Published in Circulation on May 15, 2007
Role of mitochondrial dysfunction in insulin resistance. Circ Res (2008) 3.45
C/EBPβ controls exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell (2010) 2.68
Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure. Circ Res (2008) 2.19
Integration of cellular bioenergetics with mitochondrial quality control and autophagy. Biol Chem (2012) 2.08
Mitochondrial biogenesis in the metabolic syndrome and cardiovascular disease. J Mol Med (Berl) (2010) 1.90
Toll-like receptor-mediated inflammatory signaling reprograms cardiac energy metabolism by repressing peroxisome proliferator-activated receptor γ coactivator-1 signaling. Circ Heart Fail (2011) 1.75
Defective DNA replication impairs mitochondrial biogenesis in human failing hearts. Circ Res (2010) 1.55
PGC-1 alpha regulates expression of myocardial mitochondrial antioxidants and myocardial oxidative stress after chronic systolic overload. Antioxid Redox Signal (2010) 1.48
Cardiovascular remodelling in coronary artery disease and heart failure. Lancet (2014) 1.47
Modulating fatty acid oxidation in heart failure. Cardiovasc Res (2011) 1.37
Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in mice. J Clin Invest (2010) 1.28
Sunitinib-induced cardiotoxicity is mediated by off-target inhibition of AMP-activated protein kinase. Clin Transl Sci (2009) 1.28
Supplementation of Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032 in diet-induced obese mice is associated with gut microbial changes and reduction in obesity. PLoS One (2013) 1.26
Cancer therapy-induced cardiotoxicity: basic mechanisms and potential cardioprotective therapies. J Am Heart Assoc (2014) 1.18
Mitofusins 1 and 2 are essential for postnatal metabolic remodeling in heart. Circ Res (2012) 1.16
Protein kinase A-regulated assembly of a MEF2{middle dot}HDAC4 repressor complex controls c-Jun expression in vascular smooth muscle cells. J Biol Chem (2009) 1.08
PGC-1 alpha serine 570 phosphorylation and GCN5-mediated acetylation by angiotensin II drive catalase down-regulation and vascular hypertrophy. J Biol Chem (2009) 1.05
The PGC-1 cascade as a therapeutic target for heart failure. J Mol Cell Cardiol (2010) 1.04
The emerging characterization of lysine residue deacetylation on the modulation of mitochondrial function and cardiovascular biology. Circ Res (2009) 1.00
Targeting the mitochondria to augment myocardial protection. Curr Opin Pharmacol (2008) 0.97
Peroxisome proliferator activated receptor alpha (PPARalpha) and PPAR gamma coactivator (PGC-1alpha) induce carnitine palmitoyltransferase IA (CPT-1A) via independent gene elements. Mol Cell Endocrinol (2010) 0.96
microRNA-22 promotes heart failure through coordinate suppression of PPAR/ERR-nuclear hormone receptor transcription. PLoS One (2013) 0.96
Age-dependent regulation of skeletal muscle mitochondria by the thrombospondin-1 receptor CD47. Matrix Biol (2011) 0.94
Mitochondrial remodeling in mice with cardiomyocyte-specific lipid overload. J Mol Cell Cardiol (2014) 0.94
Inactivation of Foxo3a and subsequent downregulation of PGC-1 alpha mediate nitric oxide-induced endothelial cell migration. Mol Cell Biol (2010) 0.94
Mitochondria as a potential regulator of myogenesis. ScientificWorldJournal (2013) 0.92
Defects of mtDNA replication impaired mitochondrial biogenesis during Trypanosoma cruzi infection in human cardiomyocytes and chagasic patients: the role of Nrf1/2 and antioxidant response. J Am Heart Assoc (2012) 0.92
Downregulation of oxytocin and natriuretic peptides in diabetes: possible implications in cardiomyopathy. J Physiol (2009) 0.91
Contractile Defect Caused by Mutation in MYBPC3 Revealed under Conditions Optimized for Human PSC-Cardiomyocyte Function. Cell Rep (2015) 0.89
Increased expression of fatty-acid and calcium metabolism genes in failing human heart. PLoS One (2012) 0.88
Radiation-induced alterations in mitochondria of the rat heart. Radiat Res (2014) 0.88
Decrease in mitochondrial function in rat cardiac permeabilized fibers correlates with the aging phenotype. J Gerontol A Biol Sci Med Sci (2010) 0.87
Peroxisome Proliferator-Activated Receptors and the Heart: Lessons from the Past and Future Directions. PPAR Res (2015) 0.87
Mitochondrial protein phosphorylation as a regulatory modality: implications for mitochondrial dysfunction in heart failure. Congest Heart Fail (2011) 0.87
Myocardial overexpression of Mecr, a gene of mitochondrial FAS II leads to cardiac dysfunction in mouse. PLoS One (2009) 0.86
Tracing cardiac metabolism in vivo: one substrate at a time. J Nucl Med (2010) 0.86
Glucocorticoids promote structural and functional maturation of foetal cardiomyocytes: a role for PGC-1α. Cell Death Differ (2014) 0.86
PGC1α plays a critical role in TWEAK-induced cardiac dysfunction. PLoS One (2013) 0.85
PGC-1 proteins and heart failure. Trends Cardiovasc Med (2012) 0.85
Mitochondrial network in the heart. Protein Cell (2012) 0.85
PGC-1/Spargel Counteracts High-Fat-Diet-Induced Obesity and Cardiac Lipotoxicity Downstream of TOR and Brummer ATGL Lipase. Cell Rep (2015) 0.85
Role of ROS and RNS Sources in Physiological and Pathological Conditions. Oxid Med Cell Longev (2016) 0.84
Metabolic reserve of the heart: the forgotten link between contraction and coronary flow. Prog Cardiovasc Dis (2008) 0.83
Rapamycin attenuated cardiac hypertrophy induced by isoproterenol and maintained energy homeostasis via inhibiting NF-κB activation. Mediators Inflamm (2014) 0.83
The interplay between NF-kappaB and E2F1 coordinately regulates inflammation and metabolism in human cardiac cells. PLoS One (2011) 0.83
Mitochondrial function in hypoxic ischemic injury and influence of aging. Prog Neurobiol (2016) 0.83
Alterations in mitochondrial function in cardiac hypertrophy and heart failure. Heart Fail Rev (2013) 0.81
The asymmetric binding of PGC-1α to the ERRα and ERRγ nuclear receptor homodimers involves a similar recognition mechanism. PLoS One (2013) 0.81
Mitochondria and oxidative stress in heart aging. Age (Dordr) (2016) 0.79
Enhancement of Glucose Metabolism via PGC-1α Participates in the Cardioprotection of Chronic Intermittent Hypobaric Hypoxia. Front Physiol (2016) 0.79
Molecular mechanisms for age-associated mitochondrial deficiency in skeletal muscle. J Aging Res (2012) 0.78
PPARs, Cardiovascular Metabolism, and Function: Near- or Far-from-Equilibrium Pathways. PPAR Res (2010) 0.78
Evaluation of Cardiac Mitochondrial Function by a Nuclear Imaging Technique using Technetium-99m-MIBI Uptake Kinetics. Asia Ocean J Nucl Med Biol (2013) 0.77
Peroxisome proliferator-activated receptors as stimulants of angiogenesis in cardiovascular disease and diabetes. Diabetes Metab Syndr Obes (2009) 0.77
Therapeutic effects of fenofibrate on diabetic peripheral neuropathy by improving endothelial and neural survival in db/db mice. PLoS One (2014) 0.77
Estradiol and tamoxifen regulate NRF-1 and mitochondrial function in mouse mammary gland and uterus. J Mol Endocrinol (2013) 0.77
Activated peroxisomal fatty acid metabolism improves cardiac recovery in ischemia-reperfusion. Naunyn Schmiedebergs Arch Pharmacol (2013) 0.76
TNF-like weak inducer of apoptosis aggravates left ventricular dysfunction after myocardial infarction in mice. Mediators Inflamm (2014) 0.76
Acute induction of uncoupling protein 1 by citrulline in cultured explants of white adipose tissue from lean and high-fat-diet-fed rats. Adipocyte (2015) 0.75
Validating the pharmacogenomics of chemotherapy-induced cardiotoxicity: What is missing? Pharmacol Ther (2016) 0.75
Mitochondrial Dysfunction and Immune Cell Metabolism in Sepsis. Infect Chemother (2017) 0.75
Anthracycline Chemotherapy and Cardiotoxicity. Cardiovasc Drugs Ther (2017) 0.75
Genetic Associations of PPARGC1A with Type 2 Diabetes: Differences among Populations with African Origins. J Diabetes Res (2015) 0.75
Interplay between Oxidative Stress and Nutrient Sensing Signaling in the Developmental Origins of Cardiovascular Disease. Int J Mol Sci (2017) 0.75
Quercetin Affects Erythropoiesis and Heart Mitochondrial Function in Mice. Oxid Med Cell Longev (2015) 0.75
Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity. Food Chem Toxicol (2017) 0.75
Estrogen deprivation aggravates cardiac hypertrophy in non-obese type 2 diabetic Goto-kakizaki (GK) rats. Biosci Rep (2017) 0.75
PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. J Clin Invest (2006) 6.85
PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biol (2005) 5.80
Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1. FASEB J (2002) 4.75
The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus. J Clin Invest (2002) 4.22
Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway. Cell Metab (2006) 3.66
Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle. Mol Cell Biol (2004) 3.12
Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRalpha and gamma. Cell Metab (2007) 3.00
Mitochondrial energy metabolism in heart failure: a question of balance. J Clin Invest (2005) 2.98
PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: a mechanism for transcriptional control of muscle glucose metabolism. Mol Cell Biol (2005) 2.93
Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice. Hepatology (2005) 2.72
A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content. Proc Natl Acad Sci U S A (2003) 2.68
Total skeletal muscle PGC-1 deficiency uncouples mitochondrial derangements from fiber type determination and insulin sensitivity. Cell Metab (2010) 2.63
Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart. Genes Dev (2008) 2.58
Nuclear receptor signaling and cardiac energetics. Circ Res (2004) 2.54
Transcriptional integration of mitochondrial biogenesis. Trends Endocrinol Metab (2012) 2.34
CD36 deficiency rescues lipotoxic cardiomyopathy. Circ Res (2007) 2.31
A role for the transcriptional coactivator PGC-1alpha in muscle refueling. J Biol Chem (2007) 2.19
Transcriptional activation of energy metabolic switches in the developing and hypertrophied heart. Clin Exp Pharmacol Physiol (2002) 2.14
A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes. Cell Metab (2005) 2.14
The nuclear receptor ERRalpha is required for the bioenergetic and functional adaptation to cardiac pressure overload. Cell Metab (2007) 2.11
Altered myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy. J Am Coll Cardiol (2002) 2.07
Developmental adaptation of the mouse cardiovascular system to elastin haploinsufficiency. J Clin Invest (2003) 2.05
Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs. Nature (2013) 2.00
The PPAR trio: regulators of myocardial energy metabolism in health and disease. J Mol Cell Cardiol (2008) 1.97
Dexamethasone induction of hypertension and diabetes is PPAR-alpha dependent in LDL receptor-null mice. Nat Med (2003) 1.94
Nuclear receptors PPARbeta/delta and PPARalpha direct distinct metabolic regulatory programs in the mouse heart. J Clin Invest (2007) 1.88
Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-alpha/PGC-1alpha gene regulatory pathway. Circulation (2007) 1.86
Toll-like receptor-mediated inflammatory signaling reprograms cardiac energy metabolism by repressing peroxisome proliferator-activated receptor γ coactivator-1 signaling. Circ Heart Fail (2011) 1.75
Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice. Am J Physiol Heart Circ Physiol (2009) 1.56
The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis. Am J Physiol Heart Circ Physiol (2008) 1.51
Myocardial fatty acid metabolism: independent predictor of left ventricular mass in hypertensive heart disease. Hypertension (2003) 1.39
Gene regulatory mechanisms governing energy metabolism during cardiac hypertrophic growth. Heart Fail Rev (2002) 1.36
Cardiac-specific overexpression of peroxisome proliferator-activated receptor-alpha causes insulin resistance in heart and liver. Diabetes (2005) 1.33
Decreased contractile and metabolic reserve in peroxisome proliferator-activated receptor-alpha-null hearts can be rescued by increasing glucose transport and utilization. Circulation (2005) 1.31
Preferential oxidation of triacylglyceride-derived fatty acids in heart is augmented by the nuclear receptor PPARalpha. Circ Res (2010) 1.30
Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism. J Clin Invest (2013) 1.29
Liver fatty acid binding protein is required for high rates of hepatic fatty acid oxidation but not for the action of PPARalpha in fasting mice. FASEB J (2003) 1.26
Calcineurin and calcium/calmodulin-dependent protein kinase activate distinct metabolic gene regulatory programs in cardiac muscle. J Biol Chem (2004) 1.23
Chronic activation of PPARalpha is detrimental to cardiac recovery after ischemia. Am J Physiol Heart Circ Physiol (2005) 1.22
Peroxisome proliferator-activated receptor alpha (PPARalpha) signaling in the gene regulatory control of energy metabolism in the normal and diseased heart. J Mol Cell Cardiol (2002) 1.21
A role for peroxisome proliferator-activated receptor γ coactivator-1 in the control of mitochondrial dynamics during postnatal cardiac growth. Circ Res (2013) 1.18
Mouse models of mitochondrial dysfunction and heart failure. J Mol Cell Cardiol (2004) 1.17
The nuclear receptor PPARβ/δ programs muscle glucose metabolism in cooperation with AMPK and MEF2. Genes Dev (2011) 1.17
Chronic inhibition of pyruvate dehydrogenase in heart triggers an adaptive metabolic response. J Biol Chem (2011) 1.11
Ubiquitin proteasome-dependent degradation of the transcriptional coactivator PGC-1{alpha} via the N-terminal pathway. J Biol Chem (2010) 1.08
The PGC-1 cascade as a therapeutic target for heart failure. J Mol Cell Cardiol (2010) 1.04
PPARalpha-mediated remodeling of repolarizing voltage-gated K+ (Kv) channels in a mouse model of metabolic cardiomyopathy. J Mol Cell Cardiol (2008) 1.01
PPARalpha suppresses insulin secretion and induces UCP2 in insulinoma cells. J Lipid Res (2002) 1.00
Fatty acid synthase modulates homeostatic responses to myocardial stress. J Biol Chem (2011) 0.98
Perturbations in the gene regulatory pathways controlling mitochondrial energy production in the failing heart. Biochim Biophys Acta (2012) 0.98
Cell biology: Ageing theories unified. Nature (2011) 0.98
G-protein signaling participates in the development of diabetic cardiomyopathy. Diabetes (2004) 0.95
PPARs of the heart: three is a crowd. Circ Res (2003) 0.94
Bcl3 interacts cooperatively with peroxisome proliferator-activated receptor gamma (PPARgamma) coactivator 1alpha to coactivate nuclear receptors estrogen-related receptor alpha and PPARalpha. Mol Cell Biol (2009) 0.93
A role for peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1) in the regulation of cardiac mitochondrial phospholipid biosynthesis. J Biol Chem (2013) 0.91
Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis. J Clin Invest (2015) 0.91
Hypoxic reprogramming. Nat Genet (2008) 0.90
Retinoid X receptor alpha represses GATA-4-mediated transcription via a retinoid-dependent interaction with the cardiac-enriched repressor FOG-2. J Biol Chem (2002) 0.90
Signalling in cardiac metabolism. Cardiovasc Res (2008) 0.90
PGC-1α activity in nigral dopamine neurons determines vulnerability to α-synuclein. Acta Neuropathol Commun (2015) 0.89
Fetal PGC-1α overexpression programs adult pancreatic β-cell dysfunction. Diabetes (2012) 0.89
The transcriptional coactivators, PGC-1α and β, cooperate to maintain cardiac mitochondrial function during the early stages of insulin resistance. J Mol Cell Cardiol (2011) 0.88
PGC1α plays a critical role in TWEAK-induced cardiac dysfunction. PLoS One (2013) 0.85
Differential effects of luminal arginine and glutamine on metalloproteinase production in the postischemic gut. JPEN J Parenter Enteral Nutr (2008) 0.83
Interaction between PPARA genotype and beta-blocker treatment influences clinical outcomes following acute coronary syndromes. Pharmacogenomics (2008) 0.81
A PPARα promoter variant impairs ERR-dependent transactivation and decreases mortality after acute coronary ischemia in patients with diabetes. PLoS One (2010) 0.80
Novel mouse model of left ventricular pressure overload and infarction causing predictable ventricular remodelling and progression to heart failure. Clin Exp Pharmacol Physiol (2015) 0.79
Interaction between the UCP2 -866 G>A polymorphism, diabetes, and beta-blocker use among patients with acute coronary syndromes. Pharmacogenet Genomics (2010) 0.79
Peroxisome proliferator-activated receptor alpha as a genetic determinant of cardiac hypertrophic growth: culprit or innocent bystander? Circulation (2002) 0.79
Liver-specific PGC-1beta deficiency leads to impaired mitochondrial function and lipogenic response to fasting-refeeding. PLoS One (2012) 0.79
Cost of transport is increased after cold exposure in Monodelphis domestica: training for inefficiency. J Exp Biol (2005) 0.78
Cardiac nuclear receptors: architects of mitochondrial structure and function. J Clin Invest (2017) 0.75
MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling. J Clin Invest (2016) 0.75
Identification of Inhibitors of triacylglyceride accumulation in muscle cells: comparing HTS results from 1536-well plate-based and high-content platforms. J Biomol Screen (2013) 0.75
Cardiovascular drug discovery in the academic setting: building infrastructure, harnessing strengths, and seeking synergies. J Cardiovasc Transl Res (2010) 0.75