Multiple variants in vascular endothelial growth factor (VEGFA) are risk factors for time to severe retinopathy in type 1 diabetes: the DCCT/EDIC genetics study.

PubWeight™: 1.34‹?› | Rank: Top 10%

🔗 View Article (PMID 17513698)

Published in Diabetes on May 18, 2007

Authors

Hussam Al-Kateb1, Lucia Mirea, Xinlei Xie, Lei Sun, Michelle Liu, Hongtao Chen, Shelley B Bull, Andrew P Boright, Andrew D Paterson, DCCT/EDIC Research Group

Author Affiliations

1: Program in Genetics and Genome Biology, Hospital of Sick Children Research Institute, Toronto, ON, Canada.

Articles citing this

Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG 2100. J Clin Oncol (2008) 5.38

A unified framework for association analysis with multiple related phenotypes. PLoS One (2013) 1.81

Multiple superoxide dismutase 1/splicing factor serine alanine 15 variants are associated with the development and progression of diabetic nephropathy: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Genetics study. Diabetes (2007) 1.65

Diabetic retinopathy: targeting vasoregression. Diabetes (2011) 1.51

Genome-wide meta-analysis for severe diabetic retinopathy. Hum Mol Genet (2011) 1.36

Diabetes control and complications trial/epidemiology of diabetes interventions and complications study at 30 years: advances and contributions. Diabetes (2013) 1.31

The role of genetics in susceptibility to diabetic retinopathy. Int Ophthalmol Clin (2009) 1.30

The diabetes control and complications trial/epidemiology of diabetes interventions and complications study at 30 years: summary and future directions. Diabetes Care (2014) 1.07

Polymorphisms in the vascular endothelial growth factor gene and the risk of diabetic retinopathy in Chinese patients with type 2 diabetes. Mol Vis (2011) 1.01

Lipid and endothelium-related genes, ambient particulate matter, and heart rate variability--the VA Normative Aging Study. J Epidemiol Community Health (2010) 0.94

Genetics of diabetes complications. Curr Diab Rep (2010) 0.93

Diabetic retinopathy and systemic factors. Middle East Afr J Ophthalmol (2015) 0.91

Deciphering the therapeutic mechanisms of Xiao-Ke-An in treatment of type 2 diabetes in mice by a Fangjiomics approach. Acta Pharmacol Sin (2015) 0.88

Association of VEGF gene polymorphisms with diabetic retinopathy: a meta-analysis. PLoS One (2013) 0.84

Candidate gene association study for diabetic retinopathy in Chinese patients with type 2 diabetes. Mol Vis (2014) 0.83

Genetics in diabetic retinopathy: current concepts and new insights. Curr Genomics (2013) 0.82

Genetic and Molecular Basis of QTL of Diabetes in Mouse: Genes and Polymorphisms. Curr Genomics (2008) 0.82

Fine mapping of a region of chromosome 11q23.3 reveals independent locus associated with risk of glioma. PLoS One (2012) 0.81

Two polymorphisms (rs699947, rs2010963) in the VEGFA gene and diabetic retinopathy: an updated meta-analysis. BMC Ophthalmol (2013) 0.80

Antimüllerian hormone among women with and without type 1 diabetes: the Epidemiology of Diabetes Interventions and Complications Study and the Michigan Bone Health and Metabolism Study. Fertil Steril (2016) 0.80

Differentially expressed microRNAs in the corpus cavernosum from a murine model with type 2 diabetes mellitus-associated erectile dysfunction. Mol Genet Genomics (2016) 0.78

Vascular endothelial growth factors: multitasking functionality in metabolism, health and disease. J Inherit Metab Dis (2015) 0.78

Optimal treatment of diabetic retinopathy. Ther Adv Endocrinol Metab (2013) 0.78

Celebrating 30 years of research accomplishments of the diabetes control and complications trial/epidemiology of diabetes interventions and complications study. Diabetes (2013) 0.78

Genetics of diabetes complications. Mamm Genome (2014) 0.78

Role of FAM18B in diabetic retinopathy. Mol Vis (2014) 0.76

Evaluation of VEGF gene polymorphisms and proliferative diabetic retinopathy in Mexican population. Int J Ophthalmol (2017) 0.75

Association between a vascular endothelial growth factor gene polymorphism (rs2146323) and diabetic retinopathy: a meta-analysis. BMC Ophthalmol (2015) 0.75

Polymorphisms of VEGFA gene and susceptibility to hemorrhage risk of brain arteriovenous malformations in a Chinese population. Acta Pharmacol Sin (2011) 0.75

Vascular Endothelial Growth Factor Gene Polymorphism is not Associated with Diabetic Retinopathy in Egyptian Patients. Middle East Afr J Ophthalmol (2016) 0.75

Genetic and epigenetic modifications in the pathogenesis of diabetic retinopathy: a molecular link to regulate gene expression. New Front Ophthalmol (2016) 0.75

Novel Genetic Actors of Diabetes-Associated Microvascular Complications: Retinopathy, Kidney Disease and Neuropathy. Rev Diabet Stud (2016) 0.75

Articles by these authors

Functional impact of global rare copy number variation in autism spectrum disorders. Nature (2010) 14.66

Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nat Genet (2007) 14.05

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02

Intensive diabetes therapy and glomerular filtration rate in type 1 diabetes. N Engl J Med (2011) 7.42

Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote. PLoS Biol (2006) 5.44

PMN-PT single crystal, high-frequency ultrasonic needle transducers for pulsed-wave Doppler application. IEEE Trans Ultrason Ferroelectr Freq Control (2007) 4.16

Unified criteria for ultrasonographic diagnosis of ADPKD. J Am Soc Nephrol (2008) 4.07

Mammographic breast density as an intermediate phenotype for breast cancer. Lancet Oncol (2005) 3.99

A genome-wide scan for common alleles affecting risk for autism. Hum Mol Genet (2010) 3.42

Genome-wide association scan for diabetic nephropathy susceptibility genes in type 1 diabetes. Diabetes (2009) 3.16

The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor. Proc Natl Acad Sci U S A (2003) 3.02

Human chromosome 7: DNA sequence and biology. Science (2003) 3.02

Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2. Nat Genet (2011) 3.02

Monozygotic twins exhibit numerous epigenetic differences: clues to twin discordance? Schizophr Bull (2003) 2.76

Cadherin-directed actin assembly: E-cadherin physically associates with the Arp2/3 complex to direct actin assembly in nascent adhesive contacts. Curr Biol (2002) 2.74

CUBN is a gene locus for albuminuria. J Am Soc Nephrol (2011) 2.70

Effects of prior intensive insulin therapy on cardiac autonomic nervous system function in type 1 diabetes mellitus: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study (DCCT/EDIC). Circulation (2009) 2.66

Reduction of selection bias in genomewide studies by resampling. Genet Epidemiol (2005) 2.66

Neuropathy among the diabetes control and complications trial cohort 8 years after trial completion. Diabetes Care (2006) 2.64

Effect of glycemic exposure on the risk of microvascular complications in the diabetes control and complications trial--revisited. Diabetes (2008) 2.60

Frequency of Evidence-Based Screening for Retinopathy in Type 1 Diabetes. N Engl J Med (2017) 2.56

Individual common variants exert weak effects on the risk for autism spectrum disorderspi. Hum Mol Genet (2012) 2.46

Stratified false discovery control for large-scale hypothesis testing with application to genome-wide association studies. Genet Epidemiol (2006) 2.45

Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Nat Genet (2013) 2.36

NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant in NCF2 that results in reduced binding to RAC2. Gut (2011) 2.26

Real-time evolution of new genes by innovation, amplification, and divergence. Science (2012) 2.22

The effect of intensive glycemic treatment on coronary artery calcification in type 1 diabetic participants of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study. Diabetes (2006) 2.20

BRITTLE CULM1, which encodes a COBRA-like protein, affects the mechanical properties of rice plants. Plant Cell (2003) 2.19

Interactions between CYP1A1 polymorphisms and cigarette smoking are associated with the risk of hepatocellular carcinoma: evidence from epidemiological studies. Mol Biol Rep (2012) 2.13

The intra-S phase checkpoint targets Dna2 to prevent stalled replication forks from reversing. Cell (2012) 2.07

The diabetes control and complications trial/epidemiology of diabetes interventions and complications study at 30 years: overview. Diabetes Care (2014) 2.04

Met induces mammary tumors with diverse histologies and is associated with poor outcome and human basal breast cancer. Proc Natl Acad Sci U S A (2009) 2.01

The effect of excess weight gain with intensive diabetes mellitus treatment on cardiovascular disease risk factors and atherosclerosis in type 1 diabetes mellitus: results from the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study (DCCT/EDIC) study. Circulation (2012) 1.92

Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction. Nat Biotechnol (2011) 1.91

Sexual dysfunction in women with type 1 diabetes: long-term findings from the DCCT/ EDIC study cohort. Diabetes Care (2009) 1.87

Evaluating the role of epigenetic histone modifications in the metabolic memory of type 1 diabetes. Diabetes (2014) 1.81

Genome-wide association identifies the ABO blood group as a major locus associated with serum levels of soluble E-selectin. Arterioscler Thromb Vasc Biol (2009) 1.80

An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells. Nat Immunol (2008) 1.79

New susceptibility loci associated with kidney disease in type 1 diabetes. PLoS Genet (2012) 1.79

Common variants in ZNF365 are associated with both mammographic density and breast cancer risk. Nat Genet (2011) 1.77

Cortactin is necessary for E-cadherin-mediated contact formation and actin reorganization. J Cell Biol (2004) 1.74

ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption. J Clin Invest (2013) 1.74

MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands. Proc Natl Acad Sci U S A (2010) 1.73

Structural and regulatory genes required to make the gas dimethyl sulfide in bacteria. Science (2007) 1.72

JAG1 expression is associated with a basal phenotype and recurrence in lymph node-negative breast cancer. Breast Cancer Res Treat (2007) 1.69

Dynamic microtubules regulate the local concentration of E-cadherin at cell-cell contacts. J Cell Sci (2006) 1.68

CC2D2A, encoding a coiled-coil and C2 domain protein, causes autosomal-recessive mental retardation with retinitis pigmentosa. Am J Hum Genet (2008) 1.67

A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. Diabetes (2009) 1.65

Multiple superoxide dismutase 1/splicing factor serine alanine 15 variants are associated with the development and progression of diabetic nephropathy: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Genetics study. Diabetes (2007) 1.65

Evaluation of disulfide reduction during receptor-mediated endocytosis by using FRET imaging. Proc Natl Acad Sci U S A (2006) 1.65

Progression of carotid artery intima-media thickness during 12 years in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study. Diabetes (2011) 1.63

Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet. Proc Natl Acad Sci U S A (2011) 1.59

Pharmacologic disruption of Polycomb Repressive Complex 2 inhibits tumorigenicity and tumor progression in prostate cancer. Mol Cancer (2011) 1.59

Sex differences in repetitive stereotyped behaviors in autism: implications for genetic liability. Am J Med Genet B Neuropsychiatr Genet (2011) 1.58

Complex two-gene modulation of lung disease severity in children with cystic fibrosis. J Clin Invest (2008) 1.57

Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes. Diabetes (2008) 1.56

TP53 mutations and outcome in osteosarcoma: a prospective, multicenter study. J Clin Oncol (2005) 1.50

Use of the Michigan Neuropathy Screening Instrument as a measure of distal symmetrical peripheral neuropathy in Type 1 diabetes: results from the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications. Diabet Med (2012) 1.50

Spectral analysis of multiplex Raman probe signatures. ACS Nano (2008) 1.49

Robust and powerful tests for rare variants using Fisher's method to combine evidence of association from two or more complementary tests. Genet Epidemiol (2012) 1.45

High-speed vibrational imaging and spectral analysis of lipid bodies by compound Raman microscopy. J Phys Chem B (2009) 1.43

Ethnic differences in relative risk of idiopathic calcium nephrolithiasis in North America. J Urol (2007) 1.42

Neuropathy and related findings in the diabetes control and complications trial/epidemiology of diabetes interventions and complications study. Diabetes Care (2014) 1.42

F gene recombination between genotype II and VII Newcastle disease virus. Virus Res (2007) 1.42

Update on cardiovascular outcomes at 30 years of the diabetes control and complications trial/epidemiology of diabetes interventions and complications study. Diabetes Care (2014) 1.42

CRYBA4, a novel human cataract gene, is also involved in microphthalmia. Am J Hum Genet (2006) 1.41

Cyclophilin A interacts with influenza A virus M1 protein and impairs the early stage of the viral replication. Cell Microbiol (2009) 1.40

Variation in SLC19A3 and Protection From Microvascular Damage in Type 1 Diabetes. Diabetes (2015) 1.40

Repeated intracoronary infusion of peripheral blood stem cells with G-CSF in patients with refractory ischemic heart failure--a pilot study. Circ J (2011) 1.39

EZH2 inhibition: targeting the crossroad of tumor invasion and angiogenesis. Cancer Metastasis Rev (2012) 1.39

Baseline markers of inflammation are associated with progression to macroalbuminuria in type 1 diabetic subjects. Diabetes Care (2013) 1.39

Expanded repeat in canine epilepsy. Science (2005) 1.37

Relationship of glycated albumin to blood glucose and HbA1c values and to retinopathy, nephropathy, and cardiovascular outcomes in the DCCT/EDIC study. Diabetes (2013) 1.37

Locus-specific heritability estimation via the bootstrap in linkage scans for quantitative trait loci. Hum Hered (2006) 1.36

Differentiation of bone marrow-derived mesenchymal stem cells from diabetic patients into insulin-producing cells in vitro. Chin Med J (Engl) (2007) 1.35

Genetic variation at the ACE gene is associated with persistent microalbuminuria and severe nephropathy in type 1 diabetes: the DCCT/EDIC Genetics Study. Diabetes (2005) 1.34