Published in Curr Opin Pharmacol on December 03, 2009
Allostery at G protein-coupled receptor homo- and heteromers: uncharted pharmacological landscapes. Pharmacol Rev (2010) 1.89
Control of lymphocyte egress from lymph nodes through β2-adrenergic receptors. J Exp Med (2014) 1.85
The significance of G protein-coupled receptor crystallography for drug discovery. Pharmacol Rev (2011) 1.39
Applying label-free dynamic mass redistribution technology to frame signaling of G protein-coupled receptors noninvasively in living cells. Nat Protoc (2011) 1.26
Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A·mGlu2) receptor heteromerization and its psychoactive behavioral function. J Biol Chem (2012) 1.00
Oligomerization of G-protein-coupled receptors: a reality. Curr Opin Pharmacol (2009) 0.95
Adrenergic receptor activation involves ATP release and feedback through purinergic receptors. Am J Physiol Cell Physiol (2010) 0.94
GPR88 reveals a discrete function of primary cilia as selective insulators of GPCR cross-talk. PLoS One (2013) 0.91
From atomic structures to neuronal functions of g protein-coupled receptors. Annu Rev Neurosci (2013) 0.90
Minireview: Nutrient sensing by G protein-coupled receptors. Mol Endocrinol (2013) 0.90
D1R/GluN1 complexes in the striatum integrate dopamine and glutamate signalling to control synaptic plasticity and cocaine-induced responses. Mol Psychiatry (2014) 0.88
Investigation of stable and transient protein-protein interactions: Past, present, and future. Proteomics (2013) 0.88
Gi-coupled γ-aminobutyric acid-B receptors cross-regulate phospholipase C and calcium in airway smooth muscle. Am J Respir Cell Mol Biol (2011) 0.88
Regulation of dopamine D1 receptor dynamics within the postsynaptic density of hippocampal glutamate synapses. PLoS One (2013) 0.86
Heterodimerization with Its splice variant blocks the ghrelin receptor 1a in a non-signaling conformation: a study with a purified heterodimer assembled into lipid discs. J Biol Chem (2013) 0.84
G-protein βγ subunits in vasorelaxing and anti-endothelinergic effects of calcitonin gene-related peptide. Br J Pharmacol (2012) 0.81
Descending control of itch transmission by the serotonergic system via 5-HT1A-facilitated GRP-GRPR signaling. Neuron (2014) 0.81
Functional selectivity in GPCR heterocomplexes. Mini Rev Med Chem (2012) 0.81
Progressive impairment of cerebellar mGluR signalling and its therapeutic potential for cerebellar ataxia in spinocerebellar ataxia type 1 model mice. J Physiol (2016) 0.81
Biomarker identification with ligand-targeted nucleoprotein assemblies. Nanomedicine (Lond) (2011) 0.81
G protein-coupled receptor heterocomplexes in neuropsychiatric disorders. Prog Mol Biol Transl Sci (2013) 0.80
Modulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors. Front Pharmacol (2015) 0.80
Biological Significance of GPCR Heteromerization in the Neuro-Endocrine System. Front Endocrinol (Lausanne) (2011) 0.78
Rapid, Facile Detection of Heterodimer Partners for Target Human G-Protein-Coupled Receptors Using a Modified Split-Ubiquitin Membrane Yeast Two-Hybrid System. PLoS One (2013) 0.76
Dynamic Cholesterol-Conditioned Dimerization of the G Protein Coupled Chemokine Receptor Type 4. PLoS Comput Biol (2016) 0.75
Dynamic Roles for the N-terminus of the Yeast G Protein-Coupled Receptor Ste2p. Biochim Biophys Acta (2017) 0.75
Co-application of the GABAB receptor agonist, baclofen, and the mGlu receptor agonist, L-CCG-I, facilitates [(3)H]GABA release from rat cortical nerve endings. J Neural Transm (Vienna) (2013) 0.75
IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels. Nucleic Acids Res (2008) 3.76
Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to GPCR oligomerization. Nat Methods (2008) 2.88
The binding sites for cocaine and dopamine in the dopamine transporter overlap. Nat Neurosci (2008) 2.72
Closed state of both binding domains of homodimeric mGlu receptors is required for full activity. Nat Struct Mol Biol (2004) 2.58
Building a new conceptual framework for receptor heteromers. Nat Chem Biol (2009) 2.41
Time-resolved FRET between GPCR ligands reveals oligomers in native tissues. Nat Chem Biol (2010) 2.15
Virtual screening workflow development guided by the "receiver operating characteristic" curve approach. Application to high-throughput docking on metabotropic glutamate receptor subtype 4. J Med Chem (2005) 2.06
G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives. Pharmacol Rev (2014) 1.82
Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR. EMBO J (2005) 1.72
Asymmetric conformational changes in a GPCR dimer controlled by G-proteins. EMBO J (2006) 1.66
Allosteric modulators of group I metabotropic glutamate receptors: novel subtype-selective ligands and therapeutic perspectives. Curr Opin Pharmacol (2002) 1.58
Activation of a dimeric metabotropic glutamate receptor by intersubunit rearrangement. J Biol Chem (2007) 1.57
N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors. Mol Pharmacol (2007) 1.56
Asymmetric functioning of dimeric metabotropic glutamate receptors disclosed by positive allosteric modulators. J Biol Chem (2005) 1.55
Development of SNAP-tag fluorogenic probes for wash-free fluorescence imaging. Chembiochem (2011) 1.51
A single subunit (GB2) is required for G-protein activation by the heterodimeric GABA(B) receptor. J Biol Chem (2001) 1.49
Dimers and beyond: The functional puzzles of class C GPCRs. Pharmacol Ther (2011) 1.48
Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses. Mol Pharmacol (2007) 1.46
The heptahelical domain of GABA(B2) is activated directly by CGP7930, a positive allosteric modulator of the GABA(B) receptor. J Biol Chem (2004) 1.45
Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors. Proc Natl Acad Sci U S A (2003) 1.44
Cell surface detection of membrane protein interaction with homogeneous time-resolved fluorescence resonance energy transfer technology. Anal Biochem (2004) 1.40
CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling. Nat Neurosci (2010) 1.38
No ligand binding in the GB2 subunit of the GABA(B) receptor is required for activation and allosteric interaction between the subunits. J Neurosci (2002) 1.36
International Union of Pharmacology. LVI. Ghrelin receptor nomenclature, distribution, and function. Pharmacol Rev (2005) 1.35
Activation mechanism of the heterodimeric GABA(B) receptor. Biochem Pharmacol (2004) 1.34
Crosstalk between GABAB and mGlu1a receptors reveals new insight into GPCR signal integration. EMBO J (2009) 1.32
PROKR2 missense mutations associated with Kallmann syndrome impair receptor signalling activity. Hum Mol Genet (2008) 1.30
Detection of antigen interactions ex vivo by proximity ligation assay: endogenous dopamine D2-adenosine A2A receptor complexes in the striatum. Biotechniques (2011) 1.27
A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors. FASEB J (2010) 1.27
Locking the dimeric GABA(B) G-protein-coupled receptor in its active state. J Neurosci (2004) 1.25
A single olfactory receptor specifically binds a set of odorant molecules. Eur J Neurosci (2002) 1.25
The metabotropic glutamate receptor mGluR5 is endocytosed by a clathrin-independent pathway. J Biol Chem (2003) 1.23
G protein activation by serotonin type 4 receptor dimers: evidence that turning on two protomers is more efficient. J Biol Chem (2011) 1.21
Closure of the Venus flytrap module of mGlu8 receptor and the activation process: Insights from mutations converting antagonists into agonists. Proc Natl Acad Sci U S A (2002) 1.21
Probing the existence of G protein-coupled receptor dimers by positive and negative ligand-dependent cooperative binding. Mol Pharmacol (2006) 1.20
Metabotropic receptors for glutamate and GABA in pain. Brain Res Rev (2008) 1.20
Real-time analysis of agonist-induced activation of protease-activated receptor 1/Galphai1 protein complex measured by bioluminescence resonance energy transfer in living cells. Mol Pharmacol (2007) 1.17
Homer-dependent cell surface expression of metabotropic glutamate receptor type 5 in neurons. Mol Cell Neurosci (2002) 1.15
Assembly-dependent surface targeting of the heterodimeric GABAB Receptor is controlled by COPI but not 14-3-3. Mol Biol Cell (2005) 1.15
Coupling of agonist binding to effector domain activation in metabotropic glutamate-like receptors. J Biol Chem (2006) 1.14
Functioning of the dimeric GABA(B) receptor extracellular domain revealed by glycan wedge scanning. EMBO J (2008) 1.14
Common structural requirements for heptahelical domain function in class A and class C G protein-coupled receptors. J Biol Chem (2007) 1.13
Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling. Proc Natl Acad Sci U S A (2012) 1.12
Electrophysiological and behavioral evidence that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parkinsonism. FASEB J (2009) 1.12
D-myo-inositol 1-phosphate as a surrogate of D-myo-inositol 1,4,5-tris phosphate to monitor G protein-coupled receptor activation. Anal Biochem (2006) 1.11
Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering. Proc Natl Acad Sci U S A (2012) 1.10
GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base. Bioinformatics (2010) 1.09
The asymmetric/symmetric activation of GPCR dimers as a possible mechanistic rationale for multiple signalling pathways. Trends Pharmacol Sci (2009) 1.09
The intracellular loops of the GB2 subunit are crucial for G-protein coupling of the heteromeric gamma-aminobutyrate B receptor. Mol Pharmacol (2002) 1.08
Interdomain movements in metabotropic glutamate receptor activation. Proc Natl Acad Sci U S A (2011) 1.07
A new family of receptor tyrosine kinases with a venus flytrap binding domain in insects and other invertebrates activated by aminoacids. PLoS One (2009) 1.07
Molecular determinants involved in the allosteric control of agonist affinity in the GABAB receptor by the GABAB2 subunit. J Biol Chem (2004) 1.05
The oligomeric state sets GABA(B) receptor signalling efficacy. EMBO J (2011) 1.05
Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base. BMC Bioinformatics (2007) 1.04
Illuminating the activation mechanisms and allosteric properties of metabotropic glutamate receptors. Proc Natl Acad Sci U S A (2013) 1.04
G protein activation by the leukotriene B4 receptor dimer. Evidence for an absence of trans-activation. J Biol Chem (2008) 1.04
GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation. J Neurosci (2010) 1.03
Differential association modes of the thrombin receptor PAR1 with Galphai1, Galpha12, and beta-arrestin 1. FASEB J (2010) 1.02
Sequential inter- and intrasubunit rearrangements during activation of dimeric metabotropic glutamate receptor 1. Sci Signal (2012) 1.01
Synthesis and biological evaluation of 1-amino-2-phosphonomethylcyclopropanecarboxylic acids, new group III metabotropic glutamate receptor agonists. J Med Chem (2007) 1.00
Identification of novel functionally selective κ-opioid receptor scaffolds. Mol Pharmacol (2013) 1.00
Dominant role of GABAB2 and Gbetagamma for GABAB receptor-mediated-ERK1/2/CREB pathway in cerebellar neurons. Cell Signal (2007) 1.00
A model for the functioning of family 3 GPCRs. Trends Pharmacol Sci (2002) 0.99
A caged, localizable rhodamine derivative for superresolution microscopy. ACS Chem Biol (2011) 0.98
The complexity of their activation mechanism opens new possibilities for the modulation of mGlu and GABAB class C G protein-coupled receptors. Neuropharmacology (2010) 0.96
Common and selective molecular determinants involved in metabotopic glutamate receptor agonist activity. J Med Chem (2002) 0.96
Discovery of a novel selective kappa-opioid receptor agonist using crystal structure-based virtual screening. J Chem Inf Model (2013) 0.96
A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential. FASEB J (2012) 0.96
Insider access: pepducin symposium explores a new approach to GPCR modulation. Ann N Y Acad Sci (2009) 0.96
Trans-activation between 7TM domains: implication in heterodimeric GABAB receptor activation. EMBO J (2010) 0.96
Inhibition of heterotrimeric G protein signaling by a small molecule acting on Galpha subunit. J Biol Chem (2009) 0.95
The metabotropic glutamate receptor mGlu7 activates phospholipase C, translocates munc-13-1 protein, and potentiates glutamate release at cerebrocortical nerve terminals. J Biol Chem (2010) 0.95
BRET and Time-resolved FRET strategy to study GPCR oligomerization: from cell lines toward native tissues. Front Endocrinol (Lausanne) (2012) 0.92
A fluorescent sensor for GABA and synthetic GABA(B) receptor ligands. J Am Chem Soc (2012) 0.91
Fluorescent ligands to investigate GPCR binding properties and oligomerization. Biochem Soc Trans (2013) 0.90
Divergent evolution in metabotropic glutamate receptors. A new receptor activated by an endogenous ligand different from glutamate in insects. J Biol Chem (2003) 0.89
The second intracellular loop of metabotropic glutamate receptors recognizes C termini of G-protein alpha-subunits. J Biol Chem (2003) 0.89
Receptor-G protein interaction studied by bioluminescence resonance energy transfer: lessons from protease-activated receptor 1. Front Endocrinol (Lausanne) (2012) 0.87
Metabotropic glutamate receptor subtype 4 selectively modulates both glutamate and GABA transmission in the striatum: implications for Parkinson's disease treatment. J Neurochem (2009) 0.86
Group III metabotropic glutamate receptors inhibit hyperalgesia in animal models of inflammation and neuropathic pain. Pain (2007) 0.86
A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists. J Med Chem (2010) 0.85
A critical pocket close to the glutamate binding site of mGlu receptors opens new possibilities for agonist design. Neuropharmacology (2010) 0.85