Published in J Immunol on May 01, 2005
Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125. Proc Natl Acad Sci U S A (2007) 2.88
Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene. Hum Mol Genet (2008) 2.42
Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense. Proc Natl Acad Sci U S A (2010) 1.31
T-cell regulator RNF125/TRAC-1 belongs to a novel family of ubiquitin ligases with zinc fingers and a ubiquitin-binding domain. Biochem J (2008) 1.05
Emerging role of ubiquitination in antiviral RIG-I signaling. Microbiol Mol Biol Rev (2012) 1.04
Downregulation of the Ubiquitin Ligase RNF125 Underlies Resistance of Melanoma Cells to BRAF Inhibitors via JAK1 Deregulation. Cell Rep (2015) 0.81
The impact of Nucleofection® on the activation state of primary human CD4 T cells. J Immunol Methods (2014) 0.80
Natural killer lytic-associated molecule plays a role in controlling tumor dissemination and metastasis. Front Immunol (2012) 0.78
The RING ubiquitin E3 RNF114 interacts with A20 and modulates NF-κB activity and T-cell activation. Cell Death Dis (2014) 0.78
Ubc13: the Lys63 ubiquitin chain building machine. Oncotarget (2016) 0.76
A C2HC zinc finger is essential for the RING-E2 interaction of the ubiquitin ligase RNF125. Sci Rep (2016) 0.75
The E3 ubiquitin ligase RNF114 and TAB1 degradation are required for maternal-to-zygotic transition. EMBO Rep (2017) 0.75
A Multifaceted Role for Myd88-Dependent Signaling in Progression of Murine Mammary Carcinoma. Breast Cancer (Auckl) (2016) 0.75
Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome. Cancer Res (2007) 3.85
MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha. Science (2002) 3.78
Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma. Blood (2007) 3.67
R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. J Pharmacol Exp Ther (2006) 3.46
R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer. Cancer Res (2010) 2.87
A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis. Nat Med (2009) 2.62
Nonproteasomal targets of the proteasome inhibitors bortezomib and carfilzomib: a link to clinical adverse events. Clin Cancer Res (2011) 2.56
Discovering patterns to extract protein-protein interactions from full texts. Bioinformatics (2004) 2.42
Chronic nicotine cell specifically upregulates functional alpha 4* nicotinic receptors: basis for both tolerance in midbrain and enhanced long-term potentiation in perforant path. J Neurosci (2007) 2.37
Fractal analysis in the detection of colonic cancer images. IEEE Trans Inf Technol Biomed (2002) 2.18
A new algorithm for the evaluation of shotgun peptide sequencing in proteomics: support vector machine classification of peptide MS/MS spectra and SEQUEST scores. J Proteome Res (2003) 2.16
Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome. Blood (2009) 2.06
Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer. Mol Cancer Ther (2014) 2.03
Inflammation and bone erosion are suppressed in models of rheumatoid arthritis following treatment with a novel Syk inhibitor. Clin Immunol (2007) 1.91
Multiple roles for the receptor tyrosine kinase axl in tumor formation. Cancer Res (2005) 1.87
Identification of open reading frames unique to a select agent: Ralstonia solanacearum race 3 biovar 2. Mol Plant Microbe Interact (2006) 1.77
Therapeutic targeting of Syk in autoimmune diabetes. J Immunol (2010) 1.69
Critical role of the ubiquitin ligase activity of UHRF1, a nuclear RING finger protein, in tumor cell growth. Mol Biol Cell (2005) 1.68
Identification of the Syk kinase inhibitor R112 by a human mast cell screen. J Allergy Clin Immunol (2006) 1.54
DJ-1 may contribute to metastasis of non-small cell lung cancer. Mol Biol Rep (2011) 1.52
Design and synthesis of an orally bioavailable and selective peptide epoxyketone proteasome inhibitor (PR-047). J Med Chem (2009) 1.50
Discovery and preclinical profile of Saxagliptin (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J Med Chem (2005) 1.49
An orally bioavailable spleen tyrosine kinase inhibitor delays disease progression and prolongs survival in murine lupus. Arthritis Rheum (2008) 1.44
The rice pentatricopeptide repeat protein RF5 restores fertility in Hong-Lian cytoplasmic male-sterile lines via a complex with the glycine-rich protein GRP162. Plant Cell (2012) 1.41
Discovery of N-phenyl nicotinamides as potent inhibitors of Kdr. Bioorg Med Chem Lett (2007) 1.39
Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells. Blood (2008) 1.37
Pharmacokinetics, pharmacodynamics, metabolism, distribution, and excretion of carfilzomib in rats. Drug Metab Dispos (2011) 1.35
Discovery of pyrazine carboxamide CB1 antagonists: the introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy of the series. Bioorg Med Chem Lett (2007) 1.32
Activation of the PKB/AKT pathway by ICAM-2. Immunity (2002) 1.31
Substrate modification with lysine 63-linked ubiquitin chains through the UBC13-UEV1A ubiquitin-conjugating enzyme. J Biol Chem (2007) 1.25
An immunocytometric assay based on dengue infection via DC-SIGN permits rapid measurement of anti-dengue neutralizing antibodies. J Virol Methods (2006) 1.22
Targeting Syk as a treatment for allergic and autoimmune disorders. Expert Opin Investig Drugs (2004) 1.20
The poxvirus p28 virulence factor is an E3 ubiquitin ligase. J Biol Chem (2004) 1.14
Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta. J Biol Chem (2004) 1.12
Syk activation in dendritic cells is essential for airway hyperresponsiveness and inflammation. Am J Respir Cell Mol Biol (2005) 1.10
Molecular mechanisms of bortezomib resistant adenocarcinoma cells. PLoS One (2011) 1.10
Comparative evaluation of three assays for measurement of dengue virus neutralizing antibodies. Am J Trop Med Hyg (2008) 1.07
Immunotoxicity assessment for the novel Spleen tyrosine kinase inhibitor R406. Toxicol Appl Pharmacol (2007) 1.06
Retrovirally delivered random cyclic Peptide libraries yield inhibitors of interleukin-4 signaling in human B cells. J Biol Chem (2002) 1.04
Reduced expression and novel splice variants of ING4 in human gastric adenocarcinoma. J Pathol (2009) 1.01
Anticancer drug release from a mesoporous silica based nanophotocage regulated by either a one- or two-photon process. J Am Chem Soc (2010) 1.01
Inhibition of spleen tyrosine kinase prevents mast cell activation and airway hyperresponsiveness. Am J Respir Crit Care Med (2005) 1.01
The impacts of short-term exposure to noise and traffic-related air pollution on heart rate variability in young healthy adults. J Expo Sci Environ Epidemiol (2013) 1.01
Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly. J Biol Chem (2002) 1.01
Synthesis and identification of new 4-arylidene curcumin analogues as potential anticancer agents targeting nuclear factor-κB signaling pathway. J Med Chem (2010) 1.00
Cell cycle regulatory E3 ubiquitin ligases as anticancer targets. Drug Resist Updat (2002) 0.99
The p.V37I exclusive genotype of GJB2: a genetic risk-indicator of postnatal permanent childhood hearing impairment. PLoS One (2012) 0.97
The co-expression of USP22 and BMI-1 may promote cancer progression and predict therapy failure in gastric carcinoma. Cell Biochem Biophys (2011) 0.96
Developmental toxicity associated with receptor tyrosine kinase Ret inhibition in reproductive toxicity testing. Birth Defects Res A Clin Mol Teratol (2009) 0.96
Down-regulation of ING4 is associated with initiation and progression of lung cancer. Histopathology (2010) 0.95
Prediction models of human plasma protein binding rate and oral bioavailability derived by using GA-CG-SVM method. J Pharm Biomed Anal (2008) 0.95
AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes. PLoS One (2013) 0.94
L-FABP T94A decreased fatty acid uptake and altered hepatic triglyceride and cholesterol accumulation in Chang liver cells stably transfected with L-FABP. Mol Cell Biochem (2010) 0.94
Drug discovery in the ubiquitin regulatory pathway. Drug Discov Today (2003) 0.94
Increased expression of CD147 and MMP-9 is correlated with poor prognosis of salivary duct carcinoma. J Cancer Res Clin Oncol (2012) 0.93
Antimycin A18 produced by an endophytic Streptomyces albidoflavus isolated from a mangrove plant. J Antibiot (Tokyo) (2010) 0.93
High-throughput screening for inhibitors of the e3 ubiquitin ligase APC. Methods Enzymol (2005) 0.92
QUAliFiER: an automated pipeline for quality assessment of gated flow cytometry data. BMC Bioinformatics (2012) 0.91
Role of polyamines in myocardial ischemia/reperfusion injury and their interactions with nitric oxide. Eur J Pharmacol (2007) 0.91
Cinnamtannin D-1 protects pancreatic β-cells from palmitic acid-induced apoptosis by attenuating oxidative stress. J Agric Food Chem (2014) 0.90
A spleen tyrosine kinase inhibitor reduces the severity of established glomerulonephritis. J Am Soc Nephrol (2009) 0.90
Development and systematic validation of qPCR assays for rapid and reliable differentiation of Xylella fastidiosa strains causing citrus variegated chlorosis. J Microbiol Methods (2012) 0.90
Telocytes in human liver fibrosis. J Cell Mol Med (2015) 0.89
Demonstration of functional alpha4-containing nicotinic receptors in the medial habenula. Neuropharmacology (2008) 0.89
Two non-allelic nuclear genes restore fertility in a gametophytic pattern and enhance abiotic stress tolerance in the hybrid rice plant. Theor Appl Genet (2011) 0.89
Fas/FasL-dependent apoptosis of hepatocytes induced in rat and patients with Clonorchis sinensis infection. Parasitol Res (2008) 0.88
Genome Sequence of a Xylella fastidiosa Strain Causing Mulberry Leaf Scorch Disease in Maryland. Genome Announc (2014) 0.88
JAK3 inhibition significantly attenuates psoriasiform skin inflammation in CD18 mutant PL/J mice. J Immunol (2009) 0.88
Granulocyte colony-stimulating factor enhances bone marrow mononuclear cell homing to the liver in a mouse model of acute hepatic injury. Dig Dis Sci (2010) 0.88
Vascular endothelial growth factor gene polymorphisms and renal cell carcinoma: A systematic review and meta-analysis. Oncol Lett (2013) 0.88
Use of MEDUSA-based data analysis and capillary HPLC-ion-trap mass spectrometry to examine complex immunoaffinity extracts of RBAp48. J Proteome Res (2003) 0.87
Multiple functional categories of proteins identified in an in vitro cellular ubiquitin affinity extract using shotgun peptide sequencing. J Proteome Res (2003) 0.87
A novel role for p21-activated protein kinase 2 in T cell activation. J Immunol (2004) 0.87
Selective inhibitors of the mutant B-Raf pathway: discovery of a potent and orally bioavailable aminoisoquinoline. J Med Chem (2009) 0.87
Prognostic value and clinicopathological differences of HIFs in colorectal cancer: evidence from meta-analysis. PLoS One (2013) 0.86
The expression and the role of protease nexin-1 on brain edema after intracerebral hemorrhage. J Neurol Sci (2008) 0.86
Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen. J Cancer Res Clin Oncol (2010) 0.86