Published in Future Microbiol on June 01, 2006
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. Proc Natl Acad Sci U S A (2008) 4.80
New medicines to improve control and contribute to the eradication of malaria. Nat Rev Drug Discov (2009) 4.00
Using genetic methods to define the targets of compounds with antimalarial activity. J Med Chem (2013) 1.06
Outlook on Thailand's genomics and computational biology research and development. PLoS Comput Biol (2008) 0.94
Characterizing the network of drugs and their affected metabolic subpathways. PLoS One (2012) 0.92
New insight-guided approaches to detect, cure, prevent and eliminate malaria. Protoplasma (2014) 0.81
Interactions between cycloguanil derivatives and wild type and resistance-associated mutant Plasmodium falciparum dihydrofolate reductases. J Comput Aided Mol Des (2009) 0.79
Selection of drug resistant mutants from random library of Plasmodium falciparum dihydrofolate reductase in Plasmodium berghei model. Malar J (2011) 0.76
FORS-D Analysis in P. falciparum can Differentiate Classes of Genes Under Selection. Evol Bioinform Online (2011) 0.75
An in silico strategy for identification of novel drug targets against Plasmodium falciparum. Parasitol Res (2017) 0.75
Insights into antifolate resistance from malarial DHFR-TS structures. Nat Struct Biol (2003) 3.20
Stepwise acquisition of pyrimethamine resistance in the malaria parasite. Proc Natl Acad Sci U S A (2009) 2.57
Novel point mutations in the dihydrofolate reductase gene of Plasmodium vivax: evidence for sequential selection by drug pressure. Antimicrob Agents Chemother (2003) 2.26
A genetically hard-wired metabolic transcriptome in Plasmodium falciparum fails to mount protective responses to lethal antifolates. PLoS Pathog (2008) 1.37
Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target. Proc Natl Acad Sci U S A (2012) 1.26
Crystal structure of dihydrofolate reductase from Plasmodium vivax: pyrimethamine displacement linked with mutation-induced resistance. Proc Natl Acad Sci U S A (2005) 1.22
Characterization, crystallization and preliminary X-ray analysis of bifunctional dihydrofolate reductase-thymidylate synthase from Plasmodium falciparum. Acta Crystallogr D Biol Crystallogr (2004) 1.13
Evaluation of an ethnopharmacologically selected Bhutanese medicinal plants for their major classes of phytochemicals and biological activities. J Ethnopharmacol (2011) 1.10
Pyrimethamine analogs as strong inhibitors of double and quadruple mutants of dihydrofolate reductase in human malaria parasites. Org Biomol Chem (2003) 1.04
Inducible knockdown of Plasmodium gene expression using the glmS ribozyme. PLoS One (2013) 1.01
Development of 2,4-diaminopyrimidines as antimalarials based on inhibition of the S108N and C59R+S108N mutants of dihydrofolate reductase from pyrimethamine-resistant Plasmodium falciparum. J Med Chem (2002) 0.99
Target guided synthesis of 5-benzyl-2,4-diamonopyrimidines: their antimalarial activities and binding affinities to wild type and mutant dihydrofolate reductases from Plasmodium falciparum. J Med Chem (2004) 0.98
Comparative proteomic profiles and the potential markers between Burkholderia pseudomallei and Burkholderia thailandensis. Mol Cell Probes (2006) 0.98
GC/GC-MS analysis, isolation and identification of bioactive essential oil components from the Bhutanese medicinal plant, Pleurospermum amabile. Nat Prod Commun (2013) 0.91
Current treatment and drug discovery against Leishmania spp. and Plasmodium spp.: a review. Curr Drug Targets (2009) 0.91
A new protoberberine alkaloid from Meconopsis simplicifolia (D. Don) Walpers with potent antimalarial activity against a multidrug resistant Plasmodium falciparum strain. J Ethnopharmacol (2013) 0.90
Phytochemical and biological activity studies of the Bhutanese medicinal plant Corydalis crispa. Nat Prod Commun (2012) 0.88
Antimalarial alkaloids from a Bhutanese traditional medicinal plant Corydalis dubia. J Ethnopharmacol (2012) 0.88
Antiplasmodial agents from the Bhutanese medicinal plant Corydalis calliantha. Phytother Res (2010) 0.88
Characterization of Plasmodium falciparum serine hydroxymethyltransferase-A potential antimalarial target. Mol Biochem Parasitol (2009) 0.88
Antiplasmodial activity of atisinium chloride from the Bhutanese medicinal plant, Aconitum orochryseum. J Ethnopharmacol (2010) 0.88
Mutational analysis of Plasmodium falciparum dihydrofolate reductase: the role of aspartate 54 and phenylalanine 223 on catalytic activity and antifolate binding. Mol Biochem Parasitol (2002) 0.87
Serine hydroxymethyltransferase from Plasmodium vivax is different in substrate specificity from its homologues. FEBS J (2009) 0.87
Exploiting structural analysis, in silico screening, and serendipity to identify novel inhibitors of drug-resistant falciparum malaria. ACS Chem Biol (2009) 0.86
Conflicting requirements of Plasmodium falciparum dihydrofolate reductase mutations conferring resistance to pyrimethamine-WR99210 combination. Antimicrob Agents Chemother (2007) 0.86
Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate. Antimicrob Agents Chemother (2010) 0.85
Evaluation of the activities of pyrimethamine analogs against Plasmodium vivax and Plasmodium falciparum dihydrofolate reductase-thymidylate synthase using in vitro enzyme inhibition and bacterial complementation assays. Antimicrob Agents Chemother (2006) 0.85
Carbonic anhydrase inhibitors. Inhibition of Plasmodium falciparum carbonic anhydrase with aromatic sulfonamides: towards antimalarials with a novel mechanism of action? Bioorg Med Chem (2005) 0.85
Plasmodium serine hydroxymethyltransferase: indispensability and display of distinct localization. Malar J (2012) 0.84
Plasmodium serine hydroxymethyltransferase as a potential anti-malarial target: inhibition studies using improved methods for enzyme production and assay. Malar J (2012) 0.84
Cloning and heterologous expression of Plasmodium ovale dihydrofolate reductase-thymidylate synthase gene. Parasitol Int (2012) 0.83
Artemisinin effectiveness in erythrocytes is reduced by heme and heme-containing proteins. Biochem Pharmacol (2007) 0.83
Effect of N-terminal truncation of Plasmodium falciparum dihydrofolate reductase on dihydrofolate reductase and thymidylate synthase activity. Mol Biochem Parasitol (2003) 0.82
Combined spatial limitation around residues 16 and 108 of Plasmodium falciparum dihydrofolate reductase explains resistance to cycloguanil. Antimicrob Agents Chemother (2012) 0.81
Trypanosomal dihydrofolate reductase reveals natural antifolate resistance. ACS Chem Biol (2011) 0.81
Characterization of human malaria parasite Plasmodium falciparum eIF4E homologue and mRNA 5' cap status. Mol Biochem Parasitol (2007) 0.81
Formation of catalytically active cross-species heterodimers of thymidylate synthase from Plasmodium falciparum and Plasmodium vivax. Mol Biol Rep (2010) 0.81
Distinct biochemical properties of human serine hydroxymethyltransferase compared with the Plasmodium enzyme: implications for selective inhibition. FEBS J (2014) 0.80
The role of tryptophan-48 in catalysis and binding of inhibitors of Plasmodium falciparum dihydrofolate reductase. Int J Parasitol (2007) 0.80
DNA hybridization enhancement using piezoelectric microagitation through a liquid coupling medium. Lab Chip (2011) 0.79
Interactions between cycloguanil derivatives and wild type and resistance-associated mutant Plasmodium falciparum dihydrofolate reductases. J Comput Aided Mol Des (2009) 0.79
Molecular characterization of Plasmodium falciparum uracil-DNA glycosylase and its potential as a new anti-malarial drug target. Malar J (2014) 0.79
Transgenic Plasmodium parasites stably expressing Plasmodium vivax dihydrofolate reductase-thymidylate synthase as in vitro and in vivo models for antifolate screening. Malar J (2011) 0.79
Flow cytometric enumeration of Plasmodium berghei-infected red blood cells stained with SYBR Green I. Acta Trop (2011) 0.79
Expression of a secretory α-glucosidase II from Apis cerana indica in Pichia pastoris and its characterization. BMC Biotechnol (2013) 0.77
Global gene expression profiling of Plasmodium falciparum in response to the anti-malarial drug pyronaridine. Malar J (2011) 0.77
Immobilization of malarial (Plasmodium falciparum) dihydrofolate reductase for the selection of tight-binding inhibitors from combinatorial library. Anal Chem (2007) 0.77
Particular interaction between pyrimethamine derivatives and quadruple mutant type dihydrofolate reductase of Plasmodium falciparum: CoMFA and quantum chemical calculations studies. J Enzyme Inhib Med Chem (2009) 0.77
Subunit complementation of thymidylate synthase in Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase. Mol Biochem Parasitol (2005) 0.77
Cytotoxic and Antimalarial Alkaloids from the Twigs of Dasymaschalon obtusipetalum. Nat Prod Commun (2015) 0.77
Improved Synthesis of the Boc and Fmoc Derivatives of 4-(2'-Aminoethyl)-6-dibenzofuranpropionic Acid: An Unnatural Amino Acid That Nucleates beta-Sheet Folding. J Org Chem (1997) 0.76
Synthesis of solution-phase combinatorial library of 4,6-diamino-1,2-dihydro-1,3,5-triazine and identification of new leads against A16V+S108T mutant dihydrofolate reductase of Plasmodium falciparum. Bioorg Med Chem (2003) 0.76
Selection of drug resistant mutants from random library of Plasmodium falciparum dihydrofolate reductase in Plasmodium berghei model. Malar J (2011) 0.76
Molecular dynamics of interactions between rigid and flexible antifolates and dihydrofolate reductase from pyrimethamine-sensitive and pyrimethamine-resistant Plasmodium falciparum. Chem Biol Drug Des (2014) 0.75
Enhancement of DNA hybridization under acoustic streaming with three-piezoelectric-transducer system. Lab Chip (2011) 0.75
Evaluation of antimycobacterial, antiplasmodial and cytotoxic activities of preussomerins isolated from the lichenicolous fungus Microsphaeropsis sp. BCC 3050. Planta Med (2002) 0.75
Small-scale in vitro culture and purification of Plasmodium berghei for transfection experiment. Mol Biochem Parasitol (2011) 0.75