| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
TGR5-mediated bile acid sensing controls glucose homeostasis.
|
Cell Metab
|
2009
|
6.91
|
|
2
|
TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading.
|
Cell Metab
|
2011
|
2.17
|
|
3
|
Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies.
|
J Med Chem
|
2008
|
1.85
|
|
4
|
Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity.
|
J Med Chem
|
2009
|
1.29
|
|
5
|
Nongenomic actions of bile acids. Synthesis and preliminary characterization of 23- and 6,23-alkyl-substituted bile acid derivatives as selective modulators for the G-protein coupled receptor TGR5.
|
J Med Chem
|
2007
|
1.28
|
|
6
|
The farnesoid X receptor promotes adipocyte differentiation and regulates adipose cell function in vivo.
|
Mol Pharmacol
|
2006
|
1.20
|
|
7
|
Molecular field analysis and 3D-quantitative structure-activity relationship study (MFA 3D-QSAR) unveil novel features of bile acid recognition at TGR5.
|
J Chem Inf Model
|
2008
|
1.01
|
|
8
|
Bile acid derivatives as ligands of the farnesoid X receptor. Synthesis, evaluation, and structure-activity relationship of a series of body and side chain modified analogues of chenodeoxycholic acid.
|
J Med Chem
|
2004
|
0.95
|
|
9
|
Back door modulation of the farnesoid X receptor: design, synthesis, and biological evaluation of a series of side chain modified chenodeoxycholic acid derivatives.
|
J Med Chem
|
2006
|
0.83
|
|
10
|
Molecular dynamics simulation of the ligand binding domain of farnesoid X receptor. Insights into helix-12 stability and coactivator peptide stabilization in response to agonist binding.
|
J Med Chem
|
2005
|
0.80
|
|
11
|
Continuous flow synthesis and scale-up of glycine- and taurine-conjugated bile salts.
|
Org Biomol Chem
|
2012
|
0.78
|
|
12
|
Beyond bile acids: targeting Farnesoid X Receptor (FXR) with natural and synthetic ligands.
|
Curr Top Med Chem
|
2014
|
0.78
|
|
13
|
Determination of bile salt critical micellization concentration on the road to drug discovery.
|
J Pharm Biomed Anal
|
2013
|
0.78
|
|
14
|
Bile acid derivatives as ligands of the farnesoid x receptor: molecular determinants for bile acid binding and receptor modulation.
|
Curr Top Med Chem
|
2014
|
0.77
|
|
15
|
Correlation between CMC and chromatographic index: simple and effective evaluation of the hydrophobic/hydrophilic balance of bile acids.
|
Anal Bioanal Chem
|
2007
|
0.76
|
|
16
|
Synthesis and quantitative structure-property relationships of side chain-modified hyodeoxycholic acid derivatives.
|
Molecules
|
2013
|
0.76
|
|
17
|
First general approach to cyclohex-3-ene-1,1-bis(phosphonates) by Diels-Alder cycloaddition of tetraethyl vinylidenebis(phosphonate) to 1,3-dienes.
|
J Org Chem
|
2003
|
0.75
|
|
18
|
Derived chromatographic indices as effective tools to study the self-aggregation process of bile acids.
|
J Pharm Biomed Anal
|
2008
|
0.75
|
|
19
|
Glucuronidation of bile acids under flow conditions: design of experiments and Koenigs-Knorr reaction optimization.
|
Org Biomol Chem
|
2014
|
0.75
|
|
20
|
Synthesis and structure-activity relationships of amino acid conjugates of cholanic acid as antagonists of the EphA2 receptor.
|
Molecules
|
2013
|
0.75
|
|
21
|
Side-chain modified bile acids: chromatographic separation of 23-methyl epimers.
|
J Sep Sci
|
2009
|
0.75
|
|
22
|
Fast chromatographic determination of the bile salt critical micellar concentration.
|
Anal Bioanal Chem
|
2011
|
0.75
|
|
23
|
HPLC/ELSD analysis of amidated bile acids: an effective and rapid way to assist continuous flow chemistry processes.
|
Talanta
|
2012
|
0.75
|