Published in J Biol Chem on May 22, 2007
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38
Distribution and evolution of circular miniproteins in flowering plants. Plant Cell (2008) 1.37
Cyclotide discovery in Gentianales revisited-identification and characterization of cyclic cystine-knot peptides and their phylogenetic distribution in Rubiaceae plants. Biopolymers (2013) 1.10
Uterotonic plants and their bioactive constituents. Planta Med (2010) 1.04
Characterizing circular peptides in mixtures: sequence fragment assembly of cyclotides from a violet plant by MALDI-TOF/TOF mass spectrometry. Amino Acids (2012) 0.98
Modulation of conotoxin structure and function is achieved through a multienzyme complex in the venom glands of cone snails. J Biol Chem (2012) 0.96
Antimicrobial Peptides from Plants. Pharmaceuticals (Basel) (2015) 0.96
Do plant cyclotides have potential as immunosuppressant peptides? J Nat Prod (2012) 0.94
Chaperones and foldases in endoplasmic reticulum stress signaling in plants. Plant Signal Behav (2011) 0.89
Global cyclotide adventure: a journey dedicated to the discovery of circular peptides from flowering plants. Biopolymers (2010) 0.88
Cyclotides Suppress Human T-Lymphocyte Proliferation by an Interleukin 2-Dependent Mechanism. PLoS One (2013) 0.87
Insights into processing and cyclization events associated with biosynthesis of the cyclic Peptide kalata B1. J Biol Chem (2012) 0.86
Ribosomal biosynthesis of the cyclic peptide toxins of Amanita mushrooms. Biopolymers (2010) 0.86
Protein disulfide isomerase-2 of Arabidopsis mediates protein folding and localizes to both the secretory pathway and nucleus, where it interacts with maternal effect embryo arrest factor. Mol Cells (2011) 0.86
Immunosuppressive activity of an aqueous Viola tricolor herbal extract. J Ethnopharmacol (2013) 0.83
Regulatory interplay between soybean root and soybean cyst nematode during a resistant and susceptible reaction. BMC Plant Biol (2014) 0.82
Identification of candidates for cyclotide biosynthesis and cyclisation by expressed sequence tag analysis of Oldenlandia affinis. BMC Genomics (2010) 0.82
Immunosuppressive peptides and their therapeutic applications. Drug Discov Today (2013) 0.80
Oral activity of a nature-derived cyclic peptide for the treatment of multiple sclerosis. Proc Natl Acad Sci U S A (2016) 0.80
Various mechanisms in cyclopeptide production from precursors synthesized independently of non-ribosomal peptide synthetases. Acta Biochim Biophys Sin (Shanghai) (2011) 0.80
Peptidomics of Circular Cysteine-Rich Plant Peptides: Analysis of the Diversity of Cyclotides from Viola tricolor by Transcriptome and Proteome Mining. J Proteome Res (2015) 0.79
Expression and characterization of protein disulfide isomerase family proteins in bread wheat. BMC Plant Biol (2015) 0.78
Variation in the Subcellular Localization and Protein Folding Activity among Arabidopsis thaliana Homologs of Protein Disulfide Isomerase. Biomolecules (2013) 0.78
Morphological and proteomic analysis reveal the role of pistil under pollination in Liriodendron chinense (Hemsl.) Sarg. PLoS One (2014) 0.77
SDF2L1, a component of the endoplasmic reticulum chaperone complex, differentially interacts with {alpha}-, {beta}-, and {theta}-defensin propeptides. J Biol Chem (2008) 0.76
Shotgun Label-free Proteomic Analysis of Clubroot (Plasmodiophora brassicae) Resistance Conferred by the Gene Rcr1 in Brassica rapa. Front Plant Sci (2016) 0.75
Proteomic Analysis Reveals the Positive Roles of the Plant-Growth-Promoting Rhizobacterium NSY50 in the Response of Cucumber Roots to Fusarium oxysporum f. sp. cucumerinum Inoculation. Front Plant Sci (2016) 0.75
Immunolocalization of cyclotides in plant cells, tissues and organ supports their role in host defense. Planta (2016) 0.75
Cooperative Protein Folding by Two Protein Thiol Disulfide Oxidoreductases and 1 in Soybean. Plant Physiol (2015) 0.75
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38
Thermal, chemical, and enzymatic stability of the cyclotide kalata B1: the importance of the cyclic cystine knot. Biochemistry (2004) 2.32
Protein disulfide isomerase: the structure of oxidative folding. Trends Biochem Sci (2006) 1.99
CyBase: a database of cyclic protein sequences and structures, with applications in protein discovery and engineering. Nucleic Acids Res (2007) 1.86
An asparaginyl endopeptidase mediates in vivo protein backbone cyclization. J Biol Chem (2007) 1.77
Discovery of genes activated by the mitochondrial unfolded protein response (mtUPR) and cognate promoter elements. PLoS One (2007) 1.72
Microcin J25 has a threaded sidechain-to-backbone ring structure and not a head-to-tail cyclized backbone. J Am Chem Soc (2003) 1.67
Processing of a 22 kDa precursor protein to produce the circular protein tricyclon A. Structure (2005) 1.67
Theta-defensins prevent HIV-1 Env-mediated fusion by binding gp41 and blocking 6-helix bundle formation. J Biol Chem (2006) 1.54
The engineering of an orally active conotoxin for the treatment of neuropathic pain. Angew Chem Int Ed Engl (2010) 1.54
Circular proteins--no end in sight. Trends Biochem Sci (2002) 1.53
ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2007) 1.50
Vicinal disulfide turns. Protein Eng (2003) 1.50
Twists, knots, and rings in proteins. Structural definition of the cyclotide framework. J Biol Chem (2002) 1.46
The cyclotide family of circular miniproteins: nature's combinatorial peptide template. Biopolymers (2006) 1.39
Biosynthesis of circular proteins in plants. Plant J (2007) 1.39
ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Res (2011) 1.38
Isolation and properties of floral defensins from ornamental tobacco and petunia. Plant Physiol (2003) 1.38
Distribution and evolution of circular miniproteins in flowering plants. Plant Cell (2008) 1.37
Engineering stable peptide toxins by means of backbone cyclization: stabilization of the alpha-conotoxin MII. Proc Natl Acad Sci U S A (2005) 1.37
The cyclotides and related macrocyclic peptides as scaffolds in drug design. Curr Opin Drug Discov Devel (2006) 1.37
Functional analysis of the alpha-defensin disulfide array in mouse cryptdin-4. J Biol Chem (2004) 1.36
Structural plasticity of the cyclic-cystine-knot framework: implications for biological activity and drug design. Biochem J (2006) 1.35
Alpha-selenoconotoxins, a new class of potent alpha7 neuronal nicotinic receptor antagonists. J Biol Chem (2006) 1.34
Albumins and their processing machinery are hijacked for cyclic peptides in sunflower. Nat Chem Biol (2011) 1.31
Cyclotides as templates in drug design. Drug Discov Today (2009) 1.31
The plant defensin, NaD1, enters the cytoplasm of Fusarium oxysporum hyphae. J Biol Chem (2008) 1.30
Analgesic alpha-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation. J Neurosci (2008) 1.29
The synthesis, structural characterization, and receptor specificity of the alpha-conotoxin Vc1.1. J Biol Chem (2006) 1.28
Permeabilization of fungal hyphae by the plant defensin NaD1 occurs through a cell wall-dependent process. J Biol Chem (2010) 1.28
Plant cyclotides disrupt epithelial cells in the midgut of lepidopteran larvae. Proc Natl Acad Sci U S A (2008) 1.28
Discovery, structure and biological activities of cyclotides. Adv Drug Deliv Rev (2009) 1.26
The three-dimensional solution structure of NaD1, a new floral defensin from Nicotiana alata and its application to a homology model of the crop defense protein alfAFP. J Mol Biol (2003) 1.26
Conopeptide characterization and classifications: an analysis using ConoServer. Toxicon (2010) 1.26
Isolation, solution structure, and insecticidal activity of kalata B2, a circular protein with a twist: do Möbius strips exist in nature? Biochemistry (2005) 1.24
Engineering pro-angiogenic peptides using stable, disulfide-rich cyclic scaffolds. Blood (2011) 1.24
Alanine scanning mutagenesis of the prototypic cyclotide reveals a cluster of residues essential for bioactivity. J Biol Chem (2008) 1.24
Properties and mechanisms of action of naturally occurring antifungal peptides. Cell Mol Life Sci (2013) 1.20
Conotoxins: natural product drug leads. Nat Prod Rep (2009) 1.19
Cyclotides: natural, circular plant peptides that possess significant activity against gastrointestinal nematode parasites of sheep. Biochemistry (2008) 1.18
Synergistic cooperation of PDI family members in peroxiredoxin 4-driven oxidative protein folding. Sci Rep (2013) 1.18
Engineering stabilized vascular endothelial growth factor-A antagonists: synthesis, structural characterization, and bioactivity of grafted analogues of cyclotides. J Med Chem (2008) 1.17
Conserved structural and sequence elements implicated in the processing of gene-encoded circular proteins. J Biol Chem (2004) 1.16
A continent of plant defense peptide diversity: cyclotides in Australian Hybanthus (Violaceae). Plant Cell (2005) 1.16
Discovery of an unusual biosynthetic origin for circular proteins in legumes. Proc Natl Acad Sci U S A (2011) 1.16
Insecticidal plant cyclotides and related cystine knot toxins. Toxicon (2006) 1.16
Discovery of cyclotides in the fabaceae plant family provides new insights into the cyclization, evolution, and distribution of circular proteins. ACS Chem Biol (2011) 1.14
Linearization of a naturally occurring circular protein maintains structure but eliminates hemolytic activity. Biochemistry (2003) 1.14
Vicinal disulfide bridge conformers by experimental methods and by ab initio and DFT molecular computations. Proteins (2004) 1.13
The cyclic cystine knot miniprotein MCoTI-II is internalized into cells by macropinocytosis. Int J Biochem Cell Biol (2007) 1.13
A novel conotoxin inhibitor of Kv1.6 channel and nAChR subtypes defines a new superfamily of conotoxins. Biochemistry (2006) 1.12
Structures of muO-conotoxins from Conus marmoreus. I nhibitors of tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels in mammalian sensory neurons. J Biol Chem (2004) 1.12
The biological activity of the prototypic cyclotide kalata b1 is modulated by the formation of multimeric pores. J Biol Chem (2009) 1.12
Identification and characterization of a new family of cell-penetrating peptides: cyclic cell-penetrating peptides. J Biol Chem (2011) 1.12
Phosphoinositide-mediated oligomerization of a defensin induces cell lysis. Elife (2014) 1.11
Retrocyclin-2: structural analysis of a potent anti-HIV theta-defensin. Biochemistry (2007) 1.11
Lysine-scanning mutagenesis reveals an amendable face of the cyclotide kalata B1 for the optimization of nematocidal activity. J Biol Chem (2010) 1.09
Disulfide mapping of the cyclotide kalata B1. Chemical proof of the cystic cystine knot motif. J Biol Chem (2003) 1.09
Structural and functional characterization of the conserved salt bridge in mammalian paneth cell alpha-defensins: solution structures of mouse CRYPTDIN-4 and (E15D)-CRYPTDIN-4. J Biol Chem (2006) 1.08
Studies on the membrane interactions of the cyclotides kalata B1 and kalata B6 on model membrane systems by surface plasmon resonance. Anal Biochem (2005) 1.07
Potential therapeutic applications of the cyclotides and related cystine knot mini-proteins. Expert Opin Investig Drugs (2007) 1.07
The role of the cyclic peptide backbone in the anti-HIV activity of the cyclotide kalata B1. FEBS Lett (2004) 1.07
Discovery, synthesis, and structure-activity relationships of conotoxins. Chem Rev (2014) 1.07
Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design. Proc Natl Acad Sci U S A (2013) 1.07
Disulfide folding pathways of cystine knot proteins. Tying the knot within the circular backbone of the cyclotides. J Biol Chem (2002) 1.06
Anti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis. J Nat Prod (2007) 1.06
Decoding the membrane activity of the cyclotide kalata B1: the importance of phosphatidylethanolamine phospholipids and lipid organization on hemolytic and anti-HIV activities. J Biol Chem (2011) 1.06
Bioactive cystine knot proteins. Curr Opin Chem Biol (2011) 1.05
Chromosomal variability of human mesenchymal stem cells cultured under hypoxic conditions. J Cell Mol Med (2012) 1.05
Backbone cyclised peptides from plants show molluscicidal activity against the rice pest Pomacea canaliculata (golden apple snail). J Agric Food Chem (2008) 1.05
Combined X-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold. J Biol Chem (2009) 1.05
CyBase: a database of cyclic protein sequence and structure. Nucleic Acids Res (2006) 1.05
Design and characterization of novel antimicrobial peptides, R-BP100 and RW-BP100, with activity against Gram-negative and Gram-positive bacteria. Biochim Biophys Acta (2012) 1.04
Enzymatic cyclization of a potent bowman-birk protease inhibitor, sunflower trypsin inhibitor-1, and solution structure of an acyclic precursor peptide. J Biol Chem (2003) 1.04
A pollen-specific RALF from tomato that regulates pollen tube elongation. Plant Physiol (2010) 1.04
Staphylococcus aureus DsbA does not have a destabilizing disulfide. A new paradigm for bacterial oxidative folding. J Biol Chem (2007) 1.04
Functional analysis of human P5, a protein disulfide isomerase homologue. J Biochem (2002) 1.03
Tissue-specific expression of head-to-tail cyclized miniproteins in Violaceae and structure determination of the root cyclotide Viola hederacea root cyclotide1. Plant Cell (2004) 1.03
Structure-activity relationships of alpha-conotoxins targeting neuronal nicotinic acetylcholine receptors. Eur J Biochem (2004) 1.02
Structure of Petunia hybrida defensin 1, a novel plant defensin with five disulfide bonds. Biochemistry (2003) 1.02