Published in Clin Cancer Res on July 15, 2007
The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance. EMBO Mol Med (2013) 1.59
Merging systems biology with pharmacodynamics. Sci Transl Med (2012) 1.39
Pgp-mediated interaction between (R)-[11C]verapamil and tariquidar at the human blood-brain barrier: a comparison with rat data. Clin Pharmacol Ther (2011) 1.33
The neuropharmacokinetics of temozolomide in patients with resectable brain tumors: potential implications for the current approach to chemoradiation. Clin Cancer Res (2009) 1.25
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The impact of bevacizumab on temozolomide concentrations in intracranial U87 gliomas. Cancer Chemother Pharmacol (2012) 0.82
Diversity of DNA damage response of astrocytes and glioblastoma cell lines with various p53 status to treatment with etoposide and temozolomide. Cancer Biol Ther (2009) 0.80
Anti-tumour efficacy on glioma models of PHA-848125, a multi-kinase inhibitor able to cross the blood-brain barrier. Br J Pharmacol (2013) 0.78
KCa3.1 channel inhibition sensitizes malignant gliomas to temozolomide treatment. Oncotarget (2016) 0.76
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Temozolomide promotes genomic and phenotypic changes in glioblastoma cells. Cancer Cell Int (2016) 0.75
An energy-aware routing protocol in wireless sensor networks. Sensors (Basel) (2009) 11.25
Predicting drug sensitivity and resistance: profiling ABC transporter genes in cancer cells. Cancer Cell (2004) 3.72
The taccalonolides: microtubule stabilizers that circumvent clinically relevant taxane resistance mechanisms. Cancer Res (2008) 2.19
Quantitative magnetic resonance imaging analysis of neovasculature volume in carotid atherosclerotic plaque. Circulation (2003) 2.15
Catch-bond model derived from allostery explains force-activated bacterial adhesion. Biophys J (2005) 2.02
The organic solute transporter alpha-beta, Ostalpha-Ostbeta, is essential for intestinal bile acid transport and homeostasis. Proc Natl Acad Sci U S A (2008) 1.83
Angiopoietin-2 induces human glioma invasion through the activation of matrix metalloprotease-2. Proc Natl Acad Sci U S A (2003) 1.79
Long-term cardiac-targeted RNA interference for the treatment of heart failure restores cardiac function and reduces pathological hypertrophy. Circulation (2009) 1.71
Angiopoietin-2 stimulates breast cancer metastasis through the alpha(5)beta(1) integrin-mediated pathway. Cancer Res (2007) 1.68
Transport of methotrexate, methotrexate polyglutamates, and 17beta-estradiol 17-(beta-D-glucuronide) by ABCG2: effects of acquired mutations at R482 on methotrexate transport. Cancer Res (2003) 1.62
Angiopoietin 2 induces glioma cell invasion by stimulating matrix metalloprotease 2 expression through the alphavbeta1 integrin and focal adhesion kinase signaling pathway. Cancer Res (2006) 1.55
No evidence for β cell neogenesis in murine adult pancreas. J Clin Invest (2013) 1.54
Randomized phase II trial of lyophilized strawberries in patients with dysplastic precancerous lesions of the esophagus. Cancer Prev Res (Phila) (2011) 1.53
Molecular epidemiology of clinical isolates of carbapenem-resistant Acinetobacter spp. from Chinese hospitals. Antimicrob Agents Chemother (2007) 1.49
Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): resistance to docetaxel. Cancer Res (2004) 1.42
MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine. J Biol Chem (2003) 1.41
Impact of angiogenesis inhibition by sunitinib on tumor distribution of temozolomide. Clin Cancer Res (2008) 1.41
Human multidrug resistance protein 7 (ABCC10) is a resistance factor for nucleoside analogues and epothilone B. Cancer Res (2009) 1.40
Merging systems biology with pharmacodynamics. Sci Transl Med (2012) 1.39
Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6). Cancer Res (2002) 1.39
Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system. Cancer Res (2002) 1.38
Analysis of the in vivo functions of Mrp3. Mol Pharmacol (2005) 1.37
Prevalence of porcine circovirus-like agent P1 in Jiangsu, China. Virol J (2011) 1.35
M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7. Proc Natl Acad Sci U S A (2014) 1.35
Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10). Mol Pharmacol (2003) 1.34
A new model for prediction of drug distribution in tumor and normal tissues: pharmacokinetics of temozolomide in glioma patients. Cancer Res (2009) 1.32
New strategies to deliver anticancer drugs to brain tumors. Expert Opin Drug Deliv (2009) 1.29
Estrogen deprivation and inhibition of breast cancer growth in vivo through activation of the orphan nuclear receptor liver X receptor. Mol Endocrinol (2007) 1.28
TGFβ receptor signaling is essential for inflammation-induced but not β-cell workload-induced β-cell proliferation. Diabetes (2012) 1.21
Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites. J Cell Sci (2004) 1.20
Preclinical pharmacokinetic/pharmacodynamic models of gefitinib and the design of equivalent dosing regimens in EGFR wild-type and mutant tumor models. Mol Cancer Ther (2008) 1.20
Differential effect of sunitinib on the distribution of temozolomide in an orthotopic glioma model. Neuro Oncol (2008) 1.19
The effect of P-glycoprotein on paclitaxel brain and brain tumor distribution in mice. Cancer Res (2003) 1.18
Embryonic mouse blood flow and oxygen correlate with early pancreatic differentiation. Dev Biol (2010) 1.17
Evaluation of the role of multidrug resistance-associated protein (Mrp) 3 and Mrp4 in hepatic basolateral excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in Abcc3-/- and Abcc4-/- mice. J Pharmacol Exp Ther (2006) 1.16
Nilotinib potentiates anticancer drug sensitivity in murine ABCB1-, ABCG2-, and ABCC10-multidrug resistance xenograft models. Cancer Lett (2012) 1.16
Cepharanthine is a potent reversal agent for MRP7(ABCC10)-mediated multidrug resistance. Biochem Pharmacol (2008) 1.16
Syk associates with clathrin and mediates phosphatidylinositol 3-kinase activation during human rhinovirus internalization. J Immunol (2008) 1.14
Mechanisms of signal transduction by ethylene: overlapping and non-overlapping signalling roles in a receptor family. AoB Plants (2013) 1.14
Stem cells from human-exfoliated deciduous teeth can differentiate into dopaminergic neuron-like cells. Stem Cells Dev (2010) 1.13
Cardiac-targeted RNA interference mediated by an AAV9 vector improves cardiac function in coxsackievirus B3 cardiomyopathy. J Mol Med (Berl) (2008) 1.13
POPED, a software for optimal experiment design in population kinetics. Comput Methods Programs Biomed (2004) 1.13
Complete genome sequence of a recombinant porcine epidemic diarrhea virus strain from eastern china. Genome Announc (2013) 1.12
Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11). Mol Pharmacol (2004) 1.12
TAM receptors affect adult brain neurogenesis by negative regulation of microglial cell activation. J Immunol (2013) 1.11
Complete genome sequence of the rearranged porcine circovirus type 2. J Virol (2012) 1.10
Disposition of artesunate and dihydroartemisinin after administration of artesunate suppositories in children from Papua New Guinea with uncomplicated malaria. Antimicrob Agents Chemother (2004) 1.10
Dedifferentiation of adult human myoblasts induced by ciliary neurotrophic factor in vitro. Mol Biol Cell (2005) 1.09
Triptolide inhibits COX-2 expression and PGE2 release by suppressing the activity of NF-kappaB and JNK in LPS-treated microglia. J Neurochem (2008) 1.09
A smad signaling network regulates islet cell proliferation. Diabetes (2013) 1.08
[Anti-tumor activity and mechanism with SSCE of Spatholobus suberctus]. Zhongguo Zhong Yao Za Zhi (2009) 1.08
The status of pharmacometrics in pregnancy: highlights from the 3(rd) American conference on pharmacometrics. Br J Clin Pharmacol (2012) 1.07
Development of a highly metastatic model that reveals a crucial role of fibronectin in lung cancer cell migration and invasion. BMC Cancer (2010) 1.07
Involvement of palladin and alpha-actinin in targeting of the Abl/Arg kinase adaptor ArgBP2 to the actin cytoskeleton. Exp Cell Res (2005) 1.07
Downregulation of miR-223 and miR-153 mediates mechanical stretch-stimulated proliferation of venous smooth muscle cells via activation of the insulin-like growth factor-1 receptor. Arch Biochem Biophys (2012) 1.06
TGF-beta isoform signaling regulates secondary transition and mesenchymal-induced endocrine development in the embryonic mouse pancreas. Dev Biol (2007) 1.06
Hypoglycemia reduces vascular endothelial growth factor A production by pancreatic beta cells as a regulator of beta cell mass. J Biol Chem (2013) 1.06
Estradiol and nicotine exposure enhances A549 bronchioloalveolar carcinoma xenograft growth in mice through the stimulation of angiogenesis. Int J Oncol (2006) 1.05
Multidrug resistance protein 4 protects bone marrow, thymus, spleen, and intestine from nucleotide analogue-induced damage. Cancer Res (2007) 1.04
CalS7 encodes a callose synthase responsible for callose deposition in the phloem. Plant J (2010) 1.04
Demonstration of the equivalent pharmacokinetic/pharmacodynamic dosing strategy in a multiple-dose study of gefitinib. Mol Cancer Ther (2009) 1.03
Leukocyte elastase induces epithelial apoptosis: role of mitochondial permeability changes and Akt. Am J Physiol Gastrointest Liver Physiol (2004) 1.03
Up-regulation of MRP4 and down-regulation of influx transporters in human leukemic cells with acquired resistance to 6-mercaptopurine. Leuk Res (2007) 1.03
Activated hepatic stellate cells promote hepatocellular carcinoma development in immunocompetent mice. Int J Cancer (2011) 1.03
Pancreatic duct cells as a source of VEGF in mice. Diabetologia (2014) 1.03
Changes in the solubility and phosphorylation of α-synuclein over the course of Parkinson's disease. Acta Neuropathol (2011) 1.03
CD44 is a phagocytic receptor. Blood (2006) 1.03
A novel porcine circovirus-like agent P1 is associated with wasting syndromes in pigs. PLoS One (2012) 1.02
The antioxidative effect of electro-acupuncture in a mouse model of Parkinson's disease. PLoS One (2011) 1.02
Minimum expected delay-based routing protocol (MEDR) for Delay Tolerant Mobile Sensor Networks. Sensors (Basel) (2010) 1.02
The formation of daodi medicinal materials. J Ethnopharmacol (2012) 1.01
Contribution of Abcc10 (Mrp7) to in vivo paclitaxel resistance as assessed in Abcc10(-/-) mice. Cancer Res (2011) 1.01
Physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 as determined from recent studies on gene-disrupted mice. Cancer Metastasis Rev (2007) 1.01
Pharmacodynamic-mediated effects of the angiogenesis inhibitor SU5416 on the tumor disposition of temozolomide in subcutaneous and intracerebral glioma xenograft models. J Pharmacol Exp Ther (2003) 1.01
Characterization of a 67Ga/68Ga radiopharmaceutical for SPECT and PET of MDR1 P-glycoprotein transport activity in vivo: validation in multidrug-resistant tumors and at the blood-brain barrier. J Nucl Med (2005) 1.01
Pharmacokinetic/pharmacodynamic modeling of crizotinib for anaplastic lymphoma kinase inhibition and antitumor efficacy in human tumor xenograft mouse models. J Pharmacol Exp Ther (2011) 1.00
Triptolide inhibits amyloid-beta1-42-induced TNF-alpha and IL-1beta production in cultured rat microglia. J Neuroimmunol (2008) 1.00
Robust population pharmacokinetic experiment design. J Pharmacokinet Pharmacodyn (2005) 1.00
Ethylene and nitric oxide are involved in maintaining ion homeostasis in Arabidopsis callus under salt stress. Planta (2009) 0.99
An evaluation of population D-optimal designs via pharmacokinetic simulations. Ann Biomed Eng (2003) 0.99
In vivo microdialysis for PK and PD studies of anticancer drugs. AAPS J (2005) 0.99
Fucoidan protects against dopaminergic neuron death in vivo and in vitro. Eur J Pharmacol (2009) 0.99
Prevention of cardiac dysfunction in acute coxsackievirus B3 cardiomyopathy by inducible expression of a soluble coxsackievirus-adenovirus receptor. Circulation (2009) 0.98
A new Tn1546 type of VanB phenotype-vanA genotype vancomycin-resistant Enterococcus faecium isolates in mainland China. Diagn Microbiol Infect Dis (2009) 0.97
Amyloid-β induces caspase-dependent loss of PSD-95 and synaptophysin through NMDA receptors. J Alzheimers Dis (2010) 0.97
Biochemical changes associated with a multidrug-resistant phenotype of a human glioma cell line with temozolomide-acquired resistance. Biochem Pharmacol (2002) 0.97
Pharmacokinetic model-predicted anticancer drug concentrations in human tumors. Clin Cancer Res (2004) 0.97
Induction of coxsackievirus-adenovirus-receptor expression during myocardial tissue formation and remodeling: identification of a cell-to-cell contact-dependent regulatory mechanism. Circulation (2003) 0.97
Effects of four Si-Wu-Tang's constituents and their combination on irradiated mice. Biol Pharm Bull (2006) 0.96
Suppression of intracranial human glioma growth after intramuscular administration of an adeno-associated viral vector expressing angiostatin. Cancer Res (2002) 0.96
Intracranial pressure waveform morphology and intracranial adaptive capacity. Am J Crit Care (2008) 0.96
Neferine, a bisbenzylisoquinline alkaloid attenuates bleomycin-induced pulmonary fibrosis. Eur J Pharmacol (2009) 0.95
In vitro intragenomic rearrangement of porcine circovirus type 2. J Virol (2012) 0.95