Published in Circ Res on March 15, 2007
CD36, a scavenger receptor involved in immunity, metabolism, angiogenesis, and behavior. Sci Signal (2009) 3.77
Cardiac remodeling in obesity. Physiol Rev (2008) 2.95
Ceramide is a cardiotoxin in lipotoxic cardiomyopathy. J Lipid Res (2008) 2.88
The Randle cycle revisited: a new head for an old hat. Am J Physiol Endocrinol Metab (2009) 2.39
PGC-1 coactivators in cardiac development and disease. Circ Res (2010) 1.86
Lipid metabolism and toxicity in the heart. Cell Metab (2012) 1.71
Cellular fatty acid uptake: a pathway under construction. Trends Endocrinol Metab (2009) 1.70
PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα deficiency despite increases in fatty acid oxidation. J Clin Invest (2010) 1.63
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Cardiac metabolism and its interactions with contraction, growth, and survival of cardiomyocytes. Circ Res (2013) 1.56
PPARs: diverse regulators in energy metabolism and metabolic diseases. Cell Res (2010) 1.43
Cardiac contractile dysfunction in insulin-resistant rats fed a high-fat diet is associated with elevated CD36-mediated fatty acid uptake and esterification. Diabetologia (2007) 1.42
Myocardial lipid accumulation in patients with pressure-overloaded heart and metabolic syndrome. J Lipid Res (2009) 1.38
Inactivation of GSK-3beta by metallothionein prevents diabetes-related changes in cardiac energy metabolism, inflammation, nitrosative damage, and remodeling. Diabetes (2009) 1.37
The VLDL receptor promotes lipotoxicity and increases mortality in mice following an acute myocardial infarction. J Clin Invest (2011) 1.36
Preferential oxidation of triacylglyceride-derived fatty acids in heart is augmented by the nuclear receptor PPARalpha. Circ Res (2010) 1.30
Adaptation and maladaptation of the heart in obesity. Hypertension (2008) 1.29
Glucocorticoids and cyclic AMP selectively increase hepatic lipin-1 expression, and insulin acts antagonistically. J Lipid Res (2008) 1.25
Opposite regulation of CD36 ubiquitination by fatty acids and insulin: effects on fatty acid uptake. J Biol Chem (2008) 1.22
Chylomicron- and VLDL-derived lipids enter the heart through different pathways: in vivo evidence for receptor- and non-receptor-mediated fatty acid uptake. J Biol Chem (2010) 1.22
CD36-dependent regulation of muscle FoxO1 and PDK4 in the PPAR delta/beta-mediated adaptation to metabolic stress. J Biol Chem (2008) 1.16
Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase. Diabetes (2009) 1.16
Chronic inhibition of pyruvate dehydrogenase in heart triggers an adaptive metabolic response. J Biol Chem (2011) 1.11
VLDL hydrolysis by LPL activates PPAR-alpha through generation of unbound fatty acids. J Lipid Res (2010) 1.08
Type 2 diabetes, mitochondrial biology and the heart. J Mol Cell Cardiol (2009) 1.03
Cardiac lipotoxicity: molecular pathways and therapeutic implications. Curr Heart Fail Rep (2013) 1.01
Metabolic therapy at the crossroad: how to optimize myocardial substrate utilization? Trends Cardiovasc Med (2009) 0.99
Gene-centric meta-analysis of lipid traits in African, East Asian and Hispanic populations. PLoS One (2012) 0.99
Transcriptional control of cardiac fuel metabolism and mitochondrial function. Cold Spring Harb Symp Quant Biol (2011) 0.98
Creating and curing fatty hearts. Curr Opin Clin Nutr Metab Care (2010) 0.98
Perturbations in the gene regulatory pathways controlling mitochondrial energy production in the failing heart. Biochim Biophys Acta (2012) 0.98
CD36 protein influences myocardial Ca2+ homeostasis and phospholipid metabolism: conduction anomalies in CD36-deficient mice during fasting. J Biol Chem (2012) 0.98
Regulatable fatty acid transport mechanisms are central to the pathophysiology of obesity, fatty liver, and metabolic syndrome. Hepatology (2008) 0.97
Diacylglycerol acyl transferase 1 overexpression detoxifies cardiac lipids in PPARγ transgenic mice. J Lipid Res (2012) 0.91
Taking diabetes to heart--deregulation of myocardial lipid metabolism in diabetic cardiomyopathy. J Am Heart Assoc (2013) 0.91
Cardiac expression of microsomal triglyceride transfer protein is increased in obesity and serves to attenuate cardiac triglyceride accumulation. PLoS One (2009) 0.90
Inhibition of serine palmitoyl transferase I reduces cardiac ceramide levels and increases glycolysis rates following diet-induced insulin resistance. PLoS One (2012) 0.88
Increased expression of fatty-acid and calcium metabolism genes in failing human heart. PLoS One (2012) 0.88
Peroxisome proliferator activated receptor-alpha (PPARα) and PPAR gamma coactivator-1alpha (PGC-1α) regulation of cardiac metabolism in diabetes. Pediatr Cardiol (2011) 0.88
The critical role of Astragalus polysaccharides for the improvement of PPARα [ correction of PPRAα]-mediated lipotoxicity in diabetic cardiomyopathy. PLoS One (2012) 0.87
CD36 inhibitors reduce postprandial hypertriglyceridemia and protect against diabetic dyslipidemia and atherosclerosis. PLoS One (2012) 0.87
Fatty acid metabolism in pulmonary arterial hypertension: role in right ventricular dysfunction and hypertrophy. Pulm Circ (2015) 0.87
The PPARalpha-PGC-1alpha Axis Controls Cardiac Energy Metabolism in Healthy and Diseased Myocardium. PPAR Res (2008) 0.86
Targeting metabolic disturbance in the diabetic heart. Cardiovasc Diabetol (2015) 0.84
Improvement of mechanical heart function by trimetazidine in db/db mice. Acta Pharmacol Sin (2010) 0.84
The complexities of diabetic cardiomyopathy: lessons from patients and animal models. Curr Diab Rep (2008) 0.84
Mechanisms of Lipid Accumulation in the Bone Morphogenetic Protein Receptor Type 2 Mutant Right Ventricle. Am J Respir Crit Care Med (2016) 0.83
Changes in cardiac substrate transporters and metabolic proteins mirror the metabolic shift in patients with aortic stenosis. PLoS One (2011) 0.82
Hepatic fat accumulation and regulation of FAT/CD36: an effect of hepatic irradiation. Int J Clin Exp Pathol (2014) 0.81
Cardiac-specific adipose triglyceride lipase overexpression protects from cardiac steatosis and dilated cardiomyopathy following diet-induced obesity. Int J Obes (Lond) (2013) 0.81
Present Insights on Cardiomyopathy in Diabetic Patients. Curr Diabetes Rev (2016) 0.81
Lipid Use and Misuse by the Heart. Circ Res (2016) 0.79
CD36 actions in the heart: Lipids, calcium, inflammation, repair and more? Biochim Biophys Acta (2016) 0.78
The mitochondria in diabetic heart failure: from pathogenesis to therapeutic promise. Antioxid Redox Signal (2015) 0.78
Therapeutic challenge to adiposity of the heart. Circ Res (2007) 0.78
Cluster Differentiating 36 (CD36) Deficiency Attenuates Obesity-Associated Oxidative Stress in the Heart. PLoS One (2016) 0.77
Assessment of myocardial metabolic flexibility and work efficiency in human type 2 diabetes using 16-[18F]fluoro-4-thiapalmitate, a novel PET fatty acid tracer. Am J Physiol Endocrinol Metab (2016) 0.77
Protein-mediated Fatty Acid Uptake in the Heart. Curr Cardiol Rev (2008) 0.76
Endothelial cell-cardiomyocyte crosstalk in diabetic cardiomyopathy. Cardiovasc Res (2016) 0.76
The anti-TNF-α antibody infliximab inhibits the expression of fat-transporter-protein FAT/CD36 in a selective hepatic-radiation mouse model. Int J Mol Sci (2015) 0.75
Inhibition of sarcolemmal FAT/CD36 by sulfo-N-succinimidyl oleate rapidly corrects metabolism and restores function in the diabetic heart following hypoxia/reoxygenation. Cardiovasc Res (2017) 0.75
AMPK Prevents Palmitic Acid-Induced Apoptosis and Lipid Accumulation in Cardiomyocytes. Lipids (2017) 0.75
PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. J Clin Invest (2006) 6.85
Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc Natl Acad Sci U S A (2003) 6.46
Shotgun lipidomics: electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples. Mass Spectrom Rev (2005) 5.98
PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biol (2005) 5.80
Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities. J Biol Chem (2004) 5.80
Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1. FASEB J (2002) 4.75
mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell (2011) 4.70
Akt1 is required for physiological cardiac growth. Circulation (2006) 4.25
The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus. J Clin Invest (2002) 4.22
Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages. J Biol Chem (2002) 4.17
Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype. Nat Med (2007) 4.11
FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response. Proc Natl Acad Sci U S A (2009) 3.99
CD36, a scavenger receptor involved in immunity, metabolism, angiogenesis, and behavior. Sci Signal (2009) 3.77
Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway. Cell Metab (2006) 3.66
Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death. J Lipid Res (2006) 3.64
ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome. Cell Metab (2006) 3.38
CD36 modulates migration of mouse and human macrophages in response to oxidized LDL and may contribute to macrophage trapping in the arterial intima. J Clin Invest (2008) 3.29
Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: a bridge to lipidomics. J Lipid Res (2003) 3.18
A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic lesions. J Biol Chem (2002) 3.17
Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle. Mol Cell Biol (2004) 3.12
A CD36-dependent signaling cascade is necessary for macrophage foam cell formation. Cell Metab (2006) 3.06
Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRalpha and gamma. Cell Metab (2007) 3.00
Mitochondrial energy metabolism in heart failure: a question of balance. J Clin Invest (2005) 2.98
PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: a mechanism for transcriptional control of muscle glucose metabolism. Mol Cell Biol (2005) 2.93
Regulation of myocardial ketone body metabolism by the gut microbiota during nutrient deprivation. Proc Natl Acad Sci U S A (2009) 2.91
CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions. J Clin Invest (2005) 2.81
OXPAT/PAT-1 is a PPAR-induced lipid droplet protein that promotes fatty acid utilization. Diabetes (2006) 2.77
Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice. Hepatology (2005) 2.72
Murine malaria parasite sequestration: CD36 is the major receptor, but cerebral pathology is unlinked to sequestration. Proc Natl Acad Sci U S A (2005) 2.71
A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content. Proc Natl Acad Sci U S A (2003) 2.68
Total skeletal muscle PGC-1 deficiency uncouples mitochondrial derangements from fiber type determination and insulin sensitivity. Cell Metab (2010) 2.63
Lipid rafts are enriched in arachidonic acid and plasmenylethanolamine and their composition is independent of caveolin-1 expression: a quantitative electrospray ionization/mass spectrometric analysis. Biochemistry (2002) 2.59
Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart. Genes Dev (2008) 2.58
Nuclear receptor signaling and cardiac energetics. Circ Res (2004) 2.54
Oxidized phosphatidylserine-CD36 interactions play an essential role in macrophage-dependent phagocytosis of apoptotic cells. J Exp Med (2006) 2.51
CD36 repression activates a multicellular stromal program shared by high mammographic density and tumor tissues. Cancer Discov (2012) 2.51
Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy. Circ Res (2004) 2.50
Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo. J Clin Invest (2004) 2.45
Automated lipid identification and quantification by multidimensional mass spectrometry-based shotgun lipidomics. Anal Chem (2009) 2.44
Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis. Gastroenterology (2007) 2.43
Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A (2011) 2.39
Multi-dimensional mass spectrometry-based shotgun lipidomics and novel strategies for lipidomic analyses. Mass Spectrom Rev (2011) 2.39
Transcriptional integration of mitochondrial biogenesis. Trends Endocrinol Metab (2012) 2.34
Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity. Diabetes (2007) 2.24
Shotgun lipidomics: multidimensional MS analysis of cellular lipidomes. Expert Rev Proteomics (2005) 2.23
A role for the transcriptional coactivator PGC-1alpha in muscle refueling. J Biol Chem (2007) 2.19
ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE. J Biol Chem (2004) 2.19
Dietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction. Gastroenterology (2009) 2.19
Toward fingerprinting cellular lipidomes directly from biological samples by two-dimensional electrospray ionization mass spectrometry. Anal Biochem (2004) 2.17
A CD36-dependent pathway enhances macrophage and adipose tissue inflammation and impairs insulin signalling. Cardiovasc Res (2010) 2.16
Decreased hepatic triglyceride accumulation and altered fatty acid uptake in mice with deletion of the liver fatty acid-binding protein gene. J Biol Chem (2003) 2.15
Transcriptional activation of energy metabolic switches in the developing and hypertrophied heart. Clin Exp Pharmacol Physiol (2002) 2.14
Adipocyte lipases and defect of lipolysis in human obesity. Diabetes (2005) 2.14
A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes. Cell Metab (2005) 2.14
The nuclear receptor ERRalpha is required for the bioenergetic and functional adaptation to cardiac pressure overload. Cell Metab (2007) 2.11
Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. Diabetes (2010) 2.10
Altered myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy. J Am Coll Cardiol (2002) 2.07
Developmental adaptation of the mouse cardiovascular system to elastin haploinsufficiency. J Clin Invest (2003) 2.05
Modulating sphingolipid biosynthetic pathway rescues photoreceptor degeneration. Science (2003) 2.02
CD36 is important for fatty acid and cholesterol uptake by the proximal but not distal intestine. J Biol Chem (2007) 2.02
Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs. Nature (2013) 2.00
FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1α pathway. Cell Metab (2011) 1.97
The PPAR trio: regulators of myocardial energy metabolism in health and disease. J Mol Cell Cardiol (2008) 1.97
Dexamethasone induction of hypertension and diabetes is PPAR-alpha dependent in LDL receptor-null mice. Nat Med (2003) 1.94
Nuclear receptors PPARbeta/delta and PPARalpha direct distinct metabolic regulatory programs in the mouse heart. J Clin Invest (2007) 1.88
Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-alpha/PGC-1alpha gene regulatory pathway. Circulation (2007) 1.86
The class B scavenger receptor CD36 mediates free radical production and tissue injury in cerebral ischemia. J Neurosci (2005) 1.84
Scavenger receptors in neurobiology and neuropathology: their role on microglia and other cells of the nervous system. Glia (2002) 1.81