Published in Mol Pharm on June 07, 2007
The role of thiols and disulfides on protein stability. Curr Protein Pept Sci (2009) 1.21
Immunogenicity of botulinum toxins. J Neural Transm (Vienna) (2012) 0.99
Multidimensional methods for the formulation of biopharmaceuticals and vaccines. J Pharm Sci (2011) 0.98
Improved data visualization techniques for analyzing macromolecule structural changes. Protein Sci (2012) 0.96
Vaccines with aluminum-containing adjuvants: optimizing vaccine efficacy and thermal stability. J Pharm Sci (2010) 0.91
The case of botulinum toxin in milk: experimental data. Appl Environ Microbiol (2010) 0.90
'Similar to' is not 'identical with', and 'identical with' is not 'the same as'. Drugs R D (2015) 0.84
Role of neurotoxin associated proteins in the low pH induced structural changes in the botulinum neurotoxin complex. Protein J (2014) 0.75
Overlooking subvisible particles in therapeutic protein products: gaps that may compromise product quality. J Pharm Sci (2009) 2.36
IpaD localizes to the tip of the type III secretion system needle of Shigella flexneri. Infect Immun (2006) 2.24
Nanotechnology in vaccine delivery. Adv Drug Deliv Rev (2008) 1.91
Barriers to nonviral gene delivery. J Pharm Sci (2003) 1.77
Biophysical characterization of PEI/DNA complexes. J Pharm Sci (2003) 1.44
Conformational stability and disassembly of Norwalk virus-like particles. Effect of pH and temperature. J Biol Chem (2006) 1.41
Silicone oil induced aggregation of proteins. J Pharm Sci (2005) 1.32
Preparation and characterization of translocator/chaperone complexes and their component proteins from Shigella flexneri. Biochemistry (2007) 1.32
Structure/function relationships of polyamidoamine/DNA dendrimers as gene delivery vehicles. J Pharm Sci (2005) 1.27
Polyanions and the proteome. Mol Cell Proteomics (2004) 1.24
Derivative absorbance spectroscopy and protein phase diagrams as tools for comprehensive protein characterization: a bGCSF case study. J Pharm Sci (2003) 1.21
Effects of adsorption to aluminum salt adjuvants on the structure and stability of model protein antigens. J Biol Chem (2005) 1.19
Identification of a human valacyclovirase: biphenyl hydrolase-like protein as valacyclovir hydrolase. J Biol Chem (2003) 1.19
Protein-excipient interactions: mechanisms and biophysical characterization applied to protein formulation development. Adv Drug Deliv Rev (2011) 1.19
Thermal stability of vaccines. J Pharm Sci (2003) 1.17
Structural stability of adenovirus type 5. J Pharm Sci (2003) 1.17
Potential inaccurate quantitation and sizing of protein aggregates by size exclusion chromatography: essential need to use orthogonal methods to assure the quality of therapeutic protein products. J Pharm Sci (2010) 1.16
Structure-function analysis of invasion plasmid antigen C (IpaC) from Shigella flexneri. J Biol Chem (2002) 1.15
Physical characterization of MxiH and PrgI, the needle component of the type III secretion apparatus from Shigella and Salmonella. Protein Sci (2006) 1.11
Conformational stability and differential structural analysis of LcrV, PcrV, BipD, and SipD from type III secretion systems. Protein Sci (2007) 1.10
Properties of synthetic spider silk fibers based on Argiope aurantia MaSp2. Biomacromolecules (2008) 1.08
A rapid, three-step process for the preformulation of a recombinant ricin toxin A-chain vaccine. J Pharm Sci (2007) 1.06
Anthrax vaccine powder formulations for nasal mucosal delivery. J Pharm Sci (2006) 1.04
Influence of aggregation on immunogenicity of recombinant human Factor VIII in hemophilia A mice. J Pharm Sci (2006) 1.04
Effect of metal cations on the conformation and inactivation of recombinant human factor VIII. J Pharm Sci (2004) 1.04
The complex inter-relationships between protein flexibility and stability. J Pharm Sci (2008) 1.02
The structure of DNA within cationic lipid/DNA complexes. Biophys J (2003) 1.01
Effects of stabilizers on the destabilization of proteins upon adsorption to aluminum salt adjuvants. J Pharm Sci (2007) 1.00
Spectroscopic and calorimetric analyses of invasion plasmid antigen D (IpaD) from Shigella flexneri reveal the presence of two structural domains. Biochemistry (2006) 1.00
Identification of properties important to protein aggregation using feature selection. BMC Bioinformatics (2013) 1.00
Oligomeric states of the Shigella translocator protein IpaB provide structural insights into formation of the type III secretion translocon. Protein Sci (2013) 0.99
Effects of solutes on empirical phase diagrams of human fibroblast growth factor 1. J Pharm Sci (2007) 0.99
Insulin containing polyethylenimine-dextran sulfate nanoparticles. Int J Pharm (2003) 0.99
Characterization of the interaction of single tryptophan containing mutants of IpaC from Shigella flexneri with phospholipid membranes. Biochemistry (2006) 0.98
A novel scoring function for discriminating hyperthermophilic and mesophilic proteins with application to predicting relative thermostability of protein mutants. BMC Bioinformatics (2010) 0.98
Multidimensional methods for the formulation of biopharmaceuticals and vaccines. J Pharm Sci (2011) 0.98
Lipid binding region (2303-2332) is involved in aggregation of recombinant human FVIII (rFVIII). J Pharm Sci (2005) 0.96
Improved data visualization techniques for analyzing macromolecule structural changes. Protein Sci (2012) 0.96
High-throughput biophysical analysis of protein therapeutics to examine interrelationships between aggregate formation and conformational stability. AAPS J (2013) 0.94
Protein instability and immunogenicity: roadblocks to clinical application of injectable protein delivery systems for sustained release. J Pharm Sci (2011) 0.94
A systematic approach to stabilizing EBA-175 RII-NG for use as a malaria vaccine. Vaccine (2006) 0.93
Structural stability of vault particles. J Pharm Sci (2009) 0.93
Biophysical characterization of Chlamydia trachomatis CT584 supports its potential role as a type III secretion needle tip protein. Biochemistry (2009) 0.92
Effects of pH and polyanions on the thermal stability of fibroblast growth factor 20. Mol Pharm (2007) 0.92
An empirical phase diagram approach to investigate conformational stability of "second-generation" functional mutants of acidic fibroblast growth factor-1. Protein Sci (2012) 0.92
Using empirical phase diagrams to understand the role of intramolecular dynamics in immunoglobulin G stability. J Pharm Sci (2009) 0.92
Parenteral immunization with IpaB/IpaD protects mice against lethal pulmonary infection by Shigella. Vaccine (2013) 0.91
Comparative kinetics of cofactor association and dissociation for the human and trypanosomal S-adenosylhomocysteine hydrolases. 1. Basic features of the association and dissociation processes. Biochemistry (2007) 0.91
Advances in vaccines against neglected tropical diseases: enhancing physical stability of a recombinant hookworm vaccine through biophysical and formulation studies. Hum Vaccin Immunother (2012) 0.90
Compatibility, physical stability, and characterization of an IgG4 monoclonal antibody after dilution into different intravenous administration bags. J Pharm Sci (2012) 0.90
Compositional effects of cationic lipid/DNA delivery systems on transgene expression in cell culture. J Pharm Sci (2004) 0.89
Aggregation kinetics of recombinant human FVIII (rFVIII). J Pharm Sci (2005) 0.89
The structural organization of cationic lipid-DNA complexes. J Biol Chem (2002) 0.89
Solution behavior of IFN-beta-1a: an empirical phase diagram based approach. J Pharm Sci (2005) 0.89
A biophysical characterization of the peptide drug pramlintide (AC137) using empirical phase diagrams. J Pharm Sci (2008) 0.89
A network-based analysis of polyanion-binding proteins utilizing human protein arrays. J Biol Chem (2007) 0.89
Investigation of protein conformational stability employing a multimodal spectrometer. Anal Chem (2011) 0.89
Electrostatic changes in phosphorylase kinase induced by its obligatory allosteric activator Ca2+. Protein Sci (2007) 0.88
An improved methodology for multidimensional high-throughput preformulation characterization of protein conformational stability. J Pharm Sci (2012) 0.88
N-terminus of IpaB provides a potential anchor to the Shigella type III secretion system tip complex protein IpaD. Biochemistry (2013) 0.88
Effect of single-point mutations on the stability and immunogenicity of a recombinant ricin A chain subunit vaccine antigen. Hum Vaccin Immunother (2013) 0.88
Evaluation of the physical stability of the EC5 domain of E-cadherin: effects of pH, temperature, ionic strength, and disulfide bonds. J Pharm Sci (2009) 0.88
Structural characterization of IgG1 mAb aggregates and particles generated under various stress conditions. J Pharm Sci (2014) 0.88
Comparison of high-throughput biophysical methods to identify stabilizing excipients for a model IgG2 monoclonal antibody: conformational stability and kinetic aggregation measurements. J Pharm Sci (2012) 0.87
Effect of polyanions on the structure and stability of repifermin (keratinocyte growth factor-2). J Pharm Sci (2007) 0.87
Investigation of protein/carbohydrate interactions in the dried state. 1. Calorimetric studies. J Pharm Sci (2002) 0.87
Stabilization of measles virus for vaccine formulation. Hum Vaccin (2008) 0.87
Physical characterization of clostridium difficile toxins and toxoids: effect of the formaldehyde crosslinking on thermal stability. J Pharm Sci (2008) 0.87
Investigation of protein/carbohydrate interactions in the dried state. 2. Diffuse reflectance FTIR studies. Int J Pharm (2002) 0.86
Stability of lyophilized human growth hormone. Int J Pharm (2008) 0.86
PROTS: a fragment based protein thermo-stability potential. Proteins (2011) 0.86
pH sensitivity of type III secretion system tip proteins. Proteins (2008) 0.86
Effect of pH and ionic strength on the physical stability of adenovirus type 5. J Pharm Sci (2006) 0.86
Physical characterization and formulation development of a recombinant pneumolysoid protein-based pneumococcal vaccine. J Pharm Sci (2012) 0.86
Effects of salts from the Hofmeister series on the conformational stability, aggregation propensity, and local flexibility of an IgG1 monoclonal antibody. Biochemistry (2013) 0.86
Physical stabilization of Norwalk virus-like particles. J Pharm Sci (2008) 0.86
Excipients differentially influence the conformational stability and pretransition dynamics of two IgG1 monoclonal antibodies. J Pharm Sci (2012) 0.85
Probing protein structure and dynamics by second-derivative ultraviolet absorption analysis of cation-{pi} interactions. Protein Sci (2006) 0.85
The inhibitory action of phospholamban involves stabilization of alpha-helices within the Ca-ATPase. Biochemistry (2002) 0.85