Published in J Biol Chem on May 15, 2007
Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase 1. J Biol Chem (2009) 1.24
Molecular basis for the structural instability of human DJ-1 induced by the L166P mutation associated with Parkinson's disease. Biochemistry (2008) 1.00
Parkinson disease-associated DJ-1 is required for the expression of the glial cell line-derived neurotrophic factor receptor RET in human neuroblastoma cells. J Biol Chem (2010) 0.95
Structural impact of three Parkinsonism-associated missense mutations on human DJ-1. Biochemistry (2008) 0.94
Dopamine-derived quinones affect the structure of the redox sensor DJ-1 through modifications at Cys-106 and Cys-53. J Biol Chem (2012) 0.88
SINEUPs are modular antisense long non-coding RNAs that increase synthesis of target proteins in cells. Front Cell Neurosci (2015) 0.88
Parkinson's disease DJ-1 L166P alters rRNA biogenesis by exclusion of TTRAP from the nucleolus and sequestration into cytoplasmic aggregates via TRAF6. PLoS One (2012) 0.87
DJ-1 protects against cell death following acute cardiac ischemia-reperfusion injury. Cell Death Dis (2014) 0.85
Parkinson's disease-associated mutations in DJ-1 modulate its dimerization in living cells. J Mol Med (Berl) (2012) 0.82
The E163K DJ-1 mutant shows specific antioxidant deficiency. Brain Res (2008) 0.82
DJ-1 cleavage by matrix metalloproteinase 3 mediates oxidative stress-induced dopaminergic cell death. Antioxid Redox Signal (2011) 0.79
A Physical Interaction between the Dopamine Transporter and DJ-1 Facilitates Increased Dopamine Reuptake. PLoS One (2015) 0.75
The effects of variants in the PARK2 (parkin), PINK1, and PARK7 (DJ-1) genes along with evidence for their pathogenicity. Curr Protein Pept Sci (2016) 0.75
A structural annotation resource for the selection of putative target proteins in the malaria parasite. Malar J (2008) 0.75
Genome-wide analysis of mammalian promoter architecture and evolution. Nat Genet (2006) 17.19
A promoter-level mammalian expression atlas. Nature (2014) 6.25
Direct generation of functional dopaminergic neurons from mouse and human fibroblasts. Nature (2011) 6.21
Somatic retrotransposition alters the genetic landscape of the human brain. Nature (2011) 4.16
Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Genome Res (2003) 3.50
Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat. Nature (2012) 3.08
Genome-wide detection and analysis of hippocampus core promoters using DeepCAGE. Genome Res (2008) 2.60
Linking promoters to functional transcripts in small samples with nanoCAGE and CAGEscan. Nat Methods (2010) 2.30
Bestrophin-2 is a candidate calcium-activated chloride channel involved in olfactory transduction. Proc Natl Acad Sci U S A (2006) 1.68
Unexpected expression of alpha- and beta-globin in mesencephalic dopaminergic neurons and glial cells. Proc Natl Acad Sci U S A (2009) 1.64
Drug resistance in HIV-1 protease: Flexibility-assisted mechanism of compensatory mutations. Protein Sci (2002) 1.54
Accurate and efficient description of protein vibrational dynamics: comparing molecular dynamics and Gaussian models. Proteins (2004) 1.51
Gene expression microarrays: glimpses of the immunological genome. Nat Immunol (2006) 1.48
Adaptive protein evolution grants organismal fitness by improving catalysis and flexibility. Proc Natl Acad Sci U S A (2008) 1.25
The metallo-beta-lactamase GOB is a mono-Zn(II) enzyme with a novel active site. J Biol Chem (2007) 1.23
Role of conformational fluctuations in the enzymatic reaction of HIV-1 protease. J Mol Biol (2002) 1.22
Redox state, oxidative stress, and molecular mechanisms of protective and toxic effects of bilirubin on cells. Curr Pharm Des (2009) 1.16
Targeting biomolecular flexibility with metadynamics. Curr Opin Struct Biol (2010) 1.16
APE1/Ref-1 regulates PTEN expression mediated by Egr-1. Free Radic Res (2008) 1.13
Polarization effects and charge transfer in the KcsA potassium channel. Biophys Chem (2006) 1.12
Insights into the binding of Phenyltiocarbamide (PTC) agonist to its target human TAS2R38 bitter receptor. PLoS One (2010) 1.12
Promoter architecture of mouse olfactory receptor genes. Genome Res (2011) 1.06
Solute-solvent charge transfer in aqueous solution. Chemphyschem (2005) 1.04
Potassium permeation through the KcsA channel: a density functional study. Biochim Biophys Acta (2002) 1.04
Suppression of artifacts and barcode bias in high-throughput transcriptome analyses utilizing template switching. Nucleic Acids Res (2012) 1.04
Evolutionarily conserved functional mechanics across pepsin-like and retroviral aspartic proteases. J Am Chem Soc (2005) 1.03
Substrate binding mechanism of HIV-1 protease from explicit-solvent atomistic simulations. J Am Chem Soc (2009) 1.02
A structural model of agonist binding to the alpha3beta4 neuronal nicotinic receptor. Br J Pharmacol (2003) 1.02
Coarse-grained model of proteins incorporating atomistic detail of the active site. Phys Rev Lett (2005) 1.02
Nerve terminals of squid photoreceptor neurons contain a heterogeneous population of mRNAs and translate a transfected reporter mRNA. Eur J Neurosci (2004) 1.00
Role of protein frame and solvent for the redox properties of azurin from Pseudomonas aeruginosa. Proc Natl Acad Sci U S A (2006) 1.00
The C-terminal Src inhibitory kinase (Csk)-mediated tyrosine phosphorylation is a novel molecular mechanism to limit P2X3 receptor function in mouse sensory neurons. J Biol Chem (2009) 1.00
Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin. Proc Natl Acad Sci U S A (2011) 0.97
Structural facets of disease-linked human prion protein mutants: a molecular dynamic study. Proteins (2010) 0.97
Convergent dynamics in the protease enzymatic superfamily. J Am Chem Soc (2006) 0.97
Form deprivation modulates retinal neurogenesis in primate experimental myopia. Proc Natl Acad Sci U S A (2006) 0.97
TRAF6 promotes atypical ubiquitination of mutant DJ-1 and alpha-synuclein and is localized to Lewy bodies in sporadic Parkinson's disease brains. Hum Mol Genet (2010) 0.97
Dynamics and energetics of water permeation through the aquaporin channel. Proteins (2004) 0.97
GOMoDo: A GPCRs online modeling and docking webserver. PLoS One (2013) 0.96
A caspase-3-cleaved fragment of the glial glutamate transporter EAAT2 is sumoylated and targeted to promyelocytic leukemia nuclear bodies in mutant SOD1-linked amyotrophic lateral sclerosis. J Biol Chem (2007) 0.96
Neuronal hemoglobin is reduced in Alzheimer's disease, argyrophilic grain disease, Parkinson's disease, and dementia with Lewy bodies. J Alzheimers Dis (2011) 0.95
Parkinson disease-associated DJ-1 is required for the expression of the glial cell line-derived neurotrophic factor receptor RET in human neuroblastoma cells. J Biol Chem (2010) 0.95
Inhibition of alpha-synuclein fibrillization by dopamine is mediated by interactions with five C-terminal residues and with E83 in the NAC region. PLoS One (2008) 0.95
Expression of circadian clock genes in retinal dopaminergic cells. Vis Neurosci (2007) 0.94
Water-assisted reaction mechanism of monozinc beta-lactamases. J Am Chem Soc (2004) 0.94
Common mechanistic features among metallo-beta-lactamases: a computational study of Aeromonas hydrophila CphA enzyme. J Biol Chem (2009) 0.94
Tetraethylammonium binding to the outer mouth of the KcsA potassium channel: implications for ion permeation. J Recept Signal Transduct Res (2002) 0.94
Dissociation of minor groove binders from DNA: insights from metadynamics simulations. Nucleic Acids Res (2008) 0.94
Quantitative and qualitative models for carcinogenicity prediction for non-congeneric chemicals using CP ANN method for regulatory uses. Mol Divers (2009) 0.93
Regulation of bestrophins by Ca2+: a theoretical and experimental study. PLoS One (2009) 0.93
Role of zinc content on the catalytic efficiency of B1 metallo beta-lactamases. J Am Chem Soc (2007) 0.91
Calculation of redox properties: understanding short- and long-range effects in rubredoxin. J Phys Chem B (2007) 0.91
Defined α-synuclein prion-like molecular assemblies spreading in cell culture. BMC Neurosci (2014) 0.90
Presynaptic functional trkB receptors mediate the release of excitatory neurotransmitters from primary afferent terminals in lamina II (substantia gelatinosa) of postnatal rat spinal cord. Dev Neurobiol (2008) 0.90
Tumor necrosis factor receptor-associated factor 6 (TRAF6) associates with huntingtin protein and promotes its atypical ubiquitination to enhance aggregate formation. J Biol Chem (2011) 0.89
Coordination numbers of K(+) and Na(+) Ions inside the selectivity filter of the KcsA potassium channel: insights from first principles molecular dynamics. Biophys J (2010) 0.89
Molecular modeling of ion channels: structural predictions. Curr Opin Chem Biol (2003) 0.89
Common structural traits across pathogenic mutants of the human prion protein and their implications for familial prion diseases. J Mol Biol (2011) 0.89
Bioinorganic chemistry of Parkinson's disease: structural determinants for the copper-mediated amyloid formation of alpha-synuclein. Inorg Chem (2010) 0.89
Water at hydrophobic interfaces delays proton surface-to-bulk transfer and provides a pathway for lateral proton diffusion. Proc Natl Acad Sci U S A (2012) 0.88
G protein inactive and active forms investigated by simulation methods. Proteins (2009) 0.88
Peptide aptamers targeting mutant p53 induce apoptosis in tumor cells. Cancer Res (2008) 0.88
Computational study of the phosphoryl transfer catalyzed by a cyclin-dependent kinase. Chemistry (2007) 0.88
Nicotine blocks the hyperpolarization-activated current Ih and severely impairs the oscillatory behavior of oriens-lacunosum moleculare interneurons. J Neurosci (2010) 0.88
Target-related applications of first principles quantum chemical methods in drug design. Chem Rev (2006) 0.88
Motor neuron impairment mediated by a sumoylated fragment of the glial glutamate transporter EAAT2. Glia (2011) 0.88
Coarse-grained/molecular mechanics of the TAS2R38 bitter taste receptor: experimentally-validated detailed structural prediction of agonist binding. PLoS One (2013) 0.87
H-bonded complexes of aniline with HF/F- and anilide with HF in terms of symmetry-adapted perturbation, atoms in molecules, and natural bond orbitals theories. J Phys Chem A (2008) 0.87
Parkinson's disease DJ-1 L166P alters rRNA biogenesis by exclusion of TTRAP from the nucleolus and sequestration into cytoplasmic aggregates via TRAF6. PLoS One (2012) 0.87
Enzymatic GTP hydrolysis: insights from an ab initio molecular dynamics study. J Am Chem Soc (2002) 0.87
Investigating biological systems using first principles Car-Parrinello molecular dynamics simulations. Curr Opin Struct Biol (2007) 0.87
Molecular dynamics study of the KcsA channel at 2.0-A resolution: stability and concerted motions within the pore. Biochim Biophys Acta (2004) 0.87
Functional genomics reveals dysregulation of cortical olfactory receptors in Parkinson disease: novel putative chemoreceptors in the human brain. J Neuropathol Exp Neurol (2013) 0.87
Interrelations between the mesomeric and electronegativity effects in para-substituted derivatives of phenol/phenolate and aniline/anilide H-bonded complexes: a DFT-based computational study. J Phys Chem A (2009) 0.86
Hybrid molecular mechanics/coarse-grained simulations for structural prediction of G-protein coupled receptor/ligand complexes. PLoS One (2012) 0.86
Mechanism of action of cyclophilin a explored by metadynamics simulations. PLoS Comput Biol (2009) 0.86
Origin of functional diversity among tetrameric voltage-gated channels. Proteins (2007) 0.86
On the zwitterionic nature of gas-phase peptides and protein ions. PLoS Comput Biol (2010) 0.86
Local synthesis of axonal and presynaptic RNA in squid model systems. Eur J Neurosci (2007) 0.86
Symmetry-adapted perturbation theory analysis of the N...HX hydrogen bonds. J Phys Chem A (2007) 0.86
Calcium binding to the transmembrane domain of the sarcoplasmic reticulum Ca2+-ATPase: insights from molecular modeling. Proteins (2003) 0.85
Adhesion to carbon nanotube conductive scaffolds forces action-potential appearance in immature rat spinal neurons. PLoS One (2013) 0.85
Ligand specificity of odorant receptors. J Mol Model (2006) 0.85
Mammalian nerve globins in search of functions. IUBMB Life (2014) 0.85
Structural determinants and hydrogen-bond network of the mononuclear zinc(II)-beta-lactamase active site. J Biol Inorg Chem (2002) 0.84
Substrate binding to mononuclear metallo-beta-lactamase from Bacillus cereus. Proteins (2004) 0.84
A molecular dynamics simulation-based interpretation of nuclear magnetic resonance multidimensional heteronuclear spectra of α-synuclein·dopamine adducts. Biochemistry (2013) 0.84
Discovery of a class of diketopiperazines as antiprion compounds. ChemMedChem (2010) 0.84
cAMP Modulation of the cytoplasmic domain in the HCN2 channel investigated by molecular simulations. Biophys J (2006) 0.84
Modeling toxicity by using supervised kohonen neural networks. J Chem Inf Comput Sci (2003) 0.84
Microseconds dynamics simulations of the outer-membrane protease T. Biophys J (2007) 0.83
Binding of novel azole-bridged dinuclear platinum(II) anticancer drugs to DNA: insights from hybrid QM/MM molecular dynamics simulations. J Phys Chem B (2006) 0.83
A novel approach to the investigation of passive molecular permeation through lipid bilayers from atomistic simulations. J Phys Chem B (2012) 0.83