Published in EMBO Rep on July 06, 2007
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PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin. J Biol Chem (2002) 1.71
Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation. J Biol Chem (2007) 1.71
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Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1. EMBO J (2002) 1.57
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Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD). J Biol Chem (2002) 1.45
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Differential effects of Parkinson's disease-associated mutations on stability and folding of DJ-1. J Biol Chem (2003) 1.45
Secretion of the Notch-1 Abeta-like peptide during Notch signaling. J Biol Chem (2006) 1.44
Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation. Proc Natl Acad Sci U S A (2002) 1.44
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Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane. J Cell Biol (2002) 1.42
Identification of distinct gamma-secretase complexes with different APH-1 variants. J Biol Chem (2004) 1.40
Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase. J Neurochem (2013) 1.40
The N-terminus of the intrinsically disordered protein α-synuclein triggers membrane binding and helix folding. Biophys J (2010) 1.39
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Expression of the Alzheimer protease BACE1 is suppressed via its 5'-untranslated region. EMBO Rep (2004) 1.27
Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase. J Biol Chem (2007) 1.27
The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity. EMBO J (2004) 1.26
Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex. J Biol Chem (2004) 1.26
Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases. Trends Cell Biol (2002) 1.26
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Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase. J Neurosci (2011) 1.26
Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes. Neurobiol Dis (2007) 1.25
Distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors. J Biol Chem (2005) 1.25
Novel γ-secretase enzyme modulators directly target presenilin protein. J Biol Chem (2011) 1.24
Assembly, trafficking and function of gamma-secretase. Neurodegener Dis (2006) 1.22