Published in Cancer Res on March 15, 2011
Protein kinase C and cancer: what we know and what we do not. Oncogene (2013) 1.09
Plumbagin, a medicinal plant (Plumbago zeylanica)-derived 1,4-naphthoquinone, inhibits growth and metastasis of human prostate cancer PC-3M-luciferase cells in an orthotopic xenograft mouse model. Mol Oncol (2012) 0.94
Activation of nuclear factor κB (NF-κB) in prostate cancer is mediated by protein kinase C epsilon (PKCepsilon). J Biol Chem (2012) 0.88
Plumbagin inhibits prostate cancer development in TRAMP mice via targeting PKCε, Stat3 and neuroendocrine markers. Carcinogenesis (2012) 0.88
Inhibition of 5-lipoxygenase triggers apoptosis in prostate cancer cells via down-regulation of protein kinase C-epsilon. Biochim Biophys Acta (2011) 0.87
Role of calcium-dependent protein kinases in chronic myeloid leukemia: combined effects of PKC and BCR-ABL signaling on cellular alterations during leukemia development. Onco Targets Ther (2014) 0.86
Genetic inhibition of protein kinase Cε attenuates necrosis in experimental pancreatitis. Am J Physiol Gastrointest Liver Physiol (2014) 0.85
Role of signaling transduction pathways in development of castration-resistant prostate cancer. Prostate Cancer (2011) 0.83
PKC-ε pseudosubstrate and catalytic activity are necessary for membrane delivery during IgG-mediated phagocytosis. J Leukoc Biol (2013) 0.80
Plumbagin Inhibits Prostate Carcinogenesis in Intact and Castrated PTEN Knockout Mice via Targeting PKCε, Stat3, and Epithelial-to-Mesenchymal Transition Markers. Cancer Prev Res (Phila) (2015) 0.80
INPP4B suppresses prostate cancer cell invasion. Cell Commun Signal (2014) 0.79
Bortezomib induces neuropathic pain through protein kinase C-mediated activation of presynaptic NMDA receptors in the spinal cord. Neuropharmacology (2017) 0.76
Protein kinase C epsilon and genetic networks in osteosarcoma metastasis. Cancers (Basel) (2013) 0.75
Diapeutic cancer-targeting alkylphosphocholine analogs may advance management of brain malignancies. CNS Oncol (2016) 0.75
Tissue-specific conditional PKCε knockout mice: a model to precisely reveal PKCε functional role in initiation, promotion and progression of cancer. Oncotarget (2016) 0.75
PKCε Is an Essential Mediator of Prostate Cancer Bone Metastasis. Mol Cancer Res (2015) 0.75
Reversing the Paradigm: Protein Kinase C as a Tumor Suppressor. Trends Pharmacol Sci (2017) 0.75
Golgi-Associated Protein Kinase C-ε Is Delivered to Phagocytic Cups: Role of Phosphatidylinositol 4-Phosphate. J Immunol (2017) 0.75
Cancer statistics, 2010. CA Cancer J Clin (2010) 103.28
Prostate cancer in a transgenic mouse. Proc Natl Acad Sci U S A (1995) 8.16
The extended protein kinase C superfamily. Biochem J (1998) 5.84
Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions. Chem Rev (2001) 4.38
Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis. J Clin Invest (2004) 3.70
Risk assessment for prostate cancer metastasis and mortality at the time of diagnosis. J Natl Cancer Inst (2009) 2.84
Elevated levels of circulating interleukin-6 and transforming growth factor-beta1 in patients with metastatic prostatic carcinoma. J Urol (1999) 2.00
Stat3 promotes metastatic progression of prostate cancer. Am J Pathol (2008) 1.85
Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors. Cancer Res (2005) 1.82
Circulating levels of interleukin-6 in patients with hormone refractory prostate cancer. Prostate (1999) 1.71
Protein kinase Cepsilon interacts with signal transducers and activators of transcription 3 (Stat3), phosphorylates Stat3Ser727, and regulates its constitutive activation in prostate cancer. Cancer Res (2007) 1.56
The epsilon isoform of protein kinase C is an oncogene when overexpressed in rat fibroblasts. Oncogene (1993) 1.50
Constitutive activation of P I3 K-Akt and NF-kappaB during prostate cancer progression in autochthonous transgenic mouse model. Prostate (2005) 1.48
Plumbagin, a medicinal plant-derived naphthoquinone, is a novel inhibitor of the growth and invasion of hormone-refractory prostate cancer. Cancer Res (2008) 1.39
Protein kinase cepsilon has the potential to advance the recurrence of human prostate cancer. Cancer Res (2002) 1.39
Eyes wide shut: protein kinase C isozymes are not the only receptors for the phorbol ester tumor promoters. Mol Carcinog (2000) 1.32
Protein kinase Cepsilon interacts with Bax and promotes survival of human prostate cancer cells. Oncogene (2003) 1.29
Stable expression of constitutively-activated STAT3 in benign prostatic epithelial cells changes their phenotype to that resembling malignant cells. Mol Cancer (2005) 1.18
Synthesis and structure-activity relationship effects on the tumor avidity of radioiodinated phospholipid ether analogues. J Med Chem (2006) 1.16
Ki-67 and PCNA expression in prostate cancer and benign prostatic hyperplasia. Clin Invest Med (2008) 1.15
Epidermal keratinocytes: regulation of multiple cell phenotypes by multiple protein kinase C isoforms. Int J Biochem Cell Biol (2004) 1.13
Integrin signaling links protein kinase Cepsilon to the protein kinase B/Akt survival pathway in recurrent prostate cancer cells. Oncogene (2004) 1.13
Protein kinase Cepsilon interacts with Stat3 and regulates its activation that is essential for the development of skin cancer. Mol Carcinog (2007) 1.12
Regulation of prostate cancer cell survival by protein kinase Cepsilon involves bad phosphorylation and modulation of the TNFalpha/JNK pathway. J Biol Chem (2010) 1.03
The protein kinase C family and lipid mediators for transmembrane signaling and cell regulation. Alcohol Clin Exp Res (2001) 0.97
A target-selected Apc-mutant rat kindred enhances the modeling of familial human colon cancer. Proc Natl Acad Sci U S A (2007) 1.81
Targeted knockdown of Notch1 inhibits invasion of human prostate cancer cells concomitant with inhibition of matrix metalloproteinase-9 and urokinase plasminogen activator. Clin Cancer Res (2009) 1.57
Protein kinase Cepsilon interacts with signal transducers and activators of transcription 3 (Stat3), phosphorylates Stat3Ser727, and regulates its constitutive activation in prostate cancer. Cancer Res (2007) 1.56
Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition? J Biol Chem (2008) 1.46
PKCepsilon overexpression, irrespective of genetic background, sensitizes skin to UVR-induced development of squamous-cell carcinomas. J Invest Dermatol (2010) 1.46
A novel biomarker for staging human prostate adenocarcinoma: overexpression of matriptase with concomitant loss of its inhibitor, hepatocyte growth factor activator inhibitor-1. Cancer Epidemiol Biomarkers Prev (2006) 1.41
Plumbagin, a medicinal plant-derived naphthoquinone, is a novel inhibitor of the growth and invasion of hormone-refractory prostate cancer. Cancer Res (2008) 1.39
Protein kinase C epsilon, which sensitizes skin to sun's UV radiation-induced cutaneous damage and development of squamous cell carcinomas, associates with Stat3. Cancer Res (2007) 1.31
A randomized, double-blind, placebo-controlled phase 3 skin cancer prevention study of {alpha}-difluoromethylornithine in subjects with previous history of skin cancer. Cancer Prev Res (Phila) (2010) 1.21
Chronic bacterial infection and inflammation incite reactive hyperplasia in a mouse model of chronic prostatitis. Prostate (2007) 1.17
Protein kinase C epsilon is an endogenous photosensitizer that enhances ultraviolet radiation-induced cutaneous damage and development of squamous cell carcinomas. Cancer Res (2004) 1.15
Apoptosis induced by selenomethionine and methioninase is superoxide mediated and p53 dependent in human prostate cancer cells. Mol Cancer Ther (2006) 1.13
Protein kinase Cepsilon interacts with Stat3 and regulates its activation that is essential for the development of skin cancer. Mol Carcinog (2007) 1.12
Targeted depletion of Polo-like kinase (Plk) 1 through lentiviral shRNA or a small-molecule inhibitor causes mitotic catastrophe and induction of apoptosis in human melanoma cells. J Invest Dermatol (2009) 1.10
Sodium selenite induces apoptosis by generation of superoxide via the mitochondrial-dependent pathway in human prostate cancer cells. Cancer Chemother Pharmacol (2008) 1.10
Selenite reactivates silenced genes by modifying DNA methylation and histones in prostate cancer cells. Carcinogenesis (2008) 1.09
Expression of p53 enhances selenite-induced superoxide production and apoptosis in human prostate cancer cells. Cancer Res (2006) 1.05
Extracellular redox state regulates features associated with prostate cancer cell invasion. Cancer Res (2008) 1.03
Increased manganese superoxide dismutase (SOD-2) is part of the mechanism for prostate tumor suppression by Mac25/insulin-like growth factor binding-protein-related protein-1. Oncogene (2003) 1.00
Thioredoxin 1 as a subcellular biomarker of redox imbalance in human prostate cancer progression. Free Radic Biol Med (2010) 0.99
Redox imbalance and biochemical changes in cancer. Cancer Res (2013) 0.97
Characterization of redox state of two human prostate carcinoma cell lines with different degrees of aggressiveness. Free Radic Biol Med (2007) 0.96
Regulation of prostate cancer cell invasion by modulation of extra- and intracellular redox balance. Free Radic Biol Med (2011) 0.96
In vivo cancer imaging by poly(ethylene glycol)-b-poly(ɛ-caprolactone) micelles containing a near-infrared probe. Nanomedicine (2011) 0.94
Plumbagin, a medicinal plant (Plumbago zeylanica)-derived 1,4-naphthoquinone, inhibits growth and metastasis of human prostate cancer PC-3M-luciferase cells in an orthotopic xenograft mouse model. Mol Oncol (2012) 0.94
Plumbagin, a plant derived natural agent inhibits the growth of pancreatic cancer cells in in vitro and in vivo via targeting EGFR, Stat3 and NF-κB signaling pathways. Int J Cancer (2012) 0.93
Effects of selenite and genistein on G2/M cell cycle arrest and apoptosis in human prostate cancer cells. Nutr Cancer (2009) 0.92
Polo-like kinase 1 (Plk1) in non-melanoma skin cancers. Cell Cycle (2009) 0.91
Protein kinase C epsilon signals ultraviolet light-induced cutaneous damage and development of squamous cell carcinoma possibly through Induction of specific cytokines in a paracrine mechanism. Photochem Photobiol (2005) 0.91
Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone), isolated from Plumbago zeylanica, inhibits ultraviolet radiation-induced development of squamous cell carcinomas. Carcinogenesis (2011) 0.90
BMI1, stem cell factor acting as novel serum-biomarker for Caucasian and African-American prostate cancer. PLoS One (2013) 0.90
Reversible modulation of cell cycle kinetics in NIH/3T3 mouse fibroblasts by inducible overexpression of mitochondrial manganese superoxide dismutase. Antioxid Redox Signal (2004) 0.89
Plumbagin inhibits prostate cancer development in TRAMP mice via targeting PKCε, Stat3 and neuroendocrine markers. Carcinogenesis (2012) 0.88
Overexpression of protein kinase C-{epsilon} in the mouse epidermis leads to a spontaneous myeloproliferative-like disease. Am J Pathol (2005) 0.85
Distinct redox profiles of selected human prostate carcinoma cell lines: implications for rational design of redox therapy. Cancers (Basel) (2011) 0.82
Early epidermal destruction with subsequent epidermal hyperplasia is a unique feature of the papilloma-independent squamous cell carcinoma phenotype in PKCepsilon overexpressing transgenic mice. Toxicol Pathol (2005) 0.81
The pharmacological features of bilirubin: the question of the century. Cell Mol Biol Lett (2015) 0.81
Methaneseleninic acid and γ-Tocopherol combination inhibits prostate tumor growth in Vivo in a xenograft mouse model. Oncotarget (2014) 0.80
α-Mangostin: a dietary antioxidant derived from the pericarp of Garcinia mangostana L. inhibits pancreatic tumor growth in xenograft mouse model. Antioxid Redox Signal (2014) 0.80
Protein kinase Cdelta-mediated signal to ornithine decarboxylase induction is independent of skin tumor suppression. Oncogene (2002) 0.80
Breast cancer imaging using the near-infrared fluorescent agent, CLR1502. Mol Imaging (2014) 0.79
Protein Kinase C ε , Which Is Linked to Ultraviolet Radiation-Induced Development of Squamous Cell Carcinomas, Stimulates Rapid Turnover of Adult Hair Follicle Stem Cells. J Skin Cancer (2013) 0.77
Calcineurin Inhibitor Minimization With Ixazomib, an Investigational Proteasome Inhibitor, for the Prevention of Antibody Mediated Rejection in a Preclinical Model. Transplantation (2015) 0.76
Differential tumor biology effects of double-initiation in a mouse skin chemical carcinogenesis model comparing wild type versus protein kinase Cepsilon overexpression mice. Toxicol Pathol (2007) 0.76
Induction of apoptosis and inhibition of papilloma formation may signal a new role for okadaic acid. Life Sci (2002) 0.76
Genetic deletion of TNFα inhibits ultraviolet radiation-induced development of cutaneous squamous cell carcinomas in PKCε transgenic mice via inhibition of cell survival signals. Carcinogenesis (2015) 0.75
Nox2 and Cyclosporine-Induced Renal Hypoxia. Transplantation (2016) 0.75
A test of rats' tolerance for 3beta-acetoxyandrosta-1,5-dien-17-one ethylene ketal (ADEK), a new anti-androgen. J Steroid Biochem Mol Biol (2008) 0.75
Mouse models of the skin: models to define mechanisms of skin carcinogenesis. J Skin Cancer (2013) 0.75
Quiz Page July 2013: a man with acute kidney injury and cutaneous purpura. Am J Kidney Dis (2013) 0.75