Published in Acta Crystallogr D Biol Crystallogr on July 17, 2013
Microseed matrix screening for optimization in protein crystallization: what have we learned? Acta Crystallogr F Struct Biol Commun (2014) 0.88
Arylamine N-acetyltransferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol (2014) 0.87
Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding. BMC Pharmacol Toxicol (2014) 0.76
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science (2007) 9.86
Crystal structure of the potassium channel KirBac1.1 in the closed state. Science (2003) 7.46
Experimental determination of the radiation dose limit for cryocooled protein crystals. Proc Natl Acad Sci U S A (2006) 5.54
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. EMBO Rep (2011) 4.89
A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages. Proc Natl Acad Sci U S A (2007) 4.04
Absorbed dose calculations for macromolecular crystals: improvements to RADDOSE. J Synchrotron Radiat (2009) 3.76
Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins. J Inorg Biochem (2006) 3.08
Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity. Nature (2007) 3.05
The structure of an integrin/talin complex reveals the basis of inside-out signal transduction. EMBO J (2009) 2.76
Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases. Structure (2009) 2.59
Determination of X-ray flux using silicon pin diodes. J Synchrotron Radiat (2009) 2.44
The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation. EMBO J (2008) 2.36
The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complex. EMBO J (2003) 2.31
Observation of decreased radiation damage at higher dose rates in room temperature protein crystallography. Structure (2007) 2.25
Radiation damage in macromolecular cryocrystallography. Curr Opin Struct Biol (2006) 2.16
Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha. Biochem J (2008) 1.95
Inhibition of 2-oxoglutarate dependent oxygenases. Chem Soc Rev (2011) 1.90
Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH). Proc Natl Acad Sci U S A (2006) 1.87
Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor. J Biol Chem (2007) 1.84
Complement activation and protein adsorption by carbon nanotubes. Mol Immunol (2005) 1.81
Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates. J Biol Chem (2006) 1.75
Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases. J Med Chem (2008) 1.74
Mechanism of Lys48-linked polyubiquitin chain recognition by the Mud1 UBA domain. EMBO J (2005) 1.70
Structure and interdomain interactions of a hybrid domain: a disulphide-rich module of the fibrillin/LTBP superfamily of matrix proteins. Structure (2009) 1.66
Crystal structures of fibronectin-binding sites from Staphylococcus aureus FnBPA in complex with fibronectin domains. Proc Natl Acad Sci U S A (2008) 1.62
Structural and mechanistic studies on γ-butyrobetaine hydroxylase. Chem Biol (2010) 1.62
Know your dose: RADDOSE. Acta Crystallogr D Biol Crystallogr (2010) 1.54
Towards an understanding of radiation damage in cryocooled macromolecular crystals. J Synchrotron Radiat (2005) 1.52
Colouring cryo-cooled crystals: online microspectrophotometry. J Synchrotron Radiat (2009) 1.51
Eukaryotic arylamine N-acetyltransferase. Investigation of substrate specificity by high-throughput screening. Biochem Pharmacol (2004) 1.32
An integrin phosphorylation switch: the effect of beta3 integrin tail phosphorylation on Dok1 and talin binding. J Biol Chem (2007) 1.31
Structure of Rpn10 and its interactions with polyubiquitin chains and the proteasome subunit Rpn12. J Biol Chem (2010) 1.31
Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches. J Med Chem (2010) 1.31
The structure of cyclin E1/CDK2: implications for CDK2 activation and CDK2-independent roles. EMBO J (2005) 1.31
Arylamine N-acetyltransferase-1 is highly expressed in breast cancers and conveys enhanced growth and resistance to etoposide in vitro. Mol Cancer Res (2003) 1.29
The structure of arylamine N-acetyltransferase from Mycobacterium smegmatis--an enzyme which inactivates the anti-tubercular drug, isoniazid. J Mol Biol (2002) 1.28
Parameters affecting the X-ray dose absorbed by macromolecular crystals. J Synchrotron Radiat (2005) 1.26
An approach to identifying novel substrates of bacterial arylamine N-acetyltransferases. Bioorg Med Chem (2003) 1.24
The solution and crystal structures of a module pair from the Staphylococcus aureus-binding site of human fibronectin--a tale with a twist. J Mol Biol (2007) 1.24
Physical and chemical considerations of damage induced in protein crystals by synchrotron radiation: a radiation chemical perspective. J Synchrotron Radiat (2002) 1.24
Simultaneous X-ray diffraction from multiple single crystals of macromolecules. Acta Crystallogr D Biol Crystallogr (2011) 1.24
Gene expression profiling of primary male breast cancers reveals two unique subgroups and identifies N-acetyltransferase-1 (NAT1) as a novel prognostic biomarker. Breast Cancer Res (2012) 1.20
Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy. Proc Natl Acad Sci U S A (2014) 1.19
Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases. Curr Opin Struct Biol (2012) 1.18
Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases. J Biol Chem (2007) 1.17
The crystal structure of the Escherichia coli RNase E apoprotein and a mechanism for RNA degradation. Structure (2008) 1.17
Identification and structural analysis of type I collagen sites in complex with fibronectin fragments. Proc Natl Acad Sci U S A (2009) 1.17
Arylamine N-acetyltransferase is required for synthesis of mycolic acids and complex lipids in Mycobacterium bovis BCG and represents a novel drug target. J Exp Med (2004) 1.14
The crystal structure of human CDK7 and its protein recognition properties. Structure (2004) 1.14
Structural insights into how 5-hydroxymethylation influences transcription factor binding. Chem Commun (Camb) (2013) 1.13
Radioprotectant screening for cryocrystallography. J Synchrotron Radiat (2006) 1.13
Characterization of a carbon-carbon hydrolase from Mycobacterium tuberculosis involved in cholesterol metabolism. J Biol Chem (2009) 1.12
Characterization of the putative operon containing arylamine N-acetyltransferase (nat) in Mycobacterium bovis BCG. Mol Microbiol (2006) 1.11
Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J Med Chem (2012) 1.09
Predicting the X-ray lifetime of protein crystals. Proc Natl Acad Sci U S A (2013) 1.09
Expression, purification, characterization and structure of Pseudomonas aeruginosa arylamine N-acetyltransferase. Biochem J (2005) 1.09
Investigation of the catalytic triad of arylamine N-acetyltransferases: essential residues required for acetyl transfer to arylamines. Biochem J (2005) 1.08
Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity. Biochem J (2004) 1.08
Room-temperature scavengers for macromolecular crystallography: increased lifetimes and modified dose dependence of the intensity decay. J Synchrotron Radiat (2009) 1.05
Asparagine beta-hydroxylation stabilizes the ankyrin repeat domain fold. Mol Biosyst (2008) 1.04
The COOH terminus of arylamine N-acetyltransferase from Salmonella typhimurium controls enzymic activity. J Biol Chem (2002) 1.04
Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor. J Biol Chem (2010) 1.04
Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. ACS Chem Biol (2013) 1.04
Structural analysis of the genes for human arylamine N-acetyltransferases and characterisation of alternative transcripts. Basic Clin Pharmacol Toxicol (2005) 1.03
Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH). J Biol Chem (2008) 1.03
The enzymes of β-lactam biosynthesis. Nat Prod Rep (2013) 1.02
Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6. J Mol Biol (2010) 1.02
Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains. FEBS J (2011) 1.01
Binding of the anti-tubercular drug isoniazid to the arylamine N-acetyltransferase protein from Mycobacterium smegmatis. Protein Sci (2005) 1.01
Prospective virtual screening with Ultrafast Shape Recognition: the identification of novel inhibitors of arylamine N-acetyltransferases. J R Soc Interface (2009) 1.00
Structural analysis of the interactions between paxillin LD motifs and alpha-parvin. Structure (2008) 1.00
Optimizing the spatial distribution of dose in X-ray macromolecular crystallography. J Synchrotron Radiat (2012) 0.99
Arylamine N-acetyltransferase 1 expression in breast cancer cell lines: a potential marker in estrogen receptor-positive tumors. Genes Chromosomes Cancer (2008) 0.99
Mouse N-acetyltransferase type 2, the homologue of human N-acetyltransferase type 1. Biochem Pharmacol (2008) 0.98
Deletion of a xenobiotic metabolizing gene in mice affects folate metabolism. Biochem Biophys Res Commun (2007) 0.98
N-acetyltransferase (Nat) 1 and 2 expression in Nat2 knockout mice. J Pharmacol Exp Ther (2006) 0.97
A previously unobserved conformation for the human Pex5p receptor suggests roles for intrinsic flexibility and rigid domain motions in ligand binding. BMC Struct Biol (2007) 0.97
Temperature stability of proteins essential for the intracellular survival of Mycobacterium tuberculosis. Biochem J (2009) 0.96
The pharmacogenetics of NAT: structural aspects. Pharmacogenomics (2002) 0.96
Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility. Endocr Relat Cancer (2010) 0.95
Insights into the mechanism of X-ray-induced disulfide-bond cleavage in lysozyme crystals based on EPR, optical absorption and X-ray diffraction studies. Acta Crystallogr D Biol Crystallogr (2013) 0.94
Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor. Bioorg Med Chem Lett (2010) 0.94
Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases. Angew Chem Int Ed Engl (2012) 0.94
Synthesis and anticancer activities of 6-amino amonafide derivatives. Anticancer Drugs (2008) 0.94
Divergence of cofactor recognition across evolution: coenzyme A binding in a prokaryotic arylamine N-acetyltransferase. J Mol Biol (2007) 0.93
Synthesis and in vitro evaluation of novel small molecule inhibitors of bacterial arylamine N-acetyltransferases (NATs). Bioorg Med Chem Lett (2003) 0.93
Structure of Mesorhizobium loti arylamine N-acetyltransferase 1. Acta Crystallogr Sect F Struct Biol Cryst Commun (2004) 0.93
Structural basis for inhibition of the fat mass and obesity associated protein (FTO). J Med Chem (2013) 0.93
Effective scavenging at cryotemperatures: further increasing the dose tolerance of protein crystals. J Synchrotron Radiat (2011) 0.93
Molecular cloning, characterisation and ligand-bound structure of an azoreductase from Pseudomonas aeruginosa. J Mol Biol (2007) 0.93
To scavenge or not to scavenge, that is STILL the question. J Synchrotron Radiat (2012) 0.92
Caenorhabditis elegans centriolar protein SAS-6 forms a spiral that is consistent with imparting a ninefold symmetry. Proc Natl Acad Sci U S A (2013) 0.92
Probing the architecture of the Mycobacterium marinum arylamine N-acetyltransferase active site. Protein Cell (2010) 0.92
Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N-acetyltransferase 2. Bioorg Med Chem (2008) 0.91
How the biotin-streptavidin interaction was made even stronger: investigation via crystallography and a chimaeric tetramer. Biochem J (2011) 0.91