Published in Nat Med on April 22, 2007
How cigarette smoke skews immune responses to promote infection, lung disease and cancer. Nat Rev Immunol (2009) 2.46
Molecular pathogenesis of emphysema. J Clin Invest (2008) 2.03
Oxidative stress-induced antibodies to carbonyl-modified protein correlate with severity of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2011) 2.02
Arterial stiffness is independently associated with emphysema severity in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2007) 2.01
Autoantibodies in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2007) 1.94
Lung dendritic cell expression of maturation molecules increases with worsening chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2009) 1.90
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The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin. Annu Rev Pathol (2012) 1.80
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Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema. Nat Med (2010) 1.67
The immunopathogenesis of chronic obstructive pulmonary disease: insights from recent research. Proc Am Thorac Soc (2007) 1.65
Cigarette smoking and inflammation: cellular and molecular mechanisms. J Dent Res (2011) 1.62
IL-17RA is required for CCL2 expression, macrophage recruitment, and emphysema in response to cigarette smoke. PLoS One (2011) 1.61
Cigarette smoke induction of osteopontin (SPP1) mediates T(H)17 inflammation in human and experimental emphysema. Sci Transl Med (2012) 1.54
Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM. Proc Natl Acad Sci U S A (2010) 1.44
Current concepts on the role of inflammation in COPD and lung cancer. Curr Opin Pharmacol (2009) 1.42
Anti-type V collagen humoral immunity in lung transplant primary graft dysfunction. J Immunol (2008) 1.42
Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease. Toxicol Appl Pharmacol (2011) 1.35
Cigarette smoke impairs clearance of apoptotic cells through oxidant-dependent activation of RhoA. Am J Respir Crit Care Med (2009) 1.31
Pulmonary-intestinal cross-talk in mucosal inflammatory disease. Mucosal Immunol (2011) 1.26
Divergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthma. Nat Immunol (2009) 1.25
HIV and chronic obstructive pulmonary disease: is it worse and why? Proc Am Thorac Soc (2011) 1.18
Cytotoxic potential of lung CD8(+) T cells increases with chronic obstructive pulmonary disease severity and with in vitro stimulation by IL-18 or IL-15. J Immunol (2010) 1.18
Sustained CTL activation by murine pulmonary epithelial cells promotes the development of COPD-like disease. J Clin Invest (2009) 1.16
Nontypeable Haemophilus influenzae in chronic obstructive pulmonary disease and lung cancer. Int J Chron Obstruct Pulmon Dis (2011) 1.11
Cardiovascular injury and repair in chronic obstructive pulmonary disease. Proc Am Thorac Soc (2008) 1.11
Chronic cigarette smoke exposure generates pathogenic T cells capable of driving COPD-like disease in Rag2-/- mice. Am J Respir Crit Care Med (2010) 1.08
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Cigarette smoke promotes dendritic cell accumulation in COPD; a Lung Tissue Research Consortium study. Respir Res (2010) 1.07
Novel autoantigens immunogenic in COPD patients. Respir Res (2009) 1.01
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MMP generated matrikines. Matrix Biol (2015) 0.99
COPD is associated with production of autoantibodies to a broad spectrum of self-antigens, correlative with disease phenotype. Immunol Res (2013) 0.99
T-regulatory cells and programmed death 1+ T cells contribute to effector T-cell dysfunction in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2014) 0.99
Lung CD8+ T cells in COPD have increased expression of bacterial TLRs. Respir Res (2013) 0.97
T lymphocyte insensitivity to corticosteroids in chronic obstructive pulmonary disease. Respir Res (2012) 0.97
Agonistic induction of PPARγ reverses cigarette smoke-induced emphysema. J Clin Invest (2014) 0.97
Autoreactive T Cells in Human Smokers is Predictive of Clinical Outcome. Front Immunol (2012) 0.96
Epithelial nuclear factor-κB signaling promotes lung carcinogenesis via recruitment of regulatory T lymphocytes. Oncogene (2011) 0.96
Chronic obstructive pulmonary disease: a view from the NHLBI. Am J Respir Crit Care Med (2008) 0.95
Inflammation in chronic obstructive pulmonary disease and its role in cardiovascular disease and lung cancer. Clin Transl Med (2015) 0.95
A novel nonhuman primate model of cigarette smoke-induced airway disease. Am J Pathol (2014) 0.95
Measurement of MMP-9 and -12 degraded elastin (ELM) provides unique information on lung tissue degradation. BMC Pulm Med (2012) 0.94
Lung disease associated with alpha1-antitrypsin deficiency. Proc Am Thorac Soc (2010) 0.94
NKG2D mediates NK cell hyperresponsiveness and influenza-induced pathologies in a mouse model of chronic obstructive pulmonary disease. J Immunol (2012) 0.94
Inflammation and immune response in COPD: where do we stand? Mediators Inflamm (2013) 0.92
IL-17A is essential to the development of elastase-induced pulmonary inflammation and emphysema in mice. Respir Res (2013) 0.91
Inflammatory cell phenotypes in AAAs: their role and potential as targets for therapy. Arterioscler Thromb Vasc Biol (2015) 0.90
Cigarette smoke triggers code red: p21CIP1/WAF1/SDI1 switches on danger responses in the lung. Am J Respir Cell Mol Biol (2008) 0.90
Basal gene expression by lung CD4+ T cells in chronic obstructive pulmonary disease identifies independent molecular correlates of airflow obstruction and emphysema extent. PLoS One (2014) 0.90
B-lymphocyte lineage cells and the respiratory system. J Allergy Clin Immunol (2013) 0.89
Expansion of CD4+CD25+ helper T cells without regulatory function in smoking and COPD. Respir Res (2011) 0.89
Persistence of pulmonary tertiary lymphoid tissues and anti-nuclear antibodies following cessation of cigarette smoke exposure. Respir Res (2014) 0.89
Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility gene. Am J Respir Crit Care Med (2010) 0.89
Heme oxygenase-1 prevents smoke induced B-cell infiltrates: a role for regulatory T cells? Respir Res (2008) 0.89
Role of T-lymphocytes and pro-inflammatory mediators in the pathogenesis of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis (2008) 0.88
Glucocorticoid insensitivity as a future target of therapy for chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis (2010) 0.88
Age-related macular degeneration and changes in the extracellular matrix. Med Sci Monit (2014) 0.88
Immunoproteomic identification of bovine pericardium xenoantigens. Biomaterials (2008) 0.88
Interfering with extracellular matrix degradation to blunt inflammation. Curr Opin Pharmacol (2008) 0.87
Functional characterization of T cell populations in a mouse model of chronic obstructive pulmonary disease. J Immunol (2012) 0.86
Persistence of Th17/Tc17 cell expression upon smoking cessation in mice with cigarette smoke-induced emphysema. Clin Dev Immunol (2013) 0.86
Increased risk of chronic obstructive pulmonary disease in patients with systemic lupus erythematosus: a population-based cohort study. PLoS One (2014) 0.85
Increased levels of (class switched) memory B cells in peripheral blood of current smokers. Respir Res (2009) 0.85
Integrative omics approach identifies interleukin-16 as a biomarker of emphysema. OMICS (2013) 0.85
RelB is differentially regulated by IkappaB Kinase-alpha in B cells and mouse lung by cigarette smoke. Am J Respir Cell Mol Biol (2008) 0.85
Cellular regulation of the inflammatory response. Toxicol Pathol (2011) 0.85
Interaction between the elastin peptide VGVAPG and human elastin binding protein. J Biol Chem (2012) 0.85
Design of a multi-center immunophenotyping analysis of peripheral blood, sputum and bronchoalveolar lavage fluid in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS). J Transl Med (2015) 0.84
Glucocorticoids relieve collectin-driven suppression of apoptotic cell uptake in murine alveolar macrophages through downregulation of SIRPα. J Immunol (2012) 0.84
Novel aspects of pathogenesis and regeneration mechanisms in COPD. Int J Chron Obstruct Pulmon Dis (2015) 0.84
Down regulation of T cell receptor expression in COPD pulmonary CD8 cells. PLoS One (2013) 0.84
Cytotoxic T cells expressing the co-stimulatory receptor NKG2 D are increased in cigarette smoking and COPD. Respir Res (2010) 0.84
Activation of C3a receptor is required in cigarette smoke-mediated emphysema. Mucosal Immunol (2014) 0.84
Oral non-typable Haemophilus influenzae enhances physiological mechanism of airways protection. Clin Exp Immunol (2010) 0.83
"B" for Bad, Beneficial, or Both? Lung Lymphoid Neogenesis in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med (2015) 0.83
Analysis of exonic elastin variants in severe, early-onset chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol (2008) 0.83
Tuberculosis: An Infection-Initiated Autoimmune Disease? Trends Immunol (2016) 0.82
Pathogenic mechanism of second hand smoke induced inflammation and COPD. Front Physiol (2012) 0.82
PLAGL2 expression-induced lung epithelium damages at bronchiolar alveolar duct junction in emphysema: bNip3- and SP-C-associated cell death/injury activity. Am J Physiol Lung Cell Mol Physiol (2009) 0.81
Induction of autoantibodies against lung matrix proteins and smoke-induced inflammation in mice. BMC Pulm Med (2010) 0.81
Relationship between the anti-inflammatory properties of salmeterol/fluticasone and the expression of CD4⁺CD25⁺Foxp3⁺ regulatory T cells in COPD. Respir Res (2011) 0.81
Dysfunctional lung anatomy and small airways degeneration in COPD. Int J Chron Obstruct Pulmon Dis (2013) 0.81
CRAC channel inhibition produces greater anti-inflammatory effects than glucocorticoids in CD8 cells from COPD patients. Clin Sci (Lond) (2014) 0.81
CD8 chemokine receptors in chronic obstructive pulmonary disease. Clin Exp Immunol (2008) 0.80
CD46 protects against chronic obstructive pulmonary disease. PLoS One (2011) 0.80
Erythromycin enhances CD4+Foxp3+ regulatory T-cell responses in a rat model of smoke-induced lung inflammation. Mediators Inflamm (2012) 0.80
Immune Dysfunction in Patients with Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc (2015) 0.80
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Hhip haploinsufficiency sensitizes mice to age-related emphysema. Proc Natl Acad Sci U S A (2016) 0.80
Prediction of cardiovascular events by using non-vascular findings on routine chest CT. PLoS One (2011) 0.79
Serum elastin-derived peptides and anti-elastin antibody in patients with systemic sclerosis. J Korean Med Sci (2012) 0.79
Natural and disease-specific autoantibodies in chronic obstructive pulmonary disease. Clin Exp Immunol (2015) 0.79
Environmental factors in primary biliary cirrhosis. Semin Liver Dis (2014) 0.78
Blunted expression of miR-199a-5p in regulatory T cells of patients with chronic obstructive pulmonary disease compared to unaffected smokers. Clin Exp Immunol (2014) 0.78
Lung inflammation in COPD: why does it matter? F1000 Med Rep (2012) 0.78
B cells in chronic obstructive pulmonary disease: moving to center stage. Am J Physiol Lung Cell Mol Physiol (2016) 0.78
CD4(+)CD25(high)CD127(-) regulatory T-cells in COPD: smoke and drugs effect. World Allergy Organ J (2016) 0.78
The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med (2004) 17.08
Changes in forced expiratory volume in 1 second over time in COPD. N Engl J Med (2011) 5.69
Characterisation of COPD heterogeneity in the ECLIPSE cohort. Respir Res (2010) 5.17
Randomized trial of endobronchial ultrasound-guided transbronchial needle aspiration under general anesthesia versus moderate sedation. Am J Respir Crit Care Med (2015) 4.57
Small-airway obstruction and emphysema in chronic obstructive pulmonary disease. N Engl J Med (2011) 4.16
Interleukin 25 promotes the initiation of proallergic type 2 responses. J Exp Med (2007) 3.91
Airway wall thickening and emphysema show independent familial aggregation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2008) 3.70
Six-minute-walk test in chronic obstructive pulmonary disease: minimal clinically important difference for death or hospitalization. Am J Respir Crit Care Med (2012) 3.44
An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema. PLoS Med (2004) 3.12
Radial artery grafts vs saphenous vein grafts in coronary artery bypass surgery: a randomized trial. JAMA (2011) 3.03
The prediction of small airway dimensions using computed tomography. Am J Respir Crit Care Med (2004) 3.02
Decreased allergic lung inflammatory cell egression and increased susceptibility to asphyxiation in MMP2-deficiency. Nat Immunol (2002) 2.83
COPD phenotypes in biomass smoke- versus tobacco smoke-exposed Mexican women. Eur Respir J (2013) 2.81
A protease-activated pathway underlying Th cell type 2 activation and allergic lung disease. J Immunol (2002) 2.71
Abdominal obesity and the risk of Barrett's esophagus. Am J Gastroenterol (2005) 2.60
Biopsy neutrophilia, neutrophil chemokine and receptor gene expression in severe exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2003) 2.59
Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype. PLoS One (2012) 2.52
Hypoalbuminemia and long-term survival after coronary artery bypass: a propensity score analysis. Ann Thorac Surg (2011) 2.25
Matrix metalloproteinases in lung: multiple, multifarious, and multifaceted. Physiol Rev (2007) 2.14
Proinflammatory role for let-7 microRNAS in experimental asthma. J Biol Chem (2010) 2.08
Survival after lung volume reduction in chronic obstructive pulmonary disease: insights from small airway pathology. Am J Respir Crit Care Med (2007) 2.04
A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. Hum Mol Genet (2011) 1.98
Early thickening of the reticular basement membrane in children with difficult asthma. Am J Respir Crit Care Med (2003) 1.94
Quantifying the extent of emphysema: factors associated with radiologists' estimations and quantitative indices of emphysema severity using the ECLIPSE cohort. Acad Radiol (2011) 1.88
Estimation of cancer mortality associated with repetitive computed tomography scanning. Am J Respir Crit Care Med (2005) 1.88
Cleavage of fibrinogen by proteinases elicits allergic responses through Toll-like receptor 4. Science (2013) 1.87
Bronchial mucosal inflammation and upregulation of CXC chemoattractants and receptors in severe exacerbations of asthma. Thorax (2007) 1.77
The July effect: impact of the beginning of the academic cycle on cardiac surgical outcomes in a cohort of 70,616 patients. Ann Thorac Surg (2009) 1.77
Quantitative computed tomography measures of emphysema and airway wall thickness are related to respiratory symptoms. Am J Respir Crit Care Med (2009) 1.75
A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairment. Am J Respir Crit Care Med (2013) 1.73
Bronchodilator responsiveness as a phenotypic characteristic of established chronic obstructive pulmonary disease. Thorax (2012) 1.72
Impact of body mass index on outcomes following critical care. Chest (2003) 1.70
Human rhinovirus proteinase 2A induces TH1 and TH2 immunity in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol (2010) 1.69
Characteristics, stability and outcomes of the 2011 GOLD COPD groups in the ECLIPSE cohort. Eur Respir J (2013) 1.66
Mouse let-7 miRNA populations exhibit RNA editing that is constrained in the 5'-seed/ cleavage/anchor regions and stabilize predicted mmu-let-7a:mRNA duplexes. Genome Res (2008) 1.66
Papillary fibroelastoma of the aortic valve: operative approaches upon incidental discovery. Tex Heart Inst J (2009) 1.65
Overlapping and independent contributions of MMP2 and MMP9 to lung allergic inflammatory cell egression through decreased CC chemokines. FASEB J (2004) 1.64
An Official American Thoracic Society/European Respiratory Society Statement: Research questions in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2015) 1.63
Thoracic or thoracoabdominal approaches to endovascular device removal and open aortic repair. Ann Thorac Surg (2012) 1.62
Lung myeloid dendritic cells coordinately induce TH1 and TH17 responses in human emphysema. Sci Transl Med (2009) 1.61
Pulmonary ventilation visualized using hyperpolarized helium-3 and xenon-129 magnetic resonance imaging: differences in COPD and relationship to emphysema. J Appl Physiol (1985) (2012) 1.60
Open repair of thoracoabdominal aortic aneurysm in the modern surgical era: contemporary outcomes in 509 patients. J Am Coll Surg (2011) 1.59
On-pump versus off-pump coronary artery bypass grafting in a cohort of 63,000 patients. Ann Thorac Surg (2009) 1.59
The Th2 lymphocyte products IL-4 and IL-13 rapidly induce airway hyperresponsiveness through direct effects on resident airway cells. Am J Respir Cell Mol Biol (2002) 1.59
Endovascular repair of ascending aortic pseudoaneurysm: technical considerations of a common carotid artery approach using the Zenith aortic cuff endograft. J Endovasc Ther (2007) 1.58
A phase 2 randomized, double-blind, placebo-controlled study of the safety and efficacy of talactoferrin in patients with severe sepsis. Crit Care Med (2013) 1.58
Statin therapy and serum transaminases among a cohort of HCV-infected veterans. Dig Dis Sci (2010) 1.57
Overexpression of methyl-CpG binding protein 2 impairs T(H)1 responses. Sci Transl Med (2012) 1.56
Evidence-based medicine among internal medicine residents in a community hospital program using smart phones. BMC Med Inform Decis Mak (2007) 1.54
Cigarette smoke induction of osteopontin (SPP1) mediates T(H)17 inflammation in human and experimental emphysema. Sci Transl Med (2012) 1.54
The effects of radiation dose and CT manufacturer on measurements of lung densitometry. Chest (2007) 1.53
Airway remodeling in subjects with severe asthma with or without chronic persistent airflow obstruction. J Allergy Clin Immunol (2009) 1.52
The impact of peripheral vascular disease on long-term survival after coronary artery bypass graft surgery. Ann Thorac Surg (2008) 1.52
Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2010) 1.51
The IBV Valve trial: a multicenter, randomized, double-blind trial of endobronchial therapy for severe emphysema. J Bronchology Interv Pulmonol (2014) 1.51
Surgery for paroxysmal atrial fibrillation in the setting of mitral valve disease: a role for pulmonary vein isolation? Ann Thorac Surg (2006) 1.51
The impact of resident work-hour restrictions on outcomes of cardiac operations. J Surg Res (2009) 1.49
Endobronchial ultrasound-guided transbronchial needle aspiration for systematic nodal staging of lung cancer in patients with N0 disease by computed tomography and integrated positron emission tomography-computed tomography. Ann Am Thorac Soc (2015) 1.49
Eotaxin and obesity. J Clin Endocrinol Metab (2005) 1.47
Interactions between leukotriene C4 and interleukin 13 signaling pathways in a mouse model of airway disease. Arch Pathol Lab Med (2006) 1.46
Is an age of 80 years or greater an important predictor of short-term outcomes of isolated aortic valve replacement in veterans? Ann Thorac Surg (2010) 1.46
The impact of placing multiple grafts to each myocardial territory on long-term survival after coronary artery bypass grafting. J Thorac Cardiovasc Surg (2009) 1.41
Comorbidity, systemic inflammation and outcomes in the ECLIPSE cohort. Respir Med (2013) 1.41
IL-33-responsive innate lymphoid cells are an important source of IL-13 in chronic rhinosinusitis with nasal polyps. Am J Respir Crit Care Med (2013) 1.40
Absence of the complement anaphylatoxin C3a receptor suppresses Th2 effector functions in a murine model of pulmonary allergy. J Immunol (2002) 1.40
Superior nationwide outcomes of endovascular versus open repair for isolated descending thoracic aortic aneurysm in 11,669 patients. J Thorac Cardiovasc Surg (2010) 1.39
Endogenous attenuation of allergic lung inflammation by syndecan-1. J Immunol (2005) 1.38
A new mechanism regulating the initiation of allergic airway inflammation. J Allergy Clin Immunol (2007) 1.37
Genome-wide association study identifies BICD1 as a susceptibility gene for emphysema. Am J Respir Crit Care Med (2010) 1.36
Type I collagen is a genetic modifier of matrix metalloproteinase 2 in murine skeletal development. Dev Dyn (2007) 1.35
CXCR2 expression in tumor cells is a poor prognostic factor and promotes invasion and metastasis in lung adenocarcinoma. Cancer Res (2012) 1.32
Identification of rhesus macaque genital microbiota by 16S pyrosequencing shows similarities to human bacterial vaginosis: implications for use as an animal model for HIV vaginal infection. AIDS Res Hum Retroviruses (2010) 1.29
Predicting outcomes from 6-minute walk distance in chronic obstructive pulmonary disease. J Am Med Dir Assoc (2011) 1.28
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The influence of radiographic phenotype and smoking status on peripheral blood biomarker patterns in chronic obstructive pulmonary disease. PLoS One (2009) 1.28