Published in Mamm Genome on May 09, 2007
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From arylamine N-acetyltransferase to folate-dependent acetyl CoA hydrolase: impact of folic acid on the activity of (HUMAN)NAT1 and its homologue (MOUSE)NAT2. PLoS One (2014) 0.83
5-methyl-tetrahydrofolate and the S-adenosylmethionine cycle in C57BL/6J mouse tissues: gender differences and effects of arylamine N-acetyltransferase-1 deletion. PLoS One (2013) 0.83
N-acetyltransferase 2 activity and folate levels. Life Sci (2009) 0.76
RNA-mediated non-mendelian inheritance of an epigenetic change in the mouse. Nature (2006) 6.90
Molecular genetics and function of NAT1 and NAT2: role in aromatic amine metabolism and carcinogenesis. Mutat Res (2002) 2.62
Sox1 directly regulates the gamma-crystallin genes and is essential for lens development in mice. Genes Dev (1998) 2.33
Kabuki syndrome: a review. Clin Genet (2005) 2.19
Unmasking Kabuki syndrome: chromosome 8p22-8p23.1 duplication revealed by comparative genomic hybridization and BAC-FISH. Clin Genet (2003) 2.00
Update on consensus arylamine N-acetyltransferase gene nomenclature. Pharmacogenetics (2000) 1.71
Maternal smoking and the risk of orofacial clefts: Susceptibility with NAT1 and NAT2 polymorphisms. Epidemiology (2004) 1.63
CpG methylation regulates the Igf2/H19 insulator. Curr Biol (2001) 1.55
Eukaryotic arylamine N-acetyltransferase. Investigation of substrate specificity by high-throughput screening. Biochem Pharmacol (2004) 1.32
Acetylation of p-aminobenzoylglutamate, a folic acid catabolite, by recombinant human arylamine N-acetyltransferase and U937 cells. Biochem J (1995) 1.29
Role of the executioner caspases during lens development. J Biol Chem (2005) 1.27
Integrity of the methylation cycle is essential for mammalian neural tube closure. Birth Defects Res A Clin Mol Teratol (2006) 1.26
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Acquired and inherited disorders of cobalamin and folate in children. Br J Haematol (2006) 1.13
Periconceptional multivitamin intake during early pregnancy, genetic variation of acetyl-N-transferase 1 (NAT1), and risk for orofacial clefts. Birth Defects Res A Clin Mol Teratol (2004) 1.13
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Structure and mechanism of arylamine N-acetyltransferases. Curr Top Med Chem (2006) 1.03
Purification of recombinant human N-acetyltransferase type 1 (NAT1) expressed in E. coli and characterization of its potential role in folate metabolism. Biochem Pharmacol (1995) 1.02
Excess methionine suppresses the methylation cycle and inhibits neural tube closure in mouse embryos. FEBS Lett (2006) 1.00
Expression of arylamine N-acetyltransferases in pre-term placentas and in human pre-implantation embryos. Hum Mol Genet (2000) 0.99
Mapping AAC1, AAC2 and AACP, the genes for arylamine N-acetyltransferases, carcinogen metabolising enzymes on human chromosome 8p22, a region frequently deleted in tumours. Cytogenet Cell Genet (1997) 0.98
Generation and analysis of mice with a targeted disruption of the arylamine N-acetyltransferase type 2 gene. Pharmacogenomics J (2003) 0.97
Triplication of 8p22-8p23 in a patient with features similar to Kabuki syndrome. Am J Med Genet A (2006) 0.97
Use of vitamin supplements and cataract: the Blue Mountains Eye Study. Am J Ophthalmol (2001) 0.97
Loss of function polymorphisms in NAT1 protect against spina bifida. Hum Genet (2006) 0.94
Immunochemical detection of arylamine N-acetyltransferase during mouse embryonic development and in adult mouse brain. Teratology (1998) 0.93
Modifications of human betaA1/betaA3-crystallins include S-methylation, glutathiolation, and truncation. Protein Sci (2004) 0.92
Major effects on teratogen-induced facial clefting in mice determined by a single genetic region. Genetics (1990) 0.91
The NAT1 C1095A polymorphism, maternal multivitamin use and smoking, and the risk of spina bifida. Birth Defects Res A Clin Mol Teratol (2005) 0.89
Redox regulation of the human xenobiotic metabolizing enzyme arylamine N-acetyltransferase 1 (NAT1). Reversible inactivation by hydrogen peroxide. J Biol Chem (2003) 0.88
Chromosome mapping of the genes for murine arylamine N-acetyltransferases (NATs), enzymes involved in the metabolism of carcinogens: identification of a novel upstream noncoding exon for murine Nat2. Cytogenet Cell Genet (2000) 0.85
N-acetyltransferase 2 phenotype may be associated with susceptibility to age-related cataract. Curr Eye Res (2005) 0.84
The mouse Cat4 locus maps to chromosome 8 and mutants express lens-corneal adhesion. Mamm Genome (1997) 0.83
Arylamine N-acetyltransferase 2 expression in the developing heart. J Histochem Cytochem (2005) 0.83
Methylenetetrahydrofolate reductase genetic polymorphisms in patients with cataract. Am J Ophthalmol (2005) 0.83
The xenobiotic-metabolizing enzymes arylamine N-acetyltransferases in human lens epithelial cells: inactivation by cellular oxidants and UVB-induced oxidative stress. Mol Pharmacol (2005) 0.81
The ldis1 lens mutation in RIIIS/J mice maps to chromosome 8 near cadherin 1. Mol Vis (2004) 0.81
Spontaneous, asymmetrical microphthalmia in C57B1/6J mice. J Craniofac Genet Dev Biol (1990) 0.79
NAT2 slow acetylator function as a risk indicator for age-related cataract formation. Pharmacogenetics (2003) 0.79
Genetic control of ocular morphogenesis: defective lens development associated with ocular anomalies in C57BL/6 mice. Exp Eye Res (1993) 0.79
Abnormal eye development associated with Cat4a, a dominant mouse cataract mutation on chromosome 8. Invest Ophthalmol Vis Sci (1998) 0.76
Maternal folate status and risk of neural tube defects. Lancet (1996) 0.75
Sex, side, and severity in spontaneous malformations of fetal A/JKt mice, and their associations with each other and with fetal weight. Teratology (1979) 0.75
Effects of H-2 and vitamin A on eye defects in congenic mice. Proc Soc Exp Biol Med (1992) 0.75
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A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages. Proc Natl Acad Sci U S A (2007) 4.04
Complement activation and protein adsorption by carbon nanotubes. Mol Immunol (2005) 1.81
Eukaryotic arylamine N-acetyltransferase. Investigation of substrate specificity by high-throughput screening. Biochem Pharmacol (2004) 1.32
Arylamine N-acetyltransferase-1 is highly expressed in breast cancers and conveys enhanced growth and resistance to etoposide in vitro. Mol Cancer Res (2003) 1.29
The structure of arylamine N-acetyltransferase from Mycobacterium smegmatis--an enzyme which inactivates the anti-tubercular drug, isoniazid. J Mol Biol (2002) 1.28
An approach to identifying novel substrates of bacterial arylamine N-acetyltransferases. Bioorg Med Chem (2003) 1.24
A CD74-dependent MHC class I endolysosomal cross-presentation pathway. Nat Immunol (2012) 1.23
Gene expression profiling of primary male breast cancers reveals two unique subgroups and identifies N-acetyltransferase-1 (NAT1) as a novel prognostic biomarker. Breast Cancer Res (2012) 1.20
Arylamine N-acetyltransferases: structural and functional implications of polymorphisms. Toxicology (2008) 1.15
Arylamine N-acetyltransferase is required for synthesis of mycolic acids and complex lipids in Mycobacterium bovis BCG and represents a novel drug target. J Exp Med (2004) 1.14
Characterization of a carbon-carbon hydrolase from Mycobacterium tuberculosis involved in cholesterol metabolism. J Biol Chem (2009) 1.12
Characterization of the putative operon containing arylamine N-acetyltransferase (nat) in Mycobacterium bovis BCG. Mol Microbiol (2006) 1.11
Expression, purification, characterization and structure of Pseudomonas aeruginosa arylamine N-acetyltransferase. Biochem J (2005) 1.09
Investigation of the catalytic triad of arylamine N-acetyltransferases: essential residues required for acetyl transfer to arylamines. Biochem J (2005) 1.08
The COOH terminus of arylamine N-acetyltransferase from Salmonella typhimurium controls enzymic activity. J Biol Chem (2002) 1.04
Structural analysis of the genes for human arylamine N-acetyltransferases and characterisation of alternative transcripts. Basic Clin Pharmacol Toxicol (2005) 1.03
Binding of the anti-tubercular drug isoniazid to the arylamine N-acetyltransferase protein from Mycobacterium smegmatis. Protein Sci (2005) 1.01
Prospective virtual screening with Ultrafast Shape Recognition: the identification of novel inhibitors of arylamine N-acetyltransferases. J R Soc Interface (2009) 1.00
Arylamine N-acetyltransferase 1 expression in breast cancer cell lines: a potential marker in estrogen receptor-positive tumors. Genes Chromosomes Cancer (2008) 0.99
Deletion of a xenobiotic metabolizing gene in mice affects folate metabolism. Biochem Biophys Res Commun (2007) 0.98
Arylamine N-acetyltransferases in mycobacteria. Curr Drug Metab (2008) 0.98
Mouse N-acetyltransferase type 2, the homologue of human N-acetyltransferase type 1. Biochem Pharmacol (2008) 0.98
N-acetyltransferase (Nat) 1 and 2 expression in Nat2 knockout mice. J Pharmacol Exp Ther (2006) 0.97
Temperature stability of proteins essential for the intracellular survival of Mycobacterium tuberculosis. Biochem J (2009) 0.96
The pharmacogenetics of NAT: structural aspects. Pharmacogenomics (2002) 0.96
Synthesis and anticancer activities of 6-amino amonafide derivatives. Anticancer Drugs (2008) 0.94
Structure of Mesorhizobium loti arylamine N-acetyltransferase 1. Acta Crystallogr Sect F Struct Biol Cryst Commun (2004) 0.93
Divergence of cofactor recognition across evolution: coenzyme A binding in a prokaryotic arylamine N-acetyltransferase. J Mol Biol (2007) 0.93
Synthesis and in vitro evaluation of novel small molecule inhibitors of bacterial arylamine N-acetyltransferases (NATs). Bioorg Med Chem Lett (2003) 0.93
Molecular cloning, characterisation and ligand-bound structure of an azoreductase from Pseudomonas aeruginosa. J Mol Biol (2007) 0.93
Probing the architecture of the Mycobacterium marinum arylamine N-acetyltransferase active site. Protein Cell (2010) 0.92
Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N-acetyltransferase 2. Bioorg Med Chem (2008) 0.91
Changes in consensus arylamine N-acetyltransferase gene nomenclature. Pharmacogenet Genomics (2008) 0.91
Small molecule colorimetric probes for specific detection of human arylamine N-acetyltransferase 1, a potential breast cancer biomarker. J Am Chem Soc (2010) 0.91
Multiple routes of complement activation by Mycobacterium bovis BCG. Mol Immunol (2009) 0.91
Reaction mechanism of azoreductases suggests convergent evolution with quinone oxidoreductases. Protein Cell (2010) 0.89
Association of metabolic gene polymorphisms with tobacco consumption in healthy controls. Int J Cancer (2004) 0.89
Expression and purification of the rifamycin amide synthase, RifF, an enzyme homologous to the prokaryotic arylamine N-acetyltransferases. Protein Expr Purif (2002) 0.89
Structure and transcriptional regulation of the Nat2 gene encoding for the drug-metabolizing enzyme arylamine N-acetyltransferase type 2 in mice. Biochem J (2003) 0.89
Inhibition of mycobacterial arylamine N-acetyltransferase contributes to anti-mycobacterial activity of Warburgia salutaris. Bioorg Med Chem (2007) 0.88
NMR investigation of the catalytic mechanism of arylamine N-acetyltransferase from Salmonella typhimurium. Biochim Biophys Acta (2003) 0.88
Structure of HsaD, a steroid-degrading hydrolase, from Mycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 0.87
Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars. Protein Cell (2010) 0.86
Synthesis of putative chain terminators of mycobacterial arabinan biosynthesis. Org Biomol Chem (2007) 0.85
Identification and functional characterization of novel polymorphisms associated with the genes for arylamine N-acetyltransferases in mice. Pharmacogenetics (2002) 0.85
A novel mechanism for azoreduction. J Mol Biol (2010) 0.85
Structural investigation of mutant Mycobacterium smegmatis arylamine N-acetyltransferase: a model for a naturally occurring functional polymorphism in Mycobacterium tuberculosis arylamine N-acetyltransferase. Protein Expr Purif (2003) 0.85
Mouse arylamine N-acetyltransferase 2 (Nat2) expression during embryogenesis: a potential marker for the developing neuroendocrine system. Biomarkers (2008) 0.85
Comparison of the Arylamine N-acetyltransferase from Mycobacterium marinum and Mycobacterium tuberculosis. Protein J (2009) 0.84
Arylamine N-acetyltransferase 2 expression in the developing heart. J Histochem Cytochem (2005) 0.83
Antiandrogenic and growth inhibitory effects of ring-substituted analogs of 3,3'-diindolylmethane (ring-DIMs) in hormone-responsive LNCaP human prostate cancer cells. Prostate (2011) 0.83
Over-expression, purification, and characterization of recombinant human arylamine N-acetyltransferase 1. Protein J (2005) 0.83
Downregulation of hepatic acetylation of drugs in chronic renal failure. J Am Soc Nephrol (2008) 0.83
Synthesis of Arabino glycosyl triazoles as potential inhibitors of mycobacterial cell wall biosynthesis. Bioorg Med Chem Lett (2008) 0.82
Confirmation of the role of N-acetyltransferase 2 in teratogen-induced cleft palate using transgenics and knockouts. Mol Reprod Dev (2008) 0.82
Novel small-molecule inhibitors of arylamine N-acetyltransferases: drug discovery by high-throughput screening. Comb Chem High Throughput Screen (2011) 0.82
Update on the pharmacogenetics of NATs: structural considerations. Pharmacogenomics (2008) 0.82
Kinetic characterisation of arylamine N-acetyltransferase from Pseudomonas aeruginosa. BMC Biochem (2007) 0.82
Role of tyrosine 131 in the active site of paAzoR1, an azoreductase with specificity for the inflammatory bowel disease prodrug balsalazide. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.82
Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages. PLoS One (2012) 0.81
Cloning, functional expression and characterization of Mesorhizobium loti arylamine N-acetyltransferases: rhizobial symbiosis supplies leguminous plants with the xenobiotic N-acetylation pathway. Mol Microbiol (2006) 0.80
A novel color change mechanism for breast cancer biomarker detection: naphthoquinones as specific ligands of human arylamine N-acetyltransferase 1. PLoS One (2013) 0.79
Structure of arylamine N-acetyltransferase from Mycobacterium tuberculosis determined by cross-seeding with the homologous protein from M. marinum: triumph over adversity. Acta Crystallogr D Biol Crystallogr (2013) 0.79
Stereoselective synthesis of beta-arabino glycosyl sulfones as potential inhibitors of mycobacterial cell wall biosynthesis. Carbohydr Res (2009) 0.78
Characterization of an oxidoreductase from the arylamine N-acetyltransferase operon in Mycobacterium smegmatis. FEBS J (2011) 0.78
Improvement of the expression and purification of Mycobacterium tuberculosis arylamine N-acetyltransferase (TBNAT) a potential target for novel anti-tubercular agents. Protein Expr Purif (2011) 0.78
NAT gene polymorphisms and susceptibility to Alzheimer's disease: identification of a novel NAT1 allelic variant. BMC Med Genet (2004) 0.78
Mutational and expression analysis of tbnat and its response to isoniazid. J Med Microbiol (2005) 0.78
Design, synthesis and structure-activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase. Bioorg Med Chem Lett (2013) 0.77
Activation of nitrofurazone by azoreductases: multiple activities in one enzyme. Sci Rep (2011) 0.77
Insight into the structure of Mesorhizobium loti arylamine N-acetyltransferase 2 (MLNAT2): a biochemical and computational study. FEBS Lett (2006) 0.77
Skeletal muscles express the xenobiotic-metabolizing enzyme arylamine N-acetyltransferase. J Histochem Cytochem (2003) 0.77
Pharmacogenomics of arylamine N-acetyltransferases--from drug metabolism to drug discovery. Pharmacogenomics (2002) 0.76
Mechanism-based inhibition of HsaD: a C-C bond hydrolase essential for survival of Mycobacterium tuberculosis in macrophage. FEMS Microbiol Lett (2013) 0.76
Characterisation of a putative AraC transcriptional regulator from Mycobacterium smegmatis. Tuberculosis (Edinb) (2014) 0.75
Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase. Bioorg Med Chem Lett (2010) 0.75