Published in Pharmacol Res on April 29, 2007
Paracrine mechanisms in adult stem cell signaling and therapy. Circ Res (2008) 8.49
The porcine lung as a potential model for cystic fibrosis. Am J Physiol Lung Cell Mol Physiol (2008) 2.53
Protein kinase C, an elusive therapeutic target? Nat Rev Drug Discov (2012) 2.33
Negative feedback that improves information transmission in yeast signalling. Nature (2008) 2.21
Protein kinase C in heart failure: a therapeutic target? Cardiovasc Res (2009) 1.50
Autophagy and protein kinase C are required for cardioprotection by sulfaphenazole. Am J Physiol Heart Circ Physiol (2009) 1.18
Rationally designed peptide regulators of protein kinase C. Trends Endocrinol Metab (2008) 1.17
PKC-permitted elevation of sarcolemmal KATP concentration may explain female-specific resistance to myocardial infarction. J Physiol (2009) 1.01
Discovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase (PHLPP) by chemical and virtual screening. J Med Chem (2010) 0.99
Post-ischemic activation of protein kinase C ε protects the hippocampus from cerebral ischemic injury via alterations in cerebral blood flow. Neurosci Lett (2010) 0.94
Host Kinase Activity is Required for Coxiella burnetii Parasitophorous Vacuole Formation. Front Microbiol (2010) 0.93
Activation of PKN mediates survival of cardiac myocytes in the heart during ischemia/reperfusion. Circ Res (2010) 0.92
Regulation of intermediary metabolism by the PKCdelta signalosome in mitochondria. FASEB J (2010) 0.91
Genomic, tissue expression, and protein characterization of pCLCA1, a putative modulator of cystic fibrosis in the pig. J Histochem Cytochem (2009) 0.91
Tribulosin protects rat hearts from ischemia/reperfusion injury. Acta Pharmacol Sin (2010) 0.91
Protection from doxorubicin-induced cardiomyopathy using the modified anthracycline N-benzyladriamycin-14-valerate (AD 198). J Pharmacol Exp Ther (2010) 0.90
Nociceptive-induced myocardial remote conditioning is mediated by neuronal gamma protein kinase C. Basic Res Cardiol (2013) 0.90
Local delivery of a PKCε-activating peptide limits ischemia reperfusion injury in the aged female rat heart. Am J Physiol Regul Integr Comp Physiol (2011) 0.87
Protein composition of bronchoalveolar lavage fluid and airway surface liquid from newborn pigs. Am J Physiol Lung Cell Mol Physiol (2013) 0.86
The role of hexokinase in cardioprotection - mechanism and potential for translation. Br J Pharmacol (2014) 0.84
Remote conditioning the heart overview: translatability and mechanism. Br J Pharmacol (2014) 0.84
Modulation of cardiac Na+,K+-ATPase cell surface abundance by simulated ischemia-reperfusion and ouabain preconditioning. Am J Physiol Heart Circ Physiol (2012) 0.83
Ca2+ sensitization and PKC contribute to exercise training-enhanced contractility in porcine collateral-dependent coronary arteries. Am J Physiol Heart Circ Physiol (2011) 0.83
Happy birthday protein kinase C: past, present and future of a superfamily. Pharmacol Res (2007) 0.83
Cardiac response to chronic intermittent hypoxia with a transition from adaptation to maladaptation: the role of hydrogen peroxide. Oxid Med Cell Longev (2012) 0.83
Protein kinase C and acute respiratory distress syndrome. Shock (2013) 0.82
Chronic intermittent hypobaric hypoxia protects the heart against ischemia/reperfusion injury through upregulation of antioxidant enzymes in adult guinea pigs. Acta Pharmacol Sin (2009) 0.82
Age-related differences in cardiac ischemia-reperfusion injury: effects of estrogen deficiency. Pflugers Arch (2013) 0.81
Stat3 binds to mtDNA and regulates mitochondrial gene expression in keratinocytes. J Invest Dermatol (2014) 0.81
Role of phosphoinositide 3-kinase IA (PI3K-IA) activation in cardioprotection induced by ouabain preconditioning. J Mol Cell Cardiol (2015) 0.80
Two protein kinase C isoforms, δ and ε, regulate energy homeostasis in mitochondria by transmitting opposing signals to the pyruvate dehydrogenase complex. FASEB J (2012) 0.80
Low molecular weight fibroblast growth factor-2 signals via protein kinase C and myofibrillar proteins to protect against postischemic cardiac dysfunction. Am J Physiol Heart Circ Physiol (2013) 0.79
α1A-Adrenergic receptor prevents cardiac ischemic damage through PKCδ/GLUT1/4-mediated glucose uptake. J Recept Signal Transduct Res (2015) 0.78
Structural basis for phosphorylation and lysine acetylation cross-talk in a kinase motif associated with myocardial ischemia and cardioprotection. J Biol Chem (2014) 0.78
Age-related reduction of cerebral ischemic preconditioning: myth or reality? Clin Interv Aging (2013) 0.78
Angiotensin II and ischemic preconditioning synergize to improve mitochondrial function while showing additive effects on ventricular postischemic recovery. J Cardiovasc Pharmacol (2014) 0.78
Ischemia/Reperfusion. Compr Physiol (2016) 0.78
Development of a minipig model for lung injury induced by a single high-dose radiation exposure and evaluation with thoracic computed tomography. J Radiat Res (2015) 0.77
ARF1-regulated coatomer directs the steady-state localization of protein kinase C epsilon at the Golgi apparatus. Biochim Biophys Acta (2012) 0.76
Ethanol for cardiac ischemia: the role of protein kinase c. Ther Adv Cardiovasc Dis (2008) 0.76
The effect of autologous platelet-rich plasma on bronchial stump tissue granulation after pneumonectomy: experimental study. ISRN Surg (2013) 0.76
Recent advances in renal hypoxia: insights from bench experiments and computer simulations. Am J Physiol Renal Physiol (2016) 0.75
Protein Kinase C as Regulator of Vascular Smooth Muscle Function and Potential Target in Vascular Disorders. Adv Pharmacol (2016) 0.75
Novel swine model of ricin-induced acute respiratory distress syndrome. Dis Model Mech (2017) 0.75
Effect of PKC inhibitor on experimental autoimmune myocarditis in Lewis rats. Oncotarget (2017) 0.75
Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. Science (2008) 4.32
Intracoronary KAI-9803 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction. Circulation (2008) 2.59
Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration. J Clin Invest (2013) 1.83
Aldehyde dehydrogenase activation prevents reperfusion arrhythmias by inhibiting local renin release from cardiac mast cells. Circulation (2010) 1.82
Inhibition of delta-protein kinase C protects against reperfusion injury of the ischemic heart in vivo. Circulation (2003) 1.80
Pharmacological inhibition of epsilon PKC suppresses chronic inflammation in murine cardiac transplantation model. J Mol Cell Cardiol (2007) 1.78
Protein kinase C delta mediates cerebral reperfusion injury in vivo. J Neurosci (2004) 1.71
Impaired perfusion after myocardial infarction is due to reperfusion-induced deltaPKC-mediated myocardial damage. Cardiovasc Res (2006) 1.70
Preservation of base-line hemodynamic function and loss of inducible cardioprotection in adult mice lacking protein kinase C epsilon. J Biol Chem (2003) 1.63
Protein kinase Cdelta activation induces apoptosis in response to cardiac ischemia and reperfusion damage: a mechanism involving BAD and the mitochondria. J Biol Chem (2004) 1.62
Additive protection of the ischemic heart ex vivo by combined treatment with delta-protein kinase C inhibitor and epsilon-protein kinase C activator. Circulation (2003) 1.60
Cardioprotection by epsilon-protein kinase C activation from ischemia: continuous delivery and antiarrhythmic effect of an epsilon-protein kinase C-activating peptide. Circulation (2004) 1.60
Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant. Nat Struct Mol Biol (2010) 1.57
PKC isozymes in chronic cardiac disease: possible therapeutic targets? Annu Rev Pharmacol Toxicol (2008) 1.51
Targeting aldehyde dehydrogenase 2: new therapeutic opportunities. Physiol Rev (2014) 1.51
Epsilon PKC is required for the induction of tolerance by ischemic and NMDA-mediated preconditioning in the organotypic hippocampal slice. J Neurosci (2003) 1.50
Protein kinase C in heart failure: a therapeutic target? Cardiovasc Res (2009) 1.50
Aberrant mitochondrial fission in neurons induced by protein kinase C{delta} under oxidative stress conditions in vivo. Mol Biol Cell (2010) 1.49
Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts. Am J Physiol Heart Circ Physiol (2002) 1.45
Dopamine-induced exocytosis of Na,K-ATPase is dependent on activation of protein kinase C-epsilon and -delta. Mol Biol Cell (2002) 1.45
The role of protein kinase C in cerebral ischemic and reperfusion injury. Stroke (2005) 1.44
Time-dependent and ethanol-induced cardiac protection from ischemia mediated by mitochondrial translocation of varepsilonPKC and activation of aldehyde dehydrogenase 2. J Mol Cell Cardiol (2008) 1.44
A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity. J Cell Sci (2012) 1.42
Mitochondrial aldehyde dehydrogenase and cardiac diseases. Cardiovasc Res (2010) 1.39
Aldehyde dehydrogenase 2 in cardiac protection: a new therapeutic target? Trends Cardiovasc Med (2009) 1.38
Opposing roles of delta and epsilonPKC in cardiac ischemia and reperfusion: targeting the apoptotic machinery. Arch Biochem Biophys (2003) 1.37
Epsilon protein kinase C as a potential therapeutic target for the ischemic heart. Cardiovasc Res (2006) 1.35
Reperfusion-induced translocation of deltaPKC to cardiac mitochondria prevents pyruvate dehydrogenase reactivation. Circ Res (2005) 1.34
Mitochondrial import of PKCepsilon is mediated by HSP90: a role in cardioprotection from ischaemia and reperfusion injury. Cardiovasc Res (2010) 1.30
Acute inhibition of excessive mitochondrial fission after myocardial infarction prevents long-term cardiac dysfunction. J Am Heart Assoc (2013) 1.28
Activation of aldehyde dehydrogenase 2 (ALDH2) confers cardioprotection in protein kinase C epsilon (PKCvarepsilon) knockout mice. J Mol Cell Cardiol (2009) 1.27
The PKCdelta -Abl complex communicates ER stress to the mitochondria - an essential step in subsequent apoptosis. J Cell Sci (2008) 1.26
Intracellular transport mechanisms of signal transducers. Annu Rev Physiol (2002) 1.26
The betagamma subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins. J Biol Chem (2002) 1.24
Biodistribution of intracellularly acting peptides conjugated reversibly to Tat. Biochem Biophys Res Commun (2004) 1.22
Tissue angiotensin II during progression or ventricular hypertrophy to heart failure in hypertensive rats; differential effects on PKC epsilon and PKC beta. J Mol Cell Cardiol (2002) 1.20
Ischaemic preconditioning improves proteasomal activity and increases the degradation of deltaPKC during reperfusion. Cardiovasc Res (2009) 1.18
Rationally designed peptide regulators of protein kinase C. Trends Endocrinol Metab (2008) 1.17
Suppression of deltaPKC activation after focal cerebral ischemia contributes to the protective effect of hypothermia. J Cereb Blood Flow Metab (2007) 1.17
Sustained pharmacological inhibition of deltaPKC protects against hypertensive encephalopathy through prevention of blood-brain barrier breakdown in rats. J Clin Invest (2008) 1.17
Peptides derived from the C2 domain of protein kinase C epsilon (epsilon PKC) modulate epsilon PKC activity and identify potential protein-protein interaction surfaces. J Biol Chem (2006) 1.16
Sequential activation of individual PKC isozymes in integrin-mediated muscle cell spreading: a role for MARCKS in an integrin signaling pathway. J Cell Sci (2002) 1.14
Epsilon protein kinase C mediated ischemic tolerance requires activation of the extracellular regulated kinase pathway in the organotypic hippocampal slice. J Cereb Blood Flow Metab (2004) 1.14
deltaPKC participates in the endoplasmic reticulum stress-induced response in cultured cardiac myocytes and ischemic heart. J Mol Cell Cardiol (2007) 1.11
DeltaPKC mediates microcerebrovascular dysfunction in acute ischemia and in chronic hypertensive stress in vivo. Brain Res (2007) 1.11
Insight into intra- and inter-molecular interactions of PKC: design of specific modulators of kinase function. Pharmacol Res (2007) 1.10
Exercise training restores cardiac protein quality control in heart failure. PLoS One (2012) 1.06
A critical intramolecular interaction for protein kinase Cepsilon translocation. J Biol Chem (2004) 1.06
Protein kinase C delta (deltaPKC)-annexin V interaction: a required step in deltaPKC translocation and function. J Biol Chem (2006) 1.06
Protein quality control disruption by PKCβII in heart failure; rescue by the selective PKCβII inhibitor, βIIV5-3. PLoS One (2012) 1.05
Suppression of graft coronary artery disease by a brief treatment with a selective epsilonPKC activator and a deltaPKC inhibitor in murine cardiac allografts. Circulation (2004) 1.04
Dopamine and ethanol cause translocation of epsilonPKC associated with epsilonRACK: cross-talk between cAMP-dependent protein kinase A and protein kinase C signaling pathways. Mol Pharmacol (2008) 1.04
epsilonPKC confers acute tolerance to cerebral ischemic reperfusion injury. Neurosci Lett (2008) 1.04
Protein kinase C delta cleavage initiates an aberrant signal transduction pathway after cardiac arrest and oxygen glucose deprivation. J Cereb Blood Flow Metab (2005) 1.03
ALDH2 activator inhibits increased myocardial infarction injury by nitroglycerin tolerance. Sci Transl Med (2011) 1.02
Pharmacological inhibition of epsilon-protein kinase C attenuates cardiac fibrosis and dysfunction in hypertension-induced heart failure. Hypertension (2008) 1.02
Opposing effects of delta- and zeta-protein kinase C isozymes on cardiac fibroblast proliferation: use of isozyme-selective inhibitors. J Mol Cell Cardiol (2003) 1.00
Protein kinase C epsilon and gamma: involvement in formalin-induced nociception in neonatal rats. J Pharmacol Exp Ther (2004) 1.00
Pharmacological inhibition of βIIPKC is cardioprotective in late-stage hypertrophy. J Mol Cell Cardiol (2011) 0.99
RACK1 regulates Src-mediated Sam68 and p190RhoGAP signaling. Oncogene (2004) 0.98
Isozyme-specific inhibitors and activators of protein kinase C. Methods Enzymol (2002) 0.98
Myocardial salvage in acute myocardial infarction--challenges in clinical translation. J Mol Cell Cardiol (2011) 0.98
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) phosphorylation by protein kinase Cδ (PKCδ) inhibits mitochondria elimination by lysosomal-like structures following ischemia and reoxygenation-induced injury. J Biol Chem (2013) 0.97
deltaPKC inhibition or varepsilonPKC activation repairs endothelial vascular dysfunction by regulating eNOS post-translational modification. J Mol Cell Cardiol (2009) 0.97
A personalized medicine approach for Asian Americans with the aldehyde dehydrogenase 2*2 variant. Annu Rev Pharmacol Toxicol (2014) 0.97
Centrosomal PKCbetaII and pericentrin are critical for human prostate cancer growth and angiogenesis. Cancer Res (2008) 0.96
Molecular dynamics characterization of the C2 domain of protein kinase Cbeta. J Biol Chem (2002) 0.96
A novel aldehyde dehydrogenase-3 activator leads to adult salivary stem cell enrichment in vivo. Clin Cancer Res (2011) 0.96
Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases. J Biol Chem (2011) 0.95
PKCβII inhibition attenuates myocardial infarction induced heart failure and is associated with a reduction of fibrosis and pro-inflammatory responses. J Cell Mol Med (2011) 0.94
Nitroglycerin use in myocardial infarction patients. Circ J (2011) 0.93
Highly Specific Modulators of Protein Kinase C Localization: Applications to Heart Failure. Drug Discov Today Dis Mech (2010) 0.92
Mast cells and epsilonPKC: a role in cardiac remodeling in hypertension-induced heart failure. J Mol Cell Cardiol (2008) 0.92
RBCK1, a protein kinase CbetaI (PKCbetaI)-interacting protein, regulates PKCbeta-dependent function. J Biol Chem (2006) 0.92
PKCδ activation mediates angiogenesis via NADPH oxidase activity in PC-3 prostate cancer cells. Prostate (2010) 0.90
Cell-specific role for epsilon- and betaI-protein kinase C isozymes in protecting cortical neurons and astrocytes from ischemia-like injury. Neuropharmacology (2004) 0.90
Nociceptive-induced myocardial remote conditioning is mediated by neuronal gamma protein kinase C. Basic Res Cardiol (2013) 0.90
PKC-{epsilon}-dependent survival signals in diabetic hearts. Am J Physiol Heart Circ Physiol (2005) 0.89
Common ALDH2 genetic variants predict development of hypertension in the SAPPHIRe prospective cohort: gene-environmental interaction with alcohol consumption. BMC Cardiovasc Disord (2012) 0.89
Regulation of mitochondrial processes: a target for heart failure. Drug Discov Today Dis Mech (2010) 0.89
Matrix metalloproteinases modulated by protein kinase Cε mediate resistin-induced migration of human coronary artery smooth muscle cells. J Vasc Surg (2011) 0.89
βIIPKC and εPKC isozymes as potential pharmacological targets in cardiac hypertrophy and heart failure. J Mol Cell Cardiol (2010) 0.89
Development of selective inhibitors for aldehyde dehydrogenases based on substituted indole-2,3-diones. J Med Chem (2014) 0.89
Selective activation of protein kinase C∊ in mitochondria is neuroprotective in vitro and reduces focal ischemic brain injury in mice. J Neurosci Res (2013) 0.88
Protein kinase Cgamma mediates ethanol withdrawal hyper-responsiveness of NMDA receptor currents in spinal cord motor neurons. Br J Pharmacol (2005) 0.87
PKC isozyme selective regulation of cloned human cardiac delayed slow rectifier K current. Biochem Biophys Res Commun (2003) 0.87
Prevention of NMDA-induced death of cortical neurons by inhibition of protein kinase Czeta. J Neurochem (2003) 0.86
State-specific monoclonal antibodies identify an intermediate state in epsilon protein kinase C activation. J Biol Chem (2004) 0.86
Sustained inhibition of epsilon protein kinase C inhibits vascular restenosis after balloon injury and stenting. Circulation (2010) 0.86
Exaggerated nociceptive responses on morphine withdrawal: roles of protein kinase C epsilon and gamma. Pain (2004) 0.86
β2-adrenergic receptors mediate cardioprotection through crosstalk with mitochondrial cell death pathways. J Mol Cell Cardiol (2011) 0.85
Therapeutic potential for protein kinase C inhibitor in vascular restenosis. J Cardiovasc Pharmacol Ther (2010) 0.85
Use of a novel method to find substrates of protein kinase C delta identifies M2 pyruvate kinase. Int J Biochem Cell Biol (2007) 0.84
Happy birthday protein kinase C: past, present and future of a superfamily. Pharmacol Res (2007) 0.83
Ethanol withdrawal-associated allodynia and hyperalgesia: age-dependent regulation by protein kinase C epsilon and gamma isoenzymes. J Pain (2005) 0.83
Preserved coronary endothelial function by inhibition of delta protein kinase C in a porcine acute myocardial infarction model. Int J Cardiol (2008) 0.81