Dev Biol (2006) 1.98
The transcriptional program controlled by the stem cell leukemia gene Scl/Tal1 during early embryonic hematopoietic development. Blood (2009) 1.97
Potential autoregulation of transcription factor PU.1 by an upstream regulatory element. Mol Cell Biol (2005) 1.96
Anterior definitive endoderm from ESCs reveals a role for FGF signaling. Cell Stem Cell (2008) 1.88
Condensed mitotic chromatin is accessible to transcription factors and chromatin structural proteins. J Cell Biol (2004) 1.86
Genome-wide analysis of the zebrafish ETS family identifies three genes required for hemangioblast differentiation or angiogenesis. Circ Res (2008) 1.85
Vacuum-assisted closure: microdeformations of wounds and cell proliferation. Plast Reconstr Surg (2004) 1.81
PPARalpha agonist fenofibrate suppresses tumor growth through direct and indirect angiogenesis inhibition. Proc Natl Acad Sci U S A (2008) 1.80
Analysis of multiple genomic sequence alignments: a web resource, online tools, and lessons learned from analysis of mammalian SCL loci. Genome Res (2004) 1.80
TBP dynamics in living human cells: constitutive association of TBP with mitotic chromosomes. Mol Biol Cell (2002) 1.78
Coordinate gene regulation during hematopoiesis is related to genomic organization. PLoS Biol (2007) 1.77
The potential landscape of genetic circuits imposes the arrow of time in stem cell differentiation. Biophys J (2010) 1.76
Scl is required for dorsal aorta as well as blood formation in zebrafish embryos. Blood (2005) 1.76
Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice. J Clin Invest (2011) 1.74
GATA transcription factors integrate Wnt signalling during heart development. Development (2008) 1.74
Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1. EMBO J (2008) 1.71
ETO-2 associates with SCL in erythroid cells and megakaryocytes and provides repressor functions in erythropoiesis. Mol Cell Biol (2005) 1.70
The mechanism of action of the vacuum-assisted closure device. Plast Reconstr Surg (2008) 1.68
Understanding gene circuits at cell-fate branch points for rational cell reprogramming. Trends Genet (2010) 1.67
Transcription factor-mediated lineage switching reveals plasticity in primary committed progenitor cells. EMBO J (2002) 1.66
The epidermis comprises autonomous compartments maintained by distinct stem cell populations. Cell Stem Cell (2013) 1.64
Novel binding partners of Ldb1 are required for haematopoietic development. Development (2006) 1.63
Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates. Elife (2013) 1.63
Differentiation-induced colocalization of the KH-type splicing regulatory protein with polypyrimidine tract binding protein and the c-src pre-mRNA. Mol Biol Cell (2003) 1.60
In vivo fate-tracing studies using the Scl stem cell enhancer: embryonic hematopoietic stem cells significantly contribute to adult hematopoiesis. Blood (2004) 1.58
Multistable and multistep dynamics in neutrophil differentiation. BMC Cell Biol (2006) 1.56
The roles of GATA-4, -5 and -6 in vertebrate heart development. Semin Cell Dev Biol (2004) 1.53
Acquisition of germ plasm accelerates vertebrate evolution. Science (2014) 1.53
Noise-driven stem cell and progenitor population dynamics. PLoS One (2008) 1.52
Fli1 acts at the top of the transcriptional network driving blood and endothelial development. Curr Biol (2008) 1.51
Filamin links cell shape and cytoskeletal structure to Rho regulation by controlling accumulation of p190RhoGAP in lipid rafts. J Cell Sci (2007) 1.51
Medusa structure of the gene regulatory network: dominance of transcription factors in cancer subtype classification. Exp Biol Med (Maywood) (2011) 1.50
Gene-pair expression signatures reveal lineage control. Nat Methods (2013) 1.49
Computational modeling of the hematopoietic erythroid-myeloid switch reveals insights into cooperativity, priming, and irreversibility. PLoS Comput Biol (2009) 1.48
GATA-2 regulates granulocyte-macrophage progenitor cell function. Blood (2008) 1.45
Genome-wide identification of cis-regulatory sequences controlling blood and endothelial development. Hum Mol Genet (2005) 1.43
Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells. Blood (2011) 1.41
Maps of open chromatin guide the functional follow-up of genome-wide association signals: application to hematological traits. PLoS Genet (2011) 1.41
The proto-oncogene ERG in megakaryoblastic leukemias. Cancer Res (2005) 1.40
Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition. Blood (2010) 1.39
Cited2 is an essential regulator of adult hematopoietic stem cells. Cell Stem Cell (2009) 1.39
RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis. EMBO J (2012) 1.37
NOV (CCN3) functions as a regulator of human hematopoietic stem or progenitor cells. Science (2007) 1.36
The SCL transcriptional network and BMP signaling pathway interact to regulate RUNX1 activity. Proc Natl Acad Sci U S A (2007) 1.36
High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycle. Blood (2009) 1.36
Cytochrome P450-derived eicosanoids: the neglected pathway in cancer. Cancer Metastasis Rev (2010) 1.36
The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential. Nat Immunol (2012) 1.35
The paralogous hematopoietic regulators Lyl1 and Scl are coregulated by Ets and GATA factors, but Lyl1 cannot rescue the early Scl-/- phenotype. Blood (2006) 1.35
Molecular signatures of self-renewal, differentiation, and lineage choice in multipotential hemopoietic progenitor cells in vitro. Mol Cell Biol (2004) 1.35
GATA-6 maintains BMP-4 and Nkx2 expression during cardiomyocyte precursor maturation. EMBO J (2003) 1.34
The transcription factors Scl and Lmo2 act together during development of the hemangioblast in zebrafish. Blood (2006) 1.34
Endoglin expression in the endothelium is regulated by Fli-1, Erg, and Elf-1 acting on the promoter and a -8-kb enhancer. Blood (2006) 1.32
Regulation of inflammation in cancer by eicosanoids. Prostaglandins Other Lipid Mediat (2011) 1.31
Redundancy and evolution of GATA factor requirements in development of the myocardium. Dev Biol (2007) 1.31
RNA polymerase III transcripts and the PTB protein are essential for the integrity of the perinucleolar compartment. Mol Biol Cell (2003) 1.30
Cardiopoietic factors: extracellular signals for cardiac lineage commitment. Circ Res (2011) 1.30
Evidence by molecular profiling for a placental origin of infantile hemangioma. Proc Natl Acad Sci U S A (2005) 1.28