Published in Biometals on April 24, 2007
A molecular mechanism for bacterial susceptibility to zinc. PLoS Pathog (2011) 1.61
Zinc transporter ZIP8 (SLC39A8) and zinc influence IFN-gamma expression in activated human T cells. J Leukoc Biol (2009) 1.50
Roles of zinc and metallothionein-3 in oxidative stress-induced lysosomal dysfunction, cell death, and autophagy in neurons and astrocytes. Mol Brain (2010) 1.27
Discovery of human zinc deficiency: its impact on human health and disease. Adv Nutr (2013) 1.27
The genetics of essential metal homeostasis during development. Genesis (2008) 1.19
ZIP8 regulates host defense through zinc-mediated inhibition of NF-κB. Cell Rep (2013) 1.14
CD44-mediated phagocytosis induces inside-out activation of complement receptor-3 in murine macrophages. Blood (2007) 0.97
Expression profile of human gingival fibroblasts induced by interleukin-1beta reveals central role of nuclear factor-kappa B in stabilizing human gingival fibroblasts during inflammation. J Periodontol (2009) 0.93
Sepsis: links between pathogen sensing and organ damage. Curr Pharm Des (2008) 0.90
Dietary zinc deficiency affects blood linoleic acid: dihomo-γ-linolenic acid (LA:DGLA) ratio; a sensitive physiological marker of zinc status in vivo (Gallus gallus). Nutrients (2014) 0.88
Metal ions in macrophage antimicrobial pathways: emerging roles for zinc and copper. Biosci Rep (2013) 0.86
Behavioral impairments in animal models for zinc deficiency. Front Behav Neurosci (2015) 0.84
Selectivity and specificity of small molecule fluorescent dyes/probes used for the detection of Zn2+ and Ca2+ in cells. Metallomics (2014) 0.84
Pannexin-1-dependent caspase-1 activation and secretion of IL-1beta is regulated by zinc. Eur J Immunol (2009) 0.83
Alterations in early cytokine-mediated immune responses to Plasmodium falciparum infection in Tanzanian children with mineral element deficiencies: a cross-sectional survey. Malar J (2010) 0.82
Zinc: dietary intake and impact of supplementation on immune function in elderly. Age (Dordr) (2012) 0.80
Zinc, aging, and immunosenescence: an overview. Pathobiol Aging Age Relat Dis (2015) 0.79
Zinc-gene interaction related to inflammatory/immune response in ageing. Genes Nutr (2008) 0.79
Intracellular free zinc up-regulates IFN-γ and T-bet essential for Th1 differentiation in Con-A stimulated HUT-78 cells. Biochem Biophys Res Commun (2011) 0.78
Zinc and ageing: third Zincage conference. Immun Ageing (2007) 0.76
Elaidate, an 18-carbon trans-monoenoic fatty acid, but not physiological fatty acids increases intracellular Zn(2+) in human macrophages. J Cell Biochem (2015) 0.76
The Kinetic Response of the Proteome in A549 Cells Exposed to ZnSO4 Stress. PLoS One (2015) 0.75
The essential toxin: impact of zinc on human health. Int J Environ Res Public Health (2010) 2.09
Zinc-altered immune function. J Nutr (2003) 2.06
Functional significance of zinc-related signaling pathways in immune cells. Annu Rev Nutr (2009) 1.46
Zinc and diabetes--clinical links and molecular mechanisms. J Nutr Biochem (2009) 1.45
Zinc signals are essential for lipopolysaccharide-induced signal transduction in monocytes. J Immunol (2008) 1.31
Flow cytometric measurement of labile zinc in peripheral blood mononuclear cells. Anal Biochem (2006) 1.21
Zinc supplementation for the treatment or prevention of disease: current status and future perspectives. Exp Gerontol (2007) 1.14
A new closed-tube multiplex real-time PCR to detect eleven superantigens of Streptococcus pyogenes identifies a strain without superantigen activity. Int J Med Microbiol (2007) 1.13
Superantigen genes are more important than the emm type for the invasiveness of group A Streptococcus infection. J Infect Dis (2010) 1.11
Susceptibility to tuberculosis is associated with TLR1 polymorphisms resulting in a lack of TLR1 cell surface expression. J Leukoc Biol (2011) 1.08
Zinc-dependent suppression of TNF-alpha production is mediated by protein kinase A-induced inhibition of Raf-1, I kappa B kinase beta, and NF-kappa B. J Immunol (2007) 1.06
Modulating the immune response by oral zinc supplementation: a single approach for multiple diseases. Arch Immunol Ther Exp (Warsz) (2008) 1.04
Multiple impacts of zinc on immune function. Metallomics (2014) 1.04
The immune system and the impact of zinc during aging. Immun Ageing (2009) 1.03
Effect of zinc supplementation on plasma IL-6 and MCP-1 production and NK cell function in healthy elderly: interactive influence of +647 MT1a and -174 IL-6 polymorphic alleles. Exp Gerontol (2007) 1.02
Regulatory T cells increased while IL-1β decreased during antidepressant therapy. J Psychiatr Res (2010) 1.02
Zinc signals promote IL-2-dependent proliferation of T cells. Eur J Immunol (2010) 0.97
The Th17/Treg balance is disturbed during aging. Exp Gerontol (2013) 0.97
Zinc signals and immune function. Biofactors (2013) 0.94
Disturbed zinc homeostasis in diabetic patients by in vitro and in vivo analysis of insulinomimetic activity of zinc. J Nutr Biochem (2012) 0.94
Zinc homeostasis in aging: two elusive faces of the same "metal". Rejuvenation Res (2006) 0.93
Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9. J Leukoc Biol (2007) 0.92
Immunosenescence of polymorphonuclear neutrophils. ScientificWorldJournal (2010) 0.92
Zinc status, psychological and nutritional assessment in old people recruited in five European countries: Zincage study. Biogerontology (2006) 0.91
Polymorphonuclear leucocytes selectively produce anti-inflammatory interleukin-1 receptor antagonist and chemokines, but fail to produce pro-inflammatory mediators. Immunology (2006) 0.91
Correlation between zinc status and immune function in the elderly. Biogerontology (2006) 0.90
Differential gene expression after zinc supplementation and deprivation in human leukocyte subsets. Mol Med (2007) 0.90
Mediterranean diet and plasma concentration of inflammatory markers in old and very old subjects in the ZINCAGE population study. Clin Chem Lab Med (2008) 0.90
Crosslinking of CD66B on peripheral blood neutrophils mediates the release of interleukin-8 from intracellular storage. Hum Immunol (2006) 0.90
Neutrophil immunity of the elderly. Mech Ageing Dev (2003) 0.90
Zinc deficiency and IL-6 -174G/C polymorphism in old people from different European countries: effect of zinc supplementation. ZINCAGE study. Exp Gerontol (2008) 0.88
Zinc supplementation in the elderly reduces spontaneous inflammatory cytokine release and restores T cell functions. Rejuvenation Res (2008) 0.87
TH1 and TH2 cell polarization increases with aging and is modulated by zinc supplementation. Exp Gerontol (2007) 0.87
Overproduction of monokines by leukocytes after stimulation with lipopolysaccharide in the elderly. Exp Gerontol (2002) 0.87
Contrasting contributions of complementarity-determining region 2 and hypervariable region 4 of rat BV8S2+ (Vbeta8.2) TCR to the recognition of myelin basic protein and different types of bacterial superantigens. Int Immunol (2004) 0.87
Zinc deficiency induces production of the proinflammatory cytokines IL-1β and TNFα in promyeloid cells via epigenetic and redox-dependent mechanisms. J Nutr Biochem (2012) 0.85
Assessment of gene-nutrient interactions on inflammatory status of the elderly with the use of a zinc diet score--ZINCAGE study. J Nutr Biochem (2009) 0.85
T-lymphocytes: a target for stimulatory and inhibitory effects of zinc ions. Endocr Metab Immune Disord Drug Targets (2009) 0.85
Differential regulation of TLR-dependent MyD88 and TRIF signaling pathways by free zinc ions. J Immunol (2013) 0.84
Analysis of antigen-presenting functionality of cultured rat hepatic stellate cells and transdifferentiated myofibroblasts. Biochem Biophys Res Commun (2010) 0.83
MHC class II molecules activate NFAT and the ERK group of MAPK through distinct signaling pathways in B cells. Eur J Immunol (2009) 0.83
PTEN-inhibition by zinc ions augments interleukin-2-mediated Akt phosphorylation. Metallomics (2014) 0.82
Mycoplasma arthritidis-derived superantigen (MAM) displays DNase activity. FEMS Immunol Med Microbiol (2007) 0.82
Effect of improved zinc status on T helper cell activation and TH1/TH2 ratio in healthy elderly individuals. Biogerontology (2006) 0.82
Beta-(1-->3)-D-glucan modulates DNA binding of nuclear factors kappaB, AT and IL-6 leading to an anti-inflammatory shift of the IL-1beta/IL-1 receptor antagonist ratio. BMC Immunol (2006) 0.81
Changes in chromatin structure and methylation of the human interleukin-1beta gene during monopoiesis. Immunology (2010) 0.81
Cadmium ions induce monocytic production of tumor necrosis factor-alpha by inhibiting mitogen activated protein kinase dephosphorylation. Toxicol Lett (2010) 0.81
Differential impact of zinc deficiency on phagocytosis, oxidative burst, and production of pro-inflammatory cytokines by human monocytes. Metallomics (2014) 0.80
Zinc differentially regulates mitogen-activated protein kinases in human T cells. J Nutr Biochem (2011) 0.80
Dendritic cell subsets in lymph nodes are characterized by the specific draining area and influence the phenotype and fate of primed T cells. Immunology (2007) 0.80
The consumption of cigarettes, coffee and sweets in detoxified alcoholics and its association with relapse and a family history of alcoholism. Eur Psychiatry (2005) 0.80
Mercuric ions inhibit mitogen-activated protein kinase dephosphorylation by inducing reactive oxygen species. Toxicol Appl Pharmacol (2010) 0.79
Cellular zinc homeostasis is a regulator in monocyte differentiation of HL-60 cells by 1 alpha,25-dihydroxyvitamin D3. J Leukoc Biol (2010) 0.79
T-helper type 1 cytokine release is enhanced by in vitro zinc supplementation due to increased natural killer cells. Nutrition (2006) 0.79
Zinc ions cause the thimerosal-induced signal of fluorescent calcium probes in lymphocytes. Cell Calcium (2008) 0.79
Cadmium ions promote monocytic differentiation of human leukemia HL-60 cells treated with 1α,25-dihydroxyvitamin D3. Biol Chem (2010) 0.78
IFN-gamma reduction by tricyclic antidepressants. Int J Psychiatry Med (2010) 0.78
Differential synthesis of two interleukin-1 receptor antagonist variants and interleukin-8 by peripheral blood neutrophils. Cytokine (2005) 0.78
Repletion of zinc in zinc-deficient cells strongly up-regulates IL-1β-induced IL-2 production in T-cells. Metallomics (2012) 0.78
In vitro and in vivo effects of zinc on cytokine signalling in human T cells. Exp Gerontol (2007) 0.78
Metallothionein downregulation in very old age: a phenomenon associated with cellular senescence? Rejuvenation Res (2008) 0.78
Surveillance program for former PCB-exposed workers of a transformer and capacitor recycling company, family members, employees of surrounding companies, and area residents--executive summary. J Toxicol Environ Health A (2012) 0.78
Influence of +1245 A/G MT1A polymorphism on advanced glycation end-products (AGEs) in elderly: effect of zinc supplementation. Genes Nutr (2014) 0.78
UK food standards agency workshop report: diet and immune function. Br J Nutr (2010) 0.78
Zinc as a micronutrient and its preventive role of oxidative damage in cells. Food Funct (2015) 0.78
Zinc and ageing (ZINCAGE Project). Biogerontology (2006) 0.77
The superantigen staphylococcal enterotoxin A (SEA) and monoclonal antibody L243 share a common epitope but differ in their ability to induce apoptosis via MHC-II. Immunobiology (2006) 0.77
Application of Zinpyr-1 for the investigation of zinc signals in Escherichia coli. Biometals (2013) 0.77
Effects of human Toll-like receptor 1 polymorphisms on ageing. Immun Ageing (2013) 0.77
The superantigen-induced polarization of T cells in rat peripheral lymph nodes is influenced by genetic polymorphisms in the IL-4 and IL-6 gene clusters. Int Immunol (2006) 0.77
Zinc, metallothioneins, and longevity--effect of zinc supplementation: zincage study. Ann N Y Acad Sci (2007) 0.77
Zinc signals in neutrophil granulocytes are required for the formation of neutrophil extracellular traps. Innate Immun (2012) 0.77
Effects of long-term zinc supplementation and deprivation on gene expression in human THP-1 mononuclear cells. J Trace Elem Med Biol (2008) 0.77
Impact of lead and mercuric ions on the interleukin-2-dependent proliferation and survival of T cells. Arch Toxicol (2012) 0.76
Activation of IL-1β and TNFα genes is mediated by the establishment of permissive chromatin structures during monopoiesis. Immunobiology (2012) 0.76
Superantigen-presentation by rat major histocompatibility complex class II molecules RT1.Bl and RT1.Dl. Immunology (2008) 0.75