Published in Toxicol Appl Pharmacol on March 31, 2007
Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia. Blood (2009) 5.84
Therapeutic targeting of Syk in autoimmune diabetes. J Immunol (2010) 1.69
Tumor suppressor function of Syk in human MCF10A in vitro and normal mouse mammary epithelium in vivo. PLoS One (2009) 1.03
Mast cell and T cell communication; amplification and control of adaptive immunity. Immunol Lett (2009) 0.95
Spleen tyrosine kinase inhibition prevents tissue damage after ischemia-reperfusion. Am J Physiol Gastrointest Liver Physiol (2010) 0.93
Spleen tyrosine kinase inhibition in the treatment of autoimmune, allergic and autoinflammatory diseases. Arthritis Res Ther (2010) 0.88
Analysis of the anti-proliferative and the pro-apoptotic efficacy of Syk inhibition in multiple myeloma. Exp Hematol Oncol (2015) 0.79
Syk inhibition with fostamatinib leads to transitional B lymphocyte depletion. Clin Immunol (2012) 0.79
A Novel Triazolopyridine-Based Spleen Tyrosine Kinase Inhibitor That Arrests Joint Inflammation. PLoS One (2016) 0.75
Fostamatinib Disodium. Drugs Future (2011) 0.75
An oral spleen tyrosine kinase (Syk) inhibitor for rheumatoid arthritis. N Engl J Med (2010) 5.12
R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. J Pharmacol Exp Ther (2006) 3.46
An oral Syk kinase inhibitor in the treatment of rheumatoid arthritis: a three-month randomized, placebo-controlled, phase II study in patients with active rheumatoid arthritis that did not respond to biologic agents. Arthritis Rheum (2011) 3.20
Inflammation and bone erosion are suppressed in models of rheumatoid arthritis following treatment with a novel Syk inhibitor. Clin Immunol (2007) 1.91
Therapeutic targeting of Syk in autoimmune diabetes. J Immunol (2010) 1.69
Identification of the Syk kinase inhibitor R112 by a human mast cell screen. J Allergy Clin Immunol (2006) 1.54
An orally bioavailable spleen tyrosine kinase inhibitor delays disease progression and prolongs survival in murine lupus. Arthritis Rheum (2008) 1.44
Targeting Syk as a treatment for allergic and autoimmune disorders. Expert Opin Investig Drugs (2004) 1.20
Syk activation in dendritic cells is essential for airway hyperresponsiveness and inflammation. Am J Respir Cell Mol Biol (2005) 1.10
Retrovirally delivered random cyclic Peptide libraries yield inhibitors of interleukin-4 signaling in human B cells. J Biol Chem (2002) 1.04
A novel E3 ubiquitin ligase TRAC-1 positively regulates T cell activation. J Immunol (2005) 1.04
Pharmacokinetics of fostamatinib, a spleen tyrosine kinase (SYK) inhibitor, in healthy human subjects following single and multiple oral dosing in three phase I studies. Br J Clin Pharmacol (2013) 1.04
Administration of a dual toll-like receptor 7 and toll-like receptor 8 agonist protects against influenza in rats. Antiviral Res (2006) 1.04
Inhibition of spleen tyrosine kinase prevents mast cell activation and airway hyperresponsiveness. Am J Respir Crit Care Med (2005) 1.01
Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly. J Biol Chem (2002) 1.01
An intranasal Syk-kinase inhibitor (R112) improves the symptoms of seasonal allergic rhinitis in a park environment. J Allergy Clin Immunol (2005) 0.98
Developmental toxicity associated with receptor tyrosine kinase Ret inhibition in reproductive toxicity testing. Birth Defects Res A Clin Mol Teratol (2009) 0.96
Fostamatinib, a Syk-kinase inhibitor, does not affect methotrexate pharmacokinetics in patients with rheumatoid arthritis. J Clin Pharmacol (2011) 0.92
Influenza vaccine response in adults exposed to perfluorooctanoate and perfluorooctanesulfonate. Toxicol Sci (2013) 0.90
A spleen tyrosine kinase inhibitor reduces the severity of established glomerulonephritis. J Am Soc Nephrol (2009) 0.90
JAK3 inhibition significantly attenuates psoriasiform skin inflammation in CD18 mutant PL/J mice. J Immunol (2009) 0.88
A novel role for p21-activated protein kinase 2 in T cell activation. J Immunol (2004) 0.87
Computed tomography (CT) bone segmentation of an ancient Egyptian mummy: a comparison of automated and semiautomated threshold and dual-energy techniques. J Comput Assist Tomogr (2012) 0.84
A class of small molecules that inhibit TNFalpha-induced survival and death pathways via prevention of interactions between TNFalphaRI, TRADD, and RIP1. Chem Biol (2007) 0.84
Computer visualizations: factors that influence spatial anatomy comprehension. Anat Sci Educ (2012) 0.84
Discovery and development of spleen tyrosine kinase (SYK) inhibitors. J Med Chem (2012) 0.82
Middle childhood and modern human origins. Hum Nat (2011) 0.81
Novel immunosuppression: R348, a JAK3- and Syk-inhibitor attenuates acute cardiac allograft rejection. Transplantation (2008) 0.81
Synchrotron X-ray fluorescence and trace metals in the cementum rings of human teeth. J Environ Monit (2004) 0.79
Scenes from the past: multidetector CT of Egyptian mummies of the Redpath Museum. Radiographics (2012) 0.77
The application of radiography to field studies in physical anthropology. Can Assoc Radiol J (2004) 0.76
Paleoradiology in mummy studies: the Sulman mummy project. Can Assoc Radiol J (2004) 0.76
Host resistance assays including bacterial challenge models. Methods Mol Biol (2010) 0.76
The cytotoxic T lymphocyte assay for evaluating cell-mediated immune function. Methods Mol Biol (2010) 0.76
Dimethylfumarate: potency prediction and clinical experience. Contact Dermatitis (2013) 0.76
A synthetic radiological study of brain treatment in ancient Egyptian mummies. Homo (2011) 0.75
Two-component polyethylene glycol surgical sealant influence on intraperitoneal infection in a refined rodent model. Am J Obstet Gynecol (2010) 0.75
Novel Method for Predicting Dexterous Individual Finger Movements by Imaging Muscle Activity Using a Wearable Ultrasonic System. IEEE Trans Neural Syst Rehabil Eng (2013) 0.75
Visuospatial anatomy comprehension: the role of spatial visualization ability and problem-solving strategies. Anat Sci Educ (2013) 0.75
Murine gammaherpesvirus-68 (MHV-68) is not horizontally transmitted amongst laboratory mice by cage contact. J Immunotoxicol (2014) 0.75