Published in J Nucl Med on February 01, 2005
Coordinating radiometals of copper, gallium, indium, yttrium, and zirconium for PET and SPECT imaging of disease. Chem Rev (2010) 2.70
What can gallium-68 PET add to receptor and molecular imaging? Eur J Nucl Med Mol Imaging (2007) 1.06
Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET. Proc Natl Acad Sci U S A (2011) 1.03
The 68Ge/ 68Ga generator has high potential, but when can we use 68Ga-labelled tracers in clinical routine? Eur J Nucl Med Mol Imaging (2007) 0.99
Drug delivery to brain tumors. Curr Neurol Neurosci Rep (2008) 0.98
Translational molecular imaging for cancer. Cancer Imaging (2005) 0.93
Loss of Par-1a/MARK3/C-TAK1 kinase leads to reduced adiposity, resistance to hepatic steatosis, and defective gluconeogenesis. Mol Cell Biol (2010) 0.93
Imaging of multidrug resistance in cancer. Cancer Imaging (2011) 0.90
(68)Ga-labeled radiopharmaceuticals for positron emission tomography. Nucl Med Mol Imaging (2010) 0.82
Evaluation of (64)Cu(DO3A-xy-TPEP) as a potential PET radiotracer for monitoring tumor multidrug resistance. Bioconjug Chem (2009) 0.80
Synthesis and biodistribution of lipophilic and monocationic gallium radiopharmaceuticals derived from N,N'-bis(3-aminopropyl)-N,N'-dimethylethylenediamine: potential agents for PET myocardial imaging with 68Ga. Nucl Med Biol (2009) 0.78
Metalloprobes: synthesis, characterization, and potency of a novel gallium(III) complex in human epidermal carcinoma cells. J Inorg Biochem (2007) 0.77
Future Perspectives for Brain Pharmacotherapies: Implications of Drug Transport Processes at the Blood-brain Barrier. Ther Adv Neurol Disord (2008) 0.75
A generator-produced gallium-68 radiopharmaceutical for PET imaging of myocardial perfusion. PLoS One (2014) 0.75
Interrogation of multidrug resistance (MDR1) P-glycoprotein (ABCB1) expression in human pancreatic carcinoma cells: correlation of 99mTc-Sestamibi uptake with western blot analysis. Nucl Med Commun (2014) 0.75
Whole-genome analysis informs breast cancer response to aromatase inhibition. Nature (2012) 8.03
CXCR4 regulates growth of both primary and metastatic breast cancer. Cancer Res (2004) 4.53
Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100. Blood (2008) 3.77
Predicting drug sensitivity and resistance: profiling ABC transporter genes in cancer cells. Cancer Cell (2004) 3.72
Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals. Proc Natl Acad Sci U S A (2004) 3.59
Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease. J Cell Biol (2009) 3.50
P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model. J Clin Invest (2005) 2.81
Spying on cancer: molecular imaging in vivo with genetically encoded reporters. Cancer Cell (2005) 2.74
Bioluminescence imaging of myeloperoxidase activity in vivo. Nat Med (2009) 2.43
The MRP family of drug efflux pumps. Oncogene (2003) 2.37
Noninvasive bioluminescence imaging of herpes simplex virus type 1 infection and therapy in living mice. J Virol (2002) 2.31
Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses. Cancer Res (2012) 2.24
Real-time imaging of ligand-induced IKK activation in intact cells and in living mice. Nat Methods (2005) 2.22
The taccalonolides: microtubule stabilizers that circumvent clinically relevant taxane resistance mechanisms. Cancer Res (2008) 2.19
Imaging 26S proteasome activity and inhibition in living mice. Nat Med (2003) 2.04
In vivo administration of hypomethylating agents mitigate graft-versus-host disease without sacrificing graft-versus-leukemia. Blood (2010) 2.02
Cerenkov radiation energy transfer (CRET) imaging: a novel method for optical imaging of PET isotopes in biological systems. PLoS One (2010) 2.02
The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis. Nat Cell Biol (2013) 1.93
Optical imaging of bacterial infection in living mice using a fluorescent near-infrared molecular probe. J Am Chem Soc (2006) 1.93
The organic solute transporter alpha-beta, Ostalpha-Ostbeta, is essential for intestinal bile acid transport and homeostasis. Proc Natl Acad Sci U S A (2008) 1.83
Noninvasive imaging of protein-protein interactions in living animals. Proc Natl Acad Sci U S A (2002) 1.81
Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression. Clin Cancer Res (2008) 1.75
Transport of methotrexate, methotrexate polyglutamates, and 17beta-estradiol 17-(beta-D-glucuronide) by ABCG2: effects of acquired mutations at R482 on methotrexate transport. Cancer Res (2003) 1.62
Imaging reversal of multidrug resistance in living mice with bioluminescence: MDR1 P-glycoprotein transports coelenterazine. Proc Natl Acad Sci U S A (2004) 1.56
Advances in bioluminescence imaging of live animal models. Curr Opin Biotechnol (2009) 1.55
Bioluminescence imaging reveals systemic dissemination of herpes simplex virus type 1 in the absence of interferon receptors. J Virol (2003) 1.53
Recent advances in imaging the lungs of intact small animals. Am J Respir Cell Mol Biol (2004) 1.51
Current state of imaging protein-protein interactions in vivo with genetically encoded reporters. Annu Rev Biomed Eng (2007) 1.50
Squaraine rotaxanes: superior substitutes for Cy-5 in molecular probes for near-infrared fluorescence cell imaging. Angew Chem Int Ed Engl (2007) 1.47
LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy. Proc Natl Acad Sci U S A (2010) 1.47
The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling. J Clin Invest (2012) 1.45
Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo. Cancer Res (2007) 1.44
Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): resistance to docetaxel. Cancer Res (2004) 1.42
MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine. J Biol Chem (2003) 1.41
TAT-BH4 and TAT-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo. J Immunol (2006) 1.41
Breast cancer cell targeting by prenylation inhibitors elucidated in living animals with a bioluminescence reporter. Clin Cancer Res (2012) 1.41
Revascularization of ischemic limbs after transplantation of human bone marrow cells with high aldehyde dehydrogenase activity. Blood (2009) 1.40
Human multidrug resistance protein 7 (ABCC10) is a resistance factor for nucleoside analogues and epothilone B. Cancer Res (2009) 1.40
Single-cell imaging of retinal ganglion cell apoptosis with a cell-penetrating, activatable peptide probe in an in vivo glaucoma model. Proc Natl Acad Sci U S A (2009) 1.40
Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6). Cancer Res (2002) 1.39
Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system. Cancer Res (2002) 1.38
Senescent stromal-derived osteopontin promotes preneoplastic cell growth. Cancer Res (2009) 1.38
Analysis of the in vivo functions of Mrp3. Mol Pharmacol (2005) 1.37
Granulocyte colony-stimulating factor enhances bone tumor growth in mice in an osteoclast-dependent manner. Blood (2006) 1.35
Noninvasive optical imaging of staphylococcus aureus bacterial infection in living mice using a Bis-dipicolylamine-Zinc(II) affinity group conjugated to a near-infrared fluorophore. Bioconjug Chem (2008) 1.34
Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10). Mol Pharmacol (2003) 1.34
ABCC10, ABCC11, and ABCC12. Pflugers Arch (2006) 1.34
An improved cell-penetrating, caspase-activatable, near-infrared fluorescent peptide for apoptosis imaging. Bioconjug Chem (2009) 1.34
Contribution of p53 to metastasis. Cancer Discov (2014) 1.28
Mechanics of EGF receptor/ErbB2 kinase activation revealed by luciferase fragment complementation imaging. Proc Natl Acad Sci U S A (2011) 1.27
Biochemical and in vivo characterization of a small, membrane-permeant, caspase-activatable far-red fluorescent peptide for imaging apoptosis. Biochemistry (2007) 1.27
Factors affecting human T cell engraftment, trafficking, and associated xenogeneic graft-vs-host disease in NOD/SCID beta2mnull mice. Exp Hematol (2007) 1.25
Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo. Proc Natl Acad Sci U S A (2007) 1.25
Quantitation of selective autophagic protein aggregate degradation in vitro and in vivo using luciferase reporters. Autophagy (2009) 1.25
Linkage between cellular communications, energy utilization, and proliferation in metastatic neuroendocrine cancers. Proc Natl Acad Sci U S A (2006) 1.23
Independent circadian oscillations of Period1 in specific brain areas in vivo and in vitro. J Neurosci (2005) 1.22
Molecular imaging of gene expression and protein function in vivo with PET and SPECT. J Magn Reson Imaging (2002) 1.21
Cyclic AMP suppression is sufficient to induce gliomagenesis in a mouse model of neurofibromatosis-1. Cancer Res (2010) 1.20
Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites. J Cell Sci (2004) 1.20
APT102, a novel adpase, cooperates with aspirin to disrupt bone metastasis in mice. J Cell Biochem (2008) 1.18
Chromatin remodeling underlies the senescence-associated secretory phenotype of tumor stromal fibroblasts that supports cancer progression. Cancer Res (2012) 1.17
Evaluation of the role of multidrug resistance-associated protein (Mrp) 3 and Mrp4 in hepatic basolateral excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in Abcc3-/- and Abcc4-/- mice. J Pharmacol Exp Ther (2006) 1.16
Cepharanthine is a potent reversal agent for MRP7(ABCC10)-mediated multidrug resistance. Biochem Pharmacol (2008) 1.16
Characterization of coelenterazine analogs for measurements of Renilla luciferase activity in live cells and living animals. Mol Imaging (2004) 1.16
Spectral unmixing of multicolored bioluminescence emitted from heterogeneous biological sources. Anal Chem (2006) 1.16
Dual-color click beetle luciferase heteroprotein fragment complementation assays. Chem Biol (2010) 1.16
Hedgehog signaling inhibition blocks growth of resistant tumors through effects on tumor microenvironment. Cancer Res (2011) 1.15
CD47 regulates bone mass and tumor metastasis to bone. Cancer Res (2009) 1.14
Luciferase fragment complementation imaging of conformational changes in the epidermal growth factor receptor. J Biol Chem (2009) 1.12
Quantitative analysis of permeation peptide complexes labeled with Technetium-99m: chiral and sequence-specific effects on net cell uptake. Bioconjug Chem (2003) 1.12
Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11). Mol Pharmacol (2004) 1.12
Immunodeficient mouse strains display marked variability in growth of human melanoma lung metastases. Clin Cancer Res (2009) 1.12
Synthesis and characterization of a small, membrane-permeant, caspase-activatable far-red fluorescent peptide for imaging apoptosis. J Med Chem (2005) 1.11
In vivo RNA interference-mediated ablation of MDR1 P-glycoprotein. Clin Cancer Res (2005) 1.10
Gene expression signatures and response to imatinib mesylate in gastrointestinal stromal tumor. Mol Cancer Ther (2009) 1.10
Predicting human tumor drug concentrations from a preclinical pharmacokinetic model of temozolomide brain disposition. Clin Cancer Res (2007) 1.10