Published in Am J Respir Cell Mol Biol on April 07, 2005
Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans. Br J Pharmacol (2008) 3.39
Xenobiotic, bile acid, and cholesterol transporters: function and regulation. Pharmacol Rev (2010) 2.97
OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies. Br J Pharmacol (2012) 1.74
Regulation of ACh release from guinea pig bladder urothelial cells: potential role in bladder filling sensations. Br J Pharmacol (2014) 1.42
Muscarinic receptors and ligands in cancer. Am J Physiol Cell Physiol (2008) 1.42
Non-neuronal acetylcholine and urinary bladder urothelium. Life Sci (2007) 1.27
Inhaled chemotherapy in lung cancer: future concept of nanomedicine. Int J Nanomedicine (2012) 1.18
The epithelial cholinergic system of the airways. Histochem Cell Biol (2008) 1.17
Corticosterone acts in the nucleus accumbens to enhance dopamine signaling and potentiate reinstatement of cocaine seeking. J Neurosci (2013) 0.98
Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse. Respir Res (2006) 0.96
Epithelial organic cation transporters ensure pH-dependent drug absorption in the airway. Am J Respir Cell Mol Biol (2006) 0.95
Polyamine transport by the polyspecific organic cation transporters OCT1, OCT2, and OCT3. Mol Pharm (2013) 0.92
Characterizing the molecular spatial and temporal field of injury in early-stage smoker non-small cell lung cancer patients after definitive surgery by expression profiling. Cancer Prev Res (Phila) (2012) 0.92
Muscarinic receptor subtypes in cilia-driven transport and airway epithelial development. Eur Respir J (2009) 0.91
Cholinergic regulation of airway inflammation and remodelling. J Allergy (Cairo) (2012) 0.86
Common drugs inhibit human organic cation transporter 1 (OCT1)-mediated neurotransmitter uptake. Drug Metab Dispos (2014) 0.84
Epithelium integrity is crucial for the relaxant activity of brain natriuretic peptide in human isolated bronchi. Br J Pharmacol (2011) 0.84
Muscarinic receptor antagonists: effects on pulmonary function. Handb Exp Pharmacol (2012) 0.83
Expression of choline and acetylcholine transporters in synovial tissue and cartilage of patients with rheumatoid arthritis and osteoarthritis. Cell Tissue Res (2014) 0.83
Cellular uptake of imatinib into leukemic cells is independent of human organic cation transporter 1 (OCT1). Clin Cancer Res (2013) 0.82
Luminal cholinergic signalling in airway lining fluid: a novel mechanism for activating chloride secretion via Ca²⁺-dependent Cl⁻ and K⁺ channels. Br J Pharmacol (2012) 0.80
"Tasting" the airway lining fluid. Histochem Cell Biol (2012) 0.80
Non-neuronal cholinergic system in airways and lung cancer susceptibility. Transl Lung Cancer Res (2013) 0.79
Acetylcholine released by endothelial cells facilitates flow-mediated dilatation. J Physiol (2016) 0.78
Cholinergic activity as a new target in diseases of the heart. Mol Med (2015) 0.78
Organic cation transporter variation and response to smoking cessation therapies. Nicotine Tob Res (2014) 0.78
A non-neuronal cardiac cholinergic system plays a protective role in myocardium salvage during ischemic insults. PLoS One (2012) 0.78
Polyspecific organic cation transporters and their impact on drug intracellular levels and pharmacodynamics. Pharmacol Res (2016) 0.76
Pulmonary inflammation is regulated by the levels of the vesicular acetylcholine transporter. PLoS One (2015) 0.75
Role of a Hydrophobic Pocket in Polyamine Interactions with the Polyspecific Organic Cation Transporter OCT3. J Biol Chem (2015) 0.75
Organic cation transporter 3 (OCT3) is localized to intracellular and surface membranes in select glial and neuronal cells within the basolateral amygdaloid complex of both rats and mice. Brain Struct Funct (2016) 0.75
Renal Drug Transporters and Drug Interactions. Clin Pharmacokinet (2017) 0.75
Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications. Pharm Res (2007) 3.72
Hypoxia-dependent regulation of nonphagocytic NADPH oxidase subunit NOX4 in the pulmonary vasculature. Circ Res (2007) 3.28
Chronic sildenafil treatment inhibits monocrotaline-induced pulmonary hypertension in rats. Am J Respir Crit Care Med (2003) 2.90
SGLT2 mediates glucose reabsorption in the early proximal tubule. J Am Soc Nephrol (2010) 2.85
Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion. Diabetes (2011) 2.65
Prevention of bleomycin-induced lung fibrosis by aerosolization of heparin or urokinase in rabbits. Am J Respir Crit Care Med (2003) 2.59
Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver. Hepatology (2009) 2.59
A glucose sensor hiding in a family of transporters. Proc Natl Acad Sci U S A (2003) 1.98
Autoimmunity against the β2 adrenergic receptor and muscarinic-2 receptor in complex regional pain syndrome. Pain (2011) 1.89
Acetylcholine and molecular components of its synthesis and release machinery in the urothelium. Eur Urol (2006) 1.89
Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions. Am J Pathol (2010) 1.76
Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2. Am J Pathol (2005) 1.73
TRPM5, a taste-signaling transient receptor potential ion-channel, is a ubiquitous signaling component in chemosensory cells. BMC Neurosci (2007) 1.69
Organic cation transporters (OCTs, MATEs), in vitro and in vivo evidence for the importance in drug therapy. Handb Exp Pharmacol (2011) 1.69
Pivotal Advance: Up-regulation of acetylcholine synthesis and paracrine cholinergic signaling in intravascular transplant leukocytes during rejection of rat renal allografts. J Leukoc Biol (2009) 1.67
Individual PKC-phosphorylation sites in organic cation transporter 1 determine substrate selectivity and transport regulation. J Am Soc Nephrol (2005) 1.65
Amino acids critical for substrate affinity of rat organic cation transporter 1 line the substrate binding region in a model derived from the tertiary structure of lactose permease. Mol Pharmacol (2005) 1.63
Drug specificity and intestinal membrane localization of human organic cation transporters (OCT). Biochem Pharmacol (2005) 1.62
Caveolin-1 facilitates mechanosensitive protein kinase B (Akt) signaling in vitro and in vivo. Circ Res (2005) 1.55
Role of resident alveolar macrophages in leukocyte traffic into the alveolar air space of intact mice. Am J Physiol Lung Cell Mol Physiol (2002) 1.51
Synthesis and biologic evaluation of (11)c-methyl-d-glucoside, a tracer of the sodium-dependent glucose transporters. J Nucl Med (2003) 1.51
Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus. Am J Physiol Renal Physiol (2012) 1.51
Suitability of muscarinic acetylcholine receptor antibodies for immunohistochemistry evaluated on tissue sections of receptor gene-deficient mice. Naunyn Schmiedebergs Arch Pharmacol (2008) 1.47
Cholinergic chemosensory cells in the trachea regulate breathing. Proc Natl Acad Sci U S A (2011) 1.44
Subtype-specific affinity for corticosterone of rat organic cation transporters rOCT1 and rOCT2 depends on three amino acids within the substrate binding region. Mol Pharmacol (2005) 1.43
Role of muscarinic receptor subtypes in the constriction of peripheral airways: studies on receptor-deficient mice. Mol Pharmacol (2003) 1.40
Revised immunolocalization of the Na+-D-glucose cotransporter SGLT1 in rat organs with an improved antibody. Am J Physiol Cell Physiol (2008) 1.38
Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences. Pharmacogenetics (2002) 1.34
Central role of alpha7 nicotinic receptor in differentiation of the stratified squamous epithelium. J Cell Biol (2002) 1.33
SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic Akita mice. Am J Physiol Renal Physiol (2013) 1.29
Expression of muscarinic and nicotinic acetylcholine receptors in the mouse urothelium. Life Sci (2007) 1.29
Phosphodiesterase 1 upregulation in pulmonary arterial hypertension: target for reverse-remodeling therapy. Circulation (2007) 1.28
Three-dimensional imaging and morphometric analysis of alveolar tissue from microfocal X-ray-computed tomography. Am J Physiol Lung Cell Mol Physiol (2006) 1.25
Essential role of complex II of the respiratory chain in hypoxia-induced ROS generation in the pulmonary vasculature. Am J Physiol Lung Cell Mol Physiol (2003) 1.25
Expression and distribution of cholinergic receptors in the human urothelium. Life Sci (2007) 1.20
Barrier functions and paracellular integrity in human cell culture models of the proximal respiratory unit. Eur J Pharm Biopharm (2008) 1.18
Distribution of endothelin receptor subtypes ETA and ETB in the rat kidney. J Histochem Cytochem (2006) 1.16
Antiremodeling effects of iloprost and the dual-selective phosphodiesterase 3/4 inhibitor tolafentrine in chronic experimental pulmonary hypertension. Circ Res (2004) 1.16
Rapamycin attenuates hypoxia-induced pulmonary vascular remodeling and right ventricular hypertrophy in mice. Respir Res (2007) 1.15
Histology by mass spectrometry: label-free tissue characterization obtained from high-accuracy bioanalytical imaging. Angew Chem Int Ed Engl (2010) 1.15
Mechanosensitive p27Kip1 regulation and cell cycle entry in vascular smooth muscle cells. Circulation (2003) 1.12
Transport of lamivudine [(-)-beta-L-2',3'-dideoxy-3'-thiacytidine] and high-affinity interaction of nucleoside reverse transcriptase inhibitors with human organic cation transporters 1, 2, and 3. J Pharmacol Exp Ther (2009) 1.11
Expression of Na+-D-glucose cotransporter SGLT2 in rodents is kidney-specific and exhibits sex and species differences. Am J Physiol Cell Physiol (2012) 1.10
Increase in SGLT1-mediated transport explains renal glucose reabsorption during genetic and pharmacological SGLT2 inhibition in euglycemia. Am J Physiol Renal Physiol (2013) 1.09
FRET-CLSM and double-labeling indirect immunofluorescence to detect close association of proteins in tissue sections. Lab Invest (2006) 1.08
Organic cation transporters OCT1, 2, and 3 mediate high-affinity transport of the mutagenic vital dye ethidium in the kidney proximal tubule. Am J Physiol Renal Physiol (2009) 1.06
Cell-specific nitric oxide synthase-isoenzyme expression and regulation in response to endotoxin in intact rat lungs. Lab Invest (2002) 1.06
Expression of the high-affinity choline transporter, CHT1, in the neuronal and non-neuronal cholinergic system of human and rat skin. J Invest Dermatol (2002) 1.05
DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma. Genome Med (2011) 1.05
Molecular pathways of monocyte emigration into the alveolar air space of intact mice. Am J Respir Crit Care Med (2002) 1.04
Carriers involved in targeting the cytostatic bile acid-cisplatin derivatives cis-diammine-chloro-cholylglycinate-platinum(II) and cis-diammine-bisursodeoxycholate-platinum(II) toward liver cells. Mol Pharmacol (2002) 1.03
Hypoxic vasoconstriction of partial muscular intra-acinar pulmonary arteries in murine precision cut lung slices. Respir Res (2006) 1.03
Regulation of human organic cation transporter hOCT2 by PKA, PI3K, and calmodulin-dependent kinases. Am J Physiol Renal Physiol (2002) 1.03
Mice without the regulator gene Rsc1A1 exhibit increased Na+-D-glucose cotransport in small intestine and develop obesity. Mol Cell Biol (2005) 1.02
Cell free expression and functional reconstitution of eukaryotic drug transporters. Biochemistry (2008) 1.01
Serotonin activates murine alveolar macrophages through 5-HT2C receptors. Am J Physiol Lung Cell Mol Physiol (2010) 1.01
Coexpression and spatial association of nicotinic acetylcholine receptor subunits alpha7 and alpha10 in rat sympathetic neurons. J Mol Neurosci (2006) 1.01
Localizations of Na(+)-D-glucose cotransporters SGLT1 and SGLT2 in human kidney and of SGLT1 in human small intestine, liver, lung, and heart. Pflugers Arch (2014) 1.01
Alkali cation binding and permeation in the rat organic cation transporter rOCT2. J Biol Chem (2005) 1.00
Nicotinic acetylcholine receptor subtypes in nociceptive dorsal root ganglion neurons of the adult rat. Auton Neurosci (2004) 0.99
A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters. J Pharmacol Exp Ther (2005) 0.99
Intermedin/adrenomedullin-2 is a hypoxia-induced endothelial peptide that stabilizes pulmonary microvascular permeability. Am J Physiol Lung Cell Mol Physiol (2009) 0.98
Drug uptake transporters in antiretroviral therapy. Pharmacol Ther (2011) 0.98
Localization of the Na+-D-glucose cotransporter SGLT1 in the blood-brain barrier. Histochem Cell Biol (2004) 0.98
TASK-1, TASK-2, TASK-3 and TRAAK immunoreactivities in the rat carotid body. Brain Res (2002) 0.97
Antihypertensive and laxative effects by pharmacological inhibition of sodium-proton-exchanger subtype 3-mediated sodium absorption in the gut. Hypertension (2012) 0.97
Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse. Respir Res (2006) 0.96
Nicotinic receptors on rat alveolar macrophages dampen ATP-induced increase in cytosolic calcium concentration. Respir Res (2010) 0.96
Different affinities of inhibitors to the outwardly and inwardly directed substrate binding site of organic cation transporter 2. Mol Pharmacol (2003) 0.94
Dendritic cell-nerve clusters are sites of T cell proliferation in allergic airway inflammation. Am J Pathol (2009) 0.94
The large extracellular loop of organic cation transporter 1 influences substrate affinity and is pivotal for oligomerization. J Biol Chem (2011) 0.94
Activation of the SPHK/S1P signalling pathway is coupled to muscarinic receptor-dependent regulation of peripheral airways. Respir Res (2005) 0.93
The VEGF-system in primary pulmonary angiosarcomas and haemangioendotheliomas: new potential therapeutic targets? Lung Cancer (2008) 0.92
Optical control of acetylcholinesterase with a tacrine switch. Angew Chem Int Ed Engl (2014) 0.92
Mechanical ventilation drives pneumococcal pneumonia into lung injury and sepsis in mice: protection by adrenomedullin. Crit Care (2014) 0.92
Regulation of the human organic cation transporter hOCT1. J Cell Physiol (2004) 0.92
Human organic cation transporter 1 is expressed in lymphoma cells and increases susceptibility to irinotecan and paclitaxel. J Pharmacol Exp Ther (2011) 0.92
Stereological characterization of left ventricular cardiomyocytes, capillaries, and innervation in the nondiabetic, obese mouse. Cardiovasc Pathol (2011) 0.92
Multiple nicotinic acetylcholine receptor alpha-subunits are expressed in the arterial system of the rat. Histochem Cell Biol (2002) 0.91
Expression of nicotinic acetylcholine receptors on murine alveolar macrophages. J Mol Neurosci (2006) 0.91
Autoantibodies in complex regional pain syndrome bind to a differentiation-dependent neuronal surface autoantigen. Pain (2009) 0.91
An improved method for real-time monitoring of membrane capacitance in Xenopus laevis oocytes. Biophys J (2002) 0.91
Role of acetylcholine and muscarinic receptors in serotonin-induced bronchoconstriction in the mouse. J Mol Neurosci (2006) 0.91
Expression of the high-affinity choline transporter CHT1 in rat and human arteries. J Histochem Cytochem (2003) 0.91
Nicotinic receptor alpha 7-subunits are coupled to the stimulation of nitric oxide synthase in rat dorsal root ganglion neurons. Histochem Cell Biol (2003) 0.90
Identification of cysteines in rat organic cation transporters rOCT1 (C322, C451) and rOCT2 (C451) critical for transport activity and substrate affinity. Am J Physiol Renal Physiol (2007) 0.90