Published in Nat Genet on January 30, 2011
Mammographic density and breast cancer risk: current understanding and future prospects. Breast Cancer Res (2011) 2.86
Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk. PLoS Genet (2013) 1.88
High-throughput mammographic-density measurement: a tool for risk prediction of breast cancer. Breast Cancer Res (2012) 1.63
ImmunoChip study implicates antigen presentation to T cells in narcolepsy. PLoS Genet (2013) 1.55
Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. Breast Cancer Res (2012) 1.38
11q13 is a susceptibility locus for hormone receptor positive breast cancer. Hum Mutat (2012) 1.26
Genetic variants associated with breast size also influence breast cancer risk. BMC Med Genet (2012) 1.26
Common breast cancer susceptibility variants in LSP1 and RAD51L1 are associated with mammographic density measures that predict breast cancer risk. Cancer Epidemiol Biomarkers Prev (2012) 1.26
Common variants at the 19p13.1 and ZNF365 loci are associated with ER subtypes of breast cancer and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. Cancer Epidemiol Biomarkers Prev (2012) 1.17
Genome-wide association study of breast cancer in Latinas identifies novel protective variants on 6q25. Nat Commun (2014) 1.16
Evaluating genome-wide association study-identified breast cancer risk variants in African-American women. PLoS One (2013) 1.10
Mammographic breast density and breast cancer: evidence of a shared genetic basis. Cancer Res (2012) 1.03
Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression. Am J Hum Genet (2015) 1.00
Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk. Nat Commun (2014) 1.00
Hereditary breast cancer: ever more pieces to the polygenic puzzle. Hered Cancer Clin Pract (2013) 0.99
Distribution of mammographic density and its influential factors among Chinese women. Int J Epidemiol (2014) 0.97
Fine mapping of breast cancer genome-wide association studies loci in women of African ancestry identifies novel susceptibility markers. Carcinogenesis (2013) 0.95
Novel Associations between Common Breast Cancer Susceptibility Variants and Risk-Predicting Mammographic Density Measures. Cancer Res (2015) 0.92
Polymorphisms in hormone metabolism and growth factor genes and mammographic density in Norwegian postmenopausal hormone therapy users and non-users. Breast Cancer Res (2012) 0.92
Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170. Nat Genet (2016) 0.92
DART: Denoising Algorithm based on Relevance network Topology improves molecular pathway activity inference. BMC Bioinformatics (2011) 0.91
Estrogen metabolism and mammographic density in postmenopausal women: a cross-sectional study. Cancer Epidemiol Biomarkers Prev (2012) 0.89
Identification of a novel percent mammographic density locus at 12q24. Hum Mol Genet (2012) 0.88
A nonparametric test to detect quantitative trait loci where the phenotypic distribution differs by genotypes. Genet Epidemiol (2013) 0.88
Genome-wide association study of breast cancer in the Japanese population. PLoS One (2013) 0.87
Aromatase inhibitor-induced modulation of breast density: clinical and genetic effects. Br J Cancer (2013) 0.87
Genetic variation in peroxisome proliferator-activated receptor gamma, soy, and mammographic density in Singapore Chinese women. Cancer Epidemiol Biomarkers Prev (2012) 0.86
ZNF365 promotes stability of fragile sites and telomeres. Cancer Discov (2013) 0.83
A genome-wide linkage study of mammographic density, a risk factor for breast cancer. Breast Cancer Res (2011) 0.83
Combined effects of endogenous sex hormone levels and mammographic density on postmenopausal breast cancer risk: results from the Breakthrough Generations Study. Br J Cancer (2014) 0.83
Area and volumetric density estimation in processed full-field digital mammograms for risk assessment of breast cancer. PLoS One (2014) 0.81
Association of CYP2D6 metabolizer status with mammographic density change in response to tamoxifen treatment. Breast Cancer Res (2013) 0.81
Enhancement of mammographic density measures in breast cancer risk prediction. Cancer Epidemiol Biomarkers Prev (2014) 0.80
Genetic association analysis of complex diseases incorporating intermediate phenotype information. PLoS One (2012) 0.79
Gene variations in oestrogen pathways, CYP19A1, daily 17β-estradiol and mammographic density phenotypes in premenopausal women. Breast Cancer Res (2014) 0.79
Raised mammographic density: causative mechanisms and biological consequences. Breast Cancer Res (2016) 0.79
Identification of two novel mammographic density loci at 6Q25.1. Breast Cancer Res (2015) 0.79
Genetic variation in transforming growth factor beta 1 and mammographic density in Singapore Chinese women. Cancer Res (2013) 0.78
Associations between breast density and a panel of single nucleotide polymorphisms linked to breast cancer risk: a cohort study with digital mammography. BMC Cancer (2015) 0.78
Large-scale genotyping identifies a new locus at 22q13.2 associated with female breast size. J Med Genet (2013) 0.78
High mammographic density in women of Ashkenazi Jewish descent. Breast Cancer Res (2013) 0.78
Mammographic density and breast cancer risk by family history in women of white and Asian ancestry. Cancer Causes Control (2015) 0.78
Variation in inflammatory cytokine/growth-factor genes and mammographic density in premenopausal women aged 50-55. PLoS One (2013) 0.76
Mammographic density and breast cancer in women from high risk families. Breast Cancer Res (2015) 0.76
Hormone metabolism pathway genes and mammographic density change after quitting estrogen and progestin combined hormone therapy in the California Teachers Study. Breast Cancer Res (2014) 0.76
The association of copy number variation and percent mammographic density. BMC Res Notes (2015) 0.75
A comprehensive evaluation of interaction between genetic variants and use of menopausal hormone therapy on mammographic density. Breast Cancer Res (2015) 0.75
A comprehensive survey of genetic variation in 20,691 subjects from four large cohorts. PLoS One (2017) 0.75
Stromal characteristics may hold the key to mammographic density: the evidence to date. Oncotarget (2016) 0.75
No evidence for association of inherited variation in genes involved in mitosis and percent mammographic density. Breast Cancer Res (2012) 0.75
Polymorphisms in the estrogen receptor alpha gene (ESR1), daily cycling estrogen and mammographic density phenotypes. BMC Cancer (2016) 0.75
Practical aspects of imputation-driven meta-analysis of genome-wide association studies. Hum Mol Genet (2008) 13.26
Genome-wide association study identifies five new breast cancer susceptibility loci. Nat Genet (2010) 7.62
Heritability of mammographic density, a risk factor for breast cancer. N Engl J Med (2002) 6.19
Mammographic features and breast cancer risk: effects with time, age, and menopause status. J Natl Cancer Inst (1995) 5.35
Association of mammographically defined percent breast density with epidemiologic risk factors for breast cancer (United States). Cancer Causes Control (2000) 2.85
Effects at two years of a low-fat, high-carbohydrate diet on radiologic features of the breast: results from a randomized trial. Canadian Diet and Breast Cancer Prevention Study Group. J Natl Cancer Inst (1997) 2.46
Symmetry of projection in the quantitative analysis of mammographic images. Eur J Cancer Prev (1996) 2.00
Changes in mammographic densities induced by a hormonal contraceptive designed to reduce breast cancer risk. J Natl Cancer Inst (1994) 1.87
Mammographic densities as a marker of human breast cancer risk and their use in chemoprevention. Curr Oncol Rep (2001) 1.78
Macronutrient intake and change in mammographic density at menopause: results from a randomized trial. Cancer Epidemiol Biomarkers Prev (1999) 1.24
Mammographic density as a marker of susceptibility to breast cancer: a hypothesis. IARC Sci Publ (2001) 1.22
Visually assessed breast density, breast cancer risk and the importance of the craniocaudal view. Breast Cancer Res (2008) 1.03
Is mammographic density, as currently measured, a robust surrogate marker for breast cancer? Gynecol Endocrinol (2005) 0.96
A comparison of some anthropometric parameters between an Italian and a UK population: "proof of principle" of a European project using MammoGrid. Clin Radiol (2007) 0.95
Finding the missing heritability of complex diseases. Nature (2009) 67.95
Patterns of somatic mutation in human cancer genomes. Nature (2007) 38.41
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 29.23
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet (2007) 22.96
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat Genet (2007) 21.18
A global map of p53 transcription-factor binding sites in the human genome. Cell (2006) 20.65
International network of cancer genome projects. Nature (2010) 20.35
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Multiple loci identified in a genome-wide association study of prostate cancer. Nat Genet (2008) 17.65
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet (2008) 16.92
Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet (2008) 16.25
Replicating genotype-phenotype associations. Nature (2007) 16.11
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Multiple newly identified loci associated with prostate cancer susceptibility. Nat Genet (2008) 15.43
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet (2009) 15.15
Functional impact of global rare copy number variation in autism spectrum disorders. Nature (2010) 14.66
Mammographic density and the risk and detection of breast cancer. N Engl J Med (2007) 14.32
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet (2004) 14.31
Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nat Genet (2007) 14.05
Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med (2013) 13.92
An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival. Proc Natl Acad Sci U S A (2005) 13.54
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
Statistics in medicine--reporting of subgroup analyses in clinical trials. N Engl J Med (2007) 12.55
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat Genet (2008) 10.49
Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat Genet (2009) 10.34
Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24. Nat Genet (2007) 9.88
Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations. Nat Genet (2002) 9.71
Polygenes, risk prediction, and targeted prevention of breast cancer. N Engl J Med (2008) 9.64
Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA (2010) 9.52
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet (2011) 9.23
PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene. Nat Genet (2006) 9.17
Estimation of effect size distribution from genome-wide association studies and implications for future discoveries. Nat Genet (2010) 9.07
Burden of valvular heart diseases: a population-based study. Lancet (2006) 8.94
Association of risk-reducing surgery in BRCA1 or BRCA2 mutation carriers with cancer risk and mortality. JAMA (2010) 8.93
Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet (2010) 8.89
Polygenic susceptibility to breast cancer and implications for prevention. Nat Genet (2002) 8.89
Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts. Breast Cancer Res (2005) 8.73
Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet (2010) 8.55