Protein kinase Cepsilon interacts with Stat3 and regulates its activation that is essential for the development of skin cancer.

Protein kinase C isoforms: Multi-functional regulators of cell life and death. Front Biosci (Landmark Ed) (2009) 1.93

Regulation of translocator protein 18 kDa (TSPO) expression in health and disease states. Mol Cell Endocrinol (2010) 1.60

Protein kinase C epsilon: an oncogene and emerging tumor biomarker. Mol Cancer (2009) 1.56

Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3. Cell Commun Signal (2016) 1.38

Defining a tissue stem cell-driven Runx1/Stat3 signalling axis in epithelial cancer. EMBO J (2012) 1.25

Protein kinase Cvarepsilon mediates Stat3Ser727 phosphorylation, Stat3-regulated gene expression, and cell invasion in various human cancer cell lines through integration with MAPK cascade (RAF-1, MEK1/2, and ERK1/2). Oncogene (2010) 1.20

Linear combinations of docking affinities explain quantitative differences in RTK signaling. Mol Syst Biol (2009) 1.16

Molecular mechanisms of mouse skin tumor promotion. Cancers (Basel) (2010) 1.09

Genetic ablation of PKC epsilon inhibits prostate cancer development and metastasis in transgenic mouse model of prostate adenocarcinoma. Cancer Res (2011) 0.98

Hepatitis C virus core protein augments androgen receptor-mediated signaling. J Virol (2008) 0.98

PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis. Leukemia (2013) 0.92

Intracellular interaction of interleukin (IL)-32α with protein kinase Cε (PKCε ) and STAT3 protein augments IL-6 production in THP-1 promonocytic cells. J Biol Chem (2012) 0.91

Protein kinase C epsilon regulation of translocator protein (18 kDa) Tspo gene expression is mediated through a MAPK pathway targeting STAT3 and c-Jun transcription factors. Biochemistry (2010) 0.90

The thyroid hormone receptors as modulators of skin proliferation and inflammation. J Biol Chem (2011) 0.88

Activation of protein kinase C{eta} by type I interferons. J Biol Chem (2009) 0.88

Role of calcium-dependent protein kinases in chronic myeloid leukemia: combined effects of PKC and BCR-ABL signaling on cellular alterations during leukemia development. Onco Targets Ther (2014) 0.86

Role of stat3 in skin carcinogenesis: insights gained from relevant mouse models. J Skin Cancer (2013) 0.86

Histamine stimulates the proliferation of small and large cholangiocytes by activation of both IP3/Ca2+ and cAMP-dependent signaling mechanisms. Lab Invest (2011) 0.86

Stat3 binds to mtDNA and regulates mitochondrial gene expression in keratinocytes. J Invest Dermatol (2014) 0.81

Presenilin regulates insulin signaling via a gamma-secretase-independent mechanism. J Biol Chem (2011) 0.78

Protein Kinase C ε , Which Is Linked to Ultraviolet Radiation-Induced Development of Squamous Cell Carcinomas, Stimulates Rapid Turnover of Adult Hair Follicle Stem Cells. J Skin Cancer (2013) 0.77

PKCdelta mediates thrombin-augmented fibroblast-mediated collagen gel contraction. Biochem Biophys Res Commun (2008) 0.76

Tissue-specific conditional PKCε knockout mice: a model to precisely reveal PKCε functional role in initiation, promotion and progression of cancer. Oncotarget (2016) 0.75

Protein kinase Cepsilon interacts with signal transducers and activators of transcription 3 (Stat3), phosphorylates Stat3Ser727, and regulates its constitutive activation in prostate cancer. Cancer Res (2007) 1.56

PKCepsilon overexpression, irrespective of genetic background, sensitizes skin to UVR-induced development of squamous-cell carcinomas. J Invest Dermatol (2010) 1.46

Plumbagin, a medicinal plant-derived naphthoquinone, is a novel inhibitor of the growth and invasion of hormone-refractory prostate cancer. Cancer Res (2008) 1.39

Protein kinase C epsilon, which sensitizes skin to sun's UV radiation-induced cutaneous damage and development of squamous cell carcinomas, associates with Stat3. Cancer Res (2007) 1.31

A randomized, double-blind, placebo-controlled phase 3 skin cancer prevention study of {alpha}-difluoromethylornithine in subjects with previous history of skin cancer. Cancer Prev Res (Phila) (2010) 1.21

Protein kinase Cepsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor-alpha ectodomain shedding and the development of metastatic squamous cell carcinoma in protein kinase Cepsilon transgenic mice. Cancer Res (2003) 1.15

Protein kinase C epsilon is an endogenous photosensitizer that enhances ultraviolet radiation-induced cutaneous damage and development of squamous cell carcinomas. Cancer Res (2004) 1.15

CpG PatternFinder: a Windows-based utility program for easy and rapid identification of the CpG methylation status of DNA. Biotechniques (2007) 1.07

Genetic ablation of PKC epsilon inhibits prostate cancer development and metastasis in transgenic mouse model of prostate adenocarcinoma. Cancer Res (2011) 0.98

Plumbagin, a medicinal plant (Plumbago zeylanica)-derived 1,4-naphthoquinone, inhibits growth and metastasis of human prostate cancer PC-3M-luciferase cells in an orthotopic xenograft mouse model. Mol Oncol (2012) 0.94

Protein kinase C epsilon signals ultraviolet light-induced cutaneous damage and development of squamous cell carcinoma possibly through Induction of specific cytokines in a paracrine mechanism. Photochem Photobiol (2005) 0.91

Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone), isolated from Plumbago zeylanica, inhibits ultraviolet radiation-induced development of squamous cell carcinomas. Carcinogenesis (2011) 0.90

Plumbagin inhibits prostate cancer development in TRAMP mice via targeting PKCε, Stat3 and neuroendocrine markers. Carcinogenesis (2012) 0.88

CpG analyzer, a Windows-based utility program for investigation of DNA methylation. Biotechniques (2005) 0.88

Overexpression of protein kinase C-{epsilon} in the mouse epidermis leads to a spontaneous myeloproliferative-like disease. Am J Pathol (2005) 0.85

Protein kinase C delta overexpressing transgenic mice are resistant to chemically but not to UV radiation-induced development of squamous cell carcinomas: a possible link to specific cytokines and cyclooxygenase-2. Cancer Res (2006) 0.82

Early epidermal destruction with subsequent epidermal hyperplasia is a unique feature of the papilloma-independent squamous cell carcinoma phenotype in PKCepsilon overexpressing transgenic mice. Toxicol Pathol (2005) 0.81

Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss. Cancer Res (2003) 0.80

Protein kinase Cdelta-mediated signal to ornithine decarboxylase induction is independent of skin tumor suppression. Oncogene (2002) 0.80

Consequences of periodic α-to-β(3) residue replacement for immunological recognition of peptide epitopes. ACS Chem Biol (2015) 0.80

GidA expression in Salmonella is modulated under certain environmental conditions. Curr Microbiol (2013) 0.78

Protein Kinase C ε , Which Is Linked to Ultraviolet Radiation-Induced Development of Squamous Cell Carcinomas, Stimulates Rapid Turnover of Adult Hair Follicle Stem Cells. J Skin Cancer (2013) 0.77

Induction of apoptosis and inhibition of papilloma formation may signal a new role for okadaic acid. Life Sci (2002) 0.76

Differential tumor biology effects of double-initiation in a mouse skin chemical carcinogenesis model comparing wild type versus protein kinase Cepsilon overexpression mice. Toxicol Pathol (2007) 0.76

Genetic deletion of TNFα inhibits ultraviolet radiation-induced development of cutaneous squamous cell carcinomas in PKCε transgenic mice via inhibition of cell survival signals. Carcinogenesis (2015) 0.75

Mouse models of the skin: models to define mechanisms of skin carcinogenesis. J Skin Cancer (2013) 0.75