Published in J Androl on May 09, 2007
HOP-2A - Intratesticular Hormone Levels (HOP-2A) | NCT00756561
Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth. Cancer Res (2008) 10.66
Resistance to CYP17A1 inhibition with abiraterone in castration-resistant prostate cancer: induction of steroidogenesis and androgen receptor splice variants. Clin Cancer Res (2011) 4.65
Impact of circulating cholesterol levels on growth and intratumoral androgen concentration of prostate tumors. PLoS One (2012) 1.89
Serum insulin-like factor 3 is highly correlated with intratesticular testosterone in normal men with acute, experimental gonadotropin deficiency stimulated with low-dose human chorionic gonadotropin: a randomized, controlled trial. Fertil Steril (2012) 1.44
Advances in male contraception. Endocr Rev (2008) 1.39
Suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesis. J Androl (2010) 1.34
Dose-dependent increase in intratesticular testosterone by very low-dose human chorionic gonadotropin in normal men with experimental gonadotropin deficiency. J Clin Endocrinol Metab (2010) 1.08
Serum LH correlates highly with intratesticular steroid levels in normal men. J Androl (2009) 0.95
Effects of benzo(a)pyrene on intra-testicular function in F-344 rats. Int J Environ Res Public Health (2008) 0.84
Estradiol suppresses tissue androgens and prostate cancer growth in castration resistant prostate cancer. BMC Cancer (2010) 0.82
Integrity of the blood-testis barrier in healthy men after suppression of spermatogenesis with testosterone and levonorgestrel. Hum Reprod (2012) 0.82
Acceptability of a transdermal gel-based male hormonal contraceptive in a randomized controlled trial. Contraception (2014) 0.81
Androgen synthesis in the gonadotropin-suppressed human testes can be markedly suppressed by ketoconazole. J Clin Endocrinol Metab (2013) 0.80
The effect of gonadotropin withdrawal and stimulation with human chorionic gonadotropin on intratesticular androstenedione and DHEA in normal men. J Clin Endocrinol Metab (2011) 0.80
Prostate cancer characteristics associated with response to pre-receptor targeting of the androgen axis. PLoS One (2014) 0.78
Progress and prospects in male hormonal contraception. Curr Opin Endocrinol Diabetes Obes (2008) 0.78
Male hormonal contraception: looking back and moving forward. Andrology (2015) 0.76
Complete sperm suppression in rats with dienogest plus testosterone undecanoate is facilitated through apoptosis in testicular cells. Reprod Sci (2012) 0.75
Testicular fine-needle aspiration for the assessment of intratesticular hormone concentrations. Asian J Androl (2015) 0.75
Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth. Cancer Res (2008) 10.66
Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab (2010) 7.15
Effects of Testosterone Treatment in Older Men. N Engl J Med (2016) 6.66
Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancer. Cancer Res (2007) 5.97
Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline. J Clin Endocrinol Metab (2006) 5.58
Resistance to CYP17A1 inhibition with abiraterone in castration-resistant prostate cancer: induction of steroidogenesis and androgen receptor splice variants. Clin Cancer Res (2011) 4.65
Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study. J Clin Endocrinol Metab (2002) 4.46
Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice. Nat Genet (2003) 3.78
Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T. J Clin Endocrinol Metab (2004) 3.02
Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors. Cancer Res (2011) 2.81
Prevalence and incidence of androgen deficiency in middle-aged and older men: estimates from the Massachusetts Male Aging Study. J Clin Endocrinol Metab (2004) 2.73
Persistent intraprostatic androgen concentrations after medical castration in healthy men. J Clin Endocrinol Metab (2006) 2.57
TAC3/TACR3 mutations reveal preferential activation of gonadotropin-releasing hormone release by neurokinin B in neonatal life followed by reversal in adulthood. J Clin Endocrinol Metab (2010) 2.50
Exogenous testosterone or testosterone with finasteride increases bone mineral density in older men with low serum testosterone. J Clin Endocrinol Metab (2004) 2.39
Long-term testosterone gel (AndroGel) treatment maintains beneficial effects on sexual function and mood, lean and fat mass, and bone mineral density in hypogonadal men. J Clin Endocrinol Metab (2004) 2.35
Testosterone treatment and mortality in men with low testosterone levels. J Clin Endocrinol Metab (2012) 2.29
Low serum testosterone and mortality in male veterans. Arch Intern Med (2006) 2.28
Sex steroids and all-cause and cause-specific mortality in men. Arch Intern Med (2007) 2.27
Cyclophosphamide metabolism, liver toxicity, and mortality following hematopoietic stem cell transplantation. Blood (2002) 2.23
The enzymatic activity of human aldehyde dehydrogenases 1A2 and 2 (ALDH1A2 and ALDH2) is detected by Aldefluor, inhibited by diethylaminobenzaldehyde and has significant effects on cell proliferation and drug resistance. Chem Biol Interact (2011) 2.15
Low sex hormone-binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in nonobese men. J Clin Endocrinol Metab (2006) 2.08
Low testosterone associated with obesity and the metabolic syndrome contributes to sexual dysfunction and cardiovascular disease risk in men with type 2 diabetes. Diabetes Care (2011) 1.60
GNRH1 mutations in patients with idiopathic hypogonadotropic hypogonadism. Proc Natl Acad Sci U S A (2009) 1.55
Racial differences in vasectomy utilization in the United States: data from the national survey of family growth. Urology (2009) 1.53
The effect of 5alpha-reductase inhibition with dutasteride and finasteride on semen parameters and serum hormones in healthy men. J Clin Endocrinol Metab (2007) 1.53
Clinical practice patterns in the assessment and management of low testosterone in men: an international survey of endocrinologists. Clin Endocrinol (Oxf) (2014) 1.52
Determination of free and total cortisol in plasma and urine by liquid chromatography-tandem mass spectrometry. Ther Drug Monit (2007) 1.47
Association of bioavailable, free, and total testosterone with insulin resistance: influence of sex hormone-binding globulin and body fat. Diabetes Care (2004) 1.47
The Testosterone Trials: Seven coordinated trials of testosterone treatment in elderly men. Clin Trials (2014) 1.46
Serum insulin-like factor 3 is highly correlated with intratesticular testosterone in normal men with acute, experimental gonadotropin deficiency stimulated with low-dose human chorionic gonadotropin: a randomized, controlled trial. Fertil Steril (2012) 1.44
Serum testosterone and estradiol in sudden infant death. J Pediatr (2005) 1.40
Testosterone deficiency and replacement in older men. N Engl J Med (2010) 1.39
Advances in male contraception. Endocr Rev (2008) 1.39
Clinical problem-solving. Lost in transcription. N Engl J Med (2006) 1.38
The effect of diurnal variation on clinical measurement of serum testosterone and other sex hormone levels in men. J Clin Endocrinol Metab (2008) 1.37
Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1alpha,25-dihydroxyvitamin D(3): implications for drug-induced osteomalacia. Mol Pharmacol (2005) 1.33
Increased incidence of diagnosed depressive illness in hypogonadal older men. Arch Gen Psychiatry (2004) 1.30
Intraindividual variation in levels of serum testosterone and other reproductive and adrenal hormones in men. Clin Endocrinol (Oxf) (2007) 1.30
Testosterone supplementation therapy for older men: potential benefits and risks. J Am Geriatr Soc (2003) 1.24
Incidence, natural history, and risk factors for biliary sludge and stones during pregnancy. Hepatology (2005) 1.24
Testosterone administration suppresses adiponectin levels in men. J Androl (2004) 1.24
Dihydrotestosterone and the prostate: the scientific rationale for 5alpha-reductase inhibitors in the treatment of benign prostatic hyperplasia. J Urol (2004) 1.22
Effect of medical castration on CD4+ CD25+ T cells, CD8+ T cell IFN-gamma expression, and NK cells: a physiological role for testosterone and/or its metabolites. Am J Physiol Endocrinol Metab (2005) 1.21
Cortisol levels and measures of body composition in middle-aged and older men. Clin Endocrinol (Oxf) (2007) 1.20
Computer-based order entry decreases duration of indwelling urinary catheterization in hospitalized patients. Am J Med (2003) 1.19
Serum testosterone assays--accuracy matters. J Clin Endocrinol Metab (2004) 1.19
Low-dose human chorionic gonadotropin maintains intratesticular testosterone in normal men with testosterone-induced gonadotropin suppression. J Clin Endocrinol Metab (2005) 1.19
A randomized, double-blind, placebo-controlled study of testosterone treatment in hypogonadal older men with subthreshold depression (dysthymia or minor depression). J Clin Psychiatry (2009) 1.18
Validation of a soy food-frequency questionnaire and evaluation of correlates of plasma isoflavone concentrations in postmenopausal women. Am J Clin Nutr (2003) 1.15
Targeted androgen pathway suppression in localized prostate cancer: a pilot study. J Clin Oncol (2013) 1.14
A single dose of the potent gonadotropin-releasing hormone antagonist acyline suppresses gonadotropins and testosterone for 2 weeks in healthy young men. J Clin Endocrinol Metab (2004) 1.13
Oral testosterone in oil plus dutasteride in men: a pharmacokinetic study. J Clin Endocrinol Metab (2005) 1.12
Assessment and management of low bone density in inflammatory bowel disease and performance of professional society guidelines. Inflamm Bowel Dis (2011) 1.11
Transdermal androgen therapy to augment EPO in the treatment of anemia of chronic renal disease. Am J Kidney Dis (2006) 1.06
Testosterone gel combined with depomedroxyprogesterone acetate is an effective male hormonal contraceptive regimen and is not enhanced by the addition of a GnRH antagonist. J Clin Endocrinol Metab (2006) 1.05
Determinants of the rate and extent of spermatogenic suppression during hormonal male contraception: an integrated analysis. J Clin Endocrinol Metab (2008) 1.05
Suppression of Stra8 expression in the mouse gonad by WIN 18,446. Biol Reprod (2011) 1.05
Age-related analysis of inhibin A, inhibin B, and activin a relative to the intercycle monotropic follicle-stimulating hormone rise in normal ovulatory women. J Clin Endocrinol Metab (2004) 1.05
Low testosterone levels predict incident depressive illness in older men: effects of age and medical morbidity. J Clin Psychiatry (2005) 1.04
Effects of testosterone and levonorgestrel combined with a 5alpha-reductase inhibitor or gonadotropin-releasing hormone antagonist on spermatogenesis and intratesticular steroid levels in normal men. J Clin Endocrinol Metab (2005) 1.04
Dihydrotestosterone administration does not increase intraprostatic androgen concentrations or alter prostate androgen action in healthy men: a randomized-controlled trial. J Clin Endocrinol Metab (2010) 1.04
Low testosterone is associated with decreased function and increased mortality risk: a preliminary study of men in a geriatric rehabilitation unit. J Am Geriatr Soc (2004) 1.02
Male hypogonadism : an update on diagnosis and treatment. Treat Endocrinol (2005) 1.00
Intratesticular testosterone concentrations comparable with serum levels are not sufficient to maintain normal sperm production in men receiving a hormonal contraceptive regimen. J Androl (2004) 1.00
Male hormonal contraception: effects of injections of testosterone undecanoate and depot medroxyprogesterone acetate at eight-week intervals in chinese men. J Clin Endocrinol Metab (2004) 1.00