Published in J Biol Chem on July 18, 2007
Protein sectors: evolutionary units of three-dimensional structure. Cell (2009) 3.76
An overview of enzymatic reagents for the removal of affinity tags. Protein Expr Purif (2011) 1.46
Conformational selection in trypsin-like proteases. Curr Opin Struct Biol (2012) 1.20
Engineering thrombin for selective specificity toward protein C and PAR1. J Biol Chem (2010) 1.09
Ligand binding shuttles thrombin along a continuum of zymogen- and proteinase-like states. J Biol Chem (2010) 1.08
Allostery in trypsin-like proteases suggests new therapeutic strategies. Trends Biotechnol (2011) 1.07
Crystallographic and kinetic evidence of allostery in a trypsin-like protease. Biochemistry (2011) 0.98
The transition of prothrombin to thrombin. J Thromb Haemost (2013) 0.93
How Na+ activates thrombin--a review of the functional and structural data. Biol Chem (2008) 0.92
Evidence of the E*-E equilibrium from rapid kinetics of Na+ binding to activated protein C and factor Xa. J Phys Chem B (2010) 0.89
Rigidification of the autolysis loop enhances Na(+) binding to thrombin. Biophys Chem (2011) 0.88
Allosteric control of βII-tryptase by a redox active disulfide bond. J Biol Chem (2013) 0.83
Mutagenesis studies toward understanding allostery in thrombin. Biochemistry (2009) 0.81
Reduction of the C191-C220 disulfide of α-chymotrypsinogen A reduces nucleation barriers for aggregation. Biophys Chem (2013) 0.76
The changing face of HIV in China. Nature (2008) 3.39
Hepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNR. J Virol (2003) 3.10
Dominance of HIV-1 subtype CRF01_AE in sexually acquired cases leads to a new epidemic in Yunnan province of China. PLoS Med (2006) 2.37
Evolution of enzyme cascades from embryonic development to blood coagulation. Trends Biochem Sci (2002) 1.96
Thrombin mutant W215A/E217A acts as a platelet GPIb antagonist. Arterioscler Thromb Vasc Biol (2007) 1.80
Role of Na+ and K+ in enzyme function. Physiol Rev (2006) 1.80
Molecular characterization of human immunodeficiency virus type 1 and hepatitis C virus in paid blood donors and injection drug users in china. J Virol (2004) 1.76
Molecular dissection of Na+ binding to thrombin. J Biol Chem (2004) 1.72
The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A. Blood (2011) 1.71
Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition. Nat Struct Mol Biol (2013) 1.67
Studies on the basis for the properties of fibrin produced from fibrinogen-containing gamma' chains. Blood (2005) 1.64
Protective signaling by activated protein C is mechanistically linked to protein C activation on endothelial cells. J Biol Chem (2006) 1.58
Exposure of R169 controls protein C activation and autoactivation. Blood (2012) 1.52
High prevalence of HIV infection among women and their children in Henan Province, China. J Acquir Immune Defic Syndr (2003) 1.47
Conformational selection or induced fit? A critical appraisal of the kinetic mechanism. Biochemistry (2012) 1.39
Structural identification of the pathway of long-range communication in an allosteric enzyme. Proc Natl Acad Sci U S A (2008) 1.31
Rapid kinetics of Na+ binding to thrombin. J Biol Chem (2006) 1.29
Human genital epithelial cells capture cell-free human immunodeficiency virus type 1 and transmit the virus to CD4+ Cells: implications for mechanisms of sexual transmission. J Infect Dis (2003) 1.29
Addition of a single gp120 glycan confers increased binding to dendritic cell-specific ICAM-3-grabbing nonintegrin and neutralization escape to human immunodeficiency virus type 1. J Virol (2002) 1.25
Crystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4. Proc Natl Acad Sci U S A (2007) 1.23
Conformational selection in trypsin-like proteases. Curr Opin Struct Biol (2012) 1.20
Enhancement of HIV DNA vaccine immunogenicity by the NKT cell ligand, alpha-galactosylceramide. Vaccine (2008) 1.19
The thrombin mutant W215A/E217A shows safe and potent anticoagulant and antithrombotic effects in vivo. J Biol Chem (2002) 1.19
HIV-1 subtype B' dictates the AIDS epidemic among paid blood donors in the Henan and Hubei provinces of China. AIDS (2003) 1.16
Evolution of peptidase diversity. J Biol Chem (2008) 1.16
Relative antithrombotic and antihemostatic effects of protein C activator versus low-molecular-weight heparin in primates. Blood (2007) 1.12
Iron deficiency anaemia can be improved after eradication of Helicobacter pylori. Postgrad Med J (2010) 1.11
Crystal structure of thrombin in a self-inhibited conformation. J Biol Chem (2006) 1.11
The anticoagulant thrombin mutant W215A/E217A has a collapsed primary specificity pocket. J Biol Chem (2004) 1.10
Biochemical characterization and crystal structure of endoglucanase Cel5A from the hyperthermophilic Thermotoga maritima. J Struct Biol (2010) 1.10
Engineering thrombin for selective specificity toward protein C and PAR1. J Biol Chem (2010) 1.09
Genetic characterization of diverse HIV-1 strains in an immigrant population living in New York City. J Acquir Immune Defic Syndr (2006) 1.08
Monomeric sarcosine oxidase: role of histidine 269 in catalysis. Biochemistry (2002) 1.08
Thrombomodulin changes the molecular surface of interaction and the rate of complex formation between thrombin and protein C. J Biol Chem (2004) 1.08
Identification of QTLs with main, epistatic and QTL × environment interaction effects for salt tolerance in rice seedlings under different salinity conditions. Theor Appl Genet (2012) 1.07
High-resolution NMR spectra in inhomogeneous fields via IDEAL (intermolecular dipolar-interaction enhanced all lines) method. J Am Chem Soc (2004) 1.07
Allostery in trypsin-like proteases suggests new therapeutic strategies. Trends Biotechnol (2011) 1.07
Chronic plaque psoriasis is associated with increased arterial stiffness. Dermatology (2008) 1.06
Redesigning the monovalent cation specificity of an enzyme. Proc Natl Acad Sci U S A (2003) 1.05
Identification of novel small-molecule inhibitors of severe acute respiratory syndrome-associated coronavirus by chemical genetics. Chem Biol (2004) 1.05
Phase 1 safety and immunogenicity evaluation of ADMVA, a multigenic, modified vaccinia Ankara-HIV-1 B'/C candidate vaccine. PLoS One (2010) 1.05
Conformational selection is a dominant mechanism of ligand binding. Biochemistry (2013) 1.05
Probing the structural basis of RecQ helicase function. Biophys Chem (2010) 1.04
Single amino acid substitutions in the severe acute respiratory syndrome coronavirus spike glycoprotein determine viral entry and immunogenicity of a major neutralizing domain. J Virol (2005) 1.03
Mechanism of Na(+) binding to thrombin resolved by ultra-rapid kinetics. Biophys Chem (2007) 1.01
Phase 1 safety and immunogenicity evaluation of ADVAX, a multigenic, DNA-based clade C/B' HIV-1 candidate vaccine. PLoS One (2010) 1.01
The effects of cantharidin and cantharidin derivates on tumour cells. Anticancer Agents Med Chem (2009) 1.00
Phylodynamics of HIV-1 subtype B among the men-having-sex-with-men (MSM) population in Hong Kong. PLoS One (2011) 1.00
Probing oxygen activation sites in two flavoprotein oxidases using chloride as an oxygen surrogate. Biochemistry (2011) 1.00
A study of ethnic differences in TGFβ1 gene polymorphisms and effects on the risk of radiation pneumonitis in non-small-cell lung cancer. J Thorac Oncol (2012) 1.00
Host range, growth property, and virulence of the smallpox vaccine: vaccinia virus Tian Tan strain. Virology (2005) 1.00
QTL analysis of Na+ and K+ concentrations in roots and shoots under different levels of NaCl stress in rice (Oryza sativa L.). PLoS One (2012) 0.99
Increased genetic diversity of HIV-1 circulating in Hong Kong. PLoS One (2010) 0.99
Crystal structure of thrombin in complex with fibrinogen gamma' peptide. Biophys Chem (2006) 0.99
Design, construction, and characterization of a dual-promoter multigenic DNA vaccine directed against an HIV-1 subtype C/B' recombinant. J Acquir Immune Defic Syndr (2008) 0.99
Crystallographic and kinetic evidence of allostery in a trypsin-like protease. Biochemistry (2011) 0.98
Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals. J Med Virol (2006) 0.97
Mutant N143P reveals how Na+ activates thrombin. J Biol Chem (2009) 0.97
Crystal structures of prethrombin-2 reveal alternative conformations under identical solution conditions and the mechanism of zymogen activation. Biochemistry (2011) 0.97
A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo. J Biol Chem (2005) 0.96
Crystal structure of prethrombin-1. Proc Natl Acad Sci U S A (2010) 0.96
Dissecting substrate recognition by thrombin using the inactive mutant S195A. Biophys Chem (2003) 0.96
Quinohemoprotein alcohol dehydrogenases: structure, function, and physiology. Arch Biochem Biophys (2004) 0.96
Crystal structure of thrombin bound to the uncleaved extracellular fragment of PAR1. J Biol Chem (2010) 0.96
Crystal structure of the anticoagulant slow form of thrombin. J Biol Chem (2002) 0.96
Mechanism of the anticoagulant activity of thrombin mutant W215A/E217A. J Biol Chem (2009) 0.95
Generation of novel copper sites by mutation of the axial ligand of amicyanin. Atomic resolution structures and spectroscopic properties. Biochemistry (2007) 0.95
A novel replication-competent vaccinia vector MVTT is superior to MVA for inducing high levels of neutralizing antibody via mucosal vaccination. PLoS One (2009) 0.95
Energetic and structural consequences of perturbing Gly-193 in the oxyanion hole of serine proteases. J Biol Chem (2005) 0.95
Chemical library and structure-activity relationships of 11-demethyl-12-oxo calanolide A analogues as anti-HIV-1 agents. J Med Chem (2008) 0.94
Thrombin mutant W215A/E217A treatment improves neurological outcome and reduces cerebral infarct size in a mouse model of ischemic stroke. Stroke (2011) 0.94
Heterotetrameric sarcosine oxidase: structure of a diflavin metalloenzyme at 1.85 A resolution. J Mol Biol (2006) 0.94
NikD, an unusual amino acid oxidase essential for nikkomycin biosynthesis: structures of closed and open forms at 1.15 and 1.90 A resolution. Structure (2007) 0.93
Dickkopf-1 autoantibody is a novel serological biomarker for non-small cell lung cancer. Biomarkers (2010) 0.93
Rising epidemic of HIV-1 infections among general populations in Fujian, China. J Acquir Immune Defic Syndr (2012) 0.93
Murine thrombin lacks Na+ activation but retains high catalytic activity. J Biol Chem (2006) 0.93