Published in Exp Neurol on May 08, 2007
Axonal growth therapeutics: regeneration or sprouting or plasticity? Trends Neurosci (2008) 1.66
Fibulin-3 is uniquely upregulated in malignant gliomas and promotes tumor cell motility and invasion. Mol Cancer Res (2009) 1.56
Combining peripheral nerve grafts and chondroitinase promotes functional axonal regeneration in the chronically injured spinal cord. J Neurosci (2009) 1.45
Chondroitinase ABC treatment results in greater tensile properties of self-assembled tissue-engineered articular cartilage. Tissue Eng Part A (2009) 1.29
Extracellular matrix-glial abnormalities in the amygdala and entorhinal cortex of subjects diagnosed with schizophrenia. Arch Gen Psychiatry (2010) 1.27
Intraspinal microinjection of chondroitinase ABC following injury promotes axonal regeneration out of a peripheral nerve graft bridge. Exp Neurol (2008) 1.20
Chondroitin sulfate proteoglycans potently inhibit invasion and serve as a central organizer of the brain tumor microenvironment. J Neurosci (2013) 1.20
The yellow fluorescent protein (YFP-H) mouse reveals neuroprotection as a novel mechanism underlying chondroitinase ABC-mediated repair after spinal cord injury. J Neurosci (2008) 1.17
Transgenic inhibition of astroglial NF-kappa B leads to increased axonal sparing and sprouting following spinal cord injury. J Neurochem (2009) 1.13
Calcium diffusion enhanced after cleavage of negatively charged components of brain extracellular matrix by chondroitinase ABC. J Physiol (2009) 1.10
Combination of engineered Schwann cell grafts to secrete neurotrophin and chondroitinase promotes axonal regeneration and locomotion after spinal cord injury. J Neurosci (2014) 1.08
Plasticity after spinal cord injury: relevance to recovery and approaches to facilitate it. Neurotherapeutics (2011) 1.02
Chondroitinase ABC promotes recovery of adaptive limb movements and enhances axonal growth caudal to a spinal hemisection. J Neurosci (2011) 1.01
Mammalian target of rapamycin's distinct roles and effectiveness in promoting compensatory axonal sprouting in the injured CNS. J Neurosci (2014) 0.98
Chondroitinase ABC I-mediated enhancement of oncolytic virus spread and antitumor efficacy. Clin Cancer Res (2010) 0.97
Combining chondroitinase ABC and growth factors promotes the integration of murine retinal progenitor cells transplanted into Rho(-/-) mice. Mol Vis (2011) 0.96
Krüppel-like transcription factors in the nervous system: novel players in neurite outgrowth and axon regeneration. Mol Cell Neurosci (2011) 0.94
Müller glia activation in response to inherited retinal degeneration is highly varied and disease-specific. PLoS One (2015) 0.93
Biological functions of iduronic acid in chondroitin/dermatan sulfate. FEBS J (2013) 0.91
Modification of N-glycosylation sites allows secretion of bacterial chondroitinase ABC from mammalian cells. J Biotechnol (2009) 0.90
Inhibitors of myelination: ECM changes, CSPGs and PTPs. Exp Neurol (2013) 0.86
Injured mice at the gym: review, results and considerations for combining chondroitinase and locomotor exercise to enhance recovery after spinal cord injury. Brain Res Bull (2010) 0.84
Total number, distribution, and phenotype of cells expressing chondroitin sulfate proteoglycans in the normal human amygdala. Brain Res (2008) 0.84
Molecular mechanisms of scar-sourced axon growth inhibitors. Brain Res (2014) 0.83
Bridging the lesion-engineering a permissive substrate for nerve regeneration. Regen Biomater (2015) 0.79
Chondroitin sulfate proteoglycans in the nervous system: inhibitors to repair. Biomed Res Int (2014) 0.79
Molecular mechanisms of the suppression of axon regeneration by KLF transcription factors. Neural Regen Res (2014) 0.77
Neuron-Glia Interactions in Neural Plasticity: Contributions of Neural Extracellular Matrix and Perineuronal Nets. Neural Plast (2016) 0.77
Biomaterial Approaches to Enhancing Neurorestoration after Spinal Cord Injury: Strategies for Overcoming Inherent Biological Obstacles. Biomed Res Int (2015) 0.77
Decline in arylsulfatase B and Increase in chondroitin 4-sulfotransferase combine to increase chondroitin 4-sulfate in traumatic brain injury. J Neurochem (2015) 0.76
Local Delivery of High-Dose Chondroitinase ABC in the Sub-Acute Stage Promotes Axonal Outgrowth and Functional Recovery after Complete Spinal Cord Transection. PLoS One (2015) 0.76
Migration of Adipose-derived Mesenchymal Stem Cells Stably Expressing Chondroitinase ABC In vitro. Chin Med J (Engl) (2016) 0.75
Transplantation of hUC-MSCs seeded collagen scaffolds reduces scar formation and promotes functional recovery in canines with chronic spinal cord injury. Sci Rep (2017) 0.75
Actin-resistant DNAse I Expression From Oncolytic Adenovirus Enadenotucirev Enhances Its Intratumoral Spread and Reduces Tumor Growth. Mol Ther (2015) 0.75
Understanding the NG2 Glial Scar after Spinal Cord Injury. Front Neurol (2016) 0.75
Chondroitinase ABC promotes functional recovery after spinal cord injury. Nature (2002) 8.22
Reactivation of ocular dominance plasticity in the adult visual cortex. Science (2002) 6.06
The role of chondroitin sulfate proteoglycans in regeneration and plasticity in the central nervous system. Brain Res Rev (2007) 2.42
Axonal protein synthesis and degradation are necessary for efficient growth cone regeneration. J Neurosci (2005) 2.42
Chondroitinase ABC treatment opens a window of opportunity for task-specific rehabilitation. Nat Neurosci (2009) 2.37
Can experiments in nonhuman primates expedite the translation of treatments for spinal cord injury in humans? Nat Med (2007) 2.29
Assembly of a new growth cone after axotomy: the precursor to axon regeneration. Nat Rev Neurosci (2012) 2.07
Transcriptome analysis of embryonic and adult sensory axons reveals changes in mRNA repertoire localization. RNA (2010) 2.07
Subcellular profiling reveals distinct and developmentally regulated repertoire of growth cone mRNAs. J Neurosci (2010) 2.02
Inhibiting glycosaminoglycan chain polymerization decreases the inhibitory activity of astrocyte-derived chondroitin sulfate proteoglycans. J Neurosci (2007) 1.99
Chondroitin sulphate proteoglycans in the CNS injury response. Prog Brain Res (2002) 1.70
Animals lacking link protein have attenuated perineuronal nets and persistent plasticity. Brain (2010) 1.63
Promoting plasticity in the spinal cord with chondroitinase improves functional recovery after peripheral nerve repair. Brain (2007) 1.61
Inosine promotes recovery of skilled motor function in a model of focal brain injury. Brain (2007) 1.57
Chondroitin sulfate proteoglycans in neural development and regeneration. Curr Opin Neurobiol (2005) 1.50
Building a bridge: engineering spinal cord repair. Exp Neurol (2002) 1.50
Alpha9 integrin promotes neurite outgrowth on tenascin-C and enhances sensory axon regeneration. J Neurosci (2009) 1.46
Neu3 sialidase-mediated ganglioside conversion is necessary for axon regeneration and is blocked in CNS axons. J Neurosci (2014) 1.45
Extracellular matrix and perineuronal nets in CNS repair. Dev Neurobiol (2011) 1.38
Composition of perineuronal net extracellular matrix in rat brain: a different disaccharide composition for the net-associated proteoglycans. J Biol Chem (2006) 1.36
Composition of perineuronal nets in the adult rat cerebellum and the cellular origin of their components. J Comp Neurol (2006) 1.31
Chondroitin sulfate proteoglycans and microglia prevent migration and integration of grafted Müller stem cells into degenerating retina. Stem Cells (2008) 1.31
Versican is upregulated in CNS injury and is a product of oligodendrocyte lineage cells. J Neurosci (2002) 1.29
The ability of axons to regenerate their growth cones depends on axonal type and age, and is regulated by calcium, cAMP and ERK. Eur J Neurosci (2005) 1.27
Proteoglycans in the central nervous system: plasticity, regeneration and their stimulation with chondroitinase ABC. Restor Neurol Neurosci (2008) 1.26
Role of chondroitin sulfate proteoglycans in axonal conduction in Mammalian spinal cord. J Neurosci (2010) 1.24
Integrin activation promotes axon growth on inhibitory chondroitin sulfate proteoglycans by enhancing integrin signaling. J Neurosci (2011) 1.23
The role of local protein synthesis and degradation in axon regeneration. Exp Neurol (2009) 1.23
Therapeutic time window for the application of chondroitinase ABC after spinal cord injury. Exp Neurol (2007) 1.22
Kindlin-1 enhances axon growth on inhibitory chondroitin sulfate proteoglycans and promotes sensory axon regeneration. J Neurosci (2012) 1.21
Chondroitinase combined with rehabilitation promotes recovery of forelimb function in rats with chronic spinal cord injury. J Neurosci (2011) 1.20
Distribution and synthesis of extracellular matrix proteoglycans, hyaluronan, link proteins and tenascin-R in the rat spinal cord. Eur J Neurosci (2008) 1.19
Chronic spinal hemisection in rats induces a progressive decline in transmission in uninjured fibers to motoneurons. Exp Neurol (2009) 1.18
The astrocyte/meningeal cell interface is a barrier to neurite outgrowth which can be overcome by manipulation of inhibitory molecules or axonal signalling pathways. Mol Cell Neurosci (2003) 1.16
Rab11 and its effector Rab coupling protein contribute to the trafficking of beta 1 integrins during axon growth in adult dorsal root ganglion neurons and PC12 cells. J Neurosci (2010) 1.15
Astrocytes and oligodendrocytes can be generated from NG2+ progenitors after acute brain injury: intracellular localization of oligodendrocyte transcription factor 2 is associated with their fate choice. Eur J Neurosci (2009) 1.13
Combination treatment with anti-Nogo-A and chondroitinase ABC is more effective than single treatments at enhancing functional recovery after spinal cord injury. Eur J Neurosci (2013) 1.12
Upregulation of aggrecan, link protein 1, and hyaluronan synthases during formation of perineuronal nets in the rat cerebellum. J Comp Neurol (2007) 1.11
Chondroitin 6-sulphate synthesis is up-regulated in injured CNS, induced by injury-related cytokines and enhanced in axon-growth inhibitory glia. Eur J Neurosci (2005) 1.10
Chondroitinase ABC combined with neurotrophin NT-3 secretion and NR2D expression promotes axonal plasticity and functional recovery in rats with lateral hemisection of the spinal cord. J Neurosci (2011) 1.09
A potential role for bone morphogenetic protein signalling in glial cell fate determination following adult central nervous system injury in vivo. Eur J Neurosci (2007) 1.08
ARF6 directs axon transport and traffic of integrins and regulates axon growth in adult DRG neurons. J Neurosci (2012) 1.07
Transplantation of Schwann cell line clones secreting GDNF or BDNF into the retinas of dystrophic Royal College of Surgeons rats. Invest Ophthalmol Vis Sci (2004) 1.06
Chondroitinase ABC has a long-lasting effect on chondroitin sulphate glycosaminoglycan content in the injured rat brain. J Neurochem (2007) 1.06
Schwann cell migration is integrin-dependent and inhibited by astrocyte-produced aggrecan. Glia (2010) 1.06
Microchannel electrodes for recording and stimulation: in vitro evaluation. IEEE Trans Biomed Eng (2009) 1.05
Heparan sulphate proteoglycans in glia and in the normal and injured CNS: expression of sulphotransferases and changes in sulphation. Eur J Neurosci (2008) 1.02
Population pharmacokinetics of doripenem based on data from phase 1 studies with healthy volunteers and phase 2 and 3 studies with critically ill patients. Antimicrob Agents Chemother (2010) 1.01
Expression and glycanation of the NG2 proteoglycan in developing, adult, and damaged peripheral nerve. Mol Cell Neurosci (2003) 1.00
The challenges of long-distance axon regeneration in the injured CNS. Prog Brain Res (2012) 1.00
Regulation of RPTPbeta/phosphacan expression and glycosaminoglycan epitopes in injured brain and cytokine-treated glia. Mol Cell Neurosci (2003) 0.98
A novel role for Sema3A in neuroprotection from injury mediated by activated microglia. J Neurosci (2006) 0.96
Depletion of perineuronal nets enhances recognition memory and long-term depression in the perirhinal cortex. J Neurosci (2013) 0.95
6-Sulphated chondroitins have a positive influence on axonal regeneration. PLoS One (2011) 0.95
Combination treatment with chondroitinase ABC in spinal cord injury--breaking the barrier. Neurosci Bull (2013) 0.95
Perisynaptic chondroitin sulfate proteoglycans restrict structural plasticity in an integrin-dependent manner. J Neurosci (2012) 0.95
Limited growth of severed CNS axons after treatment of adult rat brain with hyaluronidase. J Neurosci Res (2003) 0.95
Astrocyte-produced ephrins inhibit schwann cell migration via VAV2 signaling. J Neurosci (2010) 0.94
Semaphorin 3A binds to the perineuronal nets via chondroitin sulfate type E motifs in rodent brains. J Biol Chem (2013) 0.93
An experimental model of secondary progressive multiple sclerosis that shows regional variation in gliosis, remyelination, axonal and neuronal loss. J Neuroimmunol (2008) 0.93
Spinal cord repair: bridging the divide. Neurorehabil Neural Repair (2008) 0.93
The importance of A9 dopaminergic neurons in mediating the functional benefits of fetal ventral mesencephalon transplants and levodopa-induced dyskinesias. Neurobiol Dis (2006) 0.92
NG2 expression in glioblastoma identifies an actively proliferating population with an aggressive molecular signature. Neuro Oncol (2011) 0.92
In vitro modeling of perineuronal nets: hyaluronan synthase and link protein are necessary for their formation and integrity. J Neurochem (2010) 0.92
Characterization of tests of functional recovery after median and ulnar nerve injury and repair in the rat forelimb. J Peripher Nerv Syst (2007) 0.91
The role of survivin in angiogenesis during zebrafish embryonic development. BMC Dev Biol (2007) 0.91
Two separate metalloproteinase activities are responsible for the shedding and processing of the NG2 proteoglycan in vitro. Mol Cell Neurosci (2005) 0.91
Extrinsic and intrinsic factors controlling axonal regeneration after spinal cord injury. Expert Rev Mol Med (2009) 0.91
The chemorepulsive axon guidance protein semaphorin3A is a constituent of perineuronal nets in the adult rodent brain. Mol Cell Neurosci (2013) 0.91
Modification of N-glycosylation sites allows secretion of bacterial chondroitinase ABC from mammalian cells. J Biotechnol (2009) 0.90
Controlled release of chondroitinase ABC from fibrin gel reduces the level of inhibitory glycosaminoglycan chains in lesioned spinal cord. J Control Release (2010) 0.89
Activated retinal glia mediated axon regeneration in experimental glaucoma. Neurobiol Dis (2011) 0.88
The kinesin-2 family member KIF3C regulates microtubule dynamics and is required for axon growth and regeneration. J Neurosci (2013) 0.87
Axon behaviour at Schwann cell - astrocyte boundaries: manipulation of axon signalling pathways and the neural adhesion molecule L1 can enable axons to cross. Eur J Neurosci (2004) 0.86
Optimization of the decision-making process for the selection of therapeutics to undergo clinical testing for spinal cord injury in the North American Clinical Trials Network. J Neurosurg Spine (2012) 0.86
Training and anti-CSPG combination therapy for spinal cord injury. Exp Neurol (2011) 0.85
A regenerative microchannel neural interface for recording from and stimulating peripheral axons in vivo. J Neural Eng (2012) 0.85
Role of extracellular factors in axon regeneration in the CNS: implications for therapy. Regen Med (2008) 0.85
Effects of digesting chondroitin sulfate proteoglycans on plasticity in cat primary visual cortex. J Neurosci (2013) 0.84
Lentiviral vectors express chondroitinase ABC in cortical projections and promote sprouting of injured corticospinal axons. J Neurosci Methods (2011) 0.84
High sensitivity recording of afferent nerve activity using ultra-compliant microchannel electrodes: an acute in vivo validation. J Neural Eng (2012) 0.84
Microchannels as axonal amplifiers. IEEE Trans Biomed Eng (2008) 0.84
Focal expression of adeno-associated viral-mutant tau induces widespread impairment in an APP mouse model. Neurobiol Aging (2012) 0.83
Population pharmacokinetics of tapentadol immediate release (IR) in healthy subjects and patients with moderate or severe pain. Clin Pharmacokinet (2010) 0.82
Proteoglycans and brain repair. News Physiol Sci (2004) 0.82
A microchannel neuroprosthesis for bladder control after spinal cord injury in rat. Sci Transl Med (2013) 0.82