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1
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siRNA-based therapy ameliorates glomerulonephritis.
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J Am Soc Nephrol
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2010
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1.58
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2
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In situ quantitative monitoring of polyplexes and polyplex micelles in the blood circulation using intravital real-time confocal laser scanning microscopy.
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J Control Release
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2011
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1.55
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3
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Smart multilayered assembly for biocompatible siRNA delivery featuring dissolvable silica, endosome-disrupting polycation, and detachable PEG.
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ACS Nano
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2012
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1.49
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4
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PEG-detachable polyplex micelles based on disulfide-linked block catiomers as bioresponsive nonviral gene vectors.
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J Am Chem Soc
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2008
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1.35
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5
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A PEG-based biocompatible block catiomer with high buffering capacity for the construction of polyplex micelles showing efficient gene transfer toward primary cells.
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ChemMedChem
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2006
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1.28
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6
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Environment-responsive block copolymer micelles with a disulfide cross-linked core for enhanced siRNA delivery.
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Biomacromolecules
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2009
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1.25
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7
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Light-induced gene transfer from packaged DNA enveloped in a dendrimeric photosensitizer.
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Nat Mater
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2005
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1.17
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8
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Charge-conversion ternary polyplex with endosome disruption moiety: a technique for efficient and safe gene delivery.
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Angew Chem Int Ed Engl
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2008
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1.14
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9
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Bone regeneration by regulated in vivo gene transfer using biocompatible polyplex nanomicelles.
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Mol Ther
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2007
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1.13
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10
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Transfection study using multicellular tumor spheroids for screening non-viral polymeric gene vectors with low cytotoxicity and high transfection efficiencies.
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J Control Release
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2007
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1.08
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11
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Targeted polymeric micelles for siRNA treatment of experimental cancer by intravenous injection.
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ACS Nano
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2012
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1.01
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12
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Polyplex micelles with cyclic RGD peptide ligands and disulfide cross-links directing to the enhanced transfection via controlled intracellular trafficking.
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Mol Pharm
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2009
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1.01
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13
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Direct and instantaneous observation of intravenously injected substances using intravital confocal micro-videography.
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Biomed Opt Express
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2010
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0.98
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14
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PEGylated polyplex micelles from triblock catiomers with spatially ordered layering of condensed pDNA and buffering units for enhanced intracellular gene delivery.
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J Am Chem Soc
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2005
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0.96
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15
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Biomolecular robotics for chemomechanically driven guest delivery fuelled by intracellular ATP.
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Nat Chem
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2013
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0.94
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16
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A phenylboronate-functionalized polyion complex micelle for ATP-triggered release of siRNA.
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Angew Chem Int Ed Engl
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2012
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0.92
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17
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Intratracheal gene transfer of adrenomedullin using polyplex nanomicelles attenuates monocrotaline-induced pulmonary hypertension in rats.
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Mol Ther
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2009
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0.92
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18
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Polyplex micelles prepared from ω-cholesteryl PEG-polycation block copolymers for systemic gene delivery.
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Biomaterials
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2010
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0.91
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19
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High-density lipoprotein facilitates in vivo delivery of α-tocopherol-conjugated short-interfering RNA to the brain.
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Hum Gene Ther
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2011
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0.90
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20
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Polyion complex stability and gene silencing efficiency with a siRNA-grafted polymer delivery system.
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Biomaterials
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2010
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0.90
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21
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Enhanced endosomal escape of siRNA-incorporating hybrid nanoparticles from calcium phosphate and PEG-block charge-conversional polymer for efficient gene knockdown with negligible cytotoxicity.
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Biomaterials
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2011
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0.90
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22
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Precise engineering of siRNA delivery vehicles to tumors using polyion complexes and gold nanoparticles.
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ACS Nano
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2014
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0.90
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23
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Antiangiogenic gene therapy of experimental pancreatic tumor by sFlt-1 plasmid DNA carried by RGD-modified crosslinked polyplex micelles.
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J Control Release
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2010
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0.89
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24
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Transcription factor YY1 contributes to tumor growth by stabilizing hypoxia factor HIF-1α in a p53-independent manner.
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Cancer Res
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2013
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0.89
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25
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Odd-even effect of repeating aminoethylene units in the side chain of N-substituted polyaspartamides on gene transfection profiles.
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J Am Chem Soc
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2011
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0.88
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26
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Enhanced stability and gene silencing ability of siRNA-loaded polyion complexes formulated from polyaspartamide derivatives with a repetitive array of amino groups in the side chain.
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Biomaterials
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2011
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0.86
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27
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Modulated protonation of side chain aminoethylene repeats in N-substituted polyaspartamides promotes mRNA transfection.
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J Am Chem Soc
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2014
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0.86
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28
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Polyion complex micelles of pDNA with acetal-poly(ethylene glycol)-poly(2-(dimethylamino)ethyl methacrylate) block copolymer as the gene carrier system: physicochemical properties of micelles relevant to gene transfection efficacy.
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Biomacromolecules
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2004
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0.85
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29
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Combination of chondroitin sulfate and polyplex micelles from Poly(ethylene glycol)-poly{N'-[N-(2-aminoethyl)-2-aminoethyl]aspartamide} block copolymer for prolonged in vivo gene transfection with reduced toxicity.
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J Control Release
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2011
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0.84
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30
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Acidic pH-responsive siRNA conjugate for reversible carrier stability and accelerated endosomal escape with reduced IFNα-associated immune response.
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Angew Chem Int Ed Engl
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2013
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0.82
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31
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Antiangiogenic gene therapy of solid tumor by systemic injection of polyplex micelles loading plasmid DNA encoding soluble flt-1.
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Mol Pharm
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2010
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0.82
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32
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Synthetic Polyamines to Regulate mRNA Translation through the Preservative Binding of Eukaryotic Initiation Factor 4E to the Cap Structure.
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J Am Chem Soc
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2016
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0.81
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33
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Effect of polymer structure on micelles formed between siRNA and cationic block copolymer comprising thiols and amidines.
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Biomacromolecules
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2011
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0.81
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34
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Pancreatic cancer therapy by systemic administration of VEGF siRNA contained in calcium phosphate/charge-conversional polymer hybrid nanoparticles.
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J Control Release
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2012
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0.81
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35
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Introduction of stearoyl moieties into a biocompatible cationic polyaspartamide derivative, PAsp(DET), with endosomal escaping function for enhanced siRNA-mediated gene knockdown.
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J Control Release
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2010
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0.79
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36
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pDNA/poly(L-lysine) Polyplexes Functionalized with a pH-Sensitive Charge-Conversional Poly(aspartamide) Derivative for Controlled Gene Delivery to Human Umbilical Vein Endothelial Cells.
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Macromol Rapid Commun
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2010
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0.79
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37
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Dual environment-responsive polyplex carriers for enhanced intracellular delivery of plasmid DNA.
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Biomacromolecules
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2012
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0.78
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38
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Aggregation behavior of cationic nanohydrogel particles in human blood serum.
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Biomacromolecules
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2014
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0.78
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39
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Silica nanogelling of environment-responsive PEGylated polyplexes for enhanced stability and intracellular delivery of siRNA.
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Biomaterials
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2012
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0.78
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40
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Gene transfer using micellar nanovectors inhibits corneal neovascularization in vivo.
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Cornea
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2011
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0.78
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41
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PEG-detachable cationic polyaspartamide derivatives bearing stearoyl moieties for systemic siRNA delivery toward subcutaneous BxPC3 pancreatic tumor.
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J Drug Target
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2011
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0.77
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42
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Accelerated polymer-polymer click conjugation by freeze-thaw treatment.
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Bioconjug Chem
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2012
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0.77
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43
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Photochemical enhancement of transgene expression by polymeric micelles incorporating plasmid DNA and dendrimer-based photosensitizer.
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J Drug Target
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2006
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0.76
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44
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Fine-tuning of charge-conversion polymer structure for efficient endosomal escape of siRNA-loaded calcium phosphate hybrid micelles.
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Macromol Rapid Commun
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2014
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0.76
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45
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Multifunctional polyion complex micelle featuring enhanced stability, targetability, and endosome escapability for systemic siRNA delivery to subcutaneous model of lung cancer.
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Drug Deliv Transl Res
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2014
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0.75
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46
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Size-dependent knockdown potential of siRNA-loaded cationic nanohydrogel particles.
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Biomacromolecules
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2014
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0.75
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47
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Gene regulation by intracellular delivery and photodegradation of nanoparticles containing small interfering RNA.
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Macromol Biosci
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2014
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0.75
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48
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[Evaluation of the dynamics of drug delivery systems (DDS) using intravital real-time confocal laser scanning microscopy].
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Yakugaku Zasshi
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2012
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0.75
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49
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Regulated protonation of polyaspartamide derivatives bearing repeated aminoethylene side chains for efficient intracellular siRNA delivery with minimal cytotoxicity.
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Chem Commun (Camb)
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2015
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0.75
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50
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Happy Birthday Kataoka-sensei!
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Macromol Biosci
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2017
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0.75
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