| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Total homocysteine is associated with white matter hyperintensity volume: the Northern Manhattan Study.
|
Stroke
|
2005
|
1.91
|
|
2
|
Sex and menopausal status influence human dietary requirements for the nutrient choline.
|
Am J Clin Nutr
|
2007
|
1.76
|
|
3
|
Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylenetetrahydrofolate but is not essential in mice.
|
J Biol Chem
|
2008
|
1.73
|
|
4
|
Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice.
|
Am J Clin Nutr
|
2011
|
1.53
|
|
5
|
Homocysteine and methylmalonic acid: markers to predict and avoid toxicity from pemetrexed therapy.
|
Mol Cancer Ther
|
2002
|
1.51
|
|
6
|
Vitamin B12, homocysteine and carotid plaque in the era of folic acid fortification of enriched cereal grain products.
|
CMAJ
|
2005
|
1.34
|
|
7
|
Methyl balance and transmethylation fluxes in humans.
|
Am J Clin Nutr
|
2007
|
1.33
|
|
8
|
High homocysteine and thrombosis without connective tissue disorders are associated with a novel class of cystathionine beta-synthase (CBS) mutations.
|
Hum Mutat
|
2002
|
1.29
|
|
9
|
Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans.
|
Am J Clin Nutr
|
2012
|
1.17
|
|
10
|
Identification and quantitation of cobalamin and cobalamin analogues in human feces.
|
Am J Clin Nutr
|
2008
|
1.16
|
|
11
|
Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism.
|
J Biol Chem
|
2008
|
1.14
|
|
12
|
Versatility in corrinoid salvaging and remodeling pathways supports corrinoid-dependent metabolism in Dehalococcoides mccartyi.
|
Appl Environ Microbiol
|
2012
|
1.14
|
|
13
|
Screening for cobalamin deficiency in geriatric outpatients: prevalence and influence of synthetic cobalamin intake.
|
J Am Geriatr Soc
|
2002
|
1.09
|
|
14
|
Prevention of brain disease from severe 5,10-methylenetetrahydrofolate reductase deficiency.
|
Mol Genet Metab
|
2007
|
1.04
|
|
15
|
Cystathionine beta-synthase null homocystinuric mice fail to exhibit altered hemostasis or lowering of plasma homocysteine in response to betaine treatment.
|
Mol Genet Metab
|
2010
|
1.03
|
|
16
|
Vitamin B12 deficiency.
|
N Engl J Med
|
2013
|
1.03
|
|
17
|
Hyperhomocysteinemia and vitamin B-12 deficiency in elderly using Title IIIc nutrition services.
|
Am J Clin Nutr
|
2003
|
1.01
|
|
18
|
Adverse event associated with methionine loading test: a case report.
|
Arterioscler Thromb Vasc Biol
|
2002
|
1.01
|
|
19
|
MTHFR C677T genotype influences the isotopic enrichment of one-carbon metabolites in folate-compromised men consuming d9-choline.
|
Am J Clin Nutr
|
2010
|
1.01
|
|
20
|
A novel transgenic mouse model of CBS-deficient homocystinuria does not incur hepatic steatosis or fibrosis and exhibits a hypercoagulative phenotype that is ameliorated by betaine treatment.
|
Mol Genet Metab
|
2010
|
1.00
|
|
21
|
Cystathionine protects against endoplasmic reticulum stress-induced lipid accumulation, tissue injury, and apoptotic cell death.
|
J Biol Chem
|
2012
|
1.00
|
|
22
|
Impaired homocysteine transsulfuration is an indicator of alcoholic liver disease.
|
J Hepatol
|
2010
|
0.99
|
|
23
|
Nuclear localization of de novo thymidylate biosynthesis pathway is required to prevent uracil accumulation in DNA.
|
J Biol Chem
|
2011
|
0.99
|
|
24
|
Low ratio of S-adenosylmethionine to S-adenosylhomocysteine is associated with vitamin deficiency in Brazilian pregnant women and newborns.
|
Am J Clin Nutr
|
2004
|
0.98
|
|
25
|
Progressive cerebral edema associated with high methionine levels and betaine therapy in a patient with cystathionine beta-synthase (CBS) deficiency.
|
Am J Med Genet
|
2002
|
0.97
|
|
26
|
Response of elevated methylmalonic acid to three dose levels of oral cobalamin in older adults.
|
J Am Geriatr Soc
|
2002
|
0.96
|
|
27
|
S-adenosyl-L-methionine treatment for alcoholic liver disease: a double-blinded, randomized, placebo-controlled trial.
|
Alcohol Clin Exp Res
|
2011
|
0.94
|
|
28
|
Enzymatic activity of methionine adenosyltransferase variants identified in patients with persistent hypermethioninemia.
|
Mol Genet Metab
|
2010
|
0.94
|
|
29
|
Cystathionine gamma-lyase: Clinical, metabolic, genetic, and structural studies.
|
Mol Genet Metab
|
2009
|
0.93
|
|
30
|
Infantile hypermethioninemia and hyperhomocysteinemia due to high methionine intake: a diagnostic trap.
|
Mol Genet Metab
|
2003
|
0.92
|
|
31
|
Cigarette smoke extract increases S-adenosylmethionine and cystathionine in human lung epithelial-like (A549) cells.
|
Chem Biol Interact
|
2004
|
0.92
|
|
32
|
Daily intake of 4 to 7 microg dietary vitamin B-12 is associated with steady concentrations of vitamin B-12-related biomarkers in a healthy young population.
|
Am J Clin Nutr
|
2010
|
0.90
|
|
33
|
Prevalence and predictors of anemia in a population-based study of octogenarians and centenarians in Georgia.
|
J Gerontol A Biol Sci Med Sci
|
2011
|
0.89
|
|
34
|
Reduced MTHFD1 activity in male mice perturbs folate- and choline-dependent one-carbon metabolism as well as transsulfuration.
|
J Nutr
|
2012
|
0.89
|
|
35
|
Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice.
|
Am J Clin Nutr
|
2012
|
0.88
|
|
36
|
Translational upregulation of folate receptors is mediated by homocysteine via RNA-heterogeneous nuclear ribonucleoprotein E1 interactions.
|
J Clin Invest
|
2004
|
0.88
|
|
37
|
Pregnancy alters choline dynamics: results of a randomized trial using stable isotope methodology in pregnant and nonpregnant women.
|
Am J Clin Nutr
|
2013
|
0.87
|
|
38
|
Maternal folate deficiency results in selective upregulation of folate receptors and heterogeneous nuclear ribonucleoprotein-E1 associated with multiple subtle aberrations in fetal tissues.
|
Birth Defects Res A Clin Mol Teratol
|
2005
|
0.87
|
|
39
|
Long-term betaine therapy in a murine model of cystathionine beta-synthase deficient homocystinuria: decreased efficacy over time reveals a significant threshold effect between elevated homocysteine and thrombotic risk.
|
Mol Genet Metab
|
2011
|
0.86
|
|
40
|
B-vitamin deficiency is protective against DSS-induced colitis in mice.
|
Am J Physiol Gastrointest Liver Physiol
|
2011
|
0.86
|
|
41
|
Elevated methylmalonic acid is related to cognitive impairement in older adults enrolled in an elderly nutrition program.
|
J Nutr Elder
|
2005
|
0.85
|
|
42
|
Sex-specific association of sequence variants in CBS and MTRR with risk for promoter hypermethylation in the lung epithelium of smokers.
|
Carcinogenesis
|
2012
|
0.85
|
|
43
|
Relationships between gene polymorphisms of folate-related proteins and vitamins and metabolites in pregnant women and neonates.
|
Clin Chim Acta
|
2008
|
0.84
|
|
44
|
Vitamins, homocysteine, and cognition.
|
Am J Clin Nutr
|
2003
|
0.84
|
|
45
|
Two patients with hepatic mtDNA depletion syndromes and marked elevations of S-adenosylmethionine and methionine.
|
Mol Genet Metab
|
2011
|
0.84
|
|
46
|
Constitutive induction of pro-inflammatory and chemotactic cytokines in cystathionine beta-synthase deficient homocystinuria.
|
Mol Genet Metab
|
2011
|
0.83
|
|
47
|
Profiles of cognitive functioning in a population-based sample of centenarians using factor mixture analysis.
|
Exp Aging Res
|
2013
|
0.82
|
|
48
|
Evaluation of nutritional and genetic determinants of total homocysteine, methylmalonic acid and S-adenosylmethionine/S-adenosylhomocysteine values in Brazilian childbearing-age women.
|
Clin Chim Acta
|
2007
|
0.82
|
|
49
|
Age-related hearing loss, methylmalonic acid, and vitamin B12 status in older adults.
|
J Nutr Elder
|
2006
|
0.82
|
|
50
|
Altered expression of apoA-I, apoA-IV and PON-1 activity in CBS deficient homocystinuria in the presence and absence of treatment: possible implications for cardiovascular outcomes.
|
Mol Genet Metab
|
2012
|
0.80
|
|
51
|
Disruption of shmt1 impairs hippocampal neurogenesis and mnemonic function in mice.
|
J Nutr
|
2013
|
0.79
|
|
52
|
Influence of physiologic folate deficiency on human papillomavirus type 16 (HPV16)-harboring human keratinocytes in vitro and in vivo.
|
J Biol Chem
|
2012
|
0.79
|
|
53
|
Activation of a novel isoform of methionine adenosyl transferase 2A and increased S-adenosylmethionine turnover in lung epithelial cells exposed to hyperoxia.
|
Free Radic Biol Med
|
2005
|
0.78
|
|
54
|
Increased MMA concentration and body mass index are associated with spontaneous abortion in Brazilian women: a pilot study.
|
Clin Chim Acta
|
2009
|
0.78
|
|
55
|
Oxidative stress-induced regulation of the methionine metabolic pathway in human lung epithelial-like (A549) cells.
|
Mutat Res
|
2008
|
0.78
|
|
56
|
Elevated serum S-adenosylhomocysteine in cobalamin-deficient megaloblastic anemia.
|
Metabolism
|
2007
|
0.76
|
|
57
|
Population screening.
|
N Engl J Med
|
2003
|
0.75
|
|
58
|
Life-threatening megaloblastic pancytopenia with normal mean cell volume: Case series.
|
Eur J Intern Med
|
2007
|
0.75
|