Published in Pharm Res on May 01, 2007
Membrane transporters in drug development. Nat Rev Drug Discov (2010) 8.56
Inflammatory bowel disease. Annu Rev Immunol (2010) 7.10
Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation. Cell Metab (2010) 4.14
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol (2013) 3.00
Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase. J Biol Chem (2007) 2.54
The blood-testis barrier and its implications for male contraception. Pharmacol Rev (2011) 2.10
Contribution of organic cation transporter 2 (OCT2) to cisplatin-induced nephrotoxicity. Clin Pharmacol Ther (2009) 1.94
OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies. Br J Pharmacol (2012) 1.74
Molecular mechanism of action of metformin: old or new insights? Diabetologia (2013) 1.71
Pharmacokinetics and dosage adjustment in patients with renal dysfunction. Eur J Clin Pharmacol (2009) 1.51
Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin. Pharmacogenet Genomics (2010) 1.48
Unfaithful neurotransmitter transporters: focus on serotonin uptake and implications for antidepressant efficacy. Pharmacol Ther (2008) 1.44
Muscarinic receptors and ligands in cancer. Am J Physiol Cell Physiol (2008) 1.42
The zebrafish transcriptome during early development. BMC Dev Biol (2011) 1.39
Selective transport of monoamine neurotransmitters by human plasma membrane monoamine transporter and organic cation transporter 3. J Pharmacol Exp Ther (2010) 1.34
Molecular biology of the blood-brain and the blood-cerebrospinal fluid barriers: similarities and differences. Fluids Barriers CNS (2011) 1.33
Bile formation and secretion. Compr Physiol (2013) 1.32
Mechanism of cellular uptake of a ruthenium polypyridyl complex. Biochemistry (2008) 1.30
Drug transporters in the human blood-placental barrier. Br J Pharmacol (2009) 1.30
Association of Organic Cation Transporter 1 With Intolerance to Metformin in Type 2 Diabetes: A GoDARTS Study. Diabetes (2014) 1.29
Decynium-22 enhances SSRI-induced antidepressant-like effects in mice: uncovering novel targets to treat depression. J Neurosci (2013) 1.29
Organic cation transporter 3: Keeping the brake on extracellular serotonin in serotonin-transporter-deficient mice. Proc Natl Acad Sci U S A (2008) 1.29
Serotonin signaling is altered in irritable bowel syndrome with diarrhea but not in functional dyspepsia in pediatric age patients. Gastroenterology (2010) 1.27
Differential transport of platinum compounds by the human organic cation transporter hOCT2 (hSLC22A2). Br J Pharmacol (2010) 1.24
OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin. Proc Natl Acad Sci U S A (2014) 1.24
The epithelial cholinergic system of the airways. Histochem Cell Biol (2008) 1.17
Non-traditional platinum compounds for improved accumulation, oral bioavailability, and tumor targeting. Dalton Trans (2009) 1.17
The SLC36 family of proton-coupled amino acid transporters and their potential role in drug transport. Br J Pharmacol (2011) 1.13
Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmacodynamics/toxicodynamics and pharmacogenomics. Br J Pharmacol (2011) 1.11
Novel inhibitors of human organic cation/carnitine transporter (hOCTN2) via computational modeling and in vitro testing. Pharm Res (2009) 1.09
Exploring the transcriptome of ciliated cells using in silico dissection of human tissues. PLoS One (2012) 1.06
Drug transporters, the blood-testis barrier, and spermatogenesis. J Endocrinol (2010) 1.05
DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma. Genome Med (2011) 1.05
You are what you eat: influence of type and amount of food consumed on central dopamine systems and the behavioral effects of direct- and indirect-acting dopamine receptor agonists. Neuropharmacology (2012) 1.04
Drug uptake systems in liver and kidney: a historic perspective. Clin Pharmacol Ther (2009) 1.04
Drug interactions at the blood-brain barrier: fact or fantasy? Pharmacol Ther (2009) 1.03
Organic cation transporter 1 (OCT1/mOct1) is localized in the apical membrane of Caco-2 cell monolayers and enterocytes. Mol Pharmacol (2013) 1.03
Biopharmaceutical characterization of nebulized antimicrobial agents in rats: 2. Colistin. Antimicrob Agents Chemother (2014) 1.03
Non-neuronal release of ACh plays a key role in secretory response to luminal propionate in rat colon. J Physiol (2010) 1.03
Repeated swim impairs serotonin clearance via a corticosterone-sensitive mechanism: organic cation transporter 3, the smoking gun. J Neurosci (2010) 1.02
Double-transfected MDCK cells expressing human OCT1/MATE1 or OCT2/MATE1: determinants of uptake and transcellular translocation of organic cations. Br J Pharmacol (2011) 1.02
Nonexocytotic serotonin release tonically suppresses serotonergic neuron activity. J Gen Physiol (2015) 1.01
Rational design of bioactive, modularly assembled aminoglycosides targeting the RNA that causes myotonic dystrophy type 1. ACS Chem Biol (2012) 1.01
The human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5. J Biol Chem (2009) 0.99
OCT1 Expression in adipocytes could contribute to increased metformin action in obese subjects. Diabetes (2010) 0.98
Distribution of genetic polymorphisms of genes encoding drug metabolizing enzymes & drug transporters - a review with Indian perspective. Indian J Med Res (2014) 0.96
Ontogeny and regulation of the serotonin transporter: providing insights into human disorders. Pharmacol Ther (2011) 0.96
Organic cation transporter OCTs (SLC22) and MATEs (SLC47) in the human kidney. AAPS J (2013) 0.95
Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1). Naunyn Schmiedebergs Arch Pharmacol (2007) 0.95
Emerging role for drug transporters at the blood-testis barrier. Trends Pharmacol Sci (2010) 0.95
The large extracellular loop of organic cation transporter 1 influences substrate affinity and is pivotal for oligomerization. J Biol Chem (2011) 0.94
Heparan sulfate proteoglycan-mediated entry pathway for charged tri-platinum compounds: differential cellular accumulation mechanisms for platinum. Mol Pharm (2012) 0.93
Four cation-selective transporters contribute to apical uptake and accumulation of metformin in Caco-2 cell monolayers. J Pharmacol Exp Ther (2015) 0.93
Taste of a pill: organic cation transporter-3 (OCT3) mediates metformin accumulation and secretion in salivary glands. J Biol Chem (2014) 0.93
Polyamine transport by the polyspecific organic cation transporters OCT1, OCT2, and OCT3. Mol Pharm (2013) 0.92
Ondansetron can enhance cisplatin-induced nephrotoxicity via inhibition of multiple toxin and extrusion proteins (MATEs). Toxicol Appl Pharmacol (2013) 0.91
Hepatocyte nuclear factor 1 regulates the expression of the organic cation transporter 1 via binding to an evolutionary conserved region in intron 1 of the OCT1 gene. J Pharmacol Exp Ther (2013) 0.91
Exploring the cellular accumulation of metal complexes. Dalton Trans (2009) 0.90
Revisiting serotonin reuptake inhibitors and the therapeutic potential of "uptake-2" in psychiatric disorders. ACS Chem Neurosci (2013) 0.90
Impaired monoamine and organic cation uptake in choroid plexus in mice with targeted disruption of the plasma membrane monoamine transporter (Slc29a4) gene. J Biol Chem (2012) 0.90
Quantitative structure activity relationship for inhibition of human organic cation/carnitine transporter. Mol Pharm (2010) 0.90
Characterization of the disposition and toxicokinetics of N-butylpyridinium chloride in male F-344 rats and female B6C3F1 mice and its transport by organic cation transporter 2. Drug Metab Dispos (2009) 0.88
Twelve transmembrane helices form the functional core of mammalian MATE1 (multidrug and toxin extruder 1) protein. J Biol Chem (2012) 0.88
Recent advances in the molecular biology of metazoan polyamine transport. Amino Acids (2011) 0.88
Adenosine transport by plasma membrane monoamine transporter: reinvestigation and comparison with organic cations. Drug Metab Dispos (2010) 0.88
Transport of biogenic amine neurotransmitters at the mouse blood-retina and blood-brain barriers by uptake1 and uptake2. J Cereb Blood Flow Metab (2012) 0.88
Role of the plasma membrane transporter of organic cations OCT1 and its genetic variants in modern liver pharmacology. Biomed Res Int (2013) 0.87
Transcellular movement of hydroxyurea is mediated by specific solute carrier transporters. Exp Hematol (2011) 0.87
Src family kinase inhibitor Saracatinib (AZD0530) impairs oxaliplatin uptake in colorectal cancer cells and blocks organic cation transporters. Cancer Res (2010) 0.86
Human organic cation transporters 1 (SLC22A1), 2 (SLC22A2), and 3 (SLC22A3) as disposition pathways for fluoroquinolone antimicrobials. Antimicrob Agents Chemother (2013) 0.86
Genetic and epigenetic regulation of the organic cation transporter 3, SLC22A3. Pharmacogenomics J (2012) 0.86
The role of reduced intracellular concentrations of active drugs in the lack of response to anticancer chemotherapy. Acta Pharmacol Sin (2013) 0.85
OCT2 and MATE1 provide bidirectional agmatine transport. Mol Pharm (2010) 0.85
Conjunctive therapy of cisplatin with the OCT2 inhibitor cimetidine: influence on antitumor efficacy and systemic clearance. Clin Pharmacol Ther (2013) 0.85
OCT1 polymorphism is associated with response and survival time in anti-Parkinsonian drug users. Neurogenetics (2010) 0.85
Effect of gestational age on mRNA and protein expression of polyspecific organic cation transporters during pregnancy. Drug Metab Dispos (2013) 0.85
Common drugs inhibit human organic cation transporter 1 (OCT1)-mediated neurotransmitter uptake. Drug Metab Dispos (2014) 0.84
OCT1 and imatinib transport in CML: is it clinically relevant? Leukemia (2015) 0.84
Coexistence of passive and proton antiporter-mediated processes in nicotine transport at the mouse blood-brain barrier. AAPS J (2012) 0.84
Interaction of organic cation transporter 3 (SLC22A3) and amphetamine. J Neurochem (2010) 0.84
MATE1 has an external COOH terminus, consistent with a 13-helix topology. Am J Physiol Renal Physiol (2009) 0.84
Interaction of Ethambutol with human organic cation transporters of the SLC22 family indicates potential for drug-drug interactions during antituberculosis therapy. Antimicrob Agents Chemother (2013) 0.84
Selenoneine, a novel selenium-containing compound, mediates detoxification mechanisms against methylmercury accumulation and toxicity in zebrafish embryo. Mar Biotechnol (NY) (2013) 0.84
Linkage disequilibrium mapping of the chromosome 6q21-22.31 bipolar I disorder susceptibility locus. Am J Med Genet B Neuropsychiatr Genet (2010) 0.83
Expression of choline and acetylcholine transporters in synovial tissue and cartilage of patients with rheumatoid arthritis and osteoarthritis. Cell Tissue Res (2014) 0.83
Pharmacogenetics meets metabolomics: discovery of tryptophan as a new endogenous OCT2 substrate related to metformin disposition. PLoS One (2012) 0.83
Why we should be vigilant: drug cytotoxicity observed with in vitro transporter inhibition studies. Biochem Pharmacol (2010) 0.83
Expression and analysis of two novel rat organic cation transporter homologs, SLC22A17 and SLC22A23. Mol Cell Biochem (2011) 0.83
Functional significance of conserved cysteines in the human organic cation transporter 2. Am J Physiol Renal Physiol (2012) 0.83
Blockade of the high-affinity noradrenaline transporter (NET) by the selective 5-HT reuptake inhibitor escitalopram: an in vivo microdialysis study in mice. Br J Pharmacol (2013) 0.82
Influence of chronic amphetamine treatment and acute withdrawal on serotonin synthesis and clearance mechanisms in the rat ventral hippocampus. Eur J Neurosci (2012) 0.82
Potent and Selective Inhibition of Plasma Membrane Monoamine Transporter by HIV Protease Inhibitors. Drug Metab Dispos (2015) 0.82
Catecholamine/Serotonin interactions: systems thinking for brain function and disease. Adv Pharmacol (2013) 0.82
Genetic variation in drug transporters in ethnic populations. Clin Pharmacol Ther (2008) 0.82
Genetic analysis of OCT1 gene polymorphisms in an Indian population. Indian J Hum Genet (2011) 0.82
Role of solute carriers in response to anticancer drugs. Mol Cell Ther (2014) 0.81
Reduced dimethylaminoethanol in [(18)F]fluoromethylcholine: an important step towards enhanced tumour visualization. Eur J Nucl Med Mol Imaging (2010) 0.81
Colon OCTN2 gene expression is up-regulated by peroxisome proliferator-activated receptor gamma in humans and mice and contributes to local and systemic carnitine homeostasis. J Biol Chem (2010) 0.81
Serotonin in the ventral hippocampus modulates anxiety-like behavior during amphetamine withdrawal. Neuroscience (2014) 0.81
Organic cation transporter 3 contributes to norepinephrine uptake into perivascular adipose tissue. Am J Physiol Heart Circ Physiol (2015) 0.81
A glucose sensor hiding in a family of transporters. Proc Natl Acad Sci U S A (2003) 1.98
Subtype-specific affinity for corticosterone of rat organic cation transporters rOCT1 and rOCT2 depends on three amino acids within the substrate binding region. Mol Pharmacol (2005) 1.43
Central role of alpha7 nicotinic receptor in differentiation of the stratified squamous epithelium. J Cell Biol (2002) 1.33
Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium. Am J Respir Cell Mol Biol (2005) 1.16
Transport of lamivudine [(-)-beta-L-2',3'-dideoxy-3'-thiacytidine] and high-affinity interaction of nucleoside reverse transcriptase inhibitors with human organic cation transporters 1, 2, and 3. J Pharmacol Exp Ther (2009) 1.11
A new metaphyseal bone defect model in osteoporotic rats to study biomaterials for the enhancement of bone healing in osteoporotic fractures. Acta Biomater (2013) 0.92
Identification of cysteines in rat organic cation transporters rOCT1 (C322, C451) and rOCT2 (C451) critical for transport activity and substrate affinity. Am J Physiol Renal Physiol (2007) 0.90
The cation transporters rOCT1 and rOCT2 interact with bicarbonate but play only a minor role for amantadine uptake into rat renal proximal tubules. J Pharmacol Exp Ther (2002) 0.83
Cellular uptake of imatinib into leukemic cells is independent of human organic cation transporter 1 (OCT1). Clin Cancer Res (2013) 0.82