Published in Cancer Metastasis Rev on June 01, 2007
Hypoxia-inducible factors in physiology and medicine. Cell (2012) 8.16
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene (2009) 8.01
Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation. Mol Cell (2009) 3.68
The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase. Nature (2015) 3.24
Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth. Mol Cell Biol (2010) 2.17
Hypoxia, inflammation, and the tumor microenvironment in metastatic disease. Cancer Metastasis Rev (2010) 1.92
The tumor microenvironment and metastatic disease. Clin Exp Metastasis (2008) 1.91
Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis. J Clin Invest (2012) 1.71
Renal cancer-selective Englerin A induces multiple mechanisms of cell death and autophagy. J Exp Clin Cancer Res (2013) 1.50
Emerging insights into the molecular pathogenesis of uveal melanoma. Future Oncol (2008) 1.44
Short hairpin RNA interference therapy for ischemic heart disease. Circulation (2008) 1.34
Hypoxia stimulates migration of breast cancer cells via the PERK/ATF4/LAMP3-arm of the unfolded protein response. Breast Cancer Res (2013) 1.33
Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels. Nat Commun (2012) 1.30
Oncogenic KRAS modulates mitochondrial metabolism in human colon cancer cells by inducing HIF-1α and HIF-2α target genes. Mol Cancer (2010) 1.27
A novel extracellular Hsp90 mediated co-receptor function for LRP1 regulates EphA2 dependent glioblastoma cell invasion. PLoS One (2011) 1.17
Oxygen regulates epithelial-to-mesenchymal transition: insights into molecular mechanisms and relevance to disease. Kidney Int (2009) 1.16
Targeting oncogenic serine/threonine-protein kinase BRAF in cancer cells inhibits angiogenesis and abrogates hypoxia. Proc Natl Acad Sci U S A (2011) 1.16
CD24 is an effector of HIF-1-driven primary tumor growth and metastasis. Cancer Res (2012) 1.16
Tumor heterogeneity: mechanisms and bases for a reliable application of molecular marker design. Int J Mol Sci (2012) 1.15
Prognostic value of discs large homolog 7 transcript levels in prostate cancer. PLoS One (2013) 1.12
A biology-driven approach identifies the hypoxia gene signature as a predictor of the outcome of neuroblastoma patients. Mol Cancer (2010) 1.10
Microenvironment and radiation therapy. Biomed Res Int (2012) 1.06
Impact of hypoxia on the metastatic potential of human prostate cancer cells. Int J Radiat Oncol Biol Phys (2011) 1.04
Radiotherapy suppresses angiogenesis in mice through TGF-betaRI/ALK5-dependent inhibition of endothelial cell sprouting. PLoS One (2010) 1.03
Hypoxia-inducible factor-1 (HIF-1): a potential target for intervention in ocular neovascular diseases. Curr Drug Targets (2013) 1.01
CTGF is a therapeutic target for metastatic melanoma. Oncogene (2013) 1.00
Defining normoxia, physoxia and hypoxia in tumours-implications for treatment response. Br J Radiol (2014) 0.99
Prolyl hydroxylase domain (PHD) 2 affects cell migration and F-actin formation via RhoA/rho-associated kinase-dependent cofilin phosphorylation. J Biol Chem (2010) 0.96
Environmental control of invasiveness and metastatic dissemination of tumor cells: the role of tumor cell-host cell interactions. Cell Commun Signal (2010) 0.95
Meta-analysis of archived DNA microarrays identifies genes regulated by hypoxia and involved in a metastatic phenotype in cancer cells. BMC Cancer (2010) 0.93
p16 Modulates VEGF expression via its interaction with HIF-1alpha in breast cancer cells. Cancer Invest (2010) 0.91
Microenvironments and cellular characteristics in the micro tumor cords of malignant solid tumors. Int J Mol Sci (2012) 0.91
Logic Learning Machine creates explicit and stable rules stratifying neuroblastoma patients. BMC Bioinformatics (2013) 0.89
Growth factors in tumor microenvironment. Front Biosci (Landmark Ed) (2010) 0.88
Involvement of decreased hypoxia-inducible factor 1 activity and resultant G1-S cell cycle transition in radioresistance of perinecrotic tumor cells. Oncogene (2012) 0.88
Clinical significance of SNORA42 as an oncogene and a prognostic biomarker in colorectal cancer. Gut (2015) 0.86
Long-term interferon-α treatment suppresses tumor growth but promotes metastasis capacity in hepatocellular carcinoma. J Cancer Res Clin Oncol (2010) 0.85
Use of Attribute Driven Incremental Discretization and Logic Learning Machine to build a prognostic classifier for neuroblastoma patients. BMC Bioinformatics (2014) 0.85
High oxygen condition facilitates the differentiation of mouse and human pluripotent stem cells into pancreatic progenitors and insulin-producing cells. J Biol Chem (2014) 0.84
Cytochrome P450 2E1 potentiates ethanol induction of hypoxia and HIF-1α in vivo. Free Radic Biol Med (2013) 0.84
Vascular responses to radiotherapy and androgen-deprivation therapy in experimental prostate cancer. Radiat Oncol (2012) 0.84
Strategies To Assess Hypoxic/HIF-1-Active Cancer Cells for the Development of Innovative Radiation Therapy. Cancers (Basel) (2011) 0.84
The hypoxia-inducible epigenetic regulators Jmjd1a and G9a provide a mechanistic link between angiogenesis and tumor growth. Mol Cell Biol (2014) 0.83
A radiosensitivity MiRNA signature validated by the TCGA database for head and neck squamous cell carcinomas. Oncotarget (2015) 0.83
Imaging tumor hypoxia to advance radiation oncology. Antioxid Redox Signal (2014) 0.83
The Microenvironment of Cervical Carcinoma Xenografts: Associations with Lymph Node Metastasis and Its Assessment by DCE-MRI. Transl Oncol (2013) 0.82
The double-edged sword: conserved functions of extracellular hsp90 in wound healing and cancer. Cancers (Basel) (2014) 0.82
PERK Integrates Oncogenic Signaling and Cell Survival During Cancer Development. J Cell Physiol (2016) 0.82
A microfabricated platform for establishing oxygen gradients in 3-D constructs. Biomed Microdevices (2013) 0.81
Tissue inhibitor of metalloproteinases-1-induced scattered liver metastasis is mediated by hypoxia-inducible factor-1α. Clin Exp Metastasis (2010) 0.81
18F-FAZA PET imaging response tracks the reoxygenation of tumors in mice upon treatment with the mitochondrial complex I inhibitor BAY 87-2243. Clin Cancer Res (2014) 0.80
Differential gene expression and clonal selection during cellular transformation induced by adhesion deprivation. BMC Cell Biol (2010) 0.80
A novel family of fluorescent hypoxia sensors reveal strong heterogeneity in tumor hypoxia at the cellular level. EMBO J (2015) 0.80
Mechanistic Insights into Molecular Targeting and Combined Modality Therapy for Aggressive, Localized Prostate Cancer. Front Oncol (2016) 0.79
Tg737 signaling is required for hypoxia-enhanced invasion and migration of hepatoma cells. J Exp Clin Cancer Res (2012) 0.78
1α, 25-Dihydroxyvitamin D regulates hypoxia-inducible factor-1α in untransformed and Harvey-ras transfected breast epithelial cells. Cancer Lett (2010) 0.78
Methods to study the tumor microenvironment under controlled oxygen conditions. Trends Biotechnol (2014) 0.78
Tumour-associated mesenchymal stem/stromal cells: emerging therapeutic targets. Nat Rev Drug Discov (2016) 0.77
Development of a Novel Anti-HIF-1α Screening System Coupled with Biochemical and Biological Validation for Rapidly Selecting Potent Anti-Cancer Compounds. J Cancer (2014) 0.77
Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3. Epigenetics Chromatin (2016) 0.77
Hypoxia on the Expression of Hepatoma Upregulated Protein in Prostate Cancer Cells. Front Oncol (2016) 0.76
Effects of Hypoxia, Surrounding Fibroblasts, and p16 Expression on Breast Cancer Cell Migration and Invasion. J Cancer (2015) 0.76
Direct visualization of the phenotype of hypoxic tumor cells at single cell resolution in vivo using a new hypoxia probe. Intravital (2016) 0.76
Current relevance of hypoxia in head and neck cancer. Oncotarget (2016) 0.76
Hypoxia regulates the expression of the neuromedin B receptor through a mechanism dependent on hypoxia-inducible factor-1α. PLoS One (2013) 0.76
Inhibition of the Interleukin-11-STAT3 Axis Attenuates Hypoxia-Induced Migration and Invasion in MDA-MB-231 Breast Cancer Cells. Korean J Physiol Pharmacol (2014) 0.76
Licoricidin, an Active Compound in the Hexane/Ethanol Extract of Glycyrrhiza uralensis, Inhibits Lung Metastasis of 4T1 Murine Mammary Carcinoma Cells. Int J Mol Sci (2016) 0.75
The Breast Cancer Tumor Suppressor TRIM29 Is Expressed via ATM-dependent Signaling in Response to Hypoxia. J Biol Chem (2016) 0.75
Artificial neural network classifier predicts neuroblastoma patients' outcome. BMC Bioinformatics (2016) 0.75
Novel imaging approaches to head and neck cancer. Semin Oncol (2008) 0.75
Botulinum neurotoxin type A inhibits synaptic vesicle 2 expression in breast cancer cell lines. Int J Clin Exp Pathol (2015) 0.75
Polysaccharide K suppresses angiogenesis in colon cancer cells. Exp Ther Med (2012) 0.75
Identification of Metastasis-Associated Metabolic Profiles of Tumors by (1)H-HR-MAS-MRS. Neoplasia (2015) 0.75
Inhibitory effects of dieckol on hypoxia-induced epithelial-mesenchymal transition of HT29 human colorectal cancer cells. Mol Med Rep (2016) 0.75
Acid-mediated tumour cell invasion: a discrete modelling approach using the extended Potts model. Clin Exp Metastasis (2013) 0.75
Retinoblastoma protein (Rb) links hypoxia to altered mechanical properties in cancer cells as measured by an optical tweezer. Sci Rep (2017) 0.75
Lysyl oxidase is essential for hypoxia-induced metastasis. Nature (2006) 8.28
Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche. Cancer Cell (2009) 6.66
Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin. Mol Cell Biol (2002) 5.39
Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy. Int J Radiat Biol (2006) 3.98
Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia. Dev Cell (2002) 3.86
Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation. Mol Cell (2009) 3.68
JunD reduces tumor angiogenesis by protecting cells from oxidative stress. Cell (2004) 3.30
XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. Cancer Res (2004) 3.24
Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. Sci Transl Med (2011) 2.97
A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy. Cancer Cell (2008) 2.38
HIF1alpha delays premature senescence through the activation of MIF. Genes Dev (2006) 2.37
The hypoxic microenvironment of the skin contributes to Akt-mediated melanocyte transformation. Cancer Cell (2005) 2.34
Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro. Mol Cell Biol (2006) 2.27
The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO. Cell (2012) 2.25
Investigating hypoxic tumor physiology through gene expression patterns. Oncogene (2003) 2.24
Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth. Mol Cell Biol (2010) 2.17
ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation. J Biol Chem (2003) 2.09
Hypoxia links ATR and p53 through replication arrest. Mol Cell Biol (2002) 2.03
Hypoxic gene expression and metastasis. Cancer Metastasis Rev (2004) 2.01
Harnessing synthetic lethal interactions in anticancer drug discovery. Nat Rev Drug Discov (2011) 2.01
Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha. Mol Cell Biol (2003) 1.99
Identification of osteopontin as a prognostic plasma marker for head and neck squamous cell carcinomas. Clin Cancer Res (2003) 1.96
Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha. Mol Cell Biol (2005) 1.95
Hif-1alpha regulates differentiation of limb bud mesenchyme and joint development. J Cell Biol (2007) 1.95
Hypoxia, inflammation, and the tumor microenvironment in metastatic disease. Cancer Metastasis Rev (2010) 1.92
OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha. Mol Cell (2005) 1.91
MiR-210--micromanager of the hypoxia pathway. Trends Mol Med (2010) 1.90
Notch1 is an effector of Akt and hypoxia in melanoma development. J Clin Invest (2008) 1.89
Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha. J Biol Chem (2002) 1.88
The metastasis-associated gene Prl-3 is a p53 target involved in cell-cycle regulation. Mol Cell (2008) 1.88
ATM activation and signaling under hypoxic conditions. Mol Cell Biol (2008) 1.84
Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment. Cancer Cell (2009) 1.82
Effect of reduced oxygen tension on chondrogenesis and osteogenesis in adipose-derived mesenchymal cells. Am J Physiol Cell Physiol (2005) 1.76
Age decreases endothelial progenitor cell recruitment through decreases in hypoxia-inducible factor 1alpha stabilization during ischemia. Circulation (2007) 1.71
An evaluation of tumor oxygenation and gene expression in patients with early stage non-small cell lung cancers. Clin Cancer Res (2006) 1.71
The role of tumor cell-derived connective tissue growth factor (CTGF/CCN2) in pancreatic tumor growth. Cancer Res (2009) 1.64
Transient changes in oxygen tension inhibit osteogenic differentiation and Runx2 expression in osteoblasts. J Biol Chem (2004) 1.60
State of the science: an update on renal cell carcinoma. Mol Cancer Res (2012) 1.58
Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development. Development (2004) 1.58
Lysyl oxidase mediates hypoxic control of metastasis. Cancer Res (2006) 1.53
Anoxia is necessary for tumor cell toxicity caused by a low-oxygen environment. Cancer Res (2005) 1.52
AXL is an essential factor and therapeutic target for metastatic ovarian cancer. Cancer Res (2010) 1.50
The role of p53 in hypoxia-induced apoptosis. Biochem Biophys Res Commun (2005) 1.48
Galectin-1: a link between tumor hypoxia and tumor immune privilege. J Clin Oncol (2005) 1.45
Hypoxia-inducible factor-1alpha stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion. Mol Biol Cell (2007) 1.41
Adaptive myogenesis under hypoxia. Mol Cell Biol (2005) 1.38
Genome-wide analysis of p53 under hypoxic conditions. Mol Cell Biol (2006) 1.37
Angiogenesis is required for successful bone induction during distraction osteogenesis. J Bone Miner Res (2005) 1.36
Expression and prognostic significance of a panel of tissue hypoxia markers in head-and-neck squamous cell carcinomas. Int J Radiat Oncol Biol Phys (2007) 1.36
Short hairpin RNA interference therapy for ischemic heart disease. Circulation (2008) 1.34
Targeting cancer cells through autophagy for anticancer therapy. Curr Opin Cell Biol (2010) 1.34
The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis. Oncotarget (2012) 1.33
The hypoxic tumor microenvironment and gene expression. Semin Radiat Oncol (2004) 1.33
Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells. Blood (2009) 1.29
VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration. Proc Natl Acad Sci U S A (2011) 1.28
Inhibition of ATR leads to increased sensitivity to hypoxia/reoxygenation. Cancer Res (2004) 1.26
The role of ATM and ATR in the cellular response to hypoxia and re-oxygenation. DNA Repair (Amst) (2004) 1.25
Functional analysis of p53 binding under differential stresses. Mol Cell Biol (2006) 1.25
Hypoxia-inducible factor-1 activation in nonhypoxic conditions: the essential role of mitochondrial-derived reactive oxygen species. Mol Biol Cell (2010) 1.25
Hypoxia in models of lung cancer: implications for targeted therapeutics. Clin Cancer Res (2010) 1.19
Mutations in the PI3K/PTEN/TSC2 pathway contribute to mammalian target of rapamycin activity and increased translation under hypoxic conditions. Cancer Res (2006) 1.16
Comparison of hypoxia-induced replication arrest with hydroxyurea and aphidicolin-induced arrest. Mutat Res (2003) 1.15
Tumor galectin-1 mediates tumor growth and metastasis through regulation of T-cell apoptosis. Cancer Res (2011) 1.15
Distinct aerobic and hypoxic mechanisms of HIF-alpha regulation by CSN5. Genes Dev (2004) 1.15
Double knockdown of prolyl hydroxylase and factor-inhibiting hypoxia-inducible factor with nonviral minicircle gene therapy enhances stem cell mobilization and angiogenesis after myocardial infarction. Circulation (2011) 1.14
DNA damage during reoxygenation elicits a Chk2-dependent checkpoint response. Mol Cell Biol (2006) 1.13
In vitro expansion of adipose-derived adult stromal cells in hypoxia enhances early chondrogenesis. Tissue Eng (2007) 1.13
Plasma osteopontin is an independent prognostic marker for head and neck cancers. J Clin Oncol (2006) 1.11
Cross-talk between hypoxia and insulin signaling through Phd3 regulates hepatic glucose and lipid metabolism and ameliorates diabetes. Nat Med (2013) 1.10
Hypoxia upregulates osteopontin expression in NIH-3T3 cells via a Ras-activated enhancer. Oncogene (2005) 1.10
Epigenetic changes in tumor Fas levels determine immune escape and response to therapy. Cancer Cell (2002) 1.06
Oxygen sensing and the DNA-damage response. Curr Opin Cell Biol (2007) 1.05
Hypoxia inducible factor-1alpha deficiency affects chondrogenesis of adipose-derived adult stromal cells. Tissue Eng (2007) 1.04
Pharmacologically increased tumor hypoxia can be measured by 18F-Fluoroazomycin arabinoside positron emission tomography and enhances tumor response to hypoxic cytotoxin PR-104. Clin Cancer Res (2009) 1.02
Inhibition of histone deacetylase activity in reduced oxygen environment enhances the osteogenesis of mouse adipose-derived stromal cells. Tissue Eng Part A (2009) 1.01
Therapeutic exploitation of the physiological and molecular genetic alterations in head and neck cancer. Clin Cancer Res (2003) 1.01
Neurotrophic factor GDNF promotes survival of salivary stem cells. J Clin Invest (2014) 1.01
Validation of lysyl oxidase as a prognostic marker for metastasis and survival in head and neck squamous cell carcinoma: Radiation Therapy Oncology Group trial 90-03. J Clin Oncol (2009) 1.00
VEGF-independent cell-autonomous functions of HIF-1α regulating oxygen consumption in fetal cartilage are critical for chondrocyte survival. J Bone Miner Res (2012) 1.00
Toxoplasma gondii activates hypoxia-inducible factor (HIF) by stabilizing the HIF-1alpha subunit via type I activin-like receptor kinase receptor signaling. J Biol Chem (2010) 0.98
Targeting the loss of the von Hippel-Lindau tumor suppressor gene in renal cell carcinoma cells. Cancer Res (2007) 0.97
Developmental response to hypoxia. FASEB J (2004) 0.97
Identification of hypoxia-regulated proteins in head and neck cancer by proteomic and tissue array profiling. Cancer Res (2004) 0.95
4-Pyridylanilinothiazoles that selectively target von Hippel-Lindau deficient renal cell carcinoma cells by inducing autophagic cell death. J Med Chem (2010) 0.94
Dead cells don't form tumors: HIF-dependent cytotoxins. Cell Cycle (2004) 0.93
Renal oxygenation suppresses VHL loss-induced senescence that is caused by increased sensitivity to oxidative stress. Mol Cell Biol (2010) 0.93
Lack of HIF-2α in limb bud mesenchyme causes a modest and transient delay of endochondral bone development. Nat Med (2011) 0.92
Oxygen sensitivity of reporter genes: implications for preclinical imaging of tumor hypoxia. Mol Imaging (2007) 0.91
A central role for hypoxic signaling in cartilage, bone, and hematopoiesis. Curr Osteoporos Rep (2011) 0.90
Hypoxia and senescence: the impact of oxygenation on tumor suppression. Mol Cancer Res (2011) 0.89
Hypoxia-inducible regulation of a prodrug-activating enzyme for tumor-specific gene therapy. Neoplasia (2002) 0.88
HIF gene expression in cancer therapy. Methods Enzymol (2007) 0.88
Hypoxia-inducible factor-1 and p53: friends, acquaintances, or strangers? Clin Cancer Res (2006) 0.87
The apoptosis repressor with a CARD domain (ARC) gene is a direct hypoxia-inducible factor 1 target gene and promotes survival and proliferation of VHL-deficient renal cancer cells. Mol Cell Biol (2013) 0.87
Energy regulation: HIF MXIes it up with the C-MYC powerhouse. Dev Cell (2007) 0.86
Bringing H2AX into the angiogenesis family. Cancer Cell (2009) 0.84
Oxygen-dependent regulation of adipogenesis. Methods Enzymol (2004) 0.84
Targeting cancer cells by synthetic lethality: autophagy and VHL in cancer therapeutics. Cell Cycle (2008) 0.84
Checking in on hypoxia/reoxygenation. Cell Cycle (2006) 0.83