Published in Nat Rev Neurosci on June 01, 2007
5-HT4 receptor-mediated neuroprotection and neurogenesis in the enteric nervous system of adult mice. J Neurosci (2009) 2.21
Long-lived intestinal tuft cells serve as colon cancer-initiating cells. J Clin Invest (2014) 1.90
Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease. Nature (2016) 1.62
Hirschsprung-like disease is exacerbated by reduced de novo GMP synthesis. J Clin Invest (2013) 1.52
Enteric nervous system development: migration, differentiation, and disease. Am J Physiol Gastrointest Liver Physiol (2013) 1.46
Neurons refine the Caenorhabditis elegans body plan by directing axial patterning by Wnts. PLoS Biol (2013) 1.44
Development and developmental disorders of the enteric nervous system. Nat Rev Gastroenterol Hepatol (2012) 1.36
Transplanted progenitors generate functional enteric neurons in the postnatal colon. J Clin Invest (2013) 1.32
Development of enteric neuron diversity. J Cell Mol Med (2009) 1.31
Division of labor during trunk neural crest development. Dev Biol (2010) 1.23
Building a brain in the gut: development of the enteric nervous system. Clin Genet (2012) 1.21
Arginylation-dependent neural crest cell migration is essential for mouse development. PLoS Genet (2010) 1.16
Targeting of endothelin receptor-B to the neural crest. Genesis (2008) 1.15
Cell biology of embryonic migration. Birth Defects Res C Embryo Today (2008) 1.14
Colonizing while migrating: how do individual enteric neural crest cells behave? BMC Biol (2014) 1.11
Prospective identification and isolation of enteric nervous system progenitors using Sox2. Stem Cells (2011) 1.11
Phactr4 regulates directional migration of enteric neural crest through PP1, integrin signaling, and cofilin activity. Genes Dev (2012) 1.09
The developmental etiology and pathogenesis of Hirschsprung disease. Transl Res (2013) 1.09
Genetic model system studies of the development of the enteric nervous system, gut motility and Hirschsprung's disease. Neurogastroenterol Motil (2009) 1.07
Vitamin A facilitates enteric nervous system precursor migration by reducing Pten accumulation. Development (2010) 1.07
c-Ret-mediated hearing loss in mice with Hirschsprung disease. Proc Natl Acad Sci U S A (2010) 1.07
Isolation and propagation of enteric neural crest progenitor cells from mouse embryonic stem cells and embryos. Development (2010) 1.07
Human neural crest stem cells derived from human ESCs and induced pluripotent stem cells: induction, maintenance, and differentiation into functional schwann cells. Stem Cells Transl Med (2012) 1.05
Planar cell polarity genes control the connectivity of enteric neurons. J Clin Invest (2013) 1.03
A collagen VI-dependent pathogenic mechanism for Hirschsprung's disease. J Clin Invest (2015) 1.00
Enteric nervous system specific deletion of Foxd3 disrupts glial cell differentiation and activates compensatory enteric progenitors. Dev Biol (2012) 0.99
Building a second brain in the bowel. J Clin Invest (2015) 0.99
Stem cell transplantation in neurodegenerative disorders of the gastrointestinal tract: future or fiction? Gut (2011) 0.98
The timing and location of glial cell line-derived neurotrophic factor expression determine enteric nervous system structure and function. J Neurosci (2010) 0.98
Retinoic acid regulates murine enteric nervous system precursor proliferation, enhances neuronal precursor differentiation, and reduces neurite growth in vitro. Dev Biol (2008) 0.98
Endoderm-derived Sonic hedgehog and mesoderm Hand2 expression are required for enteric nervous system development in zebrafish. Dev Biol (2008) 0.98
Loss of visceral pain following colorectal distension in an endothelin-3 deficient mouse model of Hirschsprung's disease. J Physiol (2011) 0.98
Bone morphogenetic proteins regulate enteric gliogenesis by modulating ErbB3 signaling. Dev Biol (2010) 0.98
Organotypic specificity of key RET adaptor-docking sites in the pathogenesis of neurocristopathies and renal malformations in mice. J Clin Invest (2010) 0.95
RET and NRG1 interplay in Hirschsprung disease. Hum Genet (2013) 0.94
Altered neuronal density and neurotransmitter expression in the ganglionated region of Ednrb null mice: implications for Hirschsprung's disease. Neurogastroenterol Motil (2013) 0.94
A novel corrective pullthrough surgery in a mouse model of Hirschsprung's disease. J Pediatr Surg (2009) 0.94
Genetic background strongly modifies the severity of symptoms of Hirschsprung disease, but not hearing loss in rats carrying Ednrb(sl) mutations. PLoS One (2011) 0.94
Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung disease in mice and humans. J Clin Invest (2011) 0.93
Divergent fate and origin of neurosphere-like bodies from different layers of the gut. Am J Physiol Gastrointest Liver Physiol (2012) 0.91
Functional loss of semaphorin 3C and/or semaphorin 3D and their epistatic interaction with ret are critical to Hirschsprung disease liability. Am J Hum Genet (2015) 0.90
Enteric neurospheres are not specific to neural crest cultures: implications for neural stem cell therapies. PLoS One (2015) 0.90
Deletion of Pten in the mouse enteric nervous system induces ganglioneuromatosis and mimics intestinal pseudoobstruction. J Clin Invest (2009) 0.90
Comprehensive timeline of mesodermal development in the quail small intestine. Dev Dyn (2012) 0.90
Medullary thyroid carcinoma cell lines contain a self-renewing CD133+ population that is dependent on ret proto-oncogene activity. J Clin Endocrinol Metab (2009) 0.90
Balancing neural crest cell intrinsic processes with those of the microenvironment in Tcof1 haploinsufficient mice enables complete enteric nervous system formation. Hum Mol Genet (2012) 0.90
Traditional and targeted exome sequencing reveals common, rare and novel functional deleterious variants in RET-signaling complex in a cohort of living US patients with urinary tract malformations. Hum Genet (2012) 0.89
A bird's eye view of enteric nervous system development: lessons from the avian embryo. Pediatr Res (2008) 0.89
Altered goblet cell differentiation and surface mucus properties in Hirschsprung disease. PLoS One (2014) 0.88
HOXB5 cooperates with NKX2-1 in the transcription of human RET. PLoS One (2011) 0.87
Methylation analysis of EDNRB in human colon tissues of Hirschsprung's disease. Pediatr Surg Int (2013) 0.87
Mammal-restricted elements predispose human RET to folding impairment by HSCR mutations. Nat Struct Mol Biol (2010) 0.87
Expression of PROKR1 and PROKR2 in human enteric neural precursor cells and identification of sequence variants suggest a role in HSCR. PLoS One (2011) 0.86
Regional differences in neural crest morphogenesis. Cell Adh Migr (2011) 0.86
Isolation, expansion and transplantation of postnatal murine progenitor cells of the enteric nervous system. PLoS One (2014) 0.84
The microenvironment in the Hirschsprung's disease gut supports myenteric plexus growth. Int J Colorectal Dis (2012) 0.84
Isogenic enteric neural progenitor cells can replace missing neurons and glia in mice with Hirschsprung disease. Neurogastroenterol Motil (2015) 0.84
Gastrointestinal defects of the Gas1 mutant involve dysregulated Hedgehog and Ret signaling. Biol Open (2012) 0.83
Laminin-1 promotes enteric nervous system development in mouse embryo. Pediatr Surg Int (2013) 0.82
Common genetic variations in Patched1 (PTCH1) gene and risk of hirschsprung disease in the Han Chinese population. PLoS One (2013) 0.82
Gas1 is a receptor for sonic hedgehog to repel enteric axons. Proc Natl Acad Sci U S A (2014) 0.82
Novel association of severe neonatal encephalopathy and Hirschsprung disease in a male with a duplication at the Xq28 region. BMC Med Genet (2010) 0.82
Endothelin receptor B, a candidate gene from human studies at high altitude, improves cardiac tolerance to hypoxia in genetically engineered heterozygote mice. Proc Natl Acad Sci U S A (2015) 0.82
SRY interference of normal regulation of the RET gene suggests a potential role of the Y-chromosome gene in sexual dimorphism in Hirschsprung disease. Hum Mol Genet (2014) 0.81
Non-cell-autonomous effects of Ret deletion in early enteric neurogenesis. Development (2008) 0.81
Smooth muscle proteins from Hirschsprung's disease facilitates stem cell differentiation. Pediatr Surg Int (2012) 0.81
Transplanted skin-derived precursor stem cells generate enteric ganglion-like structures in vivo. J Pediatr Surg (2014) 0.81
Hearing impairments caused by genetic and environmental factors. Environ Health Prev Med (2012) 0.81
Familial Hirschsprung's disease: a systematic review. Pediatr Surg Int (2015) 0.80
Lentiviral labeling of mouse and human enteric nervous system stem cells for regenerative medicine studies. Neurogastroenterol Motil (2014) 0.80
QTL analysis identifies a modifier locus of aganglionosis in the rat model of Hirschsprung disease carrying Ednrb(sl) mutations. PLoS One (2011) 0.80
Travelling within the fetal gut: simple rules for an arduous journey. BMC Biol (2014) 0.80
Circular RNA ZNF609 functions as a competitive endogenous RNA to regulate AKT3 expression by sponging miR-150-5p in Hirschsprung's disease. Oncotarget (2016) 0.79
Partial, selective survival of nitrergic neurons in chagasic megacolon. Histochem Cell Biol (2010) 0.79
Overexpression of Bcl-2 promotes survival and differentiation of neuroepithelial stem cells after transplantation into rat aganglionic colon. Stem Cell Res Ther (2013) 0.79
Surgical Intervention to Rescue Hirschsprung Disease in a Rat Model. J Neurogastroenterol Motil (2015) 0.79
Mice lacking neurofibromin develop gastric hyperplasia. Am J Physiol Gastrointest Liver Physiol (2009) 0.79
Expression and significance of neuroligins in myenteric cells of Cajal in Hirschsprung's disease. PLoS One (2013) 0.79
The KIT gene is associated with the english spotting coat color locus and congenital megacolon in Checkered Giant rabbits (Oryctolagus cuniculus). PLoS One (2014) 0.79
A novel bidirectional interaction between endothelin-3 and retinoic acid in rat enteric nervous system precursors. PLoS One (2013) 0.78
Neuropilin 1 is essential for gastrointestinal smooth muscle contractility and motility in aged mice. PLoS One (2015) 0.78
Tcof1 acts as a modifier of Pax3 during enteric nervous system development and in the pathogenesis of colonic aganglionosis. Hum Mol Genet (2013) 0.78
Abundance and significance of neuroligin-1 and glutamate in Hirschsprung's disease. World J Gastroenterol (2015) 0.78
c-Ret-mediated hearing losses. Int J Clin Exp Pathol (2012) 0.77
NFκB signaling regulates embryonic and adult neurogenesis. Front Biol (Beijing) (2012) 0.77
Enhancer Variants Synergistically Drive Dysfunction of a Gene Regulatory Network In Hirschsprung Disease. Cell (2016) 0.77
Intestinal stem cells and stem cell-based therapy for intestinal diseases. Cytotechnology (2014) 0.77
Mutations in SCG10 are not involved in Hirschsprung disease. PLoS One (2010) 0.77
Retinoblastoma protein prevents enteric nervous system defects and intestinal pseudo-obstruction. J Clin Invest (2013) 0.77
Phactr4: a new integrin modulator required for directional migration of enteric neural crest cells. Cell Adh Migr (2012) 0.77
Expression of dishevelled gene in Hirschsprung's disease. Int J Clin Exp Pathol (2013) 0.77
Human and Murine Tissue-Engineered Colon Exhibit Diverse Neuronal Subtypes and Can Be Populated by Enteric Nervous System Progenitor Cells When Donor Colon Is Aganglionic. Tissue Eng Part A (2015) 0.77
Genotyping analysis of 3 RET polymorphisms demonstrates low somatic mutation rate in Chinese Hirschsprung disease patients. Int J Clin Exp Pathol (2015) 0.77
RET gene is a major risk factor for Hirschsprung's disease: a meta-analysis. Pediatr Surg Int (2015) 0.76
Hirschsprung's disease: clinical dysmorphology, genes, micro-RNAs, and future perspectives. Pediatr Res (2016) 0.76
A novel in vivo model of permanent intestinal aganglionosis. J Surg Res (2014) 0.76
Meis3 is required for neural crest invasion of the gut during zebrafish enteric nervous system development. Mol Biol Cell (2015) 0.76
A genome-wide association study identifies potential susceptibility loci for Hirschsprung disease. PLoS One (2014) 0.75
A durable model of Hirschsprung's colon. J Pediatr Surg (2014) 0.75
Differences in the development of autogenous nerves between the upper and lower urinary tract. Exp Ther Med (2013) 0.75
Spatial genetic patterning of the embryonic neuroepithelium generates GABAergic interneuron diversity in the adult cortex. J Neurosci (2007) 2.90
Lhx6 activity is required for the normal migration and specification of cortical interneuron subtypes. J Neurosci (2007) 2.74
Tyrosine kinase receptor RET is a key regulator of Peyer's patch organogenesis. Nature (2007) 2.65
Glial cells in the mouse enteric nervous system can undergo neurogenesis in response to injury. J Clin Invest (2011) 1.99
Enteric nervous system progenitors are coordinately controlled by the G protein-coupled receptor EDNRB and the receptor tyrosine kinase RET. Neuron (2003) 1.98
Requirement of signalling by receptor tyrosine kinase RET for the directed migration of enteric nervous system progenitor cells during mammalian embryogenesis. Development (2002) 1.92
Neuron and glia generating progenitors of the mammalian enteric nervous system isolated from foetal and postnatal gut cultures. Development (2003) 1.72
The cell-intrinsic requirement of Sox6 for cortical interneuron development. Neuron (2009) 1.66
Loss of forebrain cholinergic neurons and impairment in spatial learning and memory in LHX7-deficient mice. Eur J Neurosci (2005) 1.43
The concerted action of Meox homeobox genes is required upstream of genetic pathways essential for the formation, patterning and differentiation of somites. Development (2003) 1.37
The enteric nervous system. Dev Biol (2012) 1.30
Expression profiling the developing mammalian enteric nervous system identifies marker and candidate Hirschsprung disease genes. Proc Natl Acad Sci U S A (2006) 1.30
Contribution of neural crest-derived cells in the embryonic and adult thymus. J Immunol (2008) 1.30
Sonic hedgehog regulates the proliferation, differentiation, and migration of enteric neural crest cells in gut. J Cell Biol (2004) 1.27
Cdt1 and geminin are down-regulated upon cell cycle exit and are over-expressed in cancer-derived cell lines. Eur J Biochem (2004) 1.27
Phosphotyrosine 1062 is critical for the in vivo activity of the Ret9 receptor tyrosine kinase isoform. Mol Cell Biol (2005) 1.23
LIM homeodomain transcription factor-dependent specification of bipotential MGE progenitors into cholinergic and GABAergic striatal interneurons. Development (2009) 1.22
Interactions between Sox10, Edn3 and Ednrb during enteric nervous system and melanocyte development. Dev Biol (2006) 1.22
Targeted mutation of serine 697 in the Ret tyrosine kinase causes migration defect of enteric neural crest cells. Development (2006) 1.20
Maintenance of mammalian enteric nervous system progenitors by SOX10 and endothelin 3 signalling. Development (2006) 1.19
Hepatic stellate cells do not derive from the neural crest. J Hepatol (2005) 1.19
Enteric nervous system development: Recent progress and future challenges. Auton Neurosci (2009) 1.17
Differential RET signaling pathways drive development of the enteric lymphoid and nervous systems. Sci Signal (2012) 1.11
Prospective identification and isolation of enteric nervous system progenitors using Sox2. Stem Cells (2011) 1.11
Heterogeneity and phenotypic plasticity of glial cells in the mammalian enteric nervous system. Glia (2014) 1.09
Transgenic overexpression of galanin in the dorsal root ganglia modulates pain-related behavior. Proc Natl Acad Sci U S A (2003) 1.05
Maturation-promoting activity of SATB1 in MGE-derived cortical interneurons. Cell Rep (2012) 1.04
The LIM homeodomain transcription factors Lhx6 and Lhx7 are key regulators of mammalian dentition. Dev Biol (2009) 1.03
Planar cell polarity genes control the connectivity of enteric neurons. J Clin Invest (2013) 1.03
Differential geminin requirement for proliferation of thymocytes and mature T cells. J Immunol (2010) 1.00
Transcription factor LIM homeobox 7 (Lhx7) maintains subtype identity of cholinergic interneurons in the mammalian striatum. Proc Natl Acad Sci U S A (2012) 0.95
Geminin regulates cortical progenitor proliferation and differentiation. Stem Cells (2011) 0.95
Transcriptional regulation of cortical interneuron development. J Neurosci (2007) 0.95
The LIM homeodomain protein Lhx6 regulates maturation of interneurons and network excitability in the mammalian cortex. Cereb Cortex (2012) 0.94
Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton. Dev Biol (2009) 0.92
Ret isoform function and marker gene expression in the enteric nervous system is conserved across diverse vertebrate species. Mech Dev (2008) 0.90
Meox1Cre: a mouse line expressing Cre recombinase in somitic mesoderm. Genesis (2005) 0.89
Rac1-dependent cell cycle exit of MGE precursors and GABAergic interneuron migration to the cortex. Cereb Cortex (2011) 0.87
Emerging roles of gut microbiota and the immune system in the development of the enteric nervous system. J Clin Invest (2015) 0.86
Immune and nervous systems: more than just a superficial similarity? Immunity (2009) 0.84
Non-cell-autonomous effects of Ret deletion in early enteric neurogenesis. Development (2008) 0.81
Travelling within the fetal gut: simple rules for an arduous journey. BMC Biol (2014) 0.80
RET/GFRα signals are dispensable for thymic T cell development in vivo. PLoS One (2012) 0.79
Life without geminin. Cell Cycle (2010) 0.79
Ventilatory responses to hypercapnia and hypoxia in heterozygous c-ret newborn mice. Respir Physiol Neurobiol (2002) 0.76
Getting to the guts of enteric nervous system development. Development (2006) 0.75
Corrigendum: Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep. Nature (2017) 0.75