Published in Proc Am Thorac Soc on November 01, 2010
Expanding the clinical indications for α(1)-antitrypsin therapy. Mol Med (2012) 1.10
Modeling the influence of vitamin D deficiency on cigarette smoke-induced emphysema. Front Physiol (2013) 0.90
Treg/IL-17 ratio and Treg differentiation in patients with COPD. PLoS One (2014) 0.80
Immune-directed therapy for type 1 diabetes at the clinical level: the Immune Tolerance Network (ITN) experience. Rev Diabet Stud (2012) 0.79
Splicing variants of SERPINA1 gene in ovine milk: characterization of cDNA and identification of polymorphisms. PLoS One (2013) 0.77
Alcohol use predicts ER visits in individuals with alpha-1 antitrypsin deficiency (AATD) associated COPD. COPD (2012) 0.77
Deficiency of α-1-antitrypsin influences systemic iron homeostasis. Int J Chron Obstruct Pulmon Dis (2013) 0.77
AFM Imaging Reveals Topographic Diversity of Wild Type and Z Variant Polymers of Human α1-Proteinase Inhibitor. PLoS One (2016) 0.75
Gene Therapy for Alpha-1 Antitrypsin Deficiency Lung Disease. Ann Am Thorac Soc (2016) 0.75
α-Linoleic acid enhances the capacity of α-1 antitrypsin to inhibit lipopolysaccharide-induced IL-1β in human blood neutrophils. Mol Med (2016) 0.75
Identification of α1-Antitrypsin as a Potential Candidate for Internal Control for Human Synovial Fluid in Western Blot. Rheumatology (Sunnyvale) (2015) 0.75
NOX Modifiers-Just a Step Away from Application in the Therapy of Airway Inflammation? Antioxid Redox Signal (2014) 0.75
Neutrophil Fates in Bronchiectasis and Alpha-1 Antitrypsin Deficiency. Ann Am Thorac Soc (2016) 0.75
Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell (2005) 12.73
Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nat Cell Biol (2001) 7.22
Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J Clin Invest (2004) 6.32
Augmented Wnt signaling in a mammalian model of accelerated aging. Science (2007) 5.62
Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J Clin Invest (2000) 5.26
A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation. Nat Med (2006) 5.05
Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice. Nat Med (2005) 4.31
Immunologic aspects of chronic obstructive pulmonary disease. N Engl J Med (2009) 4.27
Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema. Am J Respir Crit Care Med (2001) 3.92
Interleukin-1 receptor antagonist: role in biology. Annu Rev Immunol (1998) 3.78
Elastin fragments drive disease progression in a murine model of emphysema. J Clin Invest (2006) 3.11
Antielastin autoimmunity in tobacco smoking-induced emphysema. Nat Med (2007) 3.05
Upregulation of gelatinases A and B, collagenases 1 and 2, and increased parenchymal cell death in COPD. Chest (2000) 2.92
Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1. J Clin Invest (1991) 2.82
Studies in alpha 1-antitrypsin deficiency. Acta Med Scand Suppl (1965) 2.77
Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease. Nat Med (2007) 2.63
Oxidative stress and apoptosis interact and cause emphysema due to vascular endothelial growth factor receptor blockade. Am J Respir Cell Mol Biol (2003) 2.59
Alpha1-antitrypsin deficiency. Lancet (2005) 2.56
Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice. Proc Natl Acad Sci U S A (2008) 2.53
4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2002) 2.38
Cystic fibrosis transmembrane conductance regulator function is suppressed in cigarette smokers. Am J Respir Crit Care Med (2006) 2.34
Telomere shortening in smokers with and without COPD. Eur Respir J (2006) 2.27
Vascular endothelial growth factor in the lung. Am J Physiol Lung Cell Mol Physiol (2006) 2.25
Cigarette smoke selectively enhances viral PAMP- and virus-induced pulmonary innate immune and remodeling responses in mice. J Clin Invest (2008) 2.24
Alveolar cell senescence in patients with pulmonary emphysema. Am J Respir Crit Care Med (2006) 2.20
Role of the Sec61 translocon in EGF receptor trafficking to the nucleus and gene expression. Mol Biol Cell (2007) 1.99
alpha1-Antitrypsin inhalation reduces airway inflammation in cystic fibrosis patients. Eur Respir J (2006) 1.98
Hypothesis: does COPD have an autoimmune component? Thorax (2003) 1.98
Z alpha1-antitrypsin polymerizes in the lung and acts as a neutrophil chemoattractant. Chest (2004) 1.88
alpha-1-Antitrypsin ameliorates cigarette smoke-induced emphysema in the mouse. Am J Respir Crit Care Med (2003) 1.88
Apoptosis and emphysema: the missing link. Am J Respir Cell Mol Biol (2003) 1.82
alpha-1 antitrypsin inhibits caspase-3 activity, preventing lung endothelial cell apoptosis. Am J Pathol (2006) 1.81
Aging and cigarette smoke: fueling the fire. Am J Respir Crit Care Med (2006) 1.76
State of the art. Cellular and molecular mechanisms of alveolar destruction in emphysema: an evolutionary perspective. Proc Am Thorac Soc (2006) 1.75
Lung-targeted VEGF inactivation leads to an emphysema phenotype in mice. J Appl Physiol (1985) (2004) 1.72
A novel antiapoptotic role for alpha1-antitrypsin in the prevention of pulmonary emphysema. Am J Respir Crit Care Med (2006) 1.72
Cigarette smoke induces cellular senescence. Am J Respir Cell Mol Biol (2006) 1.66
Augmentation therapy reduces frequency of lung infections in antitrypsin deficiency: a new hypothesis with supporting data. Chest (2000) 1.62
Alpha1-antitrypsin monotherapy prolongs islet allograft survival in mice. Proc Natl Acad Sci U S A (2005) 1.61
Shortened telomeres in circulating leukocytes of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2009) 1.57
Role of cathepsin S-dependent epithelial cell apoptosis in IFN-gamma-induced alveolar remodeling and pulmonary emphysema. J Immunol (2005) 1.53
Alpha-1-antitrypsin inhibits human immunodeficiency virus type 1. FASEB J (2001) 1.50
Evidence for excessive bronchial inflammation during an acute exacerbation of chronic obstructive pulmonary disease in patients with alpha(1)-antitrypsin deficiency (PiZ). Am J Respir Crit Care Med (1999) 1.45
Alpha-1-antitrypsin and a broad spectrum metalloprotease inhibitor, RS113456, have similar acute anti-inflammatory effects. Lab Invest (2001) 1.43
Cigarette smoke induces senescence in alveolar epithelial cells. Am J Respir Cell Mol Biol (2004) 1.41
Antiinflammatory properties of hepatic acute phase proteins: preferential induction of interleukin 1 (IL-1) receptor antagonist over IL-1 beta synthesis by human peripheral blood mononuclear cells. J Exp Med (1993) 1.39
Neutrophil accumulation in the lung in alpha 1-antitrypsin deficiency. Spontaneous release of leukotriene B4 by alveolar macrophages. J Clin Invest (1991) 1.38
The role of interleukin-8 and its receptors in inflammatory lung disease: implications for therapy. Am J Respir Med (2002) 1.38
Senescence hypothesis for the pathogenetic mechanism of chronic obstructive pulmonary disease. Proc Am Thorac Soc (2009) 1.37
Polymers of Z alpha1-antitrypsin co-localize with neutrophils in emphysematous alveoli and are chemotactic in vivo. Am J Pathol (2005) 1.36
New paradigms in the pathogenesis of chronic obstructive pulmonary disease I. Proc Am Thorac Soc (2009) 1.33
The pathogenesis of emphysema: the elastase:antielastase hypothesis 30 years later. Proc Assoc Am Physicians (1995) 1.31
Role of lung maintenance program in the heterogeneity of lung destruction in emphysema. Proc Am Thorac Soc (2006) 1.31
Functional protection by acute phase proteins alpha(1)-acid glycoprotein and alpha(1)-antitrypsin against ischemia/reperfusion injury by preventing apoptosis and inflammation. Circulation (2000) 1.30
Conformational properties of serine proteinase inhibitors (serpins) confer multiple pathophysiological roles. Biochim Biophys Acta (2001) 1.24
State of the art. Apoptosis and cell homeostasis in chronic obstructive pulmonary disease. Proc Am Thorac Soc (2006) 1.21
Alpha1-antitrypsin, old dog, new tricks. Alpha1-antitrypsin exerts in vitro anti-inflammatory activity in human monocytes by elevating cAMP. J Biol Chem (2007) 1.16
alpha1-Antitrypsin inhibits the lethal response to TNF in mice. J Immunol (1996) 1.16
Recombinant adeno-associated virus-mediated alpha-1 antitrypsin gene therapy prevents type I diabetes in NOD mice. Gene Ther (2004) 1.14
Apoptotic sphingolipid signaling by ceramides in lung endothelial cells. Am J Respir Cell Mol Biol (2008) 1.11
Alpha1-antitrypsin suppresses TNF-alpha and MMP-12 production by cigarette smoke-stimulated macrophages. Am J Respir Cell Mol Biol (2007) 1.10
Oxidative damage to nucleic acids in severe emphysema. Chest (2008) 1.10
Long-term treatment of alpha1-antitrypsin deficiency-related pulmonary emphysema with human alpha1-antitrypsin. Wissenschaftliche Arbeitsgemeinschaft zur Therapie von Lungenerkrankungen (WATL)-alpha1-AT-study group. Eur Respir J (1998) 1.03
The pathobiological mechanisms of emphysema models: what do they have in common? Pulm Pharmacol Ther (2003) 1.01
alpha 1-Proteinase inhibitor, alpha 1-antichymotrypsin, and alpha 2-macroglobulin are the antiapoptotic factors of vascular smooth muscle cells. J Biol Chem (2000) 0.99
Alpha(1)-antitrypsin inhibits epithelial Na+ transport in vitro and in vivo. Am J Respir Cell Mol Biol (2009) 0.96
The selective advantage of alpha1-antitrypsin deficiency. Am J Respir Crit Care Med (2006) 0.96
TNF-alpha-induced self expression in human lung endothelial cells is inhibited by native and oxidized alpha1-antitrypsin. Int J Biochem Cell Biol (2007) 0.93
Pulmonary epithelial neuropilin-1 deletion enhances development of cigarette smoke-induced emphysema. Am J Respir Crit Care Med (2009) 0.93
Anti-apoptotic effects of Z alpha1-antitrypsin in human bronchial epithelial cells. Eur Respir J (2009) 0.89
Alpha-1-antitrypsin stimulates fibroblast proliferation and procollagen production and activates classical MAP kinase signalling pathways. J Cell Physiol (2001) 0.89
Divergent effects of alpha1-antitrypsin on neutrophil activation, in vitro. Biochem Biophys Res Commun (2004) 0.86
Why does airway inflammation persist after the smoking stops? Thorax (2006) 0.86
Mechanism of alpha-1 antitrypsin endocytosis by lung endothelium. FASEB J (2009) 0.85
Molecular multitasking in the airspace: alpha1-antitrypsin takes on thrombin and plasmin. Am J Respir Cell Mol Biol (2007) 0.83
Immunoregulation by alpha 1 antitrypsin. J Clin Lab Immunol (1982) 0.82
The effect of alpha 1 antitrypsin on phagocyte function. J Clin Lab Immunol (1983) 0.78
Defective neutrophil chemotaxis in patients with alpha-1-antitrypsin deficiency. Eur J Pediatr (1986) 0.77
[Apoptosis in chronic obstructive pulmonary disease]. Nihon Rinsho (1999) 0.76
Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J Clin Invest (2004) 6.32
17β-Estradiol attenuates hypoxic pulmonary hypertension via estrogen receptor-mediated effects. Am J Respir Crit Care Med (2012) 1.95
Pathogenesis of chronic obstructive pulmonary disease. J Clin Invest (2012) 1.85
Apoptosis and emphysema: the missing link. Am J Respir Cell Mol Biol (2003) 1.82
State of the art. Cellular and molecular mechanisms of alveolar destruction in emphysema: an evolutionary perspective. Proc Am Thorac Soc (2006) 1.75
Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema. Nat Med (2010) 1.67
Targeted induction of lung endothelial cell apoptosis causes emphysema-like changes in the mouse. J Biol Chem (2008) 1.44
Anti-type V collagen humoral immunity in lung transplant primary graft dysfunction. J Immunol (2008) 1.42
Adipose stem cell treatment in mice attenuates lung and systemic injury induced by cigarette smoking. Am J Respir Crit Care Med (2010) 1.42
Role of lung maintenance program in the heterogeneity of lung destruction in emphysema. Proc Am Thorac Soc (2006) 1.31
Tissue transglutaminase protects epithelial ovarian cancer cells from cisplatin-induced apoptosis by promoting cell survival signaling. Carcinogenesis (2008) 1.24
Mechanisms of lung endothelial barrier disruption induced by cigarette smoke: role of oxidative stress and ceramides. Am J Physiol Lung Cell Mol Physiol (2011) 1.21
Apoptotic sphingolipid signaling by ceramides in lung endothelial cells. Am J Respir Cell Mol Biol (2008) 1.11
Lung endothelial monocyte-activating protein 2 is a mediator of cigarette smoke-induced emphysema in mice. J Clin Invest (2011) 1.10
Two-photon imaging within the murine thorax without respiratory and cardiac motion artifact. Am J Pathol (2011) 1.09
Stimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in emphysema. Am J Respir Crit Care Med (2009) 1.08
Spinal ceramide modulates the development of morphine antinociceptive tolerance via peroxynitrite-mediated nitroxidative stress and neuroimmune activation. J Pharmacol Exp Ther (2008) 1.07
Type V collagen-induced oral tolerance plus low-dose cyclosporine prevents rejection of MHC class I and II incompatible lung allografts. J Immunol (2009) 1.05
Sphingolipid-mediated inhibition of apoptotic cell clearance by alveolar macrophages. J Biol Chem (2010) 1.04
Dihydroceramide-based response to hypoxia. J Biol Chem (2011) 1.02
Pulmonary ischemia induces lung remodeling and angiogenesis. J Appl Physiol (1985) (2005) 1.00
Cigarette smoke exposure inhibits contact hypersensitivity via the generation of platelet-activating factor agonists. J Immunol (2013) 0.98
α₁-Antitrypsin modulates lung endothelial cell inflammatory responses to TNF-α. Am J Respir Cell Mol Biol (2013) 0.98
Identification of SPARC-like 1 protein as part of a biomarker panel for Alzheimer's disease in cerebrospinal fluid. J Alzheimers Dis (2012) 0.96
Plasma sphingolipids associated with chronic obstructive pulmonary disease phenotypes. Am J Respir Crit Care Med (2015) 0.95
alpha1-Antitrypsin regulates CD14 expression and soluble CD14 levels in human monocytes in vitro. Int J Biochem Cell Biol (2007) 0.94
Serum and bronchial lavage fluid concentrations of IL-8, SLPI, sCD14 and sICAM-1 in patients with COPD and asthma. Respir Med (2007) 0.93
Periostin regulates goblet cell metaplasia in a model of allergic airway inflammation. J Immunol (2011) 0.93
CFTR regulation of intracellular pH and ceramides is required for lung endothelial cell apoptosis. Am J Respir Cell Mol Biol (2009) 0.91
MSPrep--summarization, normalization and diagnostics for processing of mass spectrometry-based metabolomic data. Bioinformatics (2013) 0.90
Spinal ceramide and neuronal apoptosis in morphine antinociceptive tolerance. Neurosci Lett (2009) 0.88
The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1. J Biol Chem (2014) 0.87
Mechanism of alpha-1 antitrypsin endocytosis by lung endothelium. FASEB J (2009) 0.85
RTP801 is required for ceramide-induced cell-specific death in the murine lung. Am J Respir Cell Mol Biol (2012) 0.85
Smoking exposure induces human lung endothelial cell adaptation to apoptotic stress. Am J Respir Cell Mol Biol (2014) 0.84
In vivo knockdown of intersectin-1s alters endothelial cell phenotype and causes microvascular remodeling in the mouse lungs. Apoptosis (2013) 0.84
Cigarette smoke-induced CXCR3 receptor up-regulation mediates endothelial apoptosis. Am J Respir Cell Mol Biol (2012) 0.84
Plasma levels of alpha1-antichymotrypsin and secretory leukocyte proteinase inhibitor in healthy and chronic obstructive pulmonary disease (COPD) subjects with and without severe alpha1-antitrypsin deficiency. BMC Pulm Med (2007) 0.84
Effect of cigarette smoke exposure and structural modifications on the α-1 Antitrypsin interaction with caspases. Mol Med (2012) 0.83
Molecular multitasking in the airspace: alpha1-antitrypsin takes on thrombin and plasmin. Am J Respir Cell Mol Biol (2007) 0.83
Soluble adhesion molecules and angiotensin-converting enzyme in dementia. Neurobiol Dis (2007) 0.83
LC3 as a potential therapeutic target in hypoxia-induced pulmonary hypertension. Autophagy (2012) 0.82
A monoclonal rat anti-mouse EMAP II antibody that functionally neutralizes pro- and mature-EMAP II in vitro. J Immunol Methods (2009) 0.81
HIV envelope protein gp120-induced apoptosis in lung microvascular endothelial cells by concerted upregulation of EMAP II and its receptor, CXCR3. Am J Physiol Lung Cell Mol Physiol (2013) 0.78
Effects of Alzheimer's peptide and alpha1-antichymotrypsin on astrocyte gene expression. Neurobiol Aging (2005) 0.76
Human adipose-derived stem cells ameliorate cigarette smoke-induced murine myelosuppression via secretion of TSG-6. Stem Cells (2015) 0.75
An Official American Thoracic Society Workshop Report: Obesity and Metabolism. An Emerging Frontier in Lung Health and Disease. Ann Am Thorac Soc (2017) 0.75
Pulmonary Retention of Adipose Stromal Cells Following Intravenous Delivery Is Markedly Altered in the Presence of ARDS. Cell Transplant (2015) 0.75
High Intensity Interval Training is Superior to Continuous Training in a Pulmonary Hypertension Rat Model: 751 Board #67 June 1, 3: 30 PM - 5: 00 PM. Med Sci Sports Exerc (2016) 0.75