Published in Arterioscler Thromb Vasc Biol on June 01, 2002
Homocysteine metabolism, hyperhomocysteinaemia and vascular disease: an overview. J Inherit Metab Dis (2006) 1.42
Murine models of hyperhomocysteinemia and their vascular phenotypes. Arterioscler Thromb Vasc Biol (2008) 1.33
After the London tragedy, is it still possible to consider Phase I is safe? Br J Clin Pharmacol (2006) 1.08
Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice. Hepatology (2008) 2.91
Quantitation of choline and its metabolites in tissues and foods by liquid chromatography/electrospray ionization-isotope dilution mass spectrometry. Anal Chem (2002) 2.35
Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD). FASEB J (2005) 2.34
Diet, methyl donors and DNA methylation: interactions between dietary folate, methionine and choline. J Nutr (2002) 2.33
Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency. Gastroenterology (2010) 2.30
Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst (2007) 2.07
Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains. FASEB J (2006) 2.07
Median nerve superficial to the transverse carpal ligament. Orthopedics (2015) 1.97
Total homocysteine is associated with white matter hyperintensity volume: the Northern Manhattan Study. Stroke (2005) 1.91
DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women. Am J Clin Nutr (2013) 1.88
Common genetic polymorphisms affect the human requirement for the nutrient choline. FASEB J (2006) 1.88
Sex and menopausal status influence human dietary requirements for the nutrient choline. Am J Clin Nutr (2007) 1.76
Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylenetetrahydrofolate but is not essential in mice. J Biol Chem (2008) 1.73
Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans. Proc Natl Acad Sci U S A (2005) 1.73
Choline availability during embryonic development alters progenitor cell mitosis in developing mouse hippocampus. J Nutr (2003) 1.73
Dietary choline and betaine assessed by food-frequency questionnaire in relation to plasma total homocysteine concentration in the Framingham Offspring Study. Am J Clin Nutr (2006) 1.71
Evidence-based criteria in the nutritional context. Nutr Rev (2010) 1.68
Choline deficiency in mice and humans is associated with increased plasma homocysteine concentration after a methionine load. Am J Clin Nutr (2005) 1.66
Clinical characteristics and pharmacokinetics of purified soy isoflavones: single-dose administration to healthy men. Am J Clin Nutr (2002) 1.60
Homocysteine-betaine interactions in a murine model of 5,10-methylenetetrahydrofolate reductase deficiency. FASEB J (2003) 1.59
Diethanolamine induces hepatic choline deficiency in mice. Toxicol Sci (2002) 1.57
Glycine N-methyltransferase and regulation of S-adenosylmethionine levels. J Biol Chem (2009) 1.55
Regulation of methylbenzoate emission after pollination in snapdragon and petunia flowers. Plant Cell (2003) 1.54
Choline- and betaine-defined diets for use in clinical research and for the management of trimethylaminuria. J Am Diet Assoc (2004) 1.53
Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice. Am J Clin Nutr (2011) 1.53
Choline metabolism and risk of breast cancer in a population-based study. FASEB J (2008) 1.51
Homocysteine and methylmalonic acid: markers to predict and avoid toxicity from pemetrexed therapy. Mol Cancer Ther (2002) 1.51
Diethanolamine alters neurogenesis and induces apoptosis in fetal mouse hippocampus. FASEB J (2006) 1.47
Usual choline and betaine dietary intake and incident coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study. BMC Cardiovasc Disord (2007) 1.47
Elevated serum creatine phosphokinase in choline-deficient humans: mechanistic studies in C2C12 mouse myoblasts. Am J Clin Nutr (2004) 1.46
Creatine metabolism in combined methylmalonic aciduria and homocystinuria. Ann Neurol (2005) 1.46
Vitamin B12 deficiency as a worldwide problem. Annu Rev Nutr (2004) 1.46
Adenosine kinase deficiency is associated with developmental abnormalities and reduced transmethylation. Plant Physiol (2002) 1.43
Nutrition education in U.S. medical schools: latest update of a national survey. Acad Med (2010) 1.42
Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes. FASEB J (2007) 1.42
Status of nutrition education in medical schools. Am J Clin Nutr (2006) 1.41
Perturbations in choline metabolism cause neural tube defects in mouse embryos in vitro. FASEB J (2002) 1.41
Comparing McRoberts' and Rubin's maneuvers for initial management of shoulder dystocia: an objective evaluation. Am J Obstet Gynecol (2005) 1.40
Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas. J Biol Chem (2011) 1.40
Choline availability modulates human neuroblastoma cell proliferation and alters the methylation of the promoter region of the cyclin-dependent kinase inhibitor 3 gene. J Neurochem (2004) 1.40
Episiotomy versus fetal manipulation in managing severe shoulder dystocia: a comparison of outcomes. Am J Obstet Gynecol (2004) 1.39
Phosphatidylethanolamine-N-methyltransferase activity and dietary choline regulate liver-plasma lipid flux and essential fatty acid metabolism in mice. J Nutr (2003) 1.36
Folic acid deficiency during late gestation decreases progenitor cell proliferation and increases apoptosis in fetal mouse brain. J Nutr (2004) 1.35
Vitamin B12, homocysteine and carotid plaque in the era of folic acid fortification of enriched cereal grain products. CMAJ (2005) 1.34
Methyl balance and transmethylation fluxes in humans. Am J Clin Nutr (2007) 1.33
S-adenosylhomocysteine hydrolase deficiency in a human: a genetic disorder of methionine metabolism. Proc Natl Acad Sci U S A (2004) 1.32
Second trimester folate status and preterm birth. Am J Obstet Gynecol (2004) 1.32
Liquid chromatography-mass spectrometry-based parallel metabolic profiling of human and mouse model serum reveals putative biomarkers associated with the progression of nonalcoholic fatty liver disease. J Proteome Res (2010) 1.29
High homocysteine and thrombosis without connective tissue disorders are associated with a novel class of cystathionine beta-synthase (CBS) mutations. Hum Mutat (2002) 1.29
Zinc, gravida, infection, and iron, but not vitamin B-12 or folate status, predict hemoglobin during pregnancy in Southern Ethiopia. J Nutr (2008) 1.29
Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples. Proteomics Clin Appl (2010) 1.21
Choline deficiency alters global histone methylation and epigenetic marking at the Re1 site of the calbindin 1 gene. FASEB J (2009) 1.21
Quantification of serum and urinary S-adenosylmethionine and S-adenosylhomocysteine by stable-isotope-dilution liquid chromatography-mass spectrometry. Clin Chem (2003) 1.20
Changes in S-adenosylmethionine and GSH homeostasis during endotoxemia in mice. Lab Invest (2008) 1.19
Safety and pharmacokinetics of purified soy isoflavones: single-dose administration to postmenopausal women. Am J Clin Nutr (2002) 1.19
The Arabidopsis HOMOLOGY-DEPENDENT GENE SILENCING1 gene codes for an S-adenosyl-L-homocysteine hydrolase required for DNA methylation-dependent gene silencing. Plant Cell (2005) 1.18
Metabolomic profiling can predict which humans will develop liver dysfunction when deprived of dietary choline. FASEB J (2010) 1.18
Choline deficiency increases lymphocyte apoptosis and DNA damage in humans. Am J Clin Nutr (2006) 1.18
Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression. Curr Opin Gastroenterol (2012) 1.17
Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans. Am J Clin Nutr (2012) 1.17
BRCA1 promoter methylation is associated with increased mortality among women with breast cancer. Breast Cancer Res Treat (2008) 1.16
Repeatability and measurement error in the assessment of choline and betaine dietary intake: the Atherosclerosis Risk in Communities (ARIC) study. Nutr J (2009) 1.16
Identification and quantitation of cobalamin and cobalamin analogues in human feces. Am J Clin Nutr (2008) 1.16
The association between betaine and choline intakes and the plasma concentrations of homocysteine in women. Am J Clin Nutr (2007) 1.16
Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism. J Biol Chem (2008) 1.14
Versatility in corrinoid salvaging and remodeling pathways supports corrinoid-dependent metabolism in Dehalococcoides mccartyi. Appl Environ Microbiol (2012) 1.14
Nutrition in medicine: nutrition education for medical students and residents. Nutr Clin Pract (2010) 1.14
Mutations in human glycine N-methyltransferase give insights into its role in methionine metabolism. Hum Genet (2001) 1.12
Choline availability during embryonic development alters the localization of calretinin in developing and aging mouse hippocampus. Nutr Neurosci (2003) 1.10
Ad libitum choline intake in healthy individuals meets or exceeds the proposed adequate intake level. J Nutr (2005) 1.10
Maternal dietary choline deficiency alters angiogenesis in fetal mouse hippocampus. Proc Natl Acad Sci U S A (2010) 1.09
The role of dietary supplements during cancer therapy. J Nutr (2003) 1.09
Screening for cobalamin deficiency in geriatric outpatients: prevalence and influence of synthetic cobalamin intake. J Am Geriatr Soc (2002) 1.09
Elevated plasma total homocysteine in severe methionine adenosyltransferase I/III deficiency. Metabolism (2002) 1.08
Clinical characteristics and pharmacokinetics of purified soy isoflavones: multiple-dose administration to men with prostate neoplasia. Nutr Cancer (2004) 1.06
Maternal dietary choline availability alters the balance of netrin-1 and DCC neuronal migration proteins in fetal mouse brain hippocampus. Brain Res Dev Brain Res (2005) 1.06
Regulation of choline deficiency apoptosis by epidermal growth factor in CWSV-1 rat hepatocytes. Cell Physiol Biochem (2005) 1.05
Gene expression profiling of choline-deprived neural precursor cells isolated from mouse brain. Brain Res Mol Brain Res (2004) 1.04
Prevention of brain disease from severe 5,10-methylenetetrahydrofolate reductase deficiency. Mol Genet Metab (2007) 1.04
HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis. Gastroenterology (2010) 1.04