Published in Nat Struct Mol Biol on May 21, 2007
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Crk and CrkL adaptor proteins: networks for physiological and pathological signaling. Cell Commun Signal (2009) 1.79
Structural basis for regulation of the Crk signaling protein by a proline switch. Nat Chem Biol (2010) 1.30
Attachment of an NMR-invisible solubility enhancement tag using a sortase-mediated protein ligation method. J Biomol NMR (2009) 1.24
OnD-CRF: predicting order and disorder in proteins using [corrected] conditional random fields. Bioinformatics (2008) 1.13
Emerging roles for crk in human cancer. Genes Cancer (2010) 1.09
Domain organization differences explain Bcr-Abl's preference for CrkL over CrkII. Nat Chem Biol (2012) 1.08
A crucial role in cell spreading for the interaction of Abl PxxP motifs with Crk and Nck adaptors. J Cell Sci (2008) 1.06
The SH2 domain-containing proteins in 21 species establish the provenance and scope of phosphotyrosine signaling in eukaryotes. Sci Signal (2011) 1.03
A specific need for CRKL in p210BCR-ABL-induced transformation of mouse hematopoietic progenitors. Cancer Res (2010) 1.02
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Models of crk adaptor proteins in cancer. Genes Cancer (2012) 0.94
Distinct roles for Crk adaptor isoforms in actin reorganization induced by extracellular signals. J Cell Sci (2009) 0.93
Tuning protein autoinhibition by domain destabilization. Nat Struct Mol Biol (2011) 0.92
A novel molecular dynamics approach to evaluate the effect of phosphorylation on multimeric protein interface: the αB-Crystallin case study. BMC Bioinformatics (2016) 0.90
Molecular mechanisms of SH2- and PTB-domain-containing proteins in receptor tyrosine kinase signaling. Cold Spring Harb Perspect Biol (2013) 0.89
CrkII transgene induces atypical mammary gland development and tumorigenesis. Am J Pathol (2009) 0.87
Phosphorylation of Crk on tyrosine 251 in the RT loop of the SH3C domain promotes Abl kinase transactivation. Oncogene (2011) 0.87
The adaptor proteins p140CAP and p130CAS as molecular hubs in cell migration and invasion of cancer cells. Am J Cancer Res (2011) 0.87
Crk and ABI1: binary molecular switches that regulate abl tyrosine kinase and signaling to the cytoskeleton. Genes Cancer (2012) 0.86
CRK proteins selectively regulate T cell migration into inflamed tissues. J Clin Invest (2015) 0.84
Proteins that bind the Src homology 3 domain of CrkI have distinct roles in Crk transformation. Oncogene (2010) 0.84
Domain cooperativity in multidomain proteins: what can we learn from molecular alignment in anisotropic media? J Biomol NMR (2011) 0.82
Structural biology: CrkL is not Crk-like. Nat Chem Biol (2012) 0.82
Real-time fluorescent resonance energy transfer analysis to monitor drug resistance in chronic myelogenous leukemia. Mol Cancer Ther (2010) 0.82
Structural and functional basis of a role for CRKL in a fibroblast growth factor 8-induced feed-forward loop. Mol Cell Biol (2009) 0.81
Src, p130Cas, and Mechanotransduction in Cancer Cells. Genes Cancer (2012) 0.81
The adaptor protein Crk in immune response. Immunol Cell Biol (2013) 0.81
Genetic susceptibility on CagA-interacting molecules and gene-environment interaction with phytoestrogens: a putative risk factor for gastric cancer. PLoS One (2012) 0.81
Binding cavities and druggability of intrinsically disordered proteins. Protein Sci (2015) 0.80
Moving parts: how the adaptor protein CRK is regulated, and regulates. Nat Struct Mol Biol (2007) 0.79
Iterative tyrosine phosphorylation controls non-canonical domain utilization in Crk. Oncogene (2014) 0.78
Crk adaptors negatively regulate actin polymerization in pedestals formed by enteropathogenic Escherichia coli (EPEC) by binding to Tir effector. PLoS Pathog (2014) 0.78
Functional mechanisms and roles of adaptor proteins in abl-regulated cytoskeletal actin dynamics. J Signal Transduct (2012) 0.77
Secondary structure, a missing component of sequence-based minimotif definitions. PLoS One (2012) 0.77
Cyclophilin A promotes cell migration via the Abl-Crk signaling pathway. Nat Chem Biol (2015) 0.77
Role of Exosomal Noncoding RNAs in Lung Carcinogenesis. Biomed Res Int (2015) 0.77
Analysis of an independent tumor suppressor locus telomeric to Tp53 suggested Inpp5k and Myo1c as novel tumor suppressor gene candidates in this region. BMC Genet (2015) 0.77
Reciprocal regulation of Abl kinase by Crk Y251 and Abi1 controls invasive phenotypes in glioblastoma. Oncotarget (2015) 0.77
What's in a loop? Cell Commun Signal (2012) 0.76
Contribution of Crk adaptor proteins to host cell and bacteria interactions. Biomed Res Int (2014) 0.76
Prolyl isomerization as a molecular memory in the allosteric regulation of the signal adapter protein c-CrkII. J Biol Chem (2014) 0.75
A pre-metazoan origin of the CRK gene family and co-opted signaling network. Sci Rep (2016) 0.75
Molecular dynamics of the proline switch and its role in Crk signaling. J Phys Chem B (2014) 0.75
The Role of Crk Adaptor Proteins in T-Cell Adhesion and Migration. Front Immunol (2015) 0.75
A lack of peptide binding and decreased thermostability suggests that the CASKIN2 scaffolding protein SH3 domain may be vestigial. BMC Struct Biol (2016) 0.75
Ligand-driven conformational changes of MurD visualized by paramagnetic NMR. Sci Rep (2015) 0.75
Tyr724 phosphorylation of ELMO1 by Src is involved in cell spreading and migration via Rac1 activation. Cell Commun Signal (2015) 0.75
Bcl6 mediates the development of T follicular helper cells. Science (2009) 8.50
The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy. J Biol Chem (2007) 6.28
Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses. Mol Cell (2008) 5.20
Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions. Nat Med (2011) 4.50
Structural basis of target recognition by Atg8/LC3 during selective autophagy. Genes Cells (2008) 3.23
Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse. Proc Natl Acad Sci U S A (2008) 3.17
Atg8-family interacting motif crucial for selective autophagy. FEBS Lett (2010) 2.83
Triggering neural differentiation of ES cells by subtype switching of importin-alpha. Nat Cell Biol (2006) 2.64
Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors. Proc Natl Acad Sci U S A (2012) 2.61
PILRalpha is a herpes simplex virus-1 entry coreceptor that associates with glycoprotein B. Cell (2008) 2.49
Identification of Ser-386 of interferon regulatory factor 3 as critical target for inducible phosphorylation that determines activation. J Biol Chem (2003) 2.45
Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization. Mol Cell Biol (2005) 2.44
The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy. EMBO J (2009) 2.25
Structure of Atg5.Atg16, a complex essential for autophagy. J Biol Chem (2006) 2.18
Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation. J Biol Chem (2004) 2.01
The crystal structure of microtubule-associated protein light chain 3, a mammalian homologue of Saccharomyces cerevisiae Atg8. Genes Cells (2004) 1.98
X-ray crystal structure of IRF-3 and its functional implications. Nat Struct Biol (2003) 1.88
Crk and CrkL adaptor proteins: networks for physiological and pathological signaling. Cell Commun Signal (2009) 1.79
The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease. J Biol Chem (2003) 1.78
Tertiary structure-function analysis reveals the pathogenic signaling potentiation mechanism of Helicobacter pylori oncogenic effector CagA. Cell Host Microbe (2012) 1.72
Structural basis for the specificity and catalysis of human Atg4B responsible for mammalian autophagy. J Biol Chem (2005) 1.70
Solution structures of cytosolic RNA sensor MDA5 and LGP2 C-terminal domains: identification of the RNA recognition loop in RIG-I-like receptors. J Biol Chem (2009) 1.68
The crystal structure of plant ATG12 and its biological implication in autophagy. Autophagy (2005) 1.63
Commitment of bone marrow cells to hepatic stellate cells in mouse. J Hepatol (2004) 1.62
The crystal structure of Atg3, an autophagy-related ubiquitin carrier protein (E2) enzyme that mediates Atg8 lipidation. J Biol Chem (2007) 1.55
Crystallographic and NMR evidence for flexibility in oligosaccharyltransferases and its catalytic significance. Structure (2012) 1.52
Rapid immunohistochemistry based on alternating current electric field for intraoperative diagnosis of brain tumors. Brain Tumor Pathol (2014) 1.49
Characterization of the Atg17-Atg29-Atg31 complex specifically required for starvation-induced autophagy in Saccharomyces cerevisiae. Biochem Biophys Res Commun (2009) 1.44
In vitro reconstitution of plant Atg8 and Atg12 conjugation systems essential for autophagy. J Biol Chem (2007) 1.43
CNS lymphomatoid granulomatosis with lymph node and bone marrow involvements. Neuropathology (2008) 1.40
Structural basis of Atg8 activation by a homodimeric E1, Atg7. Mol Cell (2011) 1.38
Total synthesis of (±)-meloscine. Org Lett (2011) 1.38
Azathioprine suppresses ezrin-radixin-moesin-dependent T cell-APC conjugation through inhibition of Vav guanosine exchange activity on Rac proteins. J Immunol (2006) 1.36
Advances in high-resolution imaging and computational unfolding of the human hippocampus. Neuroimage (2009) 1.30
Oxidative stress in skeletal muscle impairs mitochondrial respiration and limits exercise capacity in type 2 diabetic mice. Am J Physiol Heart Circ Physiol (2009) 1.28
Natural killer T cells accelerate atherogenesis in mice. Blood (2004) 1.28
Promoter hypomethylation regulates CD133 expression in human gliomas. Cell Res (2008) 1.27
The human polyoma JC virus agnoprotein acts as a viroporin. PLoS Pathog (2010) 1.26
Oligosaccharides as receptors for JC virus. J Virol (2002) 1.25
Attachment of an NMR-invisible solubility enhancement tag using a sortase-mediated protein ligation method. J Biomol NMR (2009) 1.24
Autoinhibition and phosphorylation-induced activation mechanisms of human cancer and autoimmune disease-related E3 protein Cbl-b. Proc Natl Acad Sci U S A (2011) 1.21
The JAK inhibitor tofacitinib regulates synovitis through inhibition of interferon-γ and interleukin-17 production by human CD4+ T cells. Arthritis Rheum (2011) 1.20
Autophagy-related protein 8 (Atg8) family interacting motif in Atg3 mediates the Atg3-Atg8 interaction and is crucial for the cytoplasm-to-vacuole targeting pathway. J Biol Chem (2010) 1.20
Molecular recognition in dimerization between PB1 domains. J Biol Chem (2003) 1.18
Dimeric coiled-coil structure of Saccharomyces cerevisiae Atg16 and its functional significance in autophagy. J Biol Chem (2009) 1.17
Smad2 positively regulates the generation of Th17 cells. J Biol Chem (2010) 1.17
Solution structure of atypical protein kinase C PB1 domain and its mode of interaction with ZIP/p62 and MEK5. J Biol Chem (2004) 1.17
High incidence of human herpesvirus 6 infection with a high viral load in cord blood stem cell transplant recipients. Blood (2002) 1.17
Structural basis for the antiproliferative activity of the Tob-hCaf1 complex. J Biol Chem (2009) 1.16
Role of mast cells and basophils in IgE responses and in allergic airway hyperresponsiveness. J Immunol (2012) 1.15
The 3' enhancer CNS2 is a critical regulator of interleukin-4-mediated humoral immunity in follicular helper T cells. Immunity (2012) 1.14
Structure-based analyses reveal distinct binding sites for Atg2 and phosphoinositides in Atg18. J Biol Chem (2012) 1.13
Syndecan-4 prevents cardiac rupture and dysfunction after myocardial infarction. Circ Res (2011) 1.12
Atg12-Atg5 conjugate enhances E2 activity of Atg3 by rearranging its catalytic site. Nat Struct Mol Biol (2013) 1.11
Large T antigen promotes JC virus replication in G2-arrested cells by inducing ATM- and ATR-mediated G2 checkpoint signaling. J Biol Chem (2009) 1.11
IL-7/STAT5 cytokine signaling pathway is essential but insufficient for maintenance of naive CD4 T cell survival in peripheral lymphoid organs. J Immunol (2007) 1.11
Identification of FEZ1 as a protein that interacts with JC virus agnoprotein and microtubules: role of agnoprotein-induced dissociation of FEZ1 from microtubules in viral propagation. J Biol Chem (2005) 1.11
Dissociation of heterochromatin protein 1 from lamin B receptor induced by human polyomavirus agnoprotein: role in nuclear egress of viral particles. EMBO Rep (2005) 1.10
Segmental and full paternal isodisomy for chromosome 14 in three patients: narrowing the critical region and implication for the clinical features. Am J Med Genet A (2005) 1.10
STAT3 inhibition overcomes temozolomide resistance in glioblastoma by downregulating MGMT expression. Mol Cancer Ther (2012) 1.10
Differential oncogenic potential of geographically distinct Helicobacter pylori CagA isoforms in mice. Int J Cancer (2009) 1.09
Autophagy-related protein 32 acts as autophagic degron and directly initiates mitophagy. J Biol Chem (2012) 1.09
Structure of a cell polarity regulator, a complex between atypical PKC and Par6 PB1 domains. J Biol Chem (2004) 1.09
ATG systems from the protein structural point of view. Chem Rev (2009) 1.09
ApoE gene deficiency enhances the reduction of bone formation induced by a high-fat diet through the stimulation of p53-mediated apoptosis in osteoblastic cells. J Bone Miner Res (2007) 1.08
Harlequin ichthyosis model mouse reveals alveolar collapse and severe fetal skin barrier defects. Hum Mol Genet (2008) 1.07
A molecular mechanism for autoinhibition of the tandem SH3 domains of p47phox, the regulatory subunit of the phagocyte NADPH oxidase. Genes Cells (2004) 1.07
Structure of the Atg12-Atg5 conjugate reveals a platform for stimulating Atg8-PE conjugation. EMBO Rep (2012) 1.07
Elmo1 inhibits ubiquitylation of Dock180. J Cell Sci (2006) 1.06
Sustained elevation of Snail promotes glial-mesenchymal transition after irradiation in malignant glioma. Neuro Oncol (2013) 1.06
Thy1-positive mesenchymal cells promote the maturation of CD49f-positive hepatic progenitor cells in the mouse fetal liver. Hepatology (2004) 1.05
Expression of JC virus agnoprotein in progressive multifocal leukoencephalopathy brain. Acta Neuropathol (2002) 1.05
A novel FRET-based biosensor for the measurement of BCR-ABL activity and its response to drugs in living cells. Clin Cancer Res (2010) 1.04
DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines. Blood (2002) 1.04
SRC signaling is crucial in the growth of synovial sarcoma cells. Cancer Res (2013) 1.03
Molecular and immunohistochemical analysis of signaling adaptor protein Crk in human cancers. Cancer Lett (2002) 1.03
Crystal structure of the C-terminal globular domain of oligosaccharyltransferase from Archaeoglobus fulgidus at 1.75 Å resolution. Biochemistry (2012) 1.03
Membrane-dependent modulation of the mTOR activator Rheb: NMR observations of a GTPase tethered to a lipid-bilayer nanodisc. J Am Chem Soc (2013) 1.02
CrkL directs ASAP1 to peripheral focal adhesions. J Biol Chem (2003) 1.02