Published in Nat Rev Cancer on November 24, 2010
The blood-testis barrier and its implications for male contraception. Pharmacol Rev (2011) 2.10
RAC1 activation mediates Twist1-induced cancer cell migration. Nat Cell Biol (2012) 1.69
New insights into pre-BCR and BCR signalling with relevance to B cell malignancies. Nat Rev Immunol (2013) 1.66
A multiscale statistical mechanical framework integrates biophysical and genomic data to assemble cancer networks. Nat Genet (2014) 1.65
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. Nat Genet (2014) 1.41
Neuropilins are multifunctional coreceptors involved in tumor initiation, growth, metastasis and immunity. Oncotarget (2012) 1.37
Insulin-like growth factor-binding protein 2-driven glioma progression is prevented by blocking a clinically significant integrin, integrin-linked kinase, and NF-κB network. Proc Natl Acad Sci U S A (2012) 1.37
Targeting tumor cell motility to prevent metastasis. Adv Drug Deliv Rev (2011) 1.32
Extracellular inhibitors, repellents, and semaphorin/plexin/MICAL-mediated actin filament disassembly. Cytoskeleton (Hoboken) (2011) 1.12
ILK: a pseudokinase in the center stage of cell-matrix adhesion and signaling. Curr Opin Cell Biol (2012) 1.10
Prostaglandins in cancer cell adhesion, migration, and invasion. Int J Cell Biol (2012) 1.09
Modulation of dorsal root ganglion development by ErbB signaling and the scaffold protein Sorbs3. Development (2013) 1.09
Domain organization differences explain Bcr-Abl's preference for CrkL over CrkII. Nat Chem Biol (2012) 1.08
Dense fibrillar collagen is a potent inducer of invadopodia via a specific signaling network. J Cell Biol (2015) 1.07
miR-145 functions as tumor suppressor and targets two oncogenes, ANGPT2 and NEDD9, in renal cell carcinoma. J Cancer Res Clin Oncol (2014) 1.07
Overcoming EMT-associated resistance to anti-cancer drugs via Src/FAK pathway inhibition. Oncotarget (2014) 1.07
Adhesion to fibronectin regulates Hippo signaling via the FAK-Src-PI3K pathway. J Cell Biol (2015) 1.05
miR-31 is a broad regulator of β1-integrin expression and function in cancer cells. Mol Cancer Res (2011) 1.05
Fibronectin extra domain A (EDA) sustains CD133(+)/CD44(+) subpopulation of colorectal cancer cells. Stem Cell Res (2013) 1.00
Comprehensive analysis of BRCA1, BRCA2 and TP53 germline mutation and tumor characterization: a portrait of early-onset breast cancer in Brazil. PLoS One (2013) 0.99
Biochemical, proteomic, structural, and thermodynamic characterizations of integrin-linked kinase (ILK): cross-validation of the pseudokinase. J Biol Chem (2011) 0.99
NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling. Nat Struct Mol Biol (2011) 0.97
Cortactin as a target for FAK in the regulation of focal adhesion dynamics. PLoS One (2012) 0.97
New signaling pathways govern the host response to C. albicans infection in various niches. Genome Res (2015) 0.96
Proteomic cornerstones of hematopoietic stem cell differentiation: distinct signatures of multipotent progenitors and myeloid committed cells. Mol Cell Proteomics (2012) 0.96
Models of crk adaptor proteins in cancer. Genes Cancer (2012) 0.94
β1 integrin: an emerging player in the modulation of tumorigenesis and response to therapy. Cell Adh Migr (2012) 0.94
Cysteine-rich protein 61 (CCN1) domain-specific stimulation of matrix metalloproteinase-1 expression through αVβ3 integrin in human skin fibroblasts. J Biol Chem (2013) 0.93
Protein tyrosine phosphatase α phosphotyrosyl-789 binds BCAR3 to position Cas for activation at integrin-mediated focal adhesions. Mol Cell Biol (2012) 0.92
Novel Axl-driven signaling pathway and molecular signature characterize high-grade ovarian cancer patients with poor clinical outcome. Oncotarget (2015) 0.91
Regulation of p130(Cas)/BCAR1 expression in tamoxifen-sensitive and tamoxifen-resistant breast cancer cells by EGR1 and NAB2. Neoplasia (2012) 0.91
BCAR3/AND-34 can signal independent of complex formation with CAS family members or the presence of p130Cas. Cell Signal (2011) 0.91
Breast cancer antiestrogen resistance 3 (BCAR3) promotes cell motility by regulating actin cytoskeletal and adhesion remodeling in invasive breast cancer cells. PLoS One (2013) 0.89
The β1-integrin-p-FAK-p130Cas-DOCK180-RhoA-vinculin is a novel regulatory protein complex at the apical ectoplasmic specialization in adult rat testes. Spermatogenesis (2011) 0.88
CCN1 contributes to skin connective tissue aging by inducing age-associated secretory phenotype in human skin dermal fibroblasts. J Cell Commun Signal (2011) 0.88
Spatial-temporal reorganization of activated integrins. Cell Adh Migr (2012) 0.88
Integrin signaling in mammary epithelial cells and breast cancer. ISRN Oncol (2012) 0.88
Disclosure of erlotinib as a multikinase inhibitor in pancreatic ductal adenocarcinoma. Neoplasia (2011) 0.88
Identification of p130Cas/ErbB2-dependent invasive signatures in transformed mammary epithelial cells. Cell Cycle (2013) 0.87
The adaptor proteins p140CAP and p130CAS as molecular hubs in cell migration and invasion of cancer cells. Am J Cancer Res (2011) 0.87
Integrin αβ1, αvβ, α6β effectors p130Cas, Src and talin regulate carcinoma invasion and chemoresistance. Biochem Biophys Res Commun (2011) 0.87
Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5. Nat Commun (2015) 0.87
p130Cas/Cyclooxygenase-2 axis in the control of mesenchymal plasticity of breast cancer cells. Breast Cancer Res (2012) 0.86
Phosphatase of regenerating liver 3 (PRL3) provokes a tyrosine phosphoproteome to drive prometastatic signal transduction. Mol Cell Proteomics (2013) 0.86
Acquisition of the metastatic phenotype is accompanied by H2O2-dependent activation of the p130Cas signaling complex. Mol Cancer Res (2013) 0.86
αV integrin induces multicellular radioresistance in human nasopharyngeal carcinoma via activating SAPK/JNK pathway. PLoS One (2012) 0.86
PRK1/PKN1 controls migration and metastasis of androgen-independent prostate cancer cells. Oncotarget (2014) 0.85
Integrin-linked kinase regulates the niche of quiescent epidermal stem cells. Nat Commun (2015) 0.85
LPA Stimulates the Phosphorylation of p130Cas via Gαi2 in Ovarian Cancer Cells. Genes Cancer (2012) 0.85
Collagen XV inhibits epithelial to mesenchymal transition in pancreatic adenocarcinoma cells. PLoS One (2013) 0.85
Rsu1 contributes to regulation of cell adhesion and spreading by PINCH1-dependent and - independent mechanisms. J Cell Commun Signal (2013) 0.84
Identification of two regions in the p140Cap adaptor protein that retain the ability to suppress tumor cell properties. Am J Cancer Res (2013) 0.84
NSP-CAS Protein Complexes: Emerging Signaling Modules in Cancer. Genes Cancer (2012) 0.84
Sema6A and Mical1 control cell growth and survival of BRAFV600E human melanoma cells. Oncotarget (2015) 0.83
Cas and NEDD9 Contribute to Tumor Progression through Dynamic Regulation of the Cytoskeleton. Genes Cancer (2012) 0.83
FH535 inhibited migration and growth of breast cancer cells. PLoS One (2012) 0.83
p53-mediated activation of the mitochondrial protease HtrA2/Omi prevents cell invasion. J Cell Biol (2014) 0.83
Cas proteins: dodgy scaffolding in breast cancer. Breast Cancer Res (2014) 0.83
Adaptors for disorders of the brain? The cancer signaling proteins NEDD9, CASS4, and PTK2B in Alzheimer's disease. Oncoscience (2014) 0.82
CAS proteins in health and disease: an update. IUBMB Life (2014) 0.82
p130Cas acts as survival factor during PMA-induced apoptosis in HL-60 promyelocytic leukemia cells. Int J Biochem Cell Biol (2012) 0.82
Bioinformatic approaches to augment study of epithelial-to-mesenchymal transition in lung cancer. Physiol Genomics (2014) 0.82
A novel tumor suppressor function of Kindlin-3 in solid cancer. Oncotarget (2014) 0.81
Mapping of p140Cap phosphorylation sites: the EPLYA and EGLYA motifs have a key role in tyrosine phosphorylation and Csk binding, and are substrates of the Abl kinase. PLoS One (2013) 0.81
Src, p130Cas, and Mechanotransduction in Cancer Cells. Genes Cancer (2012) 0.81
Pancreatic Cancer Genetics. Int J Biol Sci (2016) 0.81
An increase in integrin-linked kinase non-canonically confers NF-κB-mediated growth advantages to gastric cancer cells by activating ERK1/2. Cell Commun Signal (2014) 0.81
Preclinical and clinical studies of the NEDD9 scaffold protein in cancer and other diseases. Gene (2015) 0.81
Expression of a phosphorylated substrate domain of p130Cas promotes PyMT-induced c-Src-dependent murine breast cancer progression. Carcinogenesis (2013) 0.81
New insights into FAK function and regulation during spermatogenesis. Histol Histopathol (2014) 0.80
Stromal cells promote anti-estrogen resistance of breast cancer cells through an insulin-like growth factor binding protein 5 (IGFBP5)/B-cell leukemia/lymphoma 3 (Bcl-3) axis. Oncotarget (2015) 0.80
Novel compound 1,3-bis (3,5-dichlorophenyl) urea inhibits lung cancer progression. Biochem Pharmacol (2013) 0.80
The integrin signalling adaptor p130CAS is also a key player in prostate cancer. Nat Rev Cancer (2011) 0.80
A critical role for p130Cas in the progression of pulmonary hypertension in humans and rodents. Am J Respir Crit Care Med (2012) 0.79
Low expression of Abelson interactor-1 is linked to acquired drug resistance in Bcr-Abl-induced leukemia. Leukemia (2014) 0.79
Prometastatic NEDD9 Regulates Individual Cell Migration via Caveolin-1-Dependent Trafficking of Integrins. Mol Cancer Res (2014) 0.79
Redox signaling at invasive microdomains in cancer cells. Free Radic Biol Med (2011) 0.79
High-prevalence and broad spectrum of Cell Adhesion and Extracellular Matrix gene pathway mutations in epithelial ovarian cancer. J Clin Bioinforma (2012) 0.79
Oligodendroglial p130Cas is a target of Fyn kinase involved in process formation, cell migration and survival. PLoS One (2014) 0.78
Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-κB Signaling. PLoS One (2015) 0.78
P130Cas attenuates epidermal growth factor (EGF) receptor internalization by modulating EGF-triggered dynamin phosphorylation. PLoS One (2011) 0.78
Profiling, Bioinformatic, and Functional Data on the Developing Olfactory/GnRH System Reveal Cellular and Molecular Pathways Essential for This Process and Potentially Relevant for the Kallmann Syndrome. Front Endocrinol (Lausanne) (2013) 0.78
Epidemiology and Inherited Predisposition for Sporadic Pancreatic Adenocarcinoma. Hematol Oncol Clin North Am (2015) 0.77
Expression pattern of bcar3, a downstream target of Gata2, and its binding partner, bcar1, during Xenopus development. Gene Expr Patterns (2015) 0.77
Identification of Novel Crk-associated Substrate (p130Cas) Variants with Functionally Distinct Focal Adhesion Kinase Binding Activities. J Biol Chem (2015) 0.77
NEDD9/Arf6-dependent endocytic trafficking of matrix metalloproteinase 14: a novel mechanism for blocking mesenchymal cell invasion and metastasis of breast cancer. Oncogene (2014) 0.77
Protein Tyrosine Kinase 6 Regulates UVB-Induced Signaling and Tumorigenesis in Mouse Skin. J Invest Dermatol (2015) 0.77
Proteasome inhibition, the pursuit of new cancer therapeutics, and the adaptor molecule p130Cas. BMC Biol (2011) 0.76
Using Pharmacokinetic Profiles and Digital Quantification of Stained Tissue Microarrays as a Medium-Throughput, Quantitative Method for Measuring the Kinetics of Early Signaling Changes Following Integrin-Linked Kinase Inhibition in an In Vivo Model of Cancer. J Histochem Cytochem (2015) 0.76
p130Cas over-expression impairs mammary branching morphogenesis in response to estrogen and EGF. PLoS One (2012) 0.76
Illustrating the interplay between the extracellular matrix and microRNAs. Int J Exp Pathol (2014) 0.76
p130Cas scaffold protein regulates ErbB2 stability by altering breast cancer cell sensitivity to autophagy. Oncotarget (2016) 0.76
Rsu1 contributes to cell adhesion and spreading in MCF10A cells via effects on P38 map kinase signaling. Cell Adh Migr (2014) 0.76
PTP1B inhibitor promotes endothelial cell motility by activating the DOCK180/Rac1 pathway. Sci Rep (2016) 0.75
Oncogenic Signaling Adaptor Proteins. J Genet Genomics (2015) 0.75
Migfilin, α-parvin and β-parvin are differentially expressed in ovarian serous carcinoma effusions, primary tumors and solid metastases. Gynecol Oncol (2012) 0.75
Ezrin Is Associated with Disease Progression in Ovarian Carcinoma. PLoS One (2016) 0.75
Temporal Phosphoproteome Dynamics Induced by an ATP Synthase Inhibitor Citreoviridin. Mol Cell Proteomics (2015) 0.75
Hydrogel Microwell Arrays Allow the Assessment of Protease-Associated Enhancement of Cancer Cell Aggregation and Survival. Microarrays (Basel) (2013) 0.75
The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries. Nat Commun (2017) 0.75
Epithelial-mesenchymal transitions in development and disease. Cell (2009) 39.17
Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol (2006) 23.04
TGFbeta in Cancer. Cell (2008) 17.44
Integrins in cancer: biological implications and therapeutic opportunities. Nat Rev Cancer (2010) 11.16
Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat Rev Mol Cell Biol (2008) 8.99
Force sensing by mechanical extension of the Src family kinase substrate p130Cas. Cell (2006) 7.35
Rac activation and inactivation control plasticity of tumor cell movement. Cell (2008) 6.01
New signals from the invasive front. Nature (2006) 5.51
Random versus directionally persistent cell migration. Nat Rev Mol Cell Biol (2009) 4.99
Mutant p53 drives invasion by promoting integrin recycling. Cell (2009) 4.75
Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene. Cell (2006) 4.68
ILK, PINCH and parvin: the tIPP of integrin signalling. Nat Rev Mol Cell Biol (2006) 4.64
Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility. Nat Cell Biol (2009) 4.39
Integrin-linked kinase: a cancer therapeutic target unique among its ILK. Nat Rev Cancer (2005) 3.83
Identification of genes that regulate epithelial cell migration using an siRNA screening approach. Nat Cell Biol (2008) 3.72
Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity. Neuron (2009) 3.54
Integrins: masters and slaves of endocytic transport. Nat Rev Mol Cell Biol (2009) 3.52
Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas. Nat Genet (1998) 3.38
p130Cas: a versatile scaffold in signaling networks. Trends Cell Biol (2006) 2.84
Stretchy proteins on stretchy substrates: the important elements of integrin-mediated rigidity sensing. Dev Cell (2010) 2.65
Signal co-operation between integrins and other receptor systems. Biochem J (2009) 2.59
Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling. J Clin Invest (2009) 2.55
Integrin-linked kinase--essential roles in physiology and cancer biology. J Cell Sci (2008) 2.43
E-cadherin-mediated adhesion inhibits ligand-dependent activation of diverse receptor tyrosine kinases. EMBO J (2004) 2.38
Two species of human CRK cDNA encode proteins with distinct biological activities. Mol Cell Biol (1992) 2.30
BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells. J Natl Cancer Inst (2000) 2.29
Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK. Nat Struct Mol Biol (2007) 2.22
MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines. Biochem Biophys Res Commun (2008) 2.15
An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression. Nat Med (2009) 2.10
The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase! EMBO J (2009) 2.10
Proteomic analysis of in vivo phosphorylated synaptic proteins. J Biol Chem (2004) 1.99
HEF1 is a necessary and specific downstream effector of FAK that promotes the migration of glioblastoma cells. Oncogene (2006) 1.94
Growth control by intracellular tension and extracellular stiffness. Trends Cell Biol (2008) 1.93
p130Cas as a new regulator of mammary epithelial cell proliferation, survival, and HER2-neu oncogene-dependent breast tumorigenesis. Cancer Res (2006) 1.92
Mechanisms of CAS substrate domain tyrosine phosphorylation by FAK and Src. Mol Cell Biol (2001) 1.91
A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction. J Cell Biol (2001) 1.84
E-cadherin homophilic ligation inhibits cell growth and epidermal growth factor receptor signaling independently of other cell interactions. Mol Biol Cell (2007) 1.84
CAS proteins in normal and pathological cell growth control. Cell Mol Life Sci (2009) 1.84
PINCH-1 is an obligate partner of integrin-linked kinase (ILK) functioning in cell shape modulation, motility, and survival. J Biol Chem (2003) 1.82
Crk and CrkL adaptor proteins: networks for physiological and pathological signaling. Cell Commun Signal (2009) 1.79
beta 1 integrin function in vivo: adhesion, migration and more. Cancer Metastasis Rev (2005) 1.79
Crk-associated substrate tyrosine phosphorylation sites are critical for invasion and metastasis of SRC-transformed cells. Mol Cancer Res (2005) 1.77
Forcing form and function: biomechanical regulation of tumor evolution. Trends Cell Biol (2010) 1.77
Isolation and chromosomal localization of CRKL, a human crk-like gene. Oncogene (1993) 1.76
Inhibitors of cyclo-oxygenase 2: a new class of anticancer agents? Lancet Oncol (2003) 1.70
Proximal protein tyrosine kinases in immunoreceptor signaling. Curr Opin Immunol (2001) 1.67
Collagen I-mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1. J Cell Biol (2008) 1.66
The pseudoactive site of ILK is essential for its binding to alpha-Parvin and localization to focal adhesions. Mol Cell (2009) 1.62
Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers. J Biol Chem (2002) 1.62
Collagen I promotes metastasis in pancreatic cancer by activating c-Jun NH(2)-terminal kinase 1 and up-regulating N-cadherin expression. Cancer Res (2006) 1.61
v-Crk activates the phosphoinositide 3-kinase/AKT pathway in transformation. Proc Natl Acad Sci U S A (2000) 1.61
Density-dependent inhibition of growth involves prevention of EGF receptor activation by E-cadherin-mediated cell-cell adhesion. Exp Cell Res (1996) 1.60
Fibronectin rigidity response through Fyn and p130Cas recruitment to the leading edge. Mol Biol Cell (2006) 1.58
The integrin linked kinase (ILK) induces an invasive phenotype via AP-1 transcription factor-dependent upregulation of matrix metalloproteinase 9 (MMP-9). Oncogene (2000) 1.58
Integrin-linked kinase is an adaptor with essential functions during mouse development. Nature (2009) 1.55
Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization. J Cell Biol (2008) 1.53
NEDD9 promotes oncogenic signaling in mammary tumor development. Cancer Res (2009) 1.53
SNIP, a novel SNAP-25-interacting protein implicated in regulated exocytosis. J Biol Chem (2000) 1.45
Mammary epithelial-specific expression of the integrin-linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice. Oncogene (2001) 1.42
Integration of cell attachment, cytoskeletal localization, and signaling by integrin-linked kinase (ILK), CH-ILKBP, and the tumor suppressor PTEN. Mol Biol Cell (2003) 1.38
p130Cas is required for mammary tumor growth and transforming growth factor-beta-mediated metastasis through regulation of Smad2/3 activity. J Biol Chem (2009) 1.37
Integrin-linked kinase expression increases with prostate tumor grade. Clin Cancer Res (2001) 1.36
Integrins and signal transduction. Adv Exp Med Biol (2010) 1.34
Integrin-linked kinase activity regulates Rac- and Cdc42-mediated actin cytoskeleton reorganization via alpha-PIX. Oncogene (2005) 1.34
The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration. J Cell Biol (2005) 1.33
Molecular cloning of a cDNA encoding a phosphoprotein, Efs, which contains a Src homology 3 domain and associates with Fyn. Oncogene (1995) 1.32
The docking protein HEF1 is an apoptotic mediator at focal adhesion sites. Mol Cell Biol (2000) 1.31
Integrin-linked kinase is a functional Mn2+-dependent protein kinase that regulates glycogen synthase kinase-3β (GSK-3beta) phosphorylation. PLoS One (2010) 1.31
Preferential dependence of breast cancer cells versus normal cells on integrin-linked kinase for protein kinase B/Akt activation and cell survival. Cancer Res (2006) 1.31
p130Cas regulates the activity of AND-34, a novel Ral, Rap1, and R-Ras guanine nucleotide exchange factor. J Biol Chem (2000) 1.31
p130Cas interacts with estrogen receptor alpha and modulates non-genomic estrogen signaling in breast cancer cells. J Cell Sci (2004) 1.29
PRL-1 tyrosine phosphatase regulates c-Src levels, adherence, and invasion in human lung cancer cells. Cancer Res (2007) 1.28
Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells. EMBO J (1998) 1.27
PINCH-1 regulates the ERK-Bim pathway and contributes to apoptosis resistance in cancer cells. J Biol Chem (2007) 1.26
Integrin-linked kinase expression increases with ovarian tumour grade and is sustained by peritoneal tumour fluid. J Pathol (2003) 1.24
SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells. Mol Cancer Ther (2008) 1.23
The signaling adapter protein PINCH is up-regulated in the stroma of common cancers, notably at invasive edges. Cancer (2002) 1.20
Increased C-CRK proto-oncogene expression is associated with an aggressive phenotype in lung adenocarcinomas. Oncogene (2003) 1.20
Increased expression of integrin-linked kinase is correlated with melanoma progression and poor patient survival. Clin Cancer Res (2003) 1.20
Regulation of invasive behavior by vascular endothelial growth factor is HEF1-dependent. Oncogene (2010) 1.19
Phosphoinositide-3 kinase-Rac1-c-Jun NH2-terminal kinase signaling mediates collagen I-induced cell scattering and up-regulation of N-cadherin expression in mouse mammary epithelial cells. Mol Biol Cell (2006) 1.17
CIZ, a zinc finger protein that interacts with p130(cas) and activates the expression of matrix metalloproteinases. Mol Cell Biol (2000) 1.16
P130Cas-associated protein (p140Cap) as a new tyrosine-phosphorylated protein involved in cell spreading. Mol Biol Cell (2003) 1.16
p130Cas mediates the transforming properties of the anaplastic lymphoma kinase. Blood (2005) 1.16
Pinch1 is required for normal development of cranial and cardiac neural crest-derived structures. Circ Res (2007) 1.15
Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth. Oncogene (2005) 1.14
Overexpression of the integrin-linked kinase mesenchymally transforms mammary epithelial cells. J Cell Sci (2001) 1.14
ILK over-expression in human colon cancer progression correlates with activation of beta-catenin, down-regulation of E-cadherin and activation of the Akt-FKHR pathway. J Pathol (2006) 1.13
A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells. Oncogene (2010) 1.12
Characterization of the kinase activity essential for tyrosine phosphorylation of p130Cas in fibroblasts. Oncogene (1997) 1.12
A novel association between p130Cas and resistance to the chemotherapeutic drug adriamycin in human breast cancer cells. Cancer Res (2008) 1.10
Thymosin beta4 triggers an epithelial-mesenchymal transition in colorectal carcinoma by upregulating integrin-linked kinase. Oncogene (2006) 1.10
p140Cap dual regulation of E-cadherin/EGFR cross-talk and Ras signalling in tumour cell scatter and proliferation. Oncogene (2010) 1.09
Constitutive CXCL12 expression induces anoikis in colorectal carcinoma cells. Gastroenterology (2008) 1.09
Tamoxifen resistance in breast cancer: elucidating mechanisms. Drugs (2001) 1.08
p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene. J Biol Chem (1996) 1.07
A novel Cas family member, HEPL, regulates FAK and cell spreading. Mol Biol Cell (2008) 1.07
p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity. EMBO J (2007) 1.06
beta1 integrin targeting to enhance radiation therapy. Int J Radiat Biol (2009) 1.06
Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity. Neuron (2009) 3.54
p130Cas: a versatile scaffold in signaling networks. Trends Cell Biol (2006) 2.84
Integrin-induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines. J Biol Chem (2001) 2.06
p130Cas as a new regulator of mammary epithelial cell proliferation, survival, and HER2-neu oncogene-dependent breast tumorigenesis. Cancer Res (2006) 1.92
Extracellular matrix, integrins, and growth factors as tailors of the stem cell niche. Curr Opin Cell Biol (2012) 1.51
Impact of glycemic and blood pressure variability on surrogate measures of cardiovascular outcomes in type 2 diabetic patients. Diabetes Care (2011) 1.45
Human ether-a-go-go-related gene 1 channels are physically linked to beta1 integrins and modulate adhesion-dependent signaling. Mol Biol Cell (2005) 1.45
The mitochondrial chaperone TRAP1 promotes neoplastic growth by inhibiting succinate dehydrogenase. Cell Metab (2013) 1.36
Integrins and signal transduction. Adv Exp Med Biol (2010) 1.34
p130Cas interacts with estrogen receptor alpha and modulates non-genomic estrogen signaling in breast cancer cells. J Cell Sci (2004) 1.29
P130Cas-associated protein (p140Cap) as a new tyrosine-phosphorylated protein involved in cell spreading. Mol Biol Cell (2003) 1.16
p130Cas mediates the transforming properties of the anaplastic lymphoma kinase. Blood (2005) 1.16
p27kip1 controls cell morphology and motility by regulating microtubule-dependent lipid raft recycling. Mol Cell Biol (2010) 1.08
Convergence of integrins and EGF receptor signaling via PI3K/Akt/FoxO pathway in early gene Egr-1 expression. J Cell Physiol (2009) 1.07
p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity. EMBO J (2007) 1.06
p130Cas is an essential transducer element in ErbB2 transformation. FASEB J (2010) 1.05
p130Cas promotes invasiveness of three-dimensional ErbB2-transformed mammary acinar structures by enhanced activation of mTOR/p70S6K and Rac1. Eur J Cell Biol (2010) 1.01
The importance of HbA1c and glucose variability in patients with type 1 and type 2 diabetes: outcome of continuous glucose monitoring (CGM). Acta Diabetol (2012) 0.98
Characterization of a multidomain adaptor protein, p140Cap, as part of a pre-synaptic complex. J Neurochem (2008) 0.91
Quantitation of multisite EGF receptor phosphorylation using mass spectrometry and a novel normalization approach. J Proteome Res (2007) 0.90
STAT5 activation induced by diabetic LDL depends on LDL glycation and occurs via src kinase activity. Diabetes (2002) 0.90
p140Cap regulates memory and synaptic plasticity through Src-mediated and citron-N-mediated actin reorganization. J Neurosci (2014) 0.89
Nongenomic effects of 17beta-estradiol in human platelets: potentiation of thrombin-induced aggregation through estrogen receptor beta and Src kinase. Blood (2004) 0.89
Identification of p130Cas/ErbB2-dependent invasive signatures in transformed mammary epithelial cells. Cell Cycle (2013) 0.87
The adaptor proteins p140CAP and p130CAS as molecular hubs in cell migration and invasion of cancer cells. Am J Cancer Res (2011) 0.87
p130Cas/Cyclooxygenase-2 axis in the control of mesenchymal plasticity of breast cancer cells. Breast Cancer Res (2012) 0.86
Systematic analysis of the epidermal growth factor receptor by mass spectrometry reveals stimulation-dependent multisite phosphorylation. Mol Cell Proteomics (2005) 0.85
SNAP-25 regulates spine formation through postsynaptic binding to p140Cap. Nat Commun (2013) 0.85
Left ventricular electromechanical delay in patients with heart failure and normal QRS duration and in patients with right and left bundle branch block. Europace (2007) 0.85
Identification of two regions in the p140Cap adaptor protein that retain the ability to suppress tumor cell properties. Am J Cancer Res (2013) 0.84
Psychological factors, including alexithymia, in the prediction of cardiovascular risk in HIV infected patients: results of a cohort study. PLoS One (2013) 0.83
Cas proteins: dodgy scaffolding in breast cancer. Breast Cancer Res (2014) 0.83
p130Cas alters the differentiation potential of mammary luminal progenitors by deregulating c-Kit activity. Stem Cells (2013) 0.81
Mapping of p140Cap phosphorylation sites: the EPLYA and EGLYA motifs have a key role in tyrosine phosphorylation and Csk binding, and are substrates of the Abl kinase. PLoS One (2013) 0.81
The interaction between KDR and interleukin-3 receptor (IL-3R) beta common modulates tumor neovascularization. Oncogene (2005) 0.76
p130Cas over-expression impairs mammary branching morphogenesis in response to estrogen and EGF. PLoS One (2012) 0.76