Published in Cell Stem Cell on October 09, 2008
Functional heterogeneity of embryonic stem cells revealed through translational amplification of an early endodermal transcript. PLoS Biol (2010) 2.38
Self-renewing endodermal progenitor lines generated from human pluripotent stem cells. Cell Stem Cell (2012) 1.94
Production of functional glucagon-secreting α-cells from human embryonic stem cells. Diabetes (2010) 1.73
A conserved Oct4/POUV-dependent network links adhesion and migration to progenitor maintenance. Curr Biol (2013) 1.54
Efficient derivation of alveolar type II cells from embryonic stem cells for in vivo application. Tissue Eng Part A (2009) 1.46
Generation of monoclonal antibodies specific for cell surface molecules expressed on early mouse endoderm. Stem Cells (2009) 1.43
Targeting SOX17 in human embryonic stem cells creates unique strategies for isolating and analyzing developing endoderm. Cell Stem Cell (2011) 1.41
A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3. J Cell Sci (2011) 1.30
Gata4 directs development of cardiac-inducing endoderm from ES cells. Dev Biol (2009) 1.23
Activin, BMP and FGF pathways cooperate to promote endoderm and pancreatic lineage cell differentiation from human embryonic stem cells. Mech Dev (2011) 1.17
A late requirement for Wnt and FGF signaling during activin-induced formation of foregut endoderm from mouse embryonic stem cells. Dev Biol (2009) 1.16
Efficient generation of hepatoblasts from human ES cells and iPS cells by transient overexpression of homeobox gene HEX. Mol Ther (2010) 1.13
The histone demethylase Jmjd3 sequentially associates with the transcription factors Tbx3 and Eomes to drive endoderm differentiation. EMBO J (2013) 1.11
Generation of multipotent foregut stem cells from human pluripotent stem cells. Stem Cell Reports (2013) 1.05
An endothelial cell niche induces hepatic specification through dual repression of Wnt and Notch signaling. Stem Cells (2011) 1.03
Contribution of hepatic lineage stage-specific donor memory to the differential potential of induced mouse pluripotent stem cells. Stem Cells (2012) 1.00
Efficient and directive generation of two distinct endoderm lineages from human ESCs and iPSCs by differentiation stage-specific SOX17 transduction. PLoS One (2011) 0.99
Coordinate Nodal and BMP inhibition directs Baf60c-dependent cardiomyocyte commitment. Genes Dev (2013) 0.96
The role of human papillomavirus type 16 E6/E7 oncoproteins in cervical epithelial-mesenchymal transition and carcinogenesis. Oncol Lett (2011) 0.89
Microfluidic-based patterning of embryonic stem cells for in vitro development studies. Lab Chip (2013) 0.85
Expression-independent gene trap vectors for random and targeted mutagenesis in embryonic stem cells. Nucleic Acids Res (2009) 0.84
Generation of functional hepatic cells from pluripotent stem cells. J Stem Cell Res Ther (2012) 0.82
PI3K/Akt1 signalling specifies foregut precursors by generating regionalized extra-cellular matrix. Elife (2013) 0.82
Growth requirements and chromosomal instability of induced pluripotent stem cells generated from adult canine fibroblasts. Stem Cells Dev (2012) 0.81
BMP-2/6 heterodimer is more effective than BMP-2 or BMP-6 homodimers as inductor of differentiation of human embryonic stem cells. PLoS One (2010) 0.81
A molecular signature for purified definitive endoderm guides differentiation and isolation of endoderm from mouse and human embryonic stem cells. Stem Cells Dev (2012) 0.81
Involvement of histone acetylation of Sox17 and Foxa2 promoters during mouse definitive endoderm differentiation revealed by microRNA profiling. PLoS One (2011) 0.80
Derivation of Endodermal Progenitors From Pluripotent Stem Cells. J Cell Physiol (2015) 0.80
MicroRNA-200a regulates Grb2 and suppresses differentiation of mouse embryonic stem cells into endoderm and mesoderm. PLoS One (2013) 0.80
Sall4 controls differentiation of pluripotent cells independently of the Nucleosome Remodelling and Deacetylation (NuRD) complex. Development (2016) 0.79
Convergence of cMyc and β-catenin on Tcf7l1 enables endoderm specification. EMBO J (2015) 0.79
Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development. Genes Dev (2015) 0.79
Analysis of regulatory network involved in mechanical induction of embryonic stem cell differentiation. PLoS One (2012) 0.79
HHEX promotes hepatic-lineage specification through the negative regulation of eomesodermin. PLoS One (2014) 0.78
Unfolded protein response is required for the definitive endodermal specification of mouse embryonic stem cells via Smad2 and β-catenin signaling. J Biol Chem (2014) 0.78
A requirement for FGF signalling in the formation of primitive streak-like intermediates from primitive ectoderm in culture. PLoS One (2010) 0.77
A system to enrich for primitive streak-derivatives, definitive endoderm and mesoderm, from pluripotent cells in culture. PLoS One (2012) 0.77
The Use of Induced Pluripotent Stem Cells for the Study and Treatment of Liver Diseases. Curr Protoc Toxicol (2016) 0.76
Endodermal stem cell populations derived from pluripotent stem cells. Curr Opin Cell Biol (2013) 0.76
Activin A Modulates CRIPTO-1/HNF4α(+) Cells to Guide Cardiac Differentiation from Human Embryonic Stem Cells. Stem Cells Int (2017) 0.75
P19 Cells Overexpressing Lhx1 Differentiate into the Definitive Endoderm by Recapitulating an Embryonic Developmental Pathway. Yonago Acta Med (2015) 0.75
Cholesterol-derived glucocorticoids control early fate specification in embryonic stem cells. Stem Cell Res (2015) 0.75
Expandable endodermal progenitors: new tools to explore endoderm and its derivatives. Cell Stem Cell (2008) 0.75
Directed differentiation of human iPSC into insulin producing cells is improved by induced expression of PDX1 and NKX6.1 factors in IPC progenitors. J Transl Med (2016) 0.75
Endoderm complexity in the mouse gastrula is revealed through the expression of spink3. Biores Open Access (2014) 0.75
Hhex Is Necessary for the Hepatic Differentiation of Mouse ES Cells and Acts via Vegf Signaling. PLoS One (2016) 0.75
In vitro differentiation and expansion of human pluripotent stem cell-derived pancreatic progenitors. Rev Diabet Stud (2014) 0.75
Functional characterisation of cis-regulatory elements governing dynamic Eomes expression in the early mouse embryo. Development (2017) 0.75
Genetic variegation of clonal architecture and propagating cells in leukaemia. Nature (2010) 8.48
Forcing cells to change lineages. Nature (2009) 5.99
DNA repair is limiting for haematopoietic stem cells during ageing. Nature (2007) 4.71
Bifurcation dynamics in lineage-commitment in bipotent progenitor cells. Dev Biol (2007) 3.49
Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia. Science (2008) 3.38
Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors. Immunity (2007) 3.26
BLUEPRINT to decode the epigenetic signature written in blood. Nat Biotechnol (2012) 3.24
Coexistence of LMPP-like and GMP-like leukemia stem cells in acute myeloid leukemia. Cancer Cell (2011) 3.12
MicroRNA expression distinguishes between germinal center B cell-like and activated B cell-like subtypes of diffuse large B cell lymphoma. Int J Cancer (2007) 2.94
Cellular differentiation hierarchies in normal and culture-adapted human embryonic stem cells. Hum Mol Genet (2005) 2.66
Genome-wide identification of TAL1's functional targets: insights into its mechanisms of action in primary erythroid cells. Genome Res (2010) 2.64
Functional and molecular characterisation of mammary side population cells. Breast Cancer Res (2002) 2.63
Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis. Blood (2005) 2.47
Functional heterogeneity of embryonic stem cells revealed through translational amplification of an early endodermal transcript. PLoS Biol (2010) 2.38
Inferring rules of lineage commitment in haematopoiesis. Nat Cell Biol (2012) 2.36
Single-cell gene expression analysis reveals genetic associations masked in whole-tissue experiments. Nat Biotechnol (2013) 2.33
CD56bright human NK cells differentiate into CD56dim cells: role of contact with peripheral fibroblasts. J Immunol (2007) 1.99
Stationary phase gene expression of Mycobacterium tuberculosis following a progressive nutrient depletion: a model for persistent organisms? Tuberculosis (Edinb) (2004) 1.92
Coordinate gene regulation during hematopoiesis is related to genomic organization. PLoS Biol (2007) 1.77
Analysis of whole-genome microarray replicates using mixed models. Bioinformatics (2003) 1.73
Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1. EMBO J (2008) 1.71
ETO-2 associates with SCL in erythroid cells and megakaryocytes and provides repressor functions in erythropoiesis. Mol Cell Biol (2005) 1.70
Targeted mutagenesis of the Hira gene results in gastrulation defects and patterning abnormalities of mesoendodermal derivatives prior to early embryonic lethality. Mol Cell Biol (2002) 1.66
Transcription factor-mediated lineage switching reveals plasticity in primary committed progenitor cells. EMBO J (2002) 1.66
Global gene expression analysis of human erythroid progenitors. Blood (2011) 1.59
A conserved Oct4/POUV-dependent network links adhesion and migration to progenitor maintenance. Curr Biol (2013) 1.54
Computational modeling of the hematopoietic erythroid-myeloid switch reveals insights into cooperativity, priming, and irreversibility. PLoS Comput Biol (2009) 1.48
Conserved roles for Oct4 homologues in maintaining multipotency during early vertebrate development. Development (2006) 1.47
GATA-2 regulates granulocyte-macrophage progenitor cell function. Blood (2008) 1.45
Totipotent embryonic stem cells arise in ground-state culture conditions. Cell Rep (2013) 1.43
Gene expression heterogeneities in embryonic stem cell populations: origin and function. Curr Opin Cell Biol (2011) 1.41
Evidence for reduced B-cell progenitors in early (low-risk) myelodysplastic syndrome. Blood (2005) 1.41
Cited2 is an essential regulator of adult hematopoietic stem cells. Cell Stem Cell (2009) 1.39
High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycle. Blood (2009) 1.36
NOV (CCN3) functions as a regulator of human hematopoietic stem or progenitor cells. Science (2007) 1.36
The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential. Nat Immunol (2012) 1.35
Molecular signatures of self-renewal, differentiation, and lineage choice in multipotential hemopoietic progenitor cells in vitro. Mol Cell Biol (2004) 1.35
Mitochondrial AKAP121 binds and targets protein tyrosine phosphatase D1, a novel positive regulator of src signaling. Mol Cell Biol (2004) 1.33
Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia. Oncogene (2004) 1.23
Modeling first-hit functions of the t(12;21) TEL-AML1 translocation in mice. Proc Natl Acad Sci U S A (2004) 1.23
Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1. PLoS Med (2007) 1.19
Generation of bivalent chromatin domains during cell fate decisions. Epigenetics Chromatin (2011) 1.17
GATA-2 and GATA-2/ER display opposing activities in the development and differentiation of blood progenitors. EMBO J (2002) 1.16
The TEL-AML1 leukemia fusion gene dysregulates the TGF-beta pathway in early B lineage progenitor cells. J Clin Invest (2009) 1.15
Notch signals inhibit the development of erythroid/megakaryocytic cells by suppressing GATA-1 activity through the induction of HES1. J Biol Chem (2004) 1.15
GATA-2/estrogen receptor chimera regulates cytokine-dependent growth of hematopoietic cells through accumulation of p21(WAF1) and p27(Kip1) proteins. Blood (2002) 1.15
Connecting variability in global transcription rate to mitochondrial variability. PLoS Biol (2010) 1.13
A homozygous mutation in HESX1 is associated with evolving hypopituitarism due to impaired repressor-corepressor interaction. J Clin Invest (2003) 1.12
MiR-142-3p controls the specification of definitive hemangioblasts during ontogeny. Dev Cell (2013) 1.12
Cellular network entropy as the energy potential in Waddington's differentiation landscape. Sci Rep (2013) 1.12
MLLT3 regulates early human erythroid and megakaryocytic cell fate. Cell Stem Cell (2008) 1.09
Human induced pluripotent stem cells are capable of B-cell lymphopoiesis. Blood (2011) 1.04
The tetraspanin CD9 affords high-purity capture of all murine hematopoietic stem cells. Cell Rep (2013) 1.04
Mitochondrial variability as a source of extrinsic cellular noise. PLoS Comput Biol (2012) 1.01
Dynamic analysis of gene expression and genome-wide transcription factor binding during lineage specification of multipotent progenitors. Cell Stem Cell (2013) 1.01
DNA methylation-independent loss of RARA gene expression in acute myeloid leukemia. Blood (2007) 1.01
Involvement of mitogen-activated protein kinase in the cytokine-regulated phosphorylation of transcription factor GATA-1. Hematol J (2004) 1.00
Receptor and secreted targets of Wnt-1/beta-catenin signalling in mouse mammary epithelial cells. BMC Cancer (2005) 0.99
Safety and immunogenicity of novel recombinant BCG and modified vaccinia virus Ankara vaccines in neonate rhesus macaques. J Virol (2010) 0.99
FGF signalling as a mediator of lineage transitions--evidence from embryonic stem cell differentiation. J Cell Biochem (2010) 0.96
Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance. Blood (2013) 0.95
Tel1/ETV6 specifies blood stem cells through the agency of VEGF signaling. Dev Cell (2010) 0.95
Transcriptional activation by Oct4 is sufficient for the maintenance and induction of pluripotency. Cell Rep (2012) 0.94
Hex acts with beta-catenin to regulate anteroposterior patterning via a Groucho-related co-repressor and Nodal. Development (2006) 0.93
GATA transcription factors inhibit cytokine-dependent growth and survival of a hematopoietic cell line through the inhibition of STAT3 activity. J Biol Chem (2005) 0.92
Role of the ERK-mediated signaling pathway in mesenchyme formation and differentiation in the sea urchin embryo. Dev Biol (2004) 0.92
GATA-2 mediated regulation of normal hematopoietic stem/progenitor cell function, myelodysplasia and myeloid leukemia. Int J Biochem Cell Biol (2011) 0.92
Transcriptional regulation of lineage commitment--a stochastic model of cell fate decisions. PLoS Comput Biol (2013) 0.91
HOXB4 can enhance the differentiation of embryonic stem cells by modulating the hematopoietic niche. Stem Cells (2012) 0.90
Investigation of microsphere-mediated cellular delivery by chemical, microscopic and gene expression analysis. Mol Biosyst (2009) 0.88
Plasticity revisited. Curr Opin Cell Biol (2002) 0.88
Inference, validation, and dynamic modeling of transcription networks in multipotent hematopoietic cells. Ann N Y Acad Sci (2007) 0.86
Characterizing embryonic gene expression patterns in the mouse using nonredundant sequence-based selection. Genome Res (2003) 0.86
Pluripotency and tumorigenicity. Nat Genet (2002) 0.85
Expression-independent gene trap vectors for random and targeted mutagenesis in embryonic stem cells. Nucleic Acids Res (2009) 0.84
A novel triple fusion reporter system for use in gene trap mutagenesis. Genesis (2007) 0.84
Molecular targeting of cancer stem cells. Cell Stem Cell (2009) 0.83
Cross talk between retinoic acid signaling and transcription factor GATA-2. Mol Cell Biol (2004) 0.83
Identification of the chemokine CCL28 as a growth and survival factor for human hematopoietic stem and progenitor cells. Blood (2013) 0.83
Microspheres as a vehicle for biomolecule delivery to neural stem cells. N Biotechnol (2009) 0.82
Differentiation of embryonic stem cells into anterior definitive endoderm. Curr Protoc Stem Cell Biol (2009) 0.82
PI3K/Akt1 signalling specifies foregut precursors by generating regionalized extra-cellular matrix. Elife (2013) 0.82