Published in Nature on February 25, 2007
Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets. Nat Immunol (2015) 2.73
New insights into the development of lymphoid tissues. Nat Rev Immunol (2010) 2.64
Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity. Nature (2014) 2.26
Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence. Nature (2016) 2.23
Development of secondary lymphoid organs. Annu Rev Immunol (2008) 2.10
Notch signaling is necessary for adult, but not fetal, development of RORγt(+) innate lymphoid cells. Nat Immunol (2011) 2.09
Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung. J Exp Med (2012) 2.03
Shared dependence on the DNA-binding factor TOX for the development of lymphoid tissue-inducer cell and NK cell lineages. Nat Immunol (2010) 1.97
Genetic analysis of basophil function in vivo. Nat Immunol (2011) 1.82
Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation. Nat Immunol (2009) 1.71
Secondary lymphoid organs: responding to genetic and environmental cues in ontogeny and the immune response. J Immunol (2009) 1.47
Embryonic stromal clones reveal developmental regulators of definitive hematopoietic stem cells. Proc Natl Acad Sci U S A (2007) 1.42
Essential, dose-dependent role for the transcription factor Gata3 in the development of IL-5+ and IL-13+ type 2 innate lymphoid cells. Proc Natl Acad Sci U S A (2013) 1.34
Dynamic imaging of experimental Leishmania donovani-induced hepatic granulomas detects Kupffer cell-restricted antigen presentation to antigen-specific CD8 T cells. PLoS Pathog (2010) 1.32
Peyer's Patches: The Immune Sensors of the Intestine. Int J Inflam (2010) 1.32
Ontogeny of stromal organizer cells during lymph node development. J Immunol (2010) 1.20
Pairing experimentation and computational modeling to understand the role of tissue inducer cells in the development of lymphoid organs. Front Immunol (2012) 1.09
Role of innate lymphocytes in infection and inflammation. Front Immunol (2012) 1.08
Dendritic cells produce CXCL13 and participate in the development of murine small intestine lymphoid tissues. Am J Pathol (2010) 1.06
Two-photon imaging of the immune system. Curr Protoc Cytom (2012) 0.99
Marginal reticular cells: a stromal subset directly descended from the lymphoid tissue organizer. Front Immunol (2012) 0.99
Natural killer receptors: the burden of a name. J Exp Med (2010) 0.98
Neuronal regulation of type 2 innate lymphoid cells via neuromedin U. Nature (2017) 0.98
Intestinal dysbiosis and bacterial enteroinvasion in a murine model of Hirschsprung's disease. J Pediatr Surg (2014) 0.97
Neuro-Immune Interactions at Barrier Surfaces. Cell (2016) 0.96
Colonic patch and colonic SILT development are independent and differentially regulated events. Mucosal Immunol (2012) 0.95
IL-7: the global builder of the innate lymphoid network and beyond, one niche at a time. Semin Immunol (2012) 0.94
Postnatal intestinal engraftment of prospectively selected enteric neural crest stem cells in a rat model of Hirschsprung disease. Neurogastroenterol Motil (2010) 0.93
Impaired Cellular Immunity in the Murine Neural Crest Conditional Deletion of Endothelin Receptor-B Model of Hirschsprung's Disease. PLoS One (2015) 0.92
Inhibition of receptor tyrosine kinases restores immunocompetence and improves immune-dependent chemotherapy against experimental leishmaniasis in mice. J Clin Invest (2010) 0.92
Critical Role for CD103(+)/CD141(+) Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma. Cancer Cell (2016) 0.91
Molecular networks discriminating mouse bladder responses to intravesical bacillus Calmette-Guerin (BCG), LPS, and TNF-alpha. BMC Immunol (2008) 0.89
Induction of intestinal lymphoid tissue formation by intrinsic and extrinsic signals. Semin Immunopathol (2009) 0.88
Mammal-restricted elements predispose human RET to folding impairment by HSCR mutations. Nat Struct Mol Biol (2010) 0.87
An evolving autoimmune microenvironment regulates the quality of effector T cell restimulation and function. Proc Natl Acad Sci U S A (2014) 0.87
Interactions between the intestinal microbiota and innate lymphoid cells. Gut Microbes (2013) 0.86
Using argument notation to engineer biological simulations with increased confidence. J R Soc Interface (2015) 0.86
Emerging roles of gut microbiota and the immune system in the development of the enteric nervous system. J Clin Invest (2015) 0.86
Genomics approach to the analysis of bacterial communities dynamics in Hirschsprung's disease-associated enterocolitis: a pilot study. Pediatr Surg Int (2010) 0.86
Signal regulatory protein α regulates the homeostasis of T lymphocytes in the spleen. J Immunol (2011) 0.85
The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function. Nature (2014) 0.85
B cell: T cell interactions occur within hepatic granulomas during experimental visceral leishmaniasis. PLoS One (2012) 0.85
Hirschsprung's associated enterocolitis. Curr Opin Pediatr (2015) 0.84
Established and emerging concepts in Hirschsprung's-associated enterocolitis. Pediatr Surg Int (2016) 0.84
TNFα-dependent development of lymphoid tissue in the absence of RORγt⁺ lymphoid tissue inducer cells. Mucosal Immunol (2013) 0.83
Intravital imaging of anti-tumor immune response and the tumor microenvironment. Semin Immunopathol (2010) 0.83
Neuroregulator RET initiates Peyer's-patch tissue genesis. Immunity (2007) 0.82
Transplantation of embryonic spleen tissue reveals a role for adult non-lymphoid cells in initiating lymphoid tissue organization. Eur J Immunol (2009) 0.82
The RET/PTC3 oncogene activates classical NF-κB by stabilizing NIK. Oncogene (2010) 0.81
Stromal cell regulation of homeostatic and inflammatory lymphoid organogenesis. Immunology (2013) 0.81
Loss of function of the mouse Sharpin gene results in Peyer's patch regression. PLoS One (2013) 0.81
Stroma cell priming in enteric lymphoid organ morphogenesis. Front Immunol (2012) 0.80
Intravital imaging of a massive lymphocyte response in the cortical dura of mice after peripheral infection by trypanosomes. PLoS Negl Trop Dis (2015) 0.80
The influence of CD4 T-cell subsets on control of CD4 T-cell-mediated graft-versus-host disease. Immunology (2008) 0.80
Cellular Organization of Neuroimmune Interactions in the Gastrointestinal Tract. Trends Immunol (2016) 0.80
RET/GFRα signals are dispensable for thymic T cell development in vivo. PLoS One (2012) 0.79
Induction of RET dependent and independent pro-inflammatory programs in human peripheral blood mononuclear cells from Hirschsprung patients. PLoS One (2013) 0.79
IFNAR1-Signalling Obstructs ICOS-mediated Humoral Immunity during Non-lethal Blood-Stage Plasmodium Infection. PLoS Pathog (2016) 0.78
The cytoskeletal scaffold Shank3 is recruited to pathogen-induced actin rearrangements. Exp Cell Res (2009) 0.78
Tumor-infiltrating lymphocytes are dynamically desensitized to antigen but are maintained by homeostatic cytokine. JCI Insight (2016) 0.78
Utilising a simulation platform to understand the effect of domain model assumptions. Nat Comput (2015) 0.77
Development and Function of Secondary and Tertiary Lymphoid Organs in the Small Intestine and the Colon. Front Immunol (2016) 0.76
Functional and phenotypic heterogeneity of group 3 innate lymphoid cells. Immunology (2016) 0.76
Genetic and epigenetic factors affect RET gene expression in breast cancer cell lines and influence survival in patients. Oncotarget (2016) 0.76
Early IL-1 Signaling Promotes iBALT Induction after Influenza Virus Infection. Front Immunol (2016) 0.75
T Cell Trafficking through Lymphatic Vessels. Front Immunol (2016) 0.75
High Endothelial Venules and Other Blood Vessels: Critical Regulators of Lymphoid Organ Development and Function. Front Immunol (2017) 0.75
Ectopic Tertiary Lymphoid Tissue in Inflammatory Bowel Disease: Protective or Provocateur? Front Immunol (2016) 0.75
Model-Driven Experimentation: A New Approach to Understand Mechanisms of Tertiary Lymphoid Tissue Formation, Function, and Therapeutic Resolution. Front Immunol (2017) 0.75
Programmed death 1 regulates memory phenotype CD4 T cell accumulation, inhibits expansion of the effector memory phenotype subset and modulates production of effector cytokines. PLoS One (2015) 0.75
The mouse cortical meninges are the site of immune responses to many different pathogens, and are accessible to intravital imaging. Methods (2017) 0.75
Ret receptor tyrosine kinase sustains proliferation and tissue maturation in intestinal epithelia. EMBO J (2017) 0.75
The Enteric Network: Interactions between the Immune and Nervous Systems of the Gut. Immunity (2017) 0.75
Transgenic mice with hematopoietic and lymphoid specific expression of Cre. Eur J Immunol (2003) 5.73
The European dimension for the mouse genome mutagenesis program. Nat Genet (2004) 3.84
The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development. Nat Immunol (2009) 3.27
Enteric nervous system development and Hirschsprung's disease: advances in genetic and stem cell studies. Nat Rev Neurosci (2007) 2.97
Spatial genetic patterning of the embryonic neuroepithelium generates GABAergic interneuron diversity in the adult cortex. J Neurosci (2007) 2.90
Lhx6 activity is required for the normal migration and specification of cortical interneuron subtypes. J Neurosci (2007) 2.74
Modulation of heterochromatin protein 1 dynamics in primary Mammalian cells. Science (2003) 2.61
Implantable cardioverter-defibrillators in tetralogy of Fallot. Circulation (2008) 2.52
A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism. Sci Transl Med (2014) 2.51
Mll has a critical role in fetal and adult hematopoietic stem cell self-renewal. Cell Stem Cell (2007) 2.23
The microRNA miR-181 is a critical cellular metabolic rheostat essential for NKT cell ontogenesis and lymphocyte development and homeostasis. Immunity (2013) 2.13
Disparities in enrollment and use of an electronic patient portal. J Gen Intern Med (2011) 2.08
Turnover and proliferation of NK cells in steady state and lymphopenic conditions. J Immunol (2004) 2.07
Glial cells in the mouse enteric nervous system can undergo neurogenesis in response to injury. J Clin Invest (2011) 1.99
Enteric nervous system progenitors are coordinately controlled by the G protein-coupled receptor EDNRB and the receptor tyrosine kinase RET. Neuron (2003) 1.98
Requirement of signalling by receptor tyrosine kinase RET for the directed migration of enteric nervous system progenitor cells during mammalian embryogenesis. Development (2002) 1.92
Polyethyleneimine is a potent mucosal adjuvant for viral glycoprotein antigens. Nat Biotechnol (2012) 1.90
The CD8alpha gene locus is regulated by the Ikaros family of proteins. Mol Cell (2002) 1.79
Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways. J Exp Med (2002) 1.78
Neuron and glia generating progenitors of the mammalian enteric nervous system isolated from foetal and postnatal gut cultures. Development (2003) 1.72
The cell-intrinsic requirement of Sox6 for cortical interneuron development. Neuron (2009) 1.66
CD34(-) cells at the apex of the human hematopoietic stem cell hierarchy have distinctive cellular and molecular signatures. Cell Stem Cell (2013) 1.65
Patient reported barriers to enrolling in a patient portal. J Am Med Inform Assoc (2011) 1.62
Trithorax-group protein ASH1 methylates histone H3 lysine 36. Gene (2007) 1.56
Degenerate self-reactive human T-cell receptor causes spontaneous autoimmune disease in mice. Nat Med (2004) 1.52
Chitin is a size-dependent regulator of macrophage TNF and IL-10 production. J Immunol (2009) 1.49
Symptoms of men and women presenting with acute coronary syndromes. Am J Cardiol (2006) 1.46
Loss of forebrain cholinergic neurons and impairment in spatial learning and memory in LHX7-deficient mice. Eur J Neurosci (2005) 1.43
Variegated expression of CD8 alpha resulting from in situ deletion of regulatory sequences. Immunity (2002) 1.40
Early growth response gene 2 (Egr-2) controls the self-tolerance of T cells and prevents the development of lupuslike autoimmune disease. J Exp Med (2008) 1.38
Identification of a macrophage-specific chromatin signature in the IL-10 locus. J Immunol (2005) 1.37
The concerted action of Meox homeobox genes is required upstream of genetic pathways essential for the formation, patterning and differentiation of somites. Development (2003) 1.37
Alveolar macrophages transport pathogens to lung draining lymph nodes. J Immunol (2009) 1.33
L-selectin shedding does not regulate constitutive T cell trafficking but controls the migration pathways of antigen-activated T lymphocytes. J Exp Med (2003) 1.32
ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses. Nat Immunol (2006) 1.31
The enteric nervous system. Dev Biol (2012) 1.30
Expression profiling the developing mammalian enteric nervous system identifies marker and candidate Hirschsprung disease genes. Proc Natl Acad Sci U S A (2006) 1.30
Contribution of neural crest-derived cells in the embryonic and adult thymus. J Immunol (2008) 1.30
Sonic hedgehog regulates the proliferation, differentiation, and migration of enteric neural crest cells in gut. J Cell Biol (2004) 1.27
HP1-beta is required for development of the cerebral neocortex and neuromuscular junctions. J Cell Biol (2008) 1.27
Cdt1 and geminin are down-regulated upon cell cycle exit and are over-expressed in cancer-derived cell lines. Eur J Biochem (2004) 1.27
Role of T and NK cells and IL7/IL7r interactions during neonatal maturation of lymph nodes. Proc Natl Acad Sci U S A (2006) 1.26
Hepatitis C virus maintains infectivity for weeks after drying on inanimate surfaces at room temperature: implications for risks of transmission. J Infect Dis (2013) 1.26
Noncontact optical imaging in mice with full angular coverage and automatic surface extraction. Appl Opt (2007) 1.23
Phosphotyrosine 1062 is critical for the in vivo activity of the Ret9 receptor tyrosine kinase isoform. Mol Cell Biol (2005) 1.23
Generalized immune activation as a direct result of activated CD4+ T cell killing. J Biol (2009) 1.22
LIM homeodomain transcription factor-dependent specification of bipotential MGE progenitors into cholinergic and GABAergic striatal interneurons. Development (2009) 1.22
Interactions between Sox10, Edn3 and Ednrb during enteric nervous system and melanocyte development. Dev Biol (2006) 1.22
Targeted mutation of serine 697 in the Ret tyrosine kinase causes migration defect of enteric neural crest cells. Development (2006) 1.20
Maintenance of mammalian enteric nervous system progenitors by SOX10 and endothelin 3 signalling. Development (2006) 1.19
Hepatic stellate cells do not derive from the neural crest. J Hepatol (2005) 1.19
TEL-AML1 promotes development of specific hematopoietic lineages consistent with preleukemic activity. Blood (2004) 1.18
Continuous MLL-ENL expression is necessary to establish a "Hox Code" and maintain immortalization of hematopoietic progenitor cells. Cancer Res (2005) 1.18
Enteric nervous system development: Recent progress and future challenges. Auton Neurosci (2009) 1.17
NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells. Nature (2012) 1.16
Three-dimensional in vivo imaging of green fluorescent protein-expressing T cells in mice with noncontact fluorescence molecular tomography. Mol Imaging (2007) 1.15
Rac GTPases play critical roles in early T-cell development. Blood (2008) 1.13
Differential RET signaling pathways drive development of the enteric lymphoid and nervous systems. Sci Signal (2012) 1.11
The relative efficiency of acquisition of MHC:peptide complexes and cross-presentation depends on dendritic cell type. J Immunol (2008) 1.11
Prospective identification and isolation of enteric nervous system progenitors using Sox2. Stem Cells (2011) 1.11
Heterogeneity and phenotypic plasticity of glial cells in the mammalian enteric nervous system. Glia (2014) 1.09
Pairing experimentation and computational modeling to understand the role of tissue inducer cells in the development of lymphoid organs. Front Immunol (2012) 1.09
Transgenic overexpression of galanin in the dorsal root ganglia modulates pain-related behavior. Proc Natl Acad Sci U S A (2003) 1.05
Position effect variegation and imprinting of transgenes in lymphocytes. Nucleic Acids Res (2008) 1.05
Maturation-promoting activity of SATB1 in MGE-derived cortical interneurons. Cell Rep (2012) 1.04
Sudden death and defibrillators in transposition of the great arteries with intra-atrial baffles: a multicenter study. Circ Arrhythm Electrophysiol (2008) 1.04
Insulin induces SOCS-6 expression and its binding to the p85 monomer of phosphoinositide 3-kinase, resulting in improvement in glucose metabolism. J Biol Chem (2004) 1.03
Constitutively active protein kinase B enhances Lck and Erk activities and influences thymocyte selection and activation. J Immunol (2003) 1.03
The LIM homeodomain transcription factors Lhx6 and Lhx7 are key regulators of mammalian dentition. Dev Biol (2009) 1.03
Planar cell polarity genes control the connectivity of enteric neurons. J Clin Invest (2013) 1.03
CD4+CD25+ regulatory cells contribute to the regulation of colonic Th2 granulomatous pathology caused by schistosome infection. PLoS Negl Trop Dis (2011) 1.02
Differential geminin requirement for proliferation of thymocytes and mature T cells. J Immunol (2010) 1.00
Chronic exposure to low levels of antigen in the periphery causes reversible functional impairment correlating with changes in CD5 levels in monoclonal CD8 T cells. J Immunol (2003) 0.99
Natural killer receptors: the burden of a name. J Exp Med (2010) 0.98
Potential of cell therapy to treat pediatric motility disorders. Semin Pediatr Surg (2009) 0.97
Geminin regulates cortical progenitor proliferation and differentiation. Stem Cells (2011) 0.95
Transcriptional regulation of cortical interneuron development. J Neurosci (2007) 0.95
Transcription factor LIM homeobox 7 (Lhx7) maintains subtype identity of cholinergic interneurons in the mammalian striatum. Proc Natl Acad Sci U S A (2012) 0.95
Dual function of histone H3 lysine 36 methyltransferase ASH1 in regulation of Hox gene expression. PLoS One (2011) 0.95
Cutting edge: Nlrp10 is essential for protective antifungal adaptive immunity against Candida albicans. J Immunol (2012) 0.94
The LIM homeodomain protein Lhx6 regulates maturation of interneurons and network excitability in the mammalian cortex. Cereb Cortex (2012) 0.94
The AXH domain adopts alternative folds the solution structure of HBP1 AXH. Structure (2005) 0.93
Carprofen inhibits the release of matrix metalloproteinases 1, 3, and 13 in the secretome of an explant model of articular cartilage stimulated with interleukin 1β. Arthritis Res Ther (2013) 0.93
Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton. Dev Biol (2009) 0.92
Stem cells for GI motility disorders. Curr Opin Pharmacol (2011) 0.92
Genetic heterogeneity in LEOPARD syndrome: two families with no mutations in PTPN11. J Hum Genet (2004) 0.91