Role of MyD88 and TLR9 in the innate immune response elicited by serotype 5 adenoviral vectors.

PubWeight™: 1.13‹?› | Rank: Top 10%

🔗 View Article (PMID 17685831)

Published in Hum Gene Ther on August 01, 2007

Authors

Tomoko Yamaguchi1, Kenji Kawabata, Naoya Koizumi, Fuminori Sakurai, Kazuko Nakashima, Haruna Sakurai, Tomomi Sasaki, Naoki Okada, Koichi Yamanishi, Hiroyuki Mizuguchi

Author Affiliations

1: Laboratory of Gene Transfer and Regulation, National Institute of Biomedical Innovation, Osaka 567-0085, Japan.

Articles citing this

Animal models of acute lung injury. Am J Physiol Lung Cell Mol Physiol (2008) 6.10

Respiratory viral infections in infants: causes, clinical symptoms, virology, and immunology. Clin Microbiol Rev (2010) 3.31

The airway epithelium: soldier in the fight against respiratory viruses. Clin Microbiol Rev (2011) 2.05

Progress and prospects: immune responses to viral vectors. Gene Ther (2009) 2.05

New insights on adenovirus as vaccine vectors. Mol Ther (2009) 1.90

Single-dose mucosal immunization with a candidate universal influenza vaccine provides rapid protection from virulent H5N1, H3N2 and H1N1 viruses. PLoS One (2010) 1.64

Multiple innate immune pathways contribute to the immunogenicity of recombinant adenovirus vaccine vectors. J Virol (2010) 1.11

Adenovirus type 5 rupture of lysosomes leads to cathepsin B-dependent mitochondrial stress and production of reactive oxygen species. J Virol (2011) 1.10

Engineering dendritic cells to enhance cancer immunotherapy. Mol Ther (2011) 1.10

Production of adenovirus vectors and their use as a delivery system for influenza vaccines. Expert Opin Biol Ther (2010) 1.01

In vivo reduction or blockade of interleukin-1β in primary osteoarthritis influences expression of mediators implicated in pathogenesis. Osteoarthritis Cartilage (2012) 0.97

Induction of type I interferon by adenovirus-encoded small RNAs. Proc Natl Acad Sci U S A (2010) 0.95

TRIF, and TRIF-interacting TLRs differentially modulate several adenovirus vector-induced immune responses. J Innate Immun (2009) 0.95

GammadeltaT cells initiate acute inflammation and injury in adenovirus-infected liver via cytokine-chemokine cross talk. J Virol (2008) 0.90

MyD88-dependent silencing of transgene expression during the innate and adaptive immune response to helper-dependent adenovirus. Hum Gene Ther (2010) 0.88

NOD2 signaling contributes to the innate immune response against helper-dependent adenovirus vectors independently of MyD88 in vivo. Hum Gene Ther (2011) 0.87

Delivery route, MyD88 signaling and cross-priming events determine the anti-tumor efficacy of an adenovirus based melanoma vaccine. Vaccine (2011) 0.87

Timely synthesis of the adenovirus type 5 E1B 55-kilodalton protein is required for efficient genome replication in normal human cells. J Virol (2012) 0.83

Enhancement of cytotoxic T-lymphocyte response in aged mice by a novel treatment with recombinant AdIL-12 and wild-type adenovirus in rapid succession. Mol Ther (2008) 0.80

Adenovirus-triggered innate signalling pathways. Eur J Microbiol Immunol (Bp) (2011) 0.79

The adenovirus genome contributes to the structural stability of the virion. Viruses (2014) 0.79

Circumventing antivector immunity: potential use of nonhuman adenoviral vectors. Hum Gene Ther (2014) 0.79

The early activation of CD8+ T cells is dependent on type I IFN signaling following intramuscular vaccination of adenovirus vector. Biomed Res Int (2014) 0.78

Adenovirus as a new agent for multiple myeloma therapies: Opportunities and restrictions. Korean J Hematol (2011) 0.78

Innate functions of immunoglobulin M lessen liver gene transfer with helper-dependent adenovirus. PLoS One (2014) 0.78

Adenoviral vector expressing murine β-defensin 2 enhances immunogenicity of an adenoviral vector based H5N1 influenza vaccine in aged mice. Virus Res (2013) 0.77

Superoxide dismutase 3 limits collagen-induced arthritis in the absence of phagocyte oxidative burst. Mediators Inflamm (2012) 0.77

Adenovirus Vector-Derived VA-RNA-Mediated Innate Immune Responses. Pharmaceutics (2011) 0.76

Key Role of the Scavenger Receptor MARCO in Mediating Adenovirus Infection and Subsequent Innate Responses of Macrophages. MBio (2017) 0.75

Articles by these authors

SOCS-1 participates in negative regulation of LPS responses. Immunity (2002) 3.39

In vivo imaging of lymph node metastasis with telomerase-specific replication-selective adenovirus. Nat Med (2006) 2.27

A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model. Blood (2009) 2.25

Long-term hematopoietic stem cells require stromal cell-derived factor-1 for colonizing bone marrow during ontogeny. Immunity (2003) 2.10

Comparison of the complete DNA sequences of the Oka varicella vaccine and its parental virus. J Virol (2002) 2.05

Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity. Science (2006) 2.02

A novel PPAR gamma gene therapy to control inflammation associated with inflammatory bowel disease in a murine model. Gastroenterology (2003) 1.91

Autoinhibitory regulation of p73 by Delta Np73 to modulate cell survival and death through a p73-specific target element within the Delta Np73 promoter. Mol Cell Biol (2002) 1.72

Functional SNPs in the distal promoter of the ST2 gene are associated with atopic dermatitis. Hum Mol Genet (2005) 1.70

Efficient generation of functional hepatocytes from human embryonic stem cells and induced pluripotent stem cells by HNF4α transduction. Mol Ther (2011) 1.61

Comparison of varicella-zoster virus-specific immunity of patients with diabetes mellitus and healthy individuals. J Infect Dis (2009) 1.60

A novel murine model of Graves' hyperthyroidism with intramuscular injection of adenovirus expressing the thyrotropin receptor. J Immunol (2002) 1.59

The molecular epidemiology of varicella-zoster virus: evidence for geographic segregation. J Infect Dis (2002) 1.58

A role of CXC chemokine ligand 12/stromal cell-derived factor-1/pre-B cell growth stimulating factor and its receptor CXCR4 in fetal and adult T cell development in vivo. J Immunol (2003) 1.52

Human herpesvirus 6B infection of the large intestine of patients with diarrhea. Clin Infect Dis (2002) 1.40

Antibody-targeted cell fusion. Nat Biotechnol (2004) 1.39

Discovery of a second form of tripartite complex containing gH-gL of human herpesvirus 6 and observations on CD46. J Virol (2004) 1.37

Human herpesvirus 6 (HHV-6) is transmitted from parent to child in an integrated form and characterization of cases with chromosomally integrated HHV-6 DNA. J Med Virol (2004) 1.36

A simple biological imaging system for detecting viable human circulating tumor cells. J Clin Invest (2009) 1.36

Targeted delivery of CX3CL1 to multiple lung tumors by mesenchymal stem cells. Stem Cells (2007) 1.35

Accumulation of heterochromatin components on the terminal repeat sequence of Kaposi's sarcoma-associated herpesvirus mediated by the latency-associated nuclear antigen. J Virol (2004) 1.34

Human herpesvirus 6 variant A glycoprotein H-glycoprotein L-glycoprotein Q complex associates with human CD46. J Virol (2003) 1.34

Classification of HHV-6A and HHV-6B as distinct viruses. Arch Virol (2013) 1.33

Human herpesvirus 6 variant A but not variant B induces fusion from without in a variety of human cells through a human herpesvirus 6 entry receptor, CD46. J Virol (2002) 1.31

Human herpesvirus-6 induces MVB formation, and virus egress occurs by an exosomal release pathway. Traffic (2008) 1.31

Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction. J Hepatol (2012) 1.28

Perivascular epithelioid cell tumor of the jejunum. Pathol Res Pract (2003) 1.27

Cloning of the varicella-zoster virus genome as an infectious bacterial artificial chromosome in Escherichia coli. Vaccine (2004) 1.27

Functional polymorphism in the suppressor of cytokine signaling 1 gene associated with adult asthma. Am J Respir Cell Mol Biol (2006) 1.23

Quantitative comparison of intracellular trafficking and nuclear transcription between adenoviral and lipoplex systems. Mol Ther (2005) 1.23

Comparison of the efficiency and safety of non-viral vector-mediated gene transfer into a wide range of human cells. Biol Pharm Bull (2002) 1.22

The effect of surface modification of amorphous silica particles on NLRP3 inflammasome mediated IL-1beta production, ROS production and endosomal rupture. Biomaterials (2010) 1.21

Intracellular processing of human herpesvirus 6 glycoproteins Q1 and Q2 into tetrameric complexes expressed on the viral envelope. J Virol (2004) 1.20

Activation of LDL receptor expression by small RNAs complementary to a noncoding transcript that overlaps the LDLR promoter. Chem Biol (2010) 1.20

3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing. Biomaterials (2012) 1.19

Chitosan capsules for colon-specific drug delivery: enhanced localization of 5-aminosalicylic acid in the large intestine accelerates healing of TNBS-induced colitis in rats. J Control Release (2002) 1.18

High incidence of human herpesvirus 6 infection with a high viral load in cord blood stem cell transplant recipients. Blood (2002) 1.17

Modified adenoviral vectors ablated for coxsackievirus-adenovirus receptor, alphav integrin, and heparan sulfate binding reduce in vivo tissue transduction and toxicity. Hum Gene Ther (2006) 1.16

Characterization of in vitro and in vivo gene transfer properties of adenovirus serotype 35 vector. Mol Ther (2003) 1.14

Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma. Hum Genet (2005) 1.14

miR-122a-regulated expression of a suicide gene prevents hepatotoxicity without altering antitumor effects in suicide gene therapy. Mol Ther (2008) 1.13

Efficient generation of hepatoblasts from human ES cells and iPS cells by transient overexpression of homeobox gene HEX. Mol Ther (2010) 1.13

Efficient adipocyte and osteoblast differentiation from mouse induced pluripotent stem cells by adenoviral transduction. Stem Cells (2009) 1.12

Innate immune response induced by gene delivery vectors. Int J Pharm (2007) 1.11

A novel strategy for the enhancement of drug absorption using a claudin modulator. Mol Pharmacol (2004) 1.11

Long-term self-renewal of human ES/iPS-derived hepatoblast-like cells on human laminin 111-coated dishes. Stem Cell Reports (2013) 1.10

Fiber-modified adenovirus vectors decrease liver toxicity through reduced IL-6 production. J Immunol (2007) 1.10

Regulation of nuclear import/export of carbohydrate response element-binding protein (ChREBP): interaction of an alpha-helix of ChREBP with the 14-3-3 proteins and regulation by phosphorylation. J Biol Chem (2008) 1.09

The human herpesvirus 6 U100 gene product is the third component of the gH-gL glycoprotein complex on the viral envelope. J Virol (2003) 1.08

Enhanced oncolysis by a tropism-modified telomerase-specific replication-selective adenoviral agent OBP-405 ('Telomelysin-RGD'). Oncogene (2005) 1.08

Activation of human mast cells through the platelet-activating factor receptor. J Allergy Clin Immunol (2010) 1.08

Prevention of autoantibody-mediated Graves'-like hyperthyroidism in mice with IL-4, a Th2 cytokine. J Immunol (2003) 1.07

RNA interfering approach for clarifying the PPARgamma pathway using lentiviral vector expressing short hairpin RNA. FEBS Lett (2004) 1.07

Activation of human herpesvirus 8 open reading frame K5 independent of ORF50 expression. Virus Res (2002) 1.07

Human herpesvirus-6 rep/U94 gene product has single-stranded DNA-binding activity. J Gen Virol (2002) 1.07

Human herpesvirus 6 encoded glycoprotein Q1 gene is essential for virus growth. Virology (2010) 1.07

NF-κB activity regulates mesenchymal stem cell accumulation at tumor sites. Cancer Res (2012) 1.06

Simultaneous real-time detection of initiator- and effector-caspase activation by double fluorescence resonance energy transfer analysis. J Pharmacol Sci (2005) 1.06

Domain mapping of a claudin-4 modulator, the C-terminal region of C-terminal fragment of Clostridium perfringens enterotoxin, by site-directed mutagenesis. Biochem Pharmacol (2008) 1.05

Poly(ADP-ribose) polymerase 1 binds to Kaposi's sarcoma-associated herpesvirus (KSHV) terminal repeat sequence and modulates KSHV replication in latency. J Virol (2004) 1.05

Titanium dioxide induces different levels of IL-1beta production dependent on its particle characteristics through caspase-1 activation mediated by reactive oxygen species and cathepsin B. Biochem Biophys Res Commun (2010) 1.05

Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) replication and transcription factor activates the K9 (vIRF) gene through two distinct cis elements by a non-DNA-binding mechanism. J Virol (2002) 1.05

CD134 is a cellular receptor specific for human herpesvirus-6B entry. Proc Natl Acad Sci U S A (2013) 1.04

Adenovirus type 5 with modified hexons induces robust transgene-specific immune responses in mice with pre-existing immunity against adenovirus type 5. J Gene Med (2009) 1.04

Generation of fiber-modified adenovirus vectors containing heterologous peptides in both the HI loop and C terminus of the fiber knob. J Gene Med (2003) 1.04

Postinfarction treatment with an adenoviral vector expressing hepatocyte growth factor relieves chronic left ventricular remodeling and dysfunction in mice. Circulation (2003) 1.03

Efficient gene transfer into mouse embryonic stem cells with adenovirus vectors. Mol Ther (2005) 1.03

Association between IFNA genotype and the risk of sarcoidosis. Hum Genet (2004) 1.03

Development of PEGylated adenovirus vector with targeting ligand. Int J Pharm (2007) 1.02

Role of tyrosine residues in modulation of claudin-4 by the C-terminal fragment of Clostridium perfringens enterotoxin. Biochem Pharmacol (2006) 1.02

Comparison of virus transcription during lytic infection of the Oka parental and vaccine strains of Varicella-Zoster virus. J Virol (2006) 1.01

Reduction of natural adenovirus tropism to mouse liver by fiber-shaft exchange in combination with both CAR- and alphav integrin-binding ablation. J Virol (2003) 1.01

Expression of coxsackie and adenovirus receptor reduces the lung metastatic potential of murine tumor cells. Int J Cancer (2007) 1.00