Published in Biochemistry on June 27, 2007
Mechanism and regulation of the Two-component FMN-dependent monooxygenase ActVA-ActVB from Streptomyces coelicolor. J Biol Chem (2008) 1.06
Characterization of chlorophenol 4-monooxygenase (TftD) and NADH:FAD oxidoreductase (TftC) of Burkholderia cepacia AC1100. J Biol Chem (2009) 1.05
Stabilization of C4a-hydroperoxyflavin in a two-component flavin-dependent monooxygenase is achieved through interactions at flavin N5 and C4a atoms. J Biol Chem (2011) 1.05
A flavin-dependent monooxygenase from Mycobacterium tuberculosis involved in cholesterol catabolism. J Biol Chem (2010) 1.04
pH-dependent studies reveal an efficient hydroxylation mechanism of the oxygenase component of p-hydroxyphenylacetate 3-hydroxylase. J Biol Chem (2010) 1.00
Structure and ligand binding properties of the epoxidase component of styrene monooxygenase . Biochemistry (2010) 0.94
LuxG is a functioning flavin reductase for bacterial luminescence. J Bacteriol (2007) 0.93
Studies on the mechanism of p-hydroxyphenylacetate 3-hydroxylase from Pseudomonas aeruginosa: a system composed of a small flavin reductase and a large flavin-dependent oxygenase. Biochemistry (2010) 0.91
Flavin-Dependent Redox Transfers by the Two-Component Diketocamphane Monooxygenases of Camphor-Grown Pseudomonas putida NCIMB 10007. Microorganisms (2016) 0.89
Interactions with the substrate phenolic group are essential for hydroxylation by the oxygenase component of p-hydroxyphenylacetate 3-hydroxylase. J Biol Chem (2011) 0.87
Structure and mechanism of styrene monooxygenase reductase: new insight into the FAD-transfer reaction. Biochemistry (2013) 0.85
Crystallization and preliminary X-ray analysis of the reductase component of p-hydroxyphenylacetate 3-hydroxylase from Acinetobacter baumannii. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.79
Reduction kinetics of a flavin oxidoreductase LuxG from Photobacterium leiognathi (TH1): half-sites reactivity. Biochemistry (2010) 0.77
Monooxygenase Substrates Mimic Flavin to Catalyze Cofactorless Oxygenations. J Biol Chem (2016) 0.77
The C-terminal domain of 4-hydroxyphenylacetate 3-hydroxylase from Acinetobacter baumannii is an autoinhibitory domain. J Biol Chem (2012) 0.76
Kinetic Mechanism of the Dechlorinating Flavin-dependent Monooxygenase HadA. J Biol Chem (2017) 0.75
Active sites of thioredoxin reductases: why selenoproteins? Proc Natl Acad Sci U S A (2003) 1.69
Dynamics involved in catalysis by single-component and two-component flavin-dependent aromatic hydroxylases. Biochem Biophys Res Commun (2005) 1.46
Protein dynamics and electrostatics in the function of p-hydroxybenzoate hydroxylase. Arch Biochem Biophys (2005) 1.41
Reaction of ferric cytochrome P450cam with peracids: kinetic characterization of intermediates on the reaction pathway. J Biol Chem (2005) 1.30
Flavin redox chemistry precedes substrate chlorination during the reaction of the flavin-dependent halogenase RebH. Biochemistry (2006) 1.28
Kinetic mechanisms of the oxygenase from a two-component enzyme, p-hydroxyphenylacetate 3-hydroxylase from Acinetobacter baumannii. J Biol Chem (2006) 1.26
Multiple pathways guide oxygen diffusion into flavoenzyme active sites. Proc Natl Acad Sci U S A (2009) 1.25
Steady-state and transient kinetic analyses of taurine/alpha-ketoglutarate dioxygenase: effects of oxygen concentration, alternative sulfonates, and active-site variants on the FeIV-oxo intermediate. Biochemistry (2005) 1.21
Adenosyltransferase tailors and delivers coenzyme B12. Nat Chem Biol (2008) 1.21
The mechanism of high Mr thioredoxin reductase from Drosophila melanogaster. J Biol Chem (2003) 1.14
Structure of the monooxygenase component of a two-component flavoprotein monooxygenase. Proc Natl Acad Sci U S A (2007) 1.13
Detection of a C4a-hydroperoxyflavin intermediate in the reaction of a flavoprotein oxidase. Biochemistry (2008) 1.11
The reductase of p-hydroxyphenylacetate 3-hydroxylase from Acinetobacter baumannii requires p-hydroxyphenylacetate for effective catalysis. Biochemistry (2005) 1.11
Structural basis for substrate binding and regioselective oxidation of monosaccharides at C3 by pyranose 2-oxidase. J Biol Chem (2006) 1.11
Vanillin suppresses in vitro invasion and in vivo metastasis of mouse breast cancer cells. Eur J Pharm Sci (2005) 1.11
Comprehensive spectroscopic, steady state, and transient kinetic studies of a representative siderophore-associated flavin monooxygenase. J Biol Chem (2010) 1.10
Protein and ligand dynamics in 4-hydroxybenzoate hydroxylase. Proc Natl Acad Sci U S A (2002) 1.10
Structural insights into rice BGlu1 beta-glucosidase oligosaccharide hydrolysis and transglycosylation. J Mol Biol (2008) 1.10
Detection of cathepsin B up-regulation in neoplastic thyroid tissues by proteomic analysis. Proteomics (2002) 1.10
Chemistry of the catalytic conversion of phthalate into its cis-dihydrodiol during the reaction of oxygen with the reduced form of phthalate dioxygenase. Biochemistry (2005) 1.08
Polymorphic variants of cytochrome P450 2B6 (CYP2B6.4-CYP2B6.9) exhibit altered rates of metabolism for bupropion and efavirenz: a charge-reversal mutation in the K139E variant (CYP2B6.8) impairs formation of a functional cytochrome p450-reductase complex. J Pharmacol Exp Ther (2011) 1.08
Vanillin suppresses metastatic potential of human cancer cells through PI3K inhibition and decreases angiogenesis in vivo. J Agric Food Chem (2009) 1.08
Mechanism and regulation of the Two-component FMN-dependent monooxygenase ActVA-ActVB from Streptomyces coelicolor. J Biol Chem (2008) 1.06
Use of 8-substituted-FAD analogues to investigate the hydroxylation mechanism of the flavoprotein 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase. Biochemistry (2004) 1.05
The 1.6 Å crystal structure of pyranose dehydrogenase from Agaricus meleagris rationalizes substrate specificity and reveals a flavin intermediate. PLoS One (2013) 1.05
Stabilization of C4a-hydroperoxyflavin in a two-component flavin-dependent monooxygenase is achieved through interactions at flavin N5 and C4a atoms. J Biol Chem (2011) 1.05
Cloning and expression of p-hydroxyphenylacetate 3-hydroxylase from Acinetobacter baumannii: evidence of the divergence of enzymes in the class of two-protein component aromatic hydroxylases. Biochim Biophys Acta (2004) 1.03
Rates of the phthalate dioxygenase reaction with oxygen are dramatically increased by interactions with phthalate and phthalate oxygenase reductase. Biochemistry (2004) 1.03
Proteomic analysis of cholangiocarcinoma cell line. Proteomics (2004) 1.03
An endochitinase A from Vibrio carchariae: cloning, expression, mass and sequence analyses, and chitin hydrolysis. Arch Biochem Biophys (2004) 1.02
Beta-glucosidase, exo-beta-glucanase and pyridoxine transglucosylase activities of rice BGlu1. Biochem J (2004) 1.02
pH-dependent studies reveal an efficient hydroxylation mechanism of the oxygenase component of p-hydroxyphenylacetate 3-hydroxylase. J Biol Chem (2010) 1.00
Antiviral isoflavonoid sulfate and steroidal glycosides from the fruits of Solanum torvum. Phytochemistry (2002) 0.99
Monitoring changing toxigenicity of a cyanobacterial bloom by molecular methods. Appl Environ Microbiol (2002) 0.98
Spectroscopic investigations of intermediates in the reaction of cytochrome P450(BM3)-F87G with surrogate oxygen atom donors. J Inorg Biochem (2006) 0.98
Elucidating the role of the proximal cysteine hydrogen-bonding network in ferric cytochrome P450cam and corresponding mutants using magnetic circular dichroism spectroscopy. Biochemistry (2011) 0.97
Kinetic characterization of the disulfide bond-forming enzyme DsbB. J Biol Chem (2007) 0.97
The substrate oxidation mechanism of pyranose 2-oxidase and other related enzymes in the glucose-methanol-choline superfamily. FEBS J (2013) 0.96
Proteomic studies of cholangiocarcinoma and hepatocellular carcinoma cell secretomes. J Biomed Biotechnol (2009) 0.95
Substitutions of the "bridging" aspartate 178 result in profound changes in the reactivity of the Rieske center of phthalate dioxygenase. Biochemistry (2006) 0.94
Kinetic mechanism of pyranose 2-oxidase from trametes multicolor. Biochemistry (2009) 0.94
Direct observation of a novel perturbed oxyferrous catalytic intermediate during reduced putidaredoxin-initiated turnover of cytochrome P-450-CAM: probing the effector role of putidaredoxin in catalysis. J Biol Chem (2005) 0.93
Proteomic analysis and abrogated expression of O-GlcNAcylated proteins associated with primary breast cancer. Proteomics (2013) 0.93
LuxG is a functioning flavin reductase for bacterial luminescence. J Bacteriol (2007) 0.93
Replacement of tyrosine residues by phenylalanine in cytochrome P450cam alters the formation of Cpd II-like species in reactions with artificial oxidants. J Biol Inorg Chem (2008) 0.93
Disulfide bond formation involves a quinhydrone-type charge-transfer complex. Proc Natl Acad Sci U S A (2003) 0.92
Acid-base catalysis in the mechanism of thioredoxin reductase from Drosophila melanogaster. Biochemistry (2008) 0.92
The structural basis of oligosaccharide binding by rice BGlu1 beta-glucosidase. J Struct Biol (2010) 0.92
A conserved active-site threonine is important for both sugar and flavin oxidations of pyranose 2-oxidase. J Biol Chem (2010) 0.92
Enzymatic properties of wild-type and active site mutants of chitinase A from Vibrio carchariae, as revealed by HPLC-MS. FEBS J (2005) 0.92
Rapid kinetics investigations of peracid oxidation of ferric cytochrome P450cam: nature and possible function of compound ES. J Inorg Biochem (2006) 0.91
The "bridging" aspartate 178 in phthalate dioxygenase facilitates interactions between the Rieske center and the iron(II)--mononuclear center. Biochemistry (2006) 0.91
Hydrogen peroxide elimination from C4a-hydroperoxyflavin in a flavoprotein oxidase occurs through a single proton transfer from flavin N5 to a peroxide leaving group. J Biol Chem (2011) 0.91
Studies on the mechanism of p-hydroxyphenylacetate 3-hydroxylase from Pseudomonas aeruginosa: a system composed of a small flavin reductase and a large flavin-dependent oxygenase. Biochemistry (2010) 0.91
Identification of acid-base catalytic residues of high-Mr thioredoxin reductase from Plasmodium falciparum. J Biol Chem (2006) 0.89
A flavonoid chrysin suppresses hypoxic survival and metastatic growth of mouse breast cancer cells. Oncol Rep (2013) 0.89
The relationship of the redox potentials of thioredoxin and thioredoxin reductase from Drosophila melanogaster to the enzymatic mechanism: reduced thioredoxin is the reductant of glutathione in Drosophila. Biochemistry (2007) 0.89
Mechanistic studies on a novel, highly potent gold-phosphole inhibitor of human glutathione reductase. J Biol Chem (2005) 0.88
Kinetic isotope effects on the noncovalent flavin mutant protein of pyranose 2-oxidase reveal insights into the flavin reduction mechanism. Biochemistry (2010) 0.88
The FAD cofactor of RebC shifts to an IN conformation upon flavin reduction. Biochemistry (2008) 0.88
Characterization of Plasmodium falciparum serine hydroxymethyltransferase-A potential antimalarial target. Mol Biochem Parasitol (2009) 0.88
H-bonding and positive charge at the N5/O4 locus are critical for covalent flavin attachment in trametes pyranose 2-oxidase. J Mol Biol (2010) 0.88
Investigations of the catalytic mechanism of thioredoxin glutathione reductase from Schistosoma mansoni. Biochemistry (2011) 0.88
Retrospective study of patients with suspected inborn errors of metabolism at Siriraj Hospital, Bangkok, Thailand (1997-2001). J Med Assoc Thai (2005) 0.87
Metabolic alteration of HepG2 in scaffold-based 3-D culture: proteomic approach. Proteomics (2010) 0.87
Mitochondrial and endoplasmic reticulum stress pathways cooperate in zearalenone-induced apoptosis of human leukemic cells. J Hematol Oncol (2010) 0.87
Exploring stemness gene expression and vasculogenic mimicry capacity in well- and poorly-differentiated hepatocellular carcinoma cell lines. Biochem Biophys Res Commun (2012) 0.87
Interactions with the substrate phenolic group are essential for hydroxylation by the oxygenase component of p-hydroxyphenylacetate 3-hydroxylase. J Biol Chem (2011) 0.87
Mutations of Trp275 and Trp397 altered the binding selectivity of Vibrio carchariae chitinase A. Biochim Biophys Acta (2007) 0.87
Serine hydroxymethyltransferase from Plasmodium vivax is different in substrate specificity from its homologues. FEBS J (2009) 0.87
Novel mutations in a Thai patient with methylmalonic acidemia. Mol Genet Metab (2003) 0.87
Aberrant O-GlcNAc-modified proteins expressed in primary colorectal cancer. Oncol Rep (2013) 0.86
Mechanistic studies with N-benzyl-1-aminobenzotriazole-inactivated CYP2B1: differential effects on the metabolism of 7-ethoxy-4-(trifluoromethyl)coumarin, testosterone, and benzphetamine. Arch Biochem Biophys (2004) 0.86
Reactivity of thioredoxin as a protein thiol-disulfide oxidoreductase. Chem Rev (2011) 0.86
Chrysin overcomes TRAIL resistance of cancer cells through Mcl-1 downregulation by inhibiting STAT3 phosphorylation. Int J Oncol (2013) 0.86
Clinical and molecular findings in Thai patients with isolated methylmalonic acidemia. Mol Genet Metab (2012) 0.85
Studies of an active site mutant of the selenoprotein thioredoxin reductase: the Ser-Cys-Cys-Ser motif of the insect orthologue is not sufficient to replace the Cys-Sec dyad in the mammalian enzyme. Free Radic Biol Med (2006) 0.85
Pseudomonas aeruginosa thiol peroxidase protects against hydrogen peroxide toxicity and displays atypical patterns of gene regulation. J Bacteriol (2012) 0.85
High levels of expression of the iron-sulfur proteins phthalate dioxygenase and phthalate dioxygenase reductase in Escherichia coli. Protein Expr Purif (2006) 0.85
Spectroscopic studies of the oxidation of ferric CYP153A6 by peracids: Insights into P450 higher oxidation states. Arch Biochem Biophys (2009) 0.85
Increased positive electrostatic potential in p-hydroxybenzoate hydroxylase accelerates hydroxylation but slows turnover. Biochemistry (2004) 0.85
Curcumin suppresses vasculogenic mimicry capacity of hepatocellular carcinoma cells through STAT3 and PI3K/AKT inhibition. Anticancer Res (2014) 0.85
Luciferase from Vibrio campbellii is more thermostable and binds reduced FMN better than its homologues. J Biochem (2007) 0.85
Oxygen reactions in p-hydroxybenzoate hydroxylase utilize the H-bond network during catalysis. Biochemistry (2004) 0.85
Kinetics of reversible reductive carbonylation of heme in human cystathionine β-synthase. Biochemistry (2013) 0.85
Engineering of pyranose 2-oxidase: improvement for biofuel cell and food applications through semi-rational protein design. J Biotechnol (2008) 0.85