Published in J Med Chem on June 28, 2007
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Behavior-dependent specialization of identified hippocampal interneurons. Nat Neurosci (2012) 1.37
No ligand binding in the GB2 subunit of the GABA(B) receptor is required for activation and allosteric interaction between the subunits. J Neurosci (2002) 1.36
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Crosstalk between GABAB and mGlu1a receptors reveals new insight into GPCR signal integration. EMBO J (2009) 1.32
PROKR2 missense mutations associated with Kallmann syndrome impair receptor signalling activity. Hum Mol Genet (2008) 1.30
Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors. Mol Pharmacol (2009) 1.29
Design, synthesis, and evaluation of a novel 4-aminomethyl-4-fluoropiperidine as a T-type Ca2+ channel antagonist. J Med Chem (2008) 1.28
A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors. FASEB J (2010) 1.27
Locking the dimeric GABA(B) G-protein-coupled receptor in its active state. J Neurosci (2004) 1.25
A single olfactory receptor specifically binds a set of odorant molecules. Eur J Neurosci (2002) 1.25
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The metabotropic glutamate receptor mGluR5 is endocytosed by a clathrin-independent pathway. J Biol Chem (2003) 1.23
Distinct physiological roles of the Gq-coupled metabotropic glutamate receptors Co-expressed in the same neuronal populations. J Cell Physiol (2002) 1.22
The subthalamic nucleus exerts opposite control on cocaine and 'natural' rewards. Nat Neurosci (2005) 1.21
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Closure of the Venus flytrap module of mGlu8 receptor and the activation process: Insights from mutations converting antagonists into agonists. Proc Natl Acad Sci U S A (2002) 1.21
Probing the existence of G protein-coupled receptor dimers by positive and negative ligand-dependent cooperative binding. Mol Pharmacol (2006) 1.20
Metabotropic receptors for glutamate and GABA in pain. Brain Res Rev (2008) 1.20
Real-time analysis of agonist-induced activation of protease-activated receptor 1/Galphai1 protein complex measured by bioluminescence resonance energy transfer in living cells. Mol Pharmacol (2007) 1.17
Enhanced food-related motivation after bilateral lesions of the subthalamic nucleus. J Neurosci (2002) 1.15
Molecular determinants of ligand selectivity in a vertebrate odorant receptor. J Neurosci (2004) 1.15
Homer-dependent cell surface expression of metabotropic glutamate receptor type 5 in neurons. Mol Cell Neurosci (2002) 1.15
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Targeting group III metabotropic glutamate receptors produces complex behavioral effects in rodent models of Parkinson's disease. J Neurosci (2007) 1.15
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Functioning of the dimeric GABA(B) receptor extracellular domain revealed by glycan wedge scanning. EMBO J (2008) 1.14
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A fluorescent ligand-binding alternative using Tag-lite® technology. J Biomol Screen (2010) 1.13
Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling. Proc Natl Acad Sci U S A (2012) 1.12
Electrophysiological and behavioral evidence that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parkinsonism. FASEB J (2009) 1.12
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D-myo-inositol 1-phosphate as a surrogate of D-myo-inositol 1,4,5-tris phosphate to monitor G protein-coupled receptor activation. Anal Biochem (2006) 1.11
Structural basis of NR2B-selective antagonist recognition by N-methyl-D-aspartate receptors. Mol Pharmacol (2008) 1.09
GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base. Bioinformatics (2010) 1.09
The asymmetric/symmetric activation of GPCR dimers as a possible mechanistic rationale for multiple signalling pathways. Trends Pharmacol Sci (2009) 1.09
The intracellular loops of the GB2 subunit are crucial for G-protein coupling of the heteromeric gamma-aminobutyrate B receptor. Mol Pharmacol (2002) 1.08
Zinc alleviates pain through high-affinity binding to the NMDA receptor NR2A subunit. Nat Neurosci (2011) 1.08
Interdomain movements in metabotropic glutamate receptor activation. Proc Natl Acad Sci U S A (2011) 1.07
A new family of receptor tyrosine kinases with a venus flytrap binding domain in insects and other invertebrates activated by aminoacids. PLoS One (2009) 1.07
Molecular determinants involved in the allosteric control of agonist affinity in the GABAB receptor by the GABAB2 subunit. J Biol Chem (2004) 1.05
The oligomeric state sets GABA(B) receptor signalling efficacy. EMBO J (2011) 1.05
Illuminating the activation mechanisms and allosteric properties of metabotropic glutamate receptors. Proc Natl Acad Sci U S A (2013) 1.04
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G protein activation by the leukotriene B4 receptor dimer. Evidence for an absence of trans-activation. J Biol Chem (2008) 1.04
GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation. J Neurosci (2010) 1.03
Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels. J Med Chem (2008) 1.03
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Differential association modes of the thrombin receptor PAR1 with Galphai1, Galpha12, and beta-arrestin 1. FASEB J (2010) 1.02
Gα(olf) mutation allows parsing the role of cAMP-dependent and extracellular signal-regulated kinase-dependent signaling in L-3,4-dihydroxyphenylalanine-induced dyskinesia. J Neurosci (2012) 1.01
Sequential inter- and intrasubunit rearrangements during activation of dimeric metabotropic glutamate receptor 1. Sci Signal (2012) 1.01
Dominant role of GABAB2 and Gbetagamma for GABAB receptor-mediated-ERK1/2/CREB pathway in cerebellar neurons. Cell Signal (2007) 1.00
Haloperidol regulates the state of phosphorylation of ribosomal protein S6 via activation of PKA and phosphorylation of DARPP-32. Neuropsychopharmacology (2011) 1.00