Published in J Clin Invest on October 16, 2008
Hypoxia, notch signalling, and prostate cancer. Nat Rev Urol (2013) 2.24
Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion. Br J Cancer (2009) 1.85
Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. J Clin Invest (2009) 1.80
From fly wings to targeted cancer therapies: a centennial for notch signaling. Cancer Cell (2014) 1.70
The PTEN-AKT3 signaling cascade as a therapeutic target in melanoma. Pigment Cell Melanoma Res (2009) 1.62
Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling. Proc Natl Acad Sci U S A (2010) 1.61
Experimental selection of hypoxia-tolerant Drosophila melanogaster. Proc Natl Acad Sci U S A (2011) 1.60
Notch inhibitors for cancer treatment. Pharmacol Ther (2013) 1.55
Role of Notch and its oncogenic signaling crosstalk in breast cancer. Biochim Biophys Acta (2010) 1.50
Endothelial HIF-2α regulates murine pathological angiogenesis and revascularization processes. J Clin Invest (2012) 1.50
Regulation of the embryonic morphogen Nodal by Notch4 facilitates manifestation of the aggressive melanoma phenotype. Cancer Res (2010) 1.49
Akt2 regulates all Akt isoforms and promotes resistance to hypoxia through induction of miR-21 upon oxygen deprivation. Cancer Res (2011) 1.48
Hypoxia-induced Jagged2 promotes breast cancer metastasis and self-renewal of cancer stem-like cells. Oncogene (2011) 1.41
HIF-1α is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway. Cell Death Differ (2011) 1.40
Melanoma: a model for testing new agents in combination therapies. J Transl Med (2010) 1.39
Hypoxia-induced down-regulation of microRNA-34a promotes EMT by targeting the Notch signaling pathway in tubular epithelial cells. PLoS One (2012) 1.34
Hypoxia-inducible factors in stem cells and cancer. J Cell Mol Med (2009) 1.27
The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness. Biochim Biophys Acta (2012) 1.26
NADPH oxidase 1 modulates WNT and NOTCH1 signaling to control the fate of proliferative progenitor cells in the colon. Mol Cell Biol (2010) 1.25
Hypoxia, melanocytes and melanoma - survival and tumor development in the permissive microenvironment of the skin. Pigment Cell Melanoma Res (2009) 1.21
Notch1 inhibition alters the CD44hi/CD24lo population and reduces the formation of brain metastases from breast cancer. Mol Cancer Res (2011) 1.18
Oxygen regulates epithelial-to-mesenchymal transition: insights into molecular mechanisms and relevance to disease. Kidney Int (2009) 1.16
Activation of the NOTCH pathway in head and neck cancer. Cancer Res (2013) 1.15
Testosterone supplementation reverses sarcopenia in aging through regulation of myostatin, c-Jun NH2-terminal kinase, Notch, and Akt signaling pathways. Endocrinology (2009) 1.11
Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia. J Cell Biol (2013) 1.10
Notch signalling in cancer progression and bone metastasis. Br J Cancer (2011) 1.09
Notch pathway is activated by MAPK signaling and influences papillary thyroid cancer proliferation. Transl Oncol (2013) 1.06
Expression and function of hypoxia inducible factor-1 alpha in human melanoma under non-hypoxic conditions. Mol Cancer (2009) 1.03
Identification of novel targets of CSL-dependent Notch signaling in hematopoiesis. PLoS One (2011) 1.02
CTGF is a therapeutic target for metastatic melanoma. Oncogene (2013) 1.00
A Notch1-neuregulin1 autocrine signaling loop contributes to melanoma growth. Oncogene (2012) 0.96
Molecular pathways: translational and therapeutic implications of the Notch signaling pathway in cancer. Clin Cancer Res (2014) 0.95
The novel gamma secretase inhibitor RO4929097 reduces the tumor initiating potential of melanoma. PLoS One (2011) 0.94
Multifactorial ERβ and NOTCH1 control of squamous differentiation and cancer. J Clin Invest (2014) 0.92
Therapeutic implications of targeting the PI3Kinase/AKT/mTOR signaling module in melanoma therapy. Am J Cancer Res (2012) 0.90
Constitutively active endothelial Notch4 causes lung arteriovenous shunts in mice. Am J Physiol Lung Cell Mol Physiol (2009) 0.90
Specific knockdown of uPA/uPAR attenuates invasion in glioblastoma cells and xenografts by inhibition of cleavage and trafficking of Notch -1 receptor. Mol Cancer (2011) 0.89
The AKT1/NF-kappaB/Notch1/PTEN axis has an important role in chemoresistance of gastric cancer cells. Cell Death Dis (2013) 0.88
Role of notch signaling in the maintenance of human mesenchymal stem cells under hypoxic conditions. Stem Cells Dev (2014) 0.87
Therapeutic Implications of Targeting AKT Signaling in Melanoma. Enzyme Res (2011) 0.85
Targeting PI3K/Akt represses Hypoxia inducible factor-1α activation and sensitizes Rhabdomyosarcoma and Ewing's sarcoma cells for apoptosis. Cancer Cell Int (2013) 0.85
UV-Induced Wnt7a in the Human Skin Microenvironment Specifies the Fate of Neural Crest-Like Cells via Suppression of Notch. J Invest Dermatol (2015) 0.85
Notch signalling in ischaemia-induced angiogenesis. Biochem Soc Trans (2009) 0.85
Dual Pten/Tp53 suppression promotes sarcoma progression by activating Notch signaling. Am J Pathol (2013) 0.84
Developmental pathways activated in melanocytes and melanoma. Arch Biochem Biophys (2014) 0.84
Noncanonical activation of Notch1 protein by membrane type 1 matrix metalloproteinase (MT1-MMP) controls melanoma cell proliferation. J Biol Chem (2014) 0.84
MicroRNA in Melanoma. Ochsner J (2010) 0.84
Notch3 is important for TGF-β-induced epithelial-mesenchymal transition in non-small cell lung cancer bone metastasis by regulating ZEB-1. Cancer Gene Ther (2014) 0.84
The Role of Hypoxia and Cancer Stem Cells in Renal Cell Carcinoma Pathogenesis. Stem Cell Rev (2015) 0.84
Function of Integrin-Linked Kinase in Modulating the Stemness of IL-6-Abundant Breast Cancer Cells by Regulating γ-Secretase-Mediated Notch1 Activation in Caveolae. Neoplasia (2015) 0.83
Notch signaling induces EMT in OSCC cell lines in a hypoxic environment. Oncol Lett (2013) 0.83
Phase 2 study of RO4929097, a gamma-secretase inhibitor, in metastatic melanoma: SWOG 0933. Cancer (2014) 0.83
Synchronized Targeting of Notch and ERBB Signaling Suppresses Melanoma Tumor Growth through Inhibition of Notch1 and ERBB3. J Invest Dermatol (2015) 0.83
Notch4 Signaling Induces a Mesenchymal-Epithelial-like Transition in Melanoma Cells to Suppress Malignant Behaviors. Cancer Res (2016) 0.82
Targeting Notch to overcome radiation resistance. Oncotarget (2016) 0.82
Notch signaling: mediator and therapeutic target of bone metastasis. Bonekey Rep (2012) 0.80
NUAK2 Amplification Coupled with PTEN Deficiency Promotes Melanoma Development via CDK Activation. Cancer Res (2015) 0.79
Detrimental effects of Notch1 signaling activated by cadmium in renal proximal tubular epithelial cells. Cell Death Dis (2014) 0.78
Phosphorylation-dependent regulation of Notch1 signaling: the fulcrum of Notch1 signaling. BMB Rep (2015) 0.78
The early antitumor immune response is necessary for tumor growth: Re-visiting Prehn's hypothesis in the human melanoma system. Oncoimmunology (2012) 0.77
Notch1 Autoactivation via Transcriptional Regulation of Furin, Which Sustains Notch1 Signaling by Processing Notch1-Activating Proteases ADAM10 and Membrane Type 1 Matrix Metalloproteinase. Mol Cell Biol (2015) 0.77
Akt1 mediates neuronal differentiation in zebrafish via a reciprocal interaction with notch signaling. PLoS One (2013) 0.77
Activated Notch1 expression is associated with angiogenesis in cutaneous melanoma. Clin Exp Med (2014) 0.77
Inflammation and Notch signaling: a crosstalk with opposite effects on tumorigenesis. Cell Death Dis (2016) 0.76
Wnt and related signaling pathways in melanomagenesis. Cancers (Basel) (2010) 0.75
The natural compound fucoidan from New Zealand Undaria pinnatifida synergizes with the ERBB inhibitor lapatinib enhancing melanoma growth inhibition. Oncotarget (2017) 0.75
A comprehensive transcriptomic analysis of differentiating embryonic stem cells in response to the overexpression of Mesogenin 1. Aging (Albany NY) (2016) 0.75
Targeting Notch enhances the efficacy of ERK inhibitors in BRAF-V600E melanoma. Oncotarget (2016) 0.75
Notch signaling in cerebrovascular diseases (Review). Mol Med Rep (2016) 0.75
Notch signalling pathway as an oncogenic factor involved in cancer development. Contemp Oncol (Pozn) (2016) 0.75
Notch ligand Delta-like 1 promotes the metastasis of melanoma by enhancing tumor adhesion. Braz J Med Biol Res (2014) 0.75
JMJD3 and NF-κB-dependent activation of Notch1 gene is required for keratinocyte migration during skin wound healing. Sci Rep (2017) 0.75
Mutations of the BRAF gene in human cancer. Nature (2002) 65.42
Notch signaling: cell fate control and signal integration in development. Science (1999) 28.83
Hypoxia--a key regulatory factor in tumour growth. Nat Rev Cancer (2002) 20.51
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BCL-2 family members and the mitochondria in apoptosis. Genes Dev (1999) 13.52
TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell (1991) 10.06
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat Cell Biol (2003) 8.42
Hypoxia requires notch signaling to maintain the undifferentiated cell state. Dev Cell (2005) 7.07
Hypoxia in cancer: significance and impact on clinical outcome. Cancer Metastasis Rev (2007) 6.91
Notch1 functions as a tumor suppressor in mouse skin. Nat Genet (2003) 6.76
Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia. Nat Med (2007) 6.55
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors. J Exp Med (2007) 4.59
Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells. Nat Med (2002) 4.04
Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia. Nat Rev Cancer (2006) 3.89
Deregulated Akt3 activity promotes development of malignant melanoma. Cancer Res (2004) 3.80
Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas. Cancer Res (2004) 3.64
Notch signaling. Clin Cancer Res (2006) 3.11
Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor. Cancer Res (2006) 3.04
Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells. Cancer Res (2006) 2.99
Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice. Proc Natl Acad Sci U S A (2006) 2.92
Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways. Proc Natl Acad Sci U S A (1997) 2.88
Induction of cyclin D1 transcription and CDK2 activity by Notch(ic): implication for cell cycle disruption in transformation by Notch(ic). Mol Cell Biol (2001) 2.74
JAGGED1 expression is associated with prostate cancer metastasis and recurrence. Cancer Res (2004) 2.59
Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers. Cancer Res (2007) 2.54
Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells. Mol Cancer Ther (2006) 2.44
Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression. J Clin Invest (2005) 2.38
The hypoxic microenvironment of the skin contributes to Akt-mediated melanocyte transformation. Cancer Cell (2005) 2.34
Overexpression of Akt converts radial growth melanoma to vertical growth melanoma. J Clin Invest (2007) 2.22
Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factor-kappaB and tumor progression. Cancer Res (2002) 2.19
NOTCH signaling as a novel cancer therapeutic target. Curr Cancer Drug Targets (2006) 2.14
Notch1 signaling promotes primary melanoma progression by activating mitogen-activated protein kinase/phosphatidylinositol 3-kinase-Akt pathways and up-regulating N-cadherin expression. Cancer Res (2006) 2.12
Mitochondrial complex III regulates hypoxic activation of HIF. Cell Death Differ (2008) 2.07
Genetic alterations in signaling pathways in melanoma. Clin Cancer Res (2006) 2.00
Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis. Proc Natl Acad Sci U S A (2001) 2.00
Measurement of absolute oxygen levels in cells and tissues using oxygen sensors and 2-nitroimidazole EF5. Methods Enzymol (2002) 1.94
Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways. Proc Natl Acad Sci U S A (2008) 1.93
Oxygen concentration determines the biological effects of NOTCH-1 signaling in adenocarcinoma of the lung. Cancer Res (2007) 1.88
Off the beaten pathway: the complex cross talk between Notch and NF-kappaB. Lab Invest (2007) 1.80
Notch signaling: the demise of elegant simplicity. Curr Opin Genet Dev (2004) 1.79
Suppression of renal cell carcinoma growth by inhibition of Notch signaling in vitro and in vivo. J Clin Invest (2008) 1.76
Inhibition of Notch signaling induces apoptosis of myeloma cells and enhances sensitivity to chemotherapy. Blood (2007) 1.65
Activated Notch1 signaling cooperates with papillomavirus oncogenes in transformation and generates resistance to apoptosis on matrix withdrawal through PKB/Akt. Virology (2001) 1.63
Chemotherapy and targeted therapy combinations in advanced melanoma. Clin Cancer Res (2006) 1.63
Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors. EMBO J (1999) 1.61
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Role of nuclear factor-kappa B in melanoma. Cancer Metastasis Rev (2005) 1.41
p53-independent NOXA induction overcomes apoptotic resistance of malignant melanomas. Mol Cancer Ther (2004) 1.40
The role of translation in neoplastic transformation from a pathologist's point of view. Oncogene (2004) 1.34
The reactive oxygen-driven tumor: relevance to melanoma. Pigment Cell Melanoma Res (2008) 1.31
Molecular targets in melanoma from angiogenesis to apoptosis. Clin Cancer Res (2006) 1.30
Epidermal Ras blockade demonstrates spatially localized Ras promotion of proliferation and inhibition of differentiation. Oncogene (2002) 1.30
Analysis of N- and K-ras mutations in the distinctive tumor progression phases of melanoma. J Invest Dermatol (2001) 1.28
MAPping out arteries and veins. Sci STKE (2006) 1.26
Notch signaling in neuroblastoma. Semin Cancer Biol (2004) 1.22
Oxygen levels in normal and previously irradiated human skin as assessed by EF5 binding. J Invest Dermatol (2006) 1.17
Evidence for a role for notch signaling in the cytokine-dependent survival of activated T cells. J Immunol (2006) 1.11
Oncogenes in melanoma. Oncogene (2003) 1.07
Reciprocal regulation of Notch and PI3K/Akt signalling in T-ALL cells in vitro. J Cell Biochem (2008) 0.99
FBXW7 mutation in adult T-cell and B-cell acute lymphocytic leukemias. Leuk Res (2008) 0.92
Skin hypoxia: a promoting environmental factor in melanomagenesis. Cell Cycle (2006) 0.92
Hypoxic microenvironment as a cradle for melanoma development and progression. Cancer Biol Ther (2006) 0.90
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Atmospheric oxygen accelerates the induction of a post-mitotic phenotype in human dermal fibroblasts: the key protective role of glutathione. Differentiation (2000) 0.86
Oxygen modulates the growth of skin fibroblasts. In Vitro Cell Dev Biol Anim (2002) 0.82
Modeling gene-environment interactions in malignant melanoma. Trends Mol Med (2003) 0.79
Lysyl oxidase is essential for hypoxia-induced metastasis. Nature (2006) 8.28
Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche. Cancer Cell (2009) 6.66
Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin. Mol Cell Biol (2002) 5.39
Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness. Nat Med (2006) 4.54
Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy. Int J Radiat Biol (2006) 3.98
Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model. Nat Med (2004) 3.96
Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia. Dev Cell (2002) 3.86
Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation. Mol Cell (2009) 3.68
Skin immune sentinels in health and disease. Nat Rev Immunol (2009) 3.52
JunD reduces tumor angiogenesis by protecting cells from oxidative stress. Cell (2004) 3.30
XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. Cancer Res (2004) 3.24
The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition. J Biol Chem (2007) 3.24
Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. Sci Transl Med (2011) 2.97
Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-alpha. J Exp Med (2004) 2.63
A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy. Cancer Cell (2008) 2.38
HIF1alpha delays premature senescence through the activation of MIF. Genes Dev (2006) 2.37
The hypoxic microenvironment of the skin contributes to Akt-mediated melanocyte transformation. Cancer Cell (2005) 2.34
Uncovering histologic criteria with prognostic significance in toxic epidermal necrolysis. Arch Dermatol (2005) 2.28
Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro. Mol Cell Biol (2006) 2.27
Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells. Cancer Res (2005) 2.27
The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO. Cell (2012) 2.25
Investigating hypoxic tumor physiology through gene expression patterns. Oncogene (2003) 2.24
Overexpression of Akt converts radial growth melanoma to vertical growth melanoma. J Clin Invest (2007) 2.22
Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches. Cancer Res (2008) 2.19
Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth. Mol Cell Biol (2010) 2.17
ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation. J Biol Chem (2003) 2.09
Hypoxia, gene expression, and metastasis. Cancer Metastasis Rev (2007) 2.07
Hypoxia links ATR and p53 through replication arrest. Mol Cell Biol (2002) 2.03
Hypoxic gene expression and metastasis. Cancer Metastasis Rev (2004) 2.01
Harnessing synthetic lethal interactions in anticancer drug discovery. Nat Rev Drug Discov (2011) 2.01
Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha. Mol Cell Biol (2003) 1.99
Identification of osteopontin as a prognostic plasma marker for head and neck squamous cell carcinomas. Clin Cancer Res (2003) 1.96
Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha. Mol Cell Biol (2005) 1.95
Hif-1alpha regulates differentiation of limb bud mesenchyme and joint development. J Cell Biol (2007) 1.95
Hypoxia, inflammation, and the tumor microenvironment in metastatic disease. Cancer Metastasis Rev (2010) 1.92
OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha. Mol Cell (2005) 1.91
MiR-210--micromanager of the hypoxia pathway. Trends Mol Med (2010) 1.90
Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha. J Biol Chem (2002) 1.88
The metastasis-associated gene Prl-3 is a p53 target involved in cell-cycle regulation. Mol Cell (2008) 1.88
ATM activation and signaling under hypoxic conditions. Mol Cell Biol (2008) 1.84
Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment. Cancer Cell (2009) 1.82
Identification of a novel proinflammatory human skin-homing Vγ9Vδ2 T cell subset with a potential role in psoriasis. J Immunol (2011) 1.79
Effect of reduced oxygen tension on chondrogenesis and osteogenesis in adipose-derived mesenchymal cells. Am J Physiol Cell Physiol (2005) 1.76
Age decreases endothelial progenitor cell recruitment through decreases in hypoxia-inducible factor 1alpha stabilization during ischemia. Circulation (2007) 1.71
An evaluation of tumor oxygenation and gene expression in patients with early stage non-small cell lung cancers. Clin Cancer Res (2006) 1.71
Clonal persistence and evolution during a decade of recurrent melanoma. J Invest Dermatol (2006) 1.69
A phase 2 trial of complete resection for stage IV melanoma: results of Southwest Oncology Group Clinical Trial S9430. Cancer (2011) 1.66
The role of tumor cell-derived connective tissue growth factor (CTGF/CCN2) in pancreatic tumor growth. Cancer Res (2009) 1.64
Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells. Oncogene (2005) 1.63
Cutting edge: A critical functional role for IL-23 in psoriasis. J Immunol (2010) 1.61
Transient changes in oxygen tension inhibit osteogenic differentiation and Runx2 expression in osteoblasts. J Biol Chem (2004) 1.60
State of the science: an update on renal cell carcinoma. Mol Cancer Res (2012) 1.58
Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development. Development (2004) 1.58
A phase I trial of tumor lysate-pulsed dendritic cells in the treatment of advanced cancer. Clin Cancer Res (2002) 1.56
Lysyl oxidase mediates hypoxic control of metastasis. Cancer Res (2006) 1.53
Anoxia is necessary for tumor cell toxicity caused by a low-oxygen environment. Cancer Res (2005) 1.52
AXL is an essential factor and therapeutic target for metastatic ovarian cancer. Cancer Res (2010) 1.50
The role of p53 in hypoxia-induced apoptosis. Biochem Biophys Res Commun (2005) 1.48
Cracking the cytokine code in psoriasis. Nat Med (2007) 1.47
Galectin-1: a link between tumor hypoxia and tumor immune privilege. J Clin Oncol (2005) 1.45
Hypoxia-inducible factor-1alpha stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion. Mol Biol Cell (2007) 1.41
Enhanced killing of melanoma cells by simultaneously targeting Mcl-1 and NOXA. Cancer Res (2006) 1.41
Wnt5A regulates expression of tumor-associated antigens in melanoma via changes in signal transducers and activators of transcription 3 phosphorylation. Cancer Res (2008) 1.41
p53-independent NOXA induction overcomes apoptotic resistance of malignant melanomas. Mol Cancer Ther (2004) 1.40
Adaptive myogenesis under hypoxia. Mol Cell Biol (2005) 1.38
Genome-wide analysis of p53 under hypoxic conditions. Mol Cell Biol (2006) 1.37
Transendothelial function of human metastatic melanoma cells: role of the microenvironment in cell-fate determination. Cancer Res (2002) 1.36
Angiogenesis is required for successful bone induction during distraction osteogenesis. J Bone Miner Res (2005) 1.36
Active Notch1 confers a transformed phenotype to primary human melanocytes. Cancer Res (2009) 1.36
Expression and prognostic significance of a panel of tissue hypoxia markers in head-and-neck squamous cell carcinomas. Int J Radiat Oncol Biol Phys (2007) 1.36
Short hairpin RNA interference therapy for ischemic heart disease. Circulation (2008) 1.34
Targeting cancer cells through autophagy for anticancer therapy. Curr Opin Cell Biol (2010) 1.34
The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis. Oncotarget (2012) 1.33
The hypoxic tumor microenvironment and gene expression. Semin Radiat Oncol (2004) 1.33
The Notch ligand Jagged-1 is able to induce maturation of monocyte-derived human dendritic cells. J Immunol (2002) 1.30
Using optical coherence tomography to evaluate skin sun damage and precancer. Lasers Surg Med (2007) 1.29
Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells. Blood (2009) 1.29
VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration. Proc Natl Acad Sci U S A (2011) 1.28
Inhibition of ATR leads to increased sensitivity to hypoxia/reoxygenation. Cancer Res (2004) 1.26
Inhibition of PAX3 by TGF-beta modulates melanocyte viability. Mol Cell (2008) 1.26
The role of ATM and ATR in the cellular response to hypoxia and re-oxygenation. DNA Repair (Amst) (2004) 1.25
Functional analysis of p53 binding under differential stresses. Mol Cell Biol (2006) 1.25
Hypoxia-inducible factor-1 activation in nonhypoxic conditions: the essential role of mitochondrial-derived reactive oxygen species. Mol Biol Cell (2010) 1.25
Notch-independent regulation of Hes-1 expression by c-Jun N-terminal kinase signaling in human endothelial cells. Lab Invest (2006) 1.24
Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence. Oncogene (2003) 1.23
Conservation of genetic alterations in recurrent melanoma supports the melanoma stem cell hypothesis. Cancer Res (2008) 1.22
Focal adhesion kinase promotes the aggressive melanoma phenotype. Cancer Res (2005) 1.22
Notch signaling regulates mouse and human Th17 differentiation. J Immunol (2011) 1.21
A 'hairy' privilege. Trends Immunol (2005) 1.21
Hypoxia, melanocytes and melanoma - survival and tumor development in the permissive microenvironment of the skin. Pigment Cell Melanoma Res (2009) 1.21
4-Tertiary butyl phenol exposure sensitizes human melanocytes to dendritic cell-mediated killing: relevance to vitiligo. J Invest Dermatol (2005) 1.20
Hypoxia in models of lung cancer: implications for targeted therapeutics. Clin Cancer Res (2010) 1.19
Maintenance of hair follicle immune privilege is linked to prevention of NK cell attack. J Invest Dermatol (2007) 1.18
Random DNA fragmentation allows detection of single-copy, single-exon alterations of copy number by oligonucleotide array CGH in clinical FFPE samples. Nucleic Acids Res (2009) 1.17
Mutations in the PI3K/PTEN/TSC2 pathway contribute to mammalian target of rapamycin activity and increased translation under hypoxic conditions. Cancer Res (2006) 1.16