Published in J Nutr Biochem on May 24, 2007
Reversal of mineral ion homeostasis and soft-tissue calcification of klotho knockout mice by deletion of vitamin D 1alpha-hydroxylase. Kidney Int (2009) 2.39
The emerging role of the fibroblast growth factor-23-klotho axis in renal regulation of phosphate homeostasis. J Endocrinol (2007) 1.81
The world pandemic of vitamin D deficiency could possibly be explained by cellular inflammatory response activity induced by the renin-angiotensin system. Am J Physiol Cell Physiol (2013) 1.56
Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling. Aging (Albany NY) (2012) 1.24
Systems biology-based analysis implicates a novel role for vitamin D metabolism in the pathogenesis of age-related macular degeneration. Hum Genomics (2011) 1.08
Sterol regulation of metabolism, homeostasis, and development. Annu Rev Biochem (2011) 1.08
Does Fgf23-klotho activity influence vascular and soft tissue calcification through regulating mineral ion metabolism? Kidney Int (2008) 1.06
Endocrine function in naturally long-living small mammals. Mol Cell Endocrinol (2008) 1.06
Association of leptin, 25-hydroxyvitamin D, and parathyroid hormone in women. Nutr Cancer (2009) 1.05
Mineral metabolism and aging: the fibroblast growth factor 23 enigma. Curr Opin Nephrol Hypertens (2007) 1.02
In search of antiaging modalities: evaluation of mTOR- and ROS/DNA damage-signaling by cytometry. Cytometry A (2014) 0.99
The dualistic role of vitamin D in vascular calcifications. Kidney Int (2010) 0.98
Vitamin D receptor rs2228570 polymorphism and invasive ovarian carcinoma risk: pooled analysis in five studies within the Ovarian Cancer Association Consortium. Int J Cancer (2011) 0.95
Arterial calcifications and increased expression of vitamin D receptor targets in mice lacking TIF1alpha. Proc Natl Acad Sci U S A (2008) 0.93
A novel approach for studying the temporal modulation of embryonic skeletal development using organotypic bone cultures and microcomputed tomography. Tissue Eng Part C Methods (2012) 0.92
Dietary calcium and vitamin D2 supplementation with enhanced Lentinula edodes improves osteoporosis-like symptoms and induces duodenal and renal active calcium transport gene expression in mice. Eur J Nutr (2008) 0.91
Attenuation of constitutive DNA damage signaling by 1,25-dihydroxyvitamin D3. Aging (Albany NY) (2012) 0.89
Vitamin D metabolism and effects on pluripotency genes and cell differentiation in testicular germ cell tumors in vitro and in vivo. Neoplasia (2012) 0.83
Vitamin D safety and requirements. Arch Biochem Biophys (2011) 0.79
The problems of vitamin d insufficiency in older people. Aging Dis (2012) 0.78
Hypovitaminosis D and response to cholecalciferol supplementation in patients with autoimmune and non-autoimmune rheumatic diseases. Rheumatol Int (2011) 0.78
Vitamin D deficiency remains prevalent despite increased laboratory testing in New South Wales, Australia. Singapore Med J (2014) 0.77
Reply to W.B. Grant 'Re: Vitamin D deficiency among northern Native Peoples'. Int J Circumpolar Health (2012) 0.76
Vitamin D receptor signaling improves Hutchinson-Gilford progeria syndrome cellular phenotypes. Oncotarget (2016) 0.76
The effects of 1α, 25-dihydroxyvitamin D3 and transforming growth factor-β3 on bone development in an ex vivo organotypic culture system of embryonic chick femora. PLoS One (2015) 0.75
Vitamin D deficiency contributes to vascular damage in sustained ischemic acute kidney injury. Physiol Rep (2016) 0.75
Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey. Am J Kidney Dis (2003) 15.00
Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature (1997) 13.77
Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med (2006) 12.09
Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. Nat Genet (2000) 7.41
Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. J Clin Invest (2004) 7.00
Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med (1997) 6.88
Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev (2001) 6.77
Vitamin D. Am J Physiol Renal Physiol (2005) 4.81
Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia. Proc Natl Acad Sci U S A (1997) 4.25
Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. Nat Genet (1997) 3.89
An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia. Hum Mol Genet (2004) 3.42
Gains in bone mineral density with resolution of vitamin D intoxication. Ann Intern Med (1997) 3.36
Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities. Proc Natl Acad Sci U S A (1998) 3.24
Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice. Matrix Biol (2004) 3.23
Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system. Mol Endocrinol (2003) 3.15
Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process. FASEB J (2006) 2.99
Targeted inactivation of the 25-hydroxyvitamin D(3)-1(alpha)-hydroxylase gene (CYP27B1) creates an animal model of pseudovitamin D-deficiency rickets. Endocrinology (2001) 2.87
Vitamin D and the elderly. Clin Endocrinol (Oxf) (2005) 2.77
Vitamin D supplementation and fracture incidence in elderly persons. A randomized, placebo-controlled clinical trial. Ann Intern Med (1996) 2.66
Expression of 1,25-dihydroxyvitamin D(3) receptor in the immune system. Arch Biochem Biophys (2000) 2.65
Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity. Circ Res (2005) 2.63
Aging of mesenchymal stem cells. Ageing Res Rev (2005) 2.53
Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: formal histomorphometric and biomechanical analyses. Endocrinology (1999) 2.47
Annual injection of vitamin D and fractures of aged bones. Calcif Tissue Int (1992) 2.23
Vitamin D. Am J Physiol (1999) 2.10
Hypervitaminosis D associated with drinking milk. N Engl J Med (1992) 1.90
Age, vitamin D, and solar ultraviolet. Lancet (1989) 1.82
Klotho as a regulator of fibroblast growth factor signaling and phosphate/calcium metabolism. Curr Opin Nephrol Hypertens (2006) 1.81
Genetic ablation of vitamin D activation pathway reverses biochemical and skeletal anomalies in Fgf-23-null animals. Am J Pathol (2006) 1.75
Hypervitaminosis D and premature aging: lessons learned from Fgf23 and Klotho mutant mice. Trends Mol Med (2006) 1.60
Soft tissue calcification in pediatric patients with end-stage renal disease. Kidney Int (1990) 1.55
Hyperostosis-hyperphosphatemia syndrome: a congenital disorder of O-glycosylation associated with augmented processing of fibroblast growth factor 23. J Bone Miner Res (2007) 1.52
Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med (2001) 1.51
Mitochondrial DNA mutations, energy metabolism and apoptosis in aging muscle. Ageing Res Rev (2006) 1.46
FGF-23, vitamin D and calcification: the unholy triad. Nephrol Dial Transplant (2005) 1.35
Premature aging in klotho mutant mice: cause or consequence? Ageing Res Rev (2007) 1.29
Oxidative phosphorylation and aging. Ageing Res Rev (2006) 1.24
25-hydroxyvitamin D(3)-1alpha-hydroxylase expression in normal and pathological parathyroid glands. J Clin Endocrinol Metab (2002) 1.24
Regulation of 25-hydroxyvitamin D3 1alpha-hydroxylase gene expression by parathyroid hormone and 1,25-dihydroxyvitamin D3. Arch Biochem Biophys (2000) 1.21
Klotho: a fundamental regulator of aging. Ageing Res Rev (2002) 1.09
Design and analysis in genetic studies of human ageing and longevity. Ageing Res Rev (2005) 1.06
Role of fibroblast growth factor 23 in health and in chronic kidney disease. Curr Opin Nephrol Hypertens (2005) 1.04
Life-long suppression of growth hormone-insulin-like growth factor I activity in genetically altered rats could prevent age-related renal damage. Endocrinology (2006) 1.00
Effect of fish oil on bone mineral density in aging C57BL/6 female mice. J Nutr Biochem (2006) 0.97
Disease model: human aging. Trends Mol Med (2001) 0.93
Recent findings in phosphate homeostasis. Curr Opin Nephrol Hypertens (2005) 0.92
Physical activity alters antioxidant status in exercising elderly subjects. J Nutr Biochem (2005) 0.90
Uremic tumoral calcinosis in patients receiving longterm hemodialysis therapy. J Rheumatol (1999) 0.89
Intracranial calcification and tumoural calcinosis during vitamin D therapy. Nephrology (Carlton) (2004) 0.85
Subliminal ultraviolet-B irradiation for the prevention of vitamin D deficiency in the elderly: a feasibility study. Photodermatol Photoimmunol Photomed (2001) 0.85
Calcium and vitamin D metabolism during lactation. J Mammary Gland Biol Neoplasia (1997) 0.84
Expression profiling in the aging brain: a perspective. Ageing Res Rev (2005) 0.83
On the ontogeny and interactions of phosphofructokinase in mouse tissues. Int J Biochem (1986) 0.77
Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule. FASEB J (2010) 2.91
Reversal of mineral ion homeostasis and soft-tissue calcification of klotho knockout mice by deletion of vitamin D 1alpha-hydroxylase. Kidney Int (2009) 2.39
In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23) -mediated regulation of systemic phosphate homeostasis. FASEB J (2008) 2.03
Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging. FASEB J (2010) 1.58
Premature aging in klotho mutant mice: cause or consequence? Ageing Res Rev (2007) 1.29
In vivo genetic evidence for suppressing vascular and soft-tissue calcification through the reduction of serum phosphate levels, even in the presence of high serum calcium and 1,25-dihydroxyvitamin d levels. Circ Cardiovasc Genet (2009) 1.26
The collagen-specific molecular chaperone HSP47: is there a role in fibrosis? Trends Mol Med (2006) 1.18
Does Fgf23-klotho activity influence vascular and soft tissue calcification through regulating mineral ion metabolism? Kidney Int (2008) 1.06
Mineral metabolism and aging: the fibroblast growth factor 23 enigma. Curr Opin Nephrol Hypertens (2007) 1.02
Life-long suppression of growth hormone-insulin-like growth factor I activity in genetically altered rats could prevent age-related renal damage. Endocrinology (2006) 1.00
Genetic suppression of GH-IGF-1 activity, combined with lifelong caloric restriction, prevents age-related renal damage and prolongs the life span in rats. Am J Nephrol (2008) 0.99
Low-dose local kidney irradiation inhibits progression of experimental crescentic nephritis by promoting apoptosis. Am J Nephrol (2008) 0.96
Dietary and genetic evidence for enhancing glucose metabolism and reducing obesity by inhibiting klotho functions. FASEB J (2011) 0.95
Cisplatin nephropathy: is cytotoxicity avoidable? Nephrol Dial Transplant (2007) 0.82
Genetic induction of phosphate toxicity significantly reduces the survival of hypercholesterolemic obese mice. Biochem Biophys Res Commun (2011) 0.82